Published in Methods Mol Biol on January 01, 2008
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature (2011) 5.28
Retroviral intasome assembly and inhibition of DNA strand transfer. Nature (2010) 4.99
Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol (2009) 3.11
The minimum crystal size needed for a complete diffraction data set. Acta Crystallogr D Biol Crystallogr (2010) 2.94
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol (2011) 2.42
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A (2010) 2.16
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. J Exp Med (2013) 2.04
Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol (2009) 1.98
A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity (2011) 1.94
High-resolution structure of the rotor ring of a proton-dependent ATP synthase. Nat Struct Mol Biol (2009) 1.80
T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature (2014) 1.76
Self-assembly of spider silk proteins is controlled by a pH-sensitive relay. Nature (2010) 1.68
Protein structure determination by exhaustive search of Protein Data Bank derived databases. Proc Natl Acad Sci U S A (2010) 1.66
3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases. EMBO J (2009) 1.56
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell (2008) 1.51
3'-processing and strand transfer catalysed by retroviral integrase in crystallo. EMBO J (2012) 1.49
Discovery of new enzymes and metabolic pathways by using structure and genome context. Nature (2013) 1.46
High-throughput crystallography for structural genomics. Curr Opin Struct Biol (2009) 1.44
A new type of proton coordination in an F(1)F(o)-ATP synthase rotor ring. PLoS Biol (2010) 1.43
Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat Struct Mol Biol (2017) 1.40
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature (2010) 1.35
Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature (2013) 1.34
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat Chem Biol (2013) 1.28
THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. Nat Struct Mol Biol (2009) 1.27
The structure and function of an arabinan-specific alpha-1,2-arabinofuranosidase identified from screening the activities of bacterial GH43 glycoside hydrolases. J Biol Chem (2011) 1.25
The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry (2009) 1.25
Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein. PLoS Pathog (2011) 1.24
Crystal structure of Escherichia coli CusC, the outer membrane component of a heavy metal efflux pump. PLoS One (2011) 1.21
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chem Biol (2009) 1.20
Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol Cell (2016) 1.19
Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase. PLoS One (2010) 1.17
Identification and structural analysis of type I collagen sites in complex with fibronectin fragments. Proc Natl Acad Sci U S A (2009) 1.17
Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One (2011) 1.14
Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases. J Mol Biol (2010) 1.14
Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda. PLoS One (2010) 1.14
Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem Biol (2010) 1.14
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nat Struct Mol Biol (2011) 1.12
Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding. Nat Struct Mol Biol (2010) 1.08
Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. Bioorg Med Chem (2010) 1.08
Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation. J Biol Chem (2010) 1.07
Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol (2013) 1.07
Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases. Nucleic Acids Res (2013) 1.06
Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. FASEB J (2012) 1.06
Structural basis of GDP release and gating in G protein coupled Fe2+ transport. EMBO J (2009) 1.05
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling. PLoS One (2012) 1.05
Molecular and structural insight into proNGF engagement of p75NTR and sortilin. J Mol Biol (2009) 1.05
Structural analysis of bacteriophage T4 DNA replication: a review in the Virology Journal series on bacteriophage T4 and its relatives. Virol J (2010) 1.03
Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. J Biol Chem (2011) 1.03
A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Structure (2009) 1.03
Structure of monoubiquitinated PCNA: implications for DNA polymerase switching and Okazaki fragment maturation. Cell Cycle (2012) 1.03
Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex. Nucleic Acids Res (2011) 1.02
Conformation-dependent backbone geometry restraints set a new standard for protein crystallographic refinement. FEBS J (2014) 1.01
A conserved asparagine has a structural role in ubiquitin-conjugating enzymes. Nat Chem Biol (2013) 1.01
The structure of human 15-lipoxygenase-2 with a substrate mimic. J Biol Chem (2014) 1.01
The structure of the proline utilization a proline dehydrogenase domain inactivated by N-propargylglycine provides insight into conformational changes induced by substrate binding and flavin reduction. Biochemistry (2010) 1.00
Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nat Struct Mol Biol (2013) 1.00
NKT TCR recognition of CD1d-α-C-galactosylceramide. J Immunol (2011) 0.99
High-resolution structure and mechanism of an F/V-hybrid rotor ring in a Na⁺-coupled ATP synthase. Nat Commun (2014) 0.99
A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog (2013) 0.99
Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks. Elife (2014) 0.98
A novel dimerization motif in the C-terminal domain of the Thermus thermophilus DEAD box helicase Hera confers substantial flexibility. Nucleic Acids Res (2008) 0.98
Structure of a longitudinal actin dimer assembled by tandem w domains: implications for actin filament nucleation. J Mol Biol (2010) 0.98
Multidomain Carbohydrate-binding Proteins Involved in Bacteroides thetaiotaomicron Starch Metabolism. J Biol Chem (2012) 0.98
Probing the specificity determinants of amino acid recognition by arginase. Biochemistry (2009) 0.97
Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Science (2014) 0.97
Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif . Biochemistry (2009) 0.97
Portrait of an enzyme, a complete structural analysis of a multimodular {beta}-N-acetylglucosaminidase from Clostridium perfringens. J Biol Chem (2009) 0.96
Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus. J Biol Chem (2012) 0.95
Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity. Allergy (2011) 0.95
Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors. Proc Natl Acad Sci U S A (2014) 0.95
Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline. Sci Adv (2015) 0.95
Yersinia effector YopO uses actin as bait to phosphorylate proteins that regulate actin polymerization. Nat Struct Mol Biol (2015) 0.95
Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. Nucleic Acids Res (2010) 0.95
The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold. Structure (2014) 0.95
A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem (2010) 0.94
Der p 5 crystal structure provides insight into the group 5 dust mite allergens. J Biol Chem (2010) 0.94
Sustained active site rigidity during synthesis by human DNA polymerase μ. Nat Struct Mol Biol (2014) 0.93
The crystal structure of OprG from Pseudomonas aeruginosa, a potential channel for transport of hydrophobic molecules across the outer membrane. PLoS One (2010) 0.93
Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol (2012) 0.92
Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family. Proteins (2010) 0.92
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. Structure (2015) 0.92
Structure-function study of the N-terminal domain of exocyst subunit Sec3. J Biol Chem (2010) 0.92
Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors. PLoS One (2014) 0.91
Crystal structure of elongator subcomplex Elp4-6. J Biol Chem (2012) 0.91
Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J Mol Biol (2011) 0.91
Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc Natl Acad Sci U S A (2013) 0.91
Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis. J Biol Chem (2009) 0.90
Specialized peptidoglycan hydrolases sculpt the intra-bacterial niche of predatory Bdellovibrio and increase population fitness. PLoS Pathog (2012) 0.90
A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid. PLoS Pathog (2013) 0.90
Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis. Mol Cell (2013) 0.89
Implications for collagen binding from the crystallographic structure of fibronectin 6FnI1-2FnII7FnI. J Biol Chem (2010) 0.89
Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB. J Biol Chem (2013) 0.88
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nat Struct Mol Biol (2010) 0.88
Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex. J Biol Chem (2012) 0.88
Structural analysis of collagen type I interactions with human fibronectin reveals a cooperative binding mode. J Biol Chem (2013) 0.88
Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. J Mol Biol (2010) 0.88
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. Acta Crystallogr D Biol Crystallogr (2012) 0.88
The c-ring ion binding site of the ATP synthase from Bacillus pseudofirmus OF4 is adapted to alkaliphilic lifestyle. Mol Microbiol (2014) 0.87
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55
PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr (2002) 53.61
Likelihood-enhanced fast translation functions. Acta Crystallogr D Biol Crystallogr (2005) 29.38
Likelihood-enhanced fast rotation functions. Acta Crystallogr D Biol Crystallogr (2004) 23.86
Towards automated crystallographic structure refinement with phenix.refine. Acta Crystallogr D Biol Crystallogr (2012) 11.31
Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines. J Synchrotron Radiat (2002) 9.48
Engineering and characterization of a superfolder green fluorescent protein. Nat Biotechnol (2005) 9.17
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard. Acta Crystallogr D Biol Crystallogr (2007) 7.72
High-resolution structure prediction and the crystallographic phase problem. Nature (2007) 7.67
Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard. Acta Crystallogr D Biol Crystallogr (2009) 6.47
Recent developments in the PHENIX software for automated crystallographic structure determination. J Synchrotron Radiat (2003) 6.28
Structural basis for double-stranded RNA processing by Dicer. Science (2006) 5.86
Simple algorithm for a maximum-likelihood SAD function. Acta Crystallogr D Biol Crystallogr (2004) 5.77
Molecular architecture and functional model of the endocytic AP2 complex. Cell (2002) 5.44
The application of multivariate statistical techniques improves single-wavelength anomalous diffraction phasing. Acta Crystallogr D Biol Crystallogr (2003) 5.16
Automated ligand fitting by core-fragment fitting and extension into density. Acta Crystallogr D Biol Crystallogr (2006) 5.03
electronic Ligand Builder and Optimization Workbench (eLBOW): a tool for ligand coordinate and restraint generation. Acta Crystallogr D Biol Crystallogr (2009) 4.90
A robust bulk-solvent correction and anisotropic scaling procedure. Acta Crystallogr D Biol Crystallogr (2005) 4.82
SPARX, a new environment for Cryo-EM image processing. J Struct Biol (2006) 4.66
Surprises and pitfalls arising from (pseudo)symmetry. Acta Crystallogr D Biol Crystallogr (2007) 4.44
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nat Genet (2011) 4.19
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog (2011) 4.10
Recent developments in phasing and structure refinement for macromolecular crystallography. Curr Opin Struct Biol (2009) 4.09
Protein production and purification. Nat Methods (2008) 3.97
The Phenix software for automated determination of macromolecular structures. Methods (2011) 3.81
Generalized X-ray and neutron crystallographic analysis: more accurate and complete structures for biological macromolecules. Acta Crystallogr D Biol Crystallogr (2009) 3.69
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. PLoS One (2009) 3.68
Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein. Nat Biotechnol (2004) 3.68
Averaged kick maps: less noise, more signal... and probably less bias. Acta Crystallogr D Biol Crystallogr (2009) 3.62
Simultaneous femtosecond X-ray spectroscopy and diffraction of photosystem II at room temperature. Science (2013) 3.60
Robust indexing for automatic data collection. J Appl Crystallogr (2004) 3.51
A new generation of crystallographic validation tools for the protein data bank. Structure (2011) 3.41
Automated server predictions in CASP7. Proteins (2007) 3.40
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator. Nat Chem Biol (2006) 3.30
Crystallographic model quality at a glance. Acta Crystallogr D Biol Crystallogr (2009) 3.11
Iterative-build OMIT maps: map improvement by iterative model building and refinement without model bias. Acta Crystallogr D Biol Crystallogr (2008) 3.07