Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation.

PubWeight™: 2.12‹?› | Rank: Top 2%

🔗 View Article (PMID 18641634)

Published in Nat Chem Biol on July 20, 2008

Authors

Rémi Lasserre1, Xiao-Jun Guo, Fabien Conchonaud, Yannick Hamon, Omar Hawchar, Anne-Marie Bernard, Saïdi M'Homa Soudja, Pierre-François Lenne, Hervé Rigneault, Daniel Olive, Georges Bismuth, Jacques A Nunès, Bernard Payrastre, Didier Marguet, Hai-Tao He

Author Affiliations

1: Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Parc scientifique de Luminy, Case 906, F-13288 Marseille Cedex 09, France.

Articles citing this

Revitalizing membrane rafts: new tools and insights. Nat Rev Mol Cell Biol (2010) 5.03

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol (2009) 2.15

The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev (2009) 1.70

STED nanoscopy reveals molecular details of cholesterol- and cytoskeleton-modulated lipid interactions in living cells. Biophys J (2011) 1.69

Anoikis resistance: an essential prerequisite for tumor metastasis. Int J Cell Biol (2012) 1.67

Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion. Proc Natl Acad Sci U S A (2009) 1.60

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine (2015) 1.49

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A (2011) 1.39

Transient GPI-anchored protein homodimers are units for raft organization and function. Nat Chem Biol (2012) 1.26

Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts. Proc Natl Acad Sci U S A (2013) 1.26

Lipid raft: A floating island of death or survival. Toxicol Appl Pharmacol (2012) 1.25

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol (2009) 1.18

Rapid global fitting of large fluorescence lifetime imaging microscopy datasets. PLoS One (2013) 1.16

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med (2017) 1.16

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem (2009) 1.16

Use of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cells. Histochem Cell Biol (2008) 1.10

Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitors. J Biol Chem (2009) 1.10

OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. J Immunol (2011) 1.08

Direct mapping of nanoscale compositional connectivity on intact cell membranes. Proc Natl Acad Sci U S A (2010) 1.06

3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase. J Chem Biol (2009) 1.05

Nanoscale membrane organization: where biochemistry meets advanced microscopy. ACS Chem Biol (2011) 1.01

7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death. J Biol Chem (2009) 1.01

Plasma membrane organization and function: moving past lipid rafts. Mol Biol Cell (2013) 1.01

Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules. Front Immunol (2013) 0.99

Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response. J Biol Chem (2010) 0.99

A critical survey of methods to detect plasma membrane rafts. Philos Trans R Soc Lond B Biol Sci (2012) 0.99

Diffusion, transport, and cell membrane organization investigated by imaging fluorescence cross-correlation spectroscopy. Biophys J (2009) 0.97

Hemagglutinin of influenza virus partitions into the nonraft domain of model membranes. Biophys J (2010) 0.95

Epstein-Barr virus LMP1 modulates lipid raft microdomains and the vimentin cytoskeleton for signal transduction and transformation. J Virol (2012) 0.95

Plasma membrane localization of Solanum tuberosum remorin from group 1, homolog 3 is mediated by conformational changes in a novel C-terminal anchor and required for the restriction of potato virus X movement]. Plant Physiol (2012) 0.95

Lipid raft involvement in yeast cell growth and death. Front Oncol (2012) 0.90

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour. Nature (2015) 0.88

Dynamic organization of lymphocyte plasma membrane: lessons from advanced imaging methods. Immunology (2010) 0.88

Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One (2014) 0.87

Spot variation fluorescence correlation spectroscopy allows for superresolution chronoscopy of confinement times in membranes. Biophys J (2011) 0.87

Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1. Sci Signal (2013) 0.86

Imaging lipid domains in cell membranes: the advent of super-resolution fluorescence microscopy. Front Plant Sci (2013) 0.86

Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt. Br J Pharmacol (2010) 0.85

Cholesterol and benign prostate disease. Differentiation (2011) 0.85

Cell-type-specific regulation of raft-associated Akt signaling. Cell Death Dis (2011) 0.84

Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. Cell Commun Signal (2009) 0.83

Sphingolipids: the nexus between Gaucher disease and insulin resistance. Lipids Health Dis (2010) 0.82

Hemagglutinin clusters in the plasma membrane are not enriched with cholesterol and sphingolipids. Biophys J (2015) 0.82

Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics (2013) 0.81

Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. PLoS One (2013) 0.81

Fluorescence fluctuations analysis in nanoapertures: physical concepts and biological applications. Histochem Cell Biol (2008) 0.80

Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells. Int J Mol Sci (2015) 0.80

Cholesterol oxidase from Bordetella species promotes irreversible cell apoptosis in lung adenocarcinoma by cholesterol oxidation. Cell Death Dis (2014) 0.80

Microarray analysis of Akt PH domain binding employing synthetic biotinylated analogs of all seven phosphoinositide headgroup isomers. Chem Phys Lipids (2011) 0.80

Membrane dynamics shape TCR-generated signaling. Front Immunol (2012) 0.80

Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases. Bioessays (2013) 0.79

Size-based chromatography of signaling clusters in a living cell membrane. Nano Lett (2014) 0.79

An Emerging Role for PI5P in T Cell Biology. Front Immunol (2013) 0.79

Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells. Nutrition (2014) 0.78

Akt signaling dynamics in plasma membrane microdomains visualized by FRET-based reporters. Commun Integr Biol (2009) 0.77

Monitoring Phosphatidic Acid Signaling in Breast Cancer Cells Using Genetically Encoded Biosensors. Methods Mol Biol (2016) 0.77

De Novo sphingolipid synthesis is essential for Salmonella-induced autophagy and human beta-defensin 2 expression in intestinal epithelial cells. Gut Pathog (2016) 0.76

Lipid raft-based membrane order is important for antigen-specific clonal expansion of CD4(+) T lymphocytes. BMC Immunol (2014) 0.76

EGF induces rapid reorganization of plasma membrane microdomains. Commun Integr Biol (2009) 0.76

Mechanisms by Which Pleiotropic Amphiphilic n-3 PUFA Reduce Colon Cancer Risk. Curr Colorectal Cancer Rep (2014) 0.76

Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis. Respir Res (2015) 0.76

Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters. Sci Rep (2016) 0.76

Current approaches to studying membrane organization. F1000Res (2015) 0.75

Spot size variation FCS in simulations of the 2D Ising model. J Phys D Appl Phys (2016) 0.75

Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice. Cell Mol Gastroenterol Hepatol (2016) 0.75

Receptor lipid nanodomain partitioning and signaling. Cell Cycle (2016) 0.75

SDF-1α/CXCR4 Signaling in Lipid Rafts Induces Platelet Aggregation via PI3 Kinase-Dependent Akt Phosphorylation. PLoS One (2017) 0.75

The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events. Front Immunol (2012) 0.75

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling. Sci Adv (2016) 0.75

A Combination of Screening and Computational Approaches for the Identification of Novel Compounds That Decrease Mast Cell Degranulation. J Biomol Screen (2015) 0.75

Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells. PLoS One (2016) 0.75

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss. Elife (2016) 0.75

Modulation of Ras/ERK and Phosphoinositide Signaling by Long-Chain n-3 PUFA in Breast Cancer and Their Potential Complementary Role in Combination with Targeted Drugs. Nutrients (2017) 0.75

Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors. J Med Chem (2015) 0.75

Non-canonical Activation of Akt in Serum-Stimulated Fibroblasts, Revealed by Comparative Modeling of Pathway Dynamics. PLoS Comput Biol (2015) 0.75

In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation. Cell Mol Life Sci (2015) 0.75

Exploring in vivo cholesterol-mediated interactions between activated EGF receptors in plasma membrane with single-molecule optical tracking. BMC Biophys (2016) 0.75

Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis. Cell Rep (2017) 0.75

Articles by these authors

Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol (2007) 5.88

Natural killer cell signaling pathways. Science (2004) 4.00

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes. Nat Methods (2008) 3.46

Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis. Nat Cell Biol (2008) 3.44

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36

Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res (2009) 3.31

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03

Planar polarized actomyosin contractile flows control epithelial junction remodelling. Nature (2010) 2.93

A two-tiered mechanism for stabilization and immobilization of E-cadherin. Nature (2008) 2.89

Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork. EMBO J (2006) 2.87

Fluorescence correlation spectroscopy diffusion laws to probe the submicron cell membrane organization. Biophys J (2005) 2.57

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. Blood (2012) 2.57

CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J Clin Invest (2011) 2.44

PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. Cancer Res (2012) 2.43

Force generation, transmission, and integration during cell and tissue morphogenesis. Annu Rev Cell Dev Biol (2011) 2.28

CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res (2011) 2.26

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. J Cell Biol (2011) 2.22

Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood (2002) 2.21

Dynamics in the plasma membrane: how to combine fluidity and order. EMBO J (2006) 2.03

Antileukemic activity of rapamycin in acute myeloid leukemia. Blood (2004) 2.03

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science (2002) 2.01

ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nat Immunol (2004) 1.99

FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol (2008) 1.97

Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling. J Exp Med (2004) 1.92

Frontline: Characterization of BT3 molecules belonging to the B7 family expressed on immune cells. Eur J Immunol (2004) 1.92

Deficient expression of NCR in NK cells from acute myeloid leukemia: Evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction. Blood (2006) 1.87

CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. J Exp Med (2007) 1.85

The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo. Blood (2009) 1.84

PD-L2 is expressed on activated human T cells and regulates their function. Mol Immunol (2011) 1.79

Principles of E-cadherin supramolecular organization in vivo. Curr Biol (2013) 1.79

Imaging antigen-induced PI3K activation in T cells. Nat Immunol (2002) 1.76

TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J (2002) 1.75

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood (2008) 1.74

Cytomegalovirus-induced gammadelta T cells associate with reduced cancer risk after kidney transplantation. J Am Soc Nephrol (2009) 1.72

Origin, originality, functions, subversions and molecular signalling of macropinocytosis. Int J Med Microbiol (2002) 1.72

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest (2009) 1.71

Fine tuning the immune response with PI3K. Immunol Rev (2009) 1.70

Bright unidirectional fluorescence emission of molecules in a nanoaperture with plasmonic corrugations. Nano Lett (2011) 1.69

Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production. Blood (2002) 1.69

Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins. J Cell Biol (2004) 1.69

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood (2012) 1.68

The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans. Mol Biol Cell (2006) 1.66

Immunological synapses are versatile structures enabling selective T cell polarization. Immunity (2005) 1.65

The co-receptor BTLA negatively regulates human Vγ9Vδ2 T-cell proliferation: a potential way of immune escape for lymphoma cells. Blood (2013) 1.65

Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells. J Biol Chem (2003) 1.58

Diffusion analysis within single nanometric apertures reveals the ultrafine cell membrane organization. Biophys J (2006) 1.56

Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: a correlation with the proteasome status. Leuk Res (2009) 1.52

Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4+ T-lymphocyte subset in normal and mycosis fungoides skin. Cytometry A (2014) 1.48

Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control. J Immunol (2005) 1.47

PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J (2006) 1.45

An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep (2002) 1.44

Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J Exp Med (2007) 1.42

A critical role for Lyn in acute myeloid leukemia. Blood (2007) 1.40

Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res (2004) 1.38

Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment. J Cell Sci (2004) 1.37

The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Proc Natl Acad Sci U S A (2003) 1.37

A plasmonic 'antenna-in-box' platform for enhanced single-molecule analysis at micromolar concentrations. Nat Nanotechnol (2013) 1.35

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. Proc Natl Acad Sci U S A (2009) 1.35

CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers. J Immunol (2007) 1.35

Direct imaging of photonic nanojets. Opt Express (2008) 1.34

Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages. Eur J Immunol (2008) 1.34

The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J Biol Chem (2012) 1.34

Palmitoylation is required for efficient Fas cell death signaling. EMBO J (2006) 1.33

A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy. Hum Mol Genet (2006) 1.33

Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function. Hum Immunol (2004) 1.32

Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells. Blood (2009) 1.31

CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface. Blood (2008) 1.31

Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal (2011) 1.30

Phosphoinositide signaling disorders in human diseases. FEBS Lett (2003) 1.29

CD molecules 2005: human cell differentiation molecules. Blood (2005) 1.27

Plasmonic antennas for directional sorting of fluorescence emission. Nano Lett (2011) 1.26

Pathways and intermediates in forced unfolding of spectrin repeats. Structure (2002) 1.25

Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Trends Immunol (2010) 1.25

IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities. J Immunol (2003) 1.23

Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity. Blood (2003) 1.22

ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells. Cancer Res (2012) 1.22

Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle. J Clin Invest (2010) 1.21

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events. J Immunol (2009) 1.20