Published in Arthritis Rheum on July 01, 2008
Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes (2010) 1.20
Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci (2012) 1.09
FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis. Am J Pathol (2013) 1.04
Rac1 expression by fibroblasts is required for tissue repair in vivo. Am J Pathol (2009) 1.03
Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation. J Cell Commun Signal (2010) 0.96
Rac inhibition reverses the phenotype of fibrotic fibroblasts. PLoS One (2009) 0.94
Integrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts. Adv Wound Care (New Rochelle) (2013) 0.86
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. PLoS One (2015) 0.82
Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis. Respir Res (2014) 0.80
CCN2: a bona fide target for anti-fibrotic drug intervention. J Cell Commun Signal (2011) 0.78
TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells. J Cell Sci (2013) 0.78
Getting out of a sticky situation: targeting the myofibroblast in scleroderma. Open Rheumatol J (2012) 0.77
Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol (2009) 12.05
TGF-beta signaling and the fibrotic response. FASEB J (2004) 9.81
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet (2002) 7.12
A myocardial lineage derives from Tbx18 epicardial cells. Nature (2008) 6.15
2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum (2013) 5.99
All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci (2006) 5.18
Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A (2009) 3.87
A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis Rheum (2006) 3.45
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med (2008) 3.19
2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis (2013) 3.11
A polymorphism in the CTGF promoter region associated with systemic sclerosis. N Engl J Med (2007) 2.95
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. J Biol Chem (2003) 2.63
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity (2006) 2.57
Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol (2002) 2.45
Time scale and other invariants of integrative mechanical behavior in living cells. Phys Rev E Stat Nonlin Soft Matter Phys (2003) 2.42
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev (2008) 2.40
Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem (2003) 2.35
Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rheum Dis (2010) 2.30
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell (2004) 2.29
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26
Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis. Thorax (2013) 2.17
Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension. Eur Heart J (2006) 2.16
Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood (2004) 2.06
Efficacy of the specific endothelin a receptor antagonist zibotentan (ZD4054) in colorectal cancer: a preclinical study. Mol Cancer Ther (2013) 2.05
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem (2006) 1.96
Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing. J Invest Dermatol (2008) 1.92
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol (2006) 1.87
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res Ther (2005) 1.81
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genet (2011) 1.80
The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol (2003) 1.80
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int (2002) 1.77
An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor. Am J Respir Crit Care Med (2010) 1.76
Mechanisms and consequences of fibrosis in systemic sclerosis. Nat Clin Pract Rheumatol (2006) 1.73
Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. Am J Pathol (2006) 1.70
Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol (2002) 1.68
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum (2009) 1.65
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum (2010) 1.64
Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway. FASEB J (2002) 1.64
Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis. J Rheumatol (2009) 1.60
CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res (2006) 1.57
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts. Respir Res (2004) 1.55
β1 integrin-extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function. Lab Invest (2012) 1.53
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem (2004) 1.52
Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma. J Invest Dermatol (2004) 1.52
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum (2007) 1.51
Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. Ann Rheum Dis (2013) 1.51
The N. gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism. PLoS Biol (2005) 1.50
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J (2011) 1.47
CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum (2011) 1.46
Retracted GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest (2008) 1.46
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. Matrix Biol (2007) 1.46
A common cofilin activity cycle in invasive tumor cells and inflammatory cells. J Cell Sci (2009) 1.45
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum (2007) 1.45
Normal circulating serum amyloid P component concentration in systemic sclerosis. Arthritis Rheum (2007) 1.42
Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J Cell Biol (2007) 1.41
The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis. Mol Biol Cell (2014) 1.38
The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis Res Ther (2006) 1.33
Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1. Mol Cell Biol (2004) 1.32
Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep (2002) 1.31