Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.

PubWeight™: 2.44‹?› | Rank: Top 2%

🔗 View Article (PMC 2430499)

Published in J Clin Invest on July 01, 2008

Authors

Michael Rosenbaum1, Melissa Sy, Katherine Pavlovich, Rudolph L Leibel, Joy Hirsch

Author Affiliations

1: Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, USA. mr475@columbia.edu

Articles citing this

(truncated to the top 100)

Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci (2010) 3.48

Neuroimaging and obesity: current knowledge and future directions. Obes Rev (2011) 2.23

Sixteen years and counting: an update on leptin in energy balance. J Clin Invest (2011) 2.21

Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. Gut (2013) 2.01

Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab (2011) 1.99

Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int J Obes (Lond) (2009) 1.84

Inflammation, a link between obesity and cardiovascular disease. Mediators Inflamm (2010) 1.80

Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73

Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Cell Metab (2012) 1.66

fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program. Neuroimage (2012) 1.63

The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm (2010) 1.59

Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J Clin Nutr (2012) 1.54

Biology's response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol (2011) 1.53

Relation of obesity to consummatory and anticipatory food reward. Physiol Behav (2009) 1.52

Genetic approaches to understanding human obesity. J Clin Invest (2011) 1.50

Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulus. Int J Obes (Lond) (2009) 1.50

Molecular physiology of weight regulation in mice and humans. Int J Obes (Lond) (2008) 1.49

Selective reduction in neural responses to high calorie foods following gastric bypass surgery. Ann Surg (2011) 1.46

The effects of overfeeding on the neuronal response to visual food cues in thin and reduced-obese individuals. PLoS One (2009) 1.46

Leptin in human physiology and therapeutics. Front Neuroendocrinol (2010) 1.46

Sex-based differences in the behavioral and neuronal responses to food. Physiol Behav (2010) 1.45

Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. J Clin Invest (2011) 1.42

Roux-en-Y gastric bypass surgery changes food reward in rats. Int J Obes (Lond) (2010) 1.41

An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol Behav (2009) 1.35

The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans. Cell Metab (2011) 1.35

Dorsal striatum and its limbic connectivity mediate abnormal anticipatory reward processing in obesity. PLoS One (2012) 1.33

Leptin signaling in brain: A link between nutrition and cognition? Biochim Biophys Acta (2008) 1.31

Food reward, hyperphagia, and obesity. Am J Physiol Regul Integr Comp Physiol (2011) 1.31

Effects of chronic weight perturbation on energy homeostasis and brain structure in mice. Am J Physiol Regul Integr Comp Physiol (2011) 1.25

Energy intake in weight-reduced humans. Brain Res (2010) 1.21

Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr (2012) 1.19

Sex differences in the physiology of eating. Am J Physiol Regul Integr Comp Physiol (2013) 1.18

Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum. J Neurosci (2010) 1.18

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism (2014) 1.18

Brain regulation of appetite and satiety. Endocrinol Metab Clin North Am (2008) 1.15

Phenotypic and genetic variation in leptin as determinants of weight regain. Int J Obes (Lond) (2010) 1.14

Modulation of the mesolimbic dopamine system by leptin. Brain Res (2010) 1.14

"Liking" and "wanting" of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition. Am J Physiol Regul Integr Comp Physiol (2011) 1.13

Changes in neurohormonal gut peptides following bariatric surgery. Int J Obes (Lond) (2010) 1.13

Neural control of energy balance: translating circuits to therapies. Cell (2015) 1.11

Obesity, leptin, and Alzheimer's disease. Ann N Y Acad Sci (2011) 1.09

Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci (2014) 1.08

Biological mechanisms that promote weight regain following weight loss in obese humans. Physiol Behav (2013) 1.06

20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol (2014) 1.05

The effects of exercise on the neuronal response to food cues. Physiol Behav (2011) 1.05

Physiological adaptations to weight loss and factors favouring weight regain. Int J Obes (Lond) (2015) 1.04

Revisiting leptin's role in obesity and weight loss. J Clin Invest (2008) 1.02

Food reward functions as affected by obesity and bariatric surgery. Int J Obes (Lond) (2011) 1.01

Contrasting effects of leptin on food anticipatory and total locomotor activity. PLoS One (2011) 1.01

Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Front Integr Neurosci (2012) 1.00

The neurohormonal regulation of energy intake in relation to bariatric surgery for obesity. Physiol Behav (2010) 1.00

Weight loss maintenance in African American women: a systematic review of the behavioral lifestyle intervention literature. J Obes (2013) 0.98

Differences in the neuronal response to food in obesity-resistant as compared to obesity-prone individuals. Physiol Behav (2013) 0.98

Regional brain response to visual food cues is a marker of satiety that predicts food choice. Am J Clin Nutr (2012) 0.97

Appetite and body weight regulation after bariatric surgery. Obes Rev (2015) 0.96

Is your brain to blame for weight regain? Physiol Behav (2011) 0.96

Short-term plasticity of gray matter associated with leptin deficiency and replacement. J Clin Endocrinol Metab (2011) 0.94

Body weight status, eating behavior, sensitivity to reward/punishment, and gender: relationships and interdependencies. Front Psychol (2014) 0.94

Brain structure predicts risk for obesity. Appetite (2012) 0.93

Effects of weight gain and weight loss on regional fat distribution. Am J Clin Nutr (2012) 0.91

Gestational diabetes mellitus and obesity. Diabetes Care (2010) 0.91

A comparison of functional brain changes associated with surgical versus behavioral weight loss. Obesity (Silver Spring) (2013) 0.91

The role of leptin in glucose homeostasis. J Diabetes Investig (2012) 0.90

Effects of chronic leptin infusion on subsequent body weight and composition in mice: Can body weight set point be reset? Mol Metab (2014) 0.89

Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues. Synapse (2012) 0.87

Functional organization of neuronal and humoral signals regulating feeding behavior. Annu Rev Nutr (2013) 0.87

Neuroimaging, gut peptides and obesity: novel studies of the neurobiology of appetite. J Neuroendocrinol (2010) 0.87

Elevated energy intake is correlated with hyperresponsivity in attentional, gustatory, and reward brain regions while anticipating palatable food receipt. Am J Clin Nutr (2013) 0.87

The effects of overfeeding and propensity to weight gain on the neuronal responses to visual food cues. Physiol Behav (2009) 0.87

New pharmacological perspectives for the leptin receptor in the treatment of obesity. Front Endocrinol (Lausanne) (2014) 0.86

Leptin regulates dopamine responses to sustained stress in humans. J Neurosci (2012) 0.86

Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity. Nutr Metab (Lond) (2011) 0.85

Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss. Int J Obes (Lond) (2014) 0.85

Repositioning leptin as a therapy for Alzheimer's disease. Therapy (2011) 0.85

Effects of reduced weight maintenance and leptin repletion on functional connectivity of the hypothalamus in obese humans. PLoS One (2013) 0.84

Altered food-cue processing in chronically ill and recovered women with anorexia nervosa. Front Behav Neurosci (2015) 0.84

Propensity to obesity impacts the neuronal response to energy imbalance. Front Behav Neurosci (2015) 0.84

Melanocortin-3 receptors and metabolic homeostasis. Prog Mol Biol Transl Sci (2013) 0.84

Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery. Ann N Y Acad Sci (2012) 0.83

Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature. Int J Obes (Lond) (2013) 0.83

Pharmacotherapy for childhood obesity: present and future prospects. Int J Obes (Lond) (2012) 0.83

Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin-sensitive subjects without altering brain structure. J Clin Endocrinol Metab (2014) 0.83

A missing link in body weight homeostasis: the catabolic signal of the overfed state. Cell Metab (2014) 0.82

Leptin applications in 2015: what have we learned about leptin and obesity? Curr Opin Endocrinol Diabetes Obes (2015) 0.82

Effects of leptin deficiency and replacement on cerebellar response to food-related cues. Cerebellum (2013) 0.81

The use of functional MRI to study appetite control in the CNS. Exp Diabetes Res (2012) 0.81

Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss. Bone (2011) 0.80

Reduction in neural activation to high-calorie food cues in obese endometrial cancer survivors after a behavioral lifestyle intervention: a pilot study. BMC Neurosci (2012) 0.80

The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste. Behav Brain Res (2014) 0.79

The effect of reboxetine co-administration with olanzapine on metabolic and endocrine profile in schizophrenia patients. Psychopharmacology (Berl) (2013) 0.79

Neural vulnerability factors that increase risk for future weight gain. Psychol Bull (2016) 0.79

Body adiposity index (BAI) correlates with BMI and body fat pre- and post-bariatric surgery but is not an adequate substitute for BMI in severely obese women. Int J Body Compos Res (2012) 0.79

Effects of insulin detemir and NPH insulin on body weight and appetite-regulating brain regions in human type 1 diabetes: a randomized controlled trial. PLoS One (2014) 0.79

Translating tDCS into the field of obesity: mechanism-driven approaches. Front Hum Neurosci (2013) 0.79

Regulation of energy balance and body weight by the brain: a distributed system prone to disruption. Psychiatr Clin North Am (2011) 0.79

Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient. PLoS One (2013) 0.78

Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention. Nutr Diabetes (2014) 0.78

Models of energy homeostasis in response to maintenance of reduced body weight. Obesity (Silver Spring) (2016) 0.78

Cerebral activations during viewing of food stimuli in adult patients with acquired structural hypothalamic damage: a functional neuroimaging study. Int J Obes (Lond) (2015) 0.78

Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice. Obesity (Silver Spring) (2014) 0.78

Articles cited by this

Prevalence of overweight and obesity in the United States, 1999-2004. JAMA (2006) 72.59

Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage (2002) 49.90

An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage (2003) 24.48

Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. Am J Clin Nutr (1998) 8.97

Role of leptin in the neuroendocrine response to fasting. Nature (1996) 8.02

Systematic review: an evaluation of major commercial weight loss programs in the United States. Ann Intern Med (2005) 8.00

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83

Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Brain Res Rev (1996) 5.78

Trophic action of leptin on hypothalamic neurons that regulate feeding. Science (2004) 5.76

Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron (2006) 5.64

Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav (2005) 3.47

Leptin regulates striatal regions and human eating behavior. Science (2007) 3.31

The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Ann N Y Acad Sci (2001) 3.14

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10

Cortical and limbic activation during viewing of high- versus low-calorie foods. Neuroimage (2003) 2.71

Neurobiology of feeding and energy expenditure. Annu Rev Neurosci (2007) 2.64

Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol (2002) 2.55

Hunger selectively modulates corticolimbic activation to food stimuli in humans. Behav Neurosci (2001) 2.49

Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol (2004) 2.44

Exposure to appetitive food stimuli markedly activates the human brain. Neuroimage (2004) 2.13

The role of rat medial frontal cortex in effort-based decision making. J Neurosci (2002) 1.91

Functions of the left superior frontal gyrus in humans: a lesion study. Brain (2006) 1.89

An integrated functional magnetic resonance imaging procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery (2000) 1.83

Functional brain correlates of response time variability in children. Neuropsychologia (2007) 1.72

Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann N Y Acad Sci (2002) 1.66

Effect of satiety on brain activation during chocolate tasting in men and women. Am J Clin Nutr (2006) 1.55

Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol (1998) 1.52

A comparative study of different means of assessing long-term energy expenditure in humans. Am J Physiol (1996) 1.52

Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol (2006) 1.51

Development of leptin-sensitive circuits. J Neuroendocrinol (2007) 1.42

Cerebral blood flow associated with creative performance: a comparative study. Neuroimage (2007) 1.26

Grounding object concepts in perception and action: evidence from fMRI studies of tools. Cortex (2007) 1.21

Hunger and satiety in anorexia nervosa: fMRI during cognitive processing of food pictures. Brain Res (2006) 1.19

Developmental changes in the functional brain responses of adolescents to images of high and low-calorie foods. Dev Psychobiol (2005) 1.18

Novel actions of leptin in the hippocampus. Ann Med (2003) 1.13

Brain pathways controlling food intake and body weight. Exp Biol Med (Maywood) (2001) 1.11

Weight loss leads to a marked decrease in nonresting energy expenditure in ambulatory human subjects. Metabolism (1988) 1.10

Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. Appetite (2005) 1.10

Functional neuroimaging of gastric distention. J Gastrointest Surg (2003) 1.09

Human cortical specialization for food: a functional magnetic resonance imaging investigation. J Nutr (2005) 1.08

Regions of the human brain affected during a liquid-meal taste perception in the fasting state: a positron emission tomography study. Am J Clin Nutr (1999) 0.96

Energy balance of rats with lateral hypothalamic lesions. Am J Physiol (1982) 0.90

Positive affect modulates activity in the visual cortex to images of high calorie foods. Int J Neurosci (2007) 0.89

Local blood flow and glucose uptake within resting and exercising rabbit skeletal muscle. Am J Physiol (1991) 0.83

Effect of leptin on the acute feeding-induced hypothalamic serotonergic stimulation in normal rats. Regul Pept (2003) 0.81

Articles by these authors

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44

Neuroimaging and disorders of consciousness: envisioning an ethical research agenda. Am J Bioeth (2008) 10.01

Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron (2006) 5.79

The long-term stability of the human gut microbiota. Science (2013) 5.15

Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information. Nat Neurosci (2005) 4.38

Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03

The dorsal medial frontal cortex is sensitive to time on task, not response conflict or error likelihood. Neuroimage (2010) 3.82

Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49

Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43

Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron (2004) 3.26

Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol (2011) 3.25

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10

Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79

Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 2.76

Dissociable neural systems resolve conflict from emotional versus nonemotional distracters. Cereb Cortex (2007) 2.54

A neural representation of categorization uncertainty in the human brain. Neuron (2006) 2.53

Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45

Predictive codes for forthcoming perception in the frontal cortex. Science (2006) 2.29

Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol (2003) 2.28

Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Am J Clin Nutr (2007) 2.21

Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr (2008) 2.13

11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med (2009) 1.99

Neural dynamics of rejection sensitivity. J Cogn Neurosci (2007) 1.98

Detection of time-varying signals in event-related fMRI designs. Neuroimage (2008) 1.94

The neural correlates and functional integration of cognitive control in a Stroop task. Neuroimage (2005) 1.91

Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87

Neocortical connectivity during episodic memory formation. PLoS Biol (2006) 1.86

Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care (2007) 1.85

Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73

Neural systems for speech and song in autism. Brain (2012) 1.70

To eat or not to eat - how the gut talks to the brain. N Engl J Med (2003) 1.68

Mindboggle: a scatterbrained approach to automate brain labeling. Neuroimage (2004) 1.64

A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55

Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J Clin Nutr (2012) 1.54

Separate conflict-specific cognitive control mechanisms in the human brain. Neuroimage (2007) 1.53

Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49

Intentional false responding shares neural substrates with response conflict and cognitive control. Neuroimage (2005) 1.48

Selective reduction in neural responses to high calorie foods following gastric bypass surgery. Ann Surg (2011) 1.46

Dietary fat is not a major determinant of body fat. Am J Med (2002) 1.46

Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.45

Neural integration of top-down spatial and feature-based information in visual search. J Neurosci (2008) 1.42

Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr (2005) 1.34

Functional specialization within the medial frontal gyrus for perceptual go/no-go decisions based on "what," "when," and "where" related information: an fMRI study. J Cogn Neurosci (2005) 1.32

Shared and separate systems in bilingual language processing: converging evidence from eyetracking and brain imaging. Brain Lang (2003) 1.31

Mindboggle: automated brain labeling with multiple atlases. BMC Med Imaging (2005) 1.28

Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab (2006) 1.27

Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26

iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23

Responsivity to food stimuli in obese and lean binge eaters using functional MRI. Appetite (2005) 1.22

Energy intake in weight-reduced humans. Brain Res (2010) 1.21

Challenges and opportunities of defining clinical leptin resistance. Cell Metab (2012) 1.21

Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr (2012) 1.19

β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes (2013) 1.19

Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.17

Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss. Metabolism (2011) 1.17

fMRI evidence for cortical modification during learning of Mandarin lexical tone. J Cogn Neurosci (2003) 1.16

Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol (2008) 1.13

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis (2008) 1.12

Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol (2009) 1.12

Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet (2008) 1.10

Human cortical specialization for food: a functional magnetic resonance imaging investigation. J Nutr (2005) 1.08

Mistaking a house for a face: neural correlates of misperception in healthy humans. Cereb Cortex (2005) 1.04

Speech stimulation during functional MR imaging as a potential indicator of autism. Radiology (2011) 1.04

Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance. Int J Body Compos Res (2009) 1.03

Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold? Prog Brain Res (2009) 1.03

Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice. Am J Physiol Regul Integr Comp Physiol (2012) 1.01

Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousness. Arch Phys Med Rehabil (2006) 1.00

Considerations regarding the genetics of obesity. Obesity (Silver Spring) (2008) 1.00

Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol (2004) 1.00

A case of locked-in syndrome complicated by central deafness. Nat Clin Pract Neurol (2008) 0.99

Brain tissue volume changes following weight gain in adults with anorexia nervosa. Int J Eat Disord (2010) 0.99

Gray matter abnormalities in social anxiety disorder: primary, replication, and specificity studies. Biol Psychiatry (2012) 0.99

Visual and tactile guidance of dexterous manipulation tasks: an fMRI study. Percept Mot Skills (2005) 0.98

Raising consciousness. J Clin Invest (2005) 0.98

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest (2002) 0.97

Effects of weight loss and leptin on skeletal muscle in human subjects. Am J Physiol Regul Integr Comp Physiol (2011) 0.97

A translational bridge between mouse and human models of learned safety. Ann Med (2010) 0.96

In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J (2009) 0.96

Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96

Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring) (2008) 0.96

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny. Obesity (Silver Spring) (2010) 0.96

Preparatory neural activity predicts performance on a conflict task. Brain Res (2007) 0.94

Repeated exposure to media violence is associated with diminished response in an inhibitory frontolimbic network. PLoS One (2007) 0.93

Roles of the placenta in fetal brain development. Proc Natl Acad Sci U S A (2011) 0.93

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93

The dynamics of deductive reasoning: an fMRI investigation. Neuropsychologia (2008) 0.93

Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest (2015) 0.93

Neural mechanisms of grief regulation. Biol Psychiatry (2009) 0.92

Reproducibility of single- and multi-voxel 1H MRS measurements of intramyocellular lipid in overweight and lean subjects under conditions of controlled dietary calorie and fat intake. NMR Biomed (2008) 0.92

Hemodynamic impairment as a stimulus for functional brain reorganization. J Cereb Blood Flow Metab (2006) 0.90

Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. Am J Clin Nutr (2009) 0.90