Published in Crit Care on June 30, 2008
Guidance in sepsis management: navigating uncharted waters? Crit Care (2008) 0.82
Community-acquired pneumonia: identification and evaluation of nonresponders. Ther Adv Infect Dis (2013) 0.75
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA (2008) 6.29
Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force. Chest (2006) 4.77
Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly. N Engl J Med (2006) 2.32
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
Sepsis definitions: time for change. Lancet (2013) 5.63
No surgical innovation without evaluation: the IDEAL recommendations. Lancet (2009) 5.57
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med (2004) 4.56
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med (2004) 3.61
Evaluation and stages of surgical innovations. Lancet (2009) 3.04
Challenges in evaluating surgical innovation. Lancet (2009) 2.86
Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions. Crit Care Med (2010) 2.83
Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One (2012) 2.75
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest (2004) 2.72
Lateralized cognitive processes and lateralized task control in the human brain. Science (2003) 2.62
Age of transfused blood in critically ill adults. N Engl J Med (2015) 2.52
Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials. Am J Respir Crit Care Med (2012) 2.15
Analysis of neural mechanisms underlying verbal fluency in cytoarchitectonically defined stereotaxic space--the roles of Brodmann areas 44 and 45. Neuroimage (2004) 2.10
Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. J Exp Med (2006) 2.07
Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med (2004) 1.90
Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity. J Leukoc Biol (2008) 1.87
Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care (2006) 1.87
Modulation of gonadotropin-releasing hormone pulse generator sensitivity to progesterone inhibition in hyperandrogenic adolescent girls--implications for regulation of pubertal maturation. J Clin Endocrinol Metab (2009) 1.82
Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents (2011) 1.80
Interhemispheric integration of visual processing during task-driven lateralization. J Neurosci (2007) 1.78
Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test. Neuroimage (2006) 1.77
The Age of Blood Evaluation (ABLE) randomized controlled trial: study design. Transfus Med Rev (2011) 1.71
Research recruitment practices and critically ill patients. A multicenter, cross-sectional study (the Consent Study). Am J Respir Crit Care Med (2013) 1.63
Empiric antibiotic therapy for suspected ventilator-associated pneumonia: a systematic review and meta-analysis of randomized trials. Crit Care Med (2008) 1.61
Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls. J Clin Endocrinol Metab (2006) 1.55
Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: systematic review of randomized controlled trials. Crit Care Med (2010) 1.55
Evaluating the use of recombinant human activated protein C in adult severe sepsis: results of the Surviving Sepsis Campaign. Crit Care Med (2012) 1.51
Low-dose corticosteroid treatment in septic shock: a propensity-matching study. Crit Care Med (2014) 1.50
Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: a Canadian physician survey. Crit Care Med (2008) 1.48
The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab (2006) 1.46
Neurophysiological correlates of relatively enhanced local visual search in autistic adolescents. Neuroimage (2007) 1.45
Neutralization of tumor necrosis factor in preclinical models of sepsis. Shock (2005) 1.45
Predisposition, insult/infection, response, and organ dysfunction: A new model for staging severe sepsis. Crit Care Med (2009) 1.39
Participation of ICUs in critical care pandemic research: a province wide, cross-sectional survey. Crit Care Med (2013) 1.39
Estimation of estradiol in mouse serum samples: evaluation of commercial estradiol immunoassays. Endocrinology (2011) 1.31
Performing allocentric visuospatial judgments with induced distortion of the egocentric reference frame: an fMRI study with clinical implications. Neuroimage (2003) 1.28
Maturation of luteinizing hormone (gonadotropin-releasing hormone) secretion across puberty: evidence for altered regulation in obese peripubertal girls. J Clin Endocrinol Metab (2008) 1.20
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8. J Biol Chem (2007) 1.20
Critical care trainees' career goals and needs: A Canadian survey. Can Respir J (2014) 1.18
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med (2017) 1.15
Antibiotic management of suspected nosocomial ICU-acquired infection: does prolonged empiric therapy improve outcome? Intensive Care Med (2007) 1.13
Posterior parietal cortex is implicated in continuous switching between verbal fluency tasks: an fMRI study with clinical implications. Brain (2002) 1.12
Regulation of gonadotropin secretion: implications for polycystic ovary syndrome. Semin Reprod Med (2002) 1.10
Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty. Semin Reprod Med (2007) 1.10
Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10
Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study. Crit Care (2011) 1.09
The Richmond Agitation-Sedation Scale Should Not Be Used to Evaluate Neurologic Function. Crit Care Med (2016) 1.09
Low-dose steroids in adult septic shock: results of the Surviving Sepsis Campaign. Intensive Care Med (2012) 1.08
GnRH pulse frequency modulation of gonadotropin subunit gene transcription in normal gonadotropes-assessment by primary transcript assay provides evidence for roles of GnRH and follistatin. Endocrinology (2002) 1.07
In search of the hidden: an fMRI study with implications for the study of patients with autism and with acquired brain injury. Neuroimage (2003) 1.07
Mechanisms of hemispheric specialization: insights from analyses of connectivity. Neuropsychologia (2006) 1.06
Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome. J Clin Endocrinol Metab (2011) 1.05
Daily variation in endotoxin levels is associated with increased organ failure in critically ill patients. Shock (2007) 1.05
How outcomes are defined in clinical trials of mechanically ventilated adults and children. Am J Respir Crit Care Med (2014) 1.05
Burden of illness in venous thromboembolism in critical care: a multicenter observational study. J Crit Care (2005) 1.01
Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studies. Crit Care Med (2011) 1.01
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study. Crit Care (2014) 1.00
Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls. J Clin Endocrinol Metab (2005) 1.00
Left inferior parietal cortex integrates time and space during collision judgments. Neuroimage (2003) 0.99
Investigating the functional role of callosal connections with dynamic causal models. Ann N Y Acad Sci (2005) 0.99
Regulation of intracellular signaling cascades by GNRH pulse frequency in the rat pituitary: roles for CaMK II, ERK, and JNK activation. Biol Reprod (2008) 0.98
Neuroendocrine dysfunction in polycystic ovary syndrome. Steroids (2011) 0.98
The role of the Src family of tyrosine kinases after oxidant-induced lung injury in vivo. Surgery (2004) 0.95
Gastrointestinal dysfunction in the critically ill: can we measure it? Crit Care (2008) 0.95
Bench-to-bedside review: Clinical experience with the endotoxin activity assay. Crit Care (2012) 0.95
DNR directives are established early in mechanically ventilated intensive care unit patients. Can J Anaesth (2004) 0.95
Hypothalamic regulation of cyclic ovulation: evidence that the increase in gonadotropin-releasing hormone pulse frequency during the follicular phase reflects the gradual loss of the restraining effects of progesterone. J Clin Endocrinol Metab (2002) 0.94
The PIRO concept: R is for response. Crit Care (2003) 0.94
Zooming in and zooming out of the attentional focus: an FMRI study. Cereb Cortex (2008) 0.93
Twenty-five percent albumin prevents lung injury following shock/resuscitation. Crit Care Med (2003) 0.93
Hyperandrogenemia in obese peripubertal girls: correlates and potential etiological determinants. Obesity (Silver Spring) (2010) 0.92
Timing of visuo-spatial information processing: electrical source imaging related to line bisection judgements. Neuropsychologia (2007) 0.92
Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10. Hepatology (2004) 0.92
Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line. J Biol Chem (2003) 0.92
Crossed cerebral lateralization for verbal and visuo-spatial function in a pair of handedness discordant monozygotic twins: MRI and fMRI brain imaging. J Anat (2008) 0.92
Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications. Crit Care Med (2016) 0.92
Regulation of luteinizing hormone-beta and follicle-stimulating hormone (FSH)-beta gene transcription by androgens: testosterone directly stimulates FSH-beta transcription independent from its role on follistatin gene expression. Endocrinology (2003) 0.91
Measuring organ dysfunction in the intensive care unit: why and how? Can J Anaesth (2005) 0.91
Polycystic ovary syndrome in adolescence. Ann N Y Acad Sci (2008) 0.91
Obese patients with polycystic ovary syndrome: evidence that metformin does not restore sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by ovarian steroids. J Clin Endocrinol Metab (2003) 0.91
Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent. Biol Reprod (2009) 0.90
Are action and perception in near and far space additive or interactive factors? Neuroimage (2003) 0.90
The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study. J Crit Care (2008) 0.89
Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis. Crit Care Med (2006) 0.89
Blood pressure targets for vasopressor therapy: a systematic review. Shock (2015) 0.89
Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome. BMC Infect Dis (2014) 0.89
Through a glass darkly: the brave new world of in silico modeling. Crit Care Med (2004) 0.88
Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway. Surgery (2003) 0.88
The regulation of FSHbeta transcription by gonadal steroids: testosterone and estradiol modulation of the activin intracellular signaling pathway. Am J Physiol Endocrinol Metab (2007) 0.87
Functional anatomy and differential time courses of neural processing for explicit, inferred, and illusory contours. An event-related fMRI study. Neuroimage (2003) 0.87
ARDS and the multiple organ dysfunction syndrome. Common mechanisms of a common systemic process. Crit Care Clin (2002) 0.87