Implications of circadian clocks for the rhythmic delivery of cancer therapeutics.

PubWeight™: 0.87‹?›

🔗 View Article (PMID 18644767)

Published in Philos Trans A Math Phys Eng Sci on October 13, 2008

Authors

Francis Lévi1, Atilla Altinok, Jean Clairambault, Albert Goldbeter

Author Affiliations

1: INSERM, U776 'Rythmes biologiques et cancers', Villejuif 94807, France. francis.levi@inserm.fr

Articles by these authors

Toward a detailed computational model for the mammalian circadian clock. Proc Natl Acad Sci U S A (2003) 3.69

Robustness of circadian rhythms with respect to molecular noise. Proc Natl Acad Sci U S A (2002) 3.13

Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae. J Cell Biol (2003) 1.81

Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms. J Theor Biol (2004) 1.71

Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol (2010) 1.58

A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development. Proc Natl Acad Sci U S A (2004) 1.45

Nucleocytoplasmic oscillations of the yeast transcription factor Msn2: evidence for periodic PKA activation. Curr Biol (2007) 1.43

Stochastic models for circadian rhythms: effect of molecular noise on periodic and chaotic behaviour. C R Biol (2003) 1.34

Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle. Proc Natl Acad Sci U S A (2009) 1.28

Circadian rhythms and molecular noise. Chaos (2006) 1.22

The p53 protein and its molecular network: modelling a missing link between DNA damage and cell fate. Biochim Biophys Acta (2013) 1.08

Biological switches and clocks. J R Soc Interface (2008) 1.08

Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling. Eur J Pharm Sci (2008) 1.08

An automaton model for the cell cycle. Interface Focus (2010) 1.03

Entrainment of the mammalian cell cycle by the circadian clock: modeling two coupled cellular rhythms. PLoS Comput Biol (2012) 1.02

A skeleton model for the network of cyclin-dependent kinases driving the mammalian cell cycle. Interface Focus (2010) 0.99

Biological rhythms: clocks for all times. Curr Biol (2008) 0.99

An age-and-cyclin-structured cell population model for healthy and tumoral tissues. J Math Biol (2007) 0.96

Arginine biosynthesis in Escherichia coli: experimental perturbation and mathematical modeling. J Biol Chem (2007) 0.95

Modeling the circadian clock: from molecular mechanism to physiological disorders. Bioessays (2008) 0.94

A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PLoS Comput Biol (2011) 0.90

Dependence of the period on the rate of protein degradation in minimal models for circadian oscillations. Philos Trans A Math Phys Eng Sci (2009) 0.89

Amplitude of circadian oscillations entrained by 24-h light-dark cycles. J Theor Biol (2006) 0.89

Stochastic modelling of nucleocytoplasmic oscillations of the transcription factor Msn2 in yeast. J R Soc Interface (2008) 0.88

From simple to complex patterns of oscillatory behavior in a model for the mammalian cell cycle containing multiple oscillatory circuits. Chaos (2010) 0.88

A cell cycle automaton model for probing circadian patterns of anticancer drug delivery. Adv Drug Deliv Rev (2007) 0.85

Applying ecological and evolutionary theory to cancer: a long and winding road. Evol Appl (2012) 0.84

Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol (2008) 0.84

From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle. Front Physiol (2012) 0.83

Effect of positive feedback loops on the robustness of oscillations in the network of cyclin-dependent kinases driving the mammalian cell cycle. FEBS J (2012) 0.82

A spatial physiological model for p53 intracellular dynamics. J Theor Biol (2012) 0.82

Zero-order switches and developmental thresholds. Mol Syst Biol (2005) 0.82

Selection of in-phase or out-of-phase synchronization in a model based on global coupling of cells undergoing metabolic oscillations. Chaos (2008) 0.81

Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors. Bull Math Biol (2014) 0.81

Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics. Eur J Cancer (2010) 0.81

Oscillatory behavior of the nuclear localization of the transcription factors Msn2 and Msn4 in response to stress in yeast. ScientificWorldJournal (2003) 0.79

Rhythms from seconds to days. Physiological importance and therapeutic implications. IEEE Eng Med Biol Mag (2008) 0.79

A model for the enhancement of fitness in cyanobacteria based on resonance of a circadian oscillator with the external light-dark cycle. J Theor Biol (2002) 0.79

Segmentation clock: insights from computational models. Curr Biol (2003) 0.78

The dynamics of p53 in single cells: physiologically based ODE and reaction-diffusion PDE models. Phys Biol (2014) 0.78

Development and validation of computational models for mammalian circadian oscillators. OMICS (2003) 0.77

Critical phase shifts slow down circadian clock recovery: implications for jet lag. J Theor Biol (2013) 0.77

Age-structured cell population model to study the influence of growth factors on cell cycle dynamics. Math Biosci Eng (2013) 0.77

Genotype- or Phenotype-Targeting Anticancer Therapies? Lessons from Tumor Evolutionary Biology. Curr Pharm Des (2016) 0.76

[Biological oscillations: clocks for all times]. Med Sci (Paris) (2011) 0.75

Report of an EU projects workshop on systems biology held in Brussels, Belgium on 8 December 2004. Syst Biol (Stevenage) (2005) 0.75