Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 18663475)

Published in J Cancer Res Clin Oncol on July 29, 2008

Authors

Hsi-Huang Tseng1, Yaw-Huei Hwang, Kun-Tu Yeh, Jan-Gowth Chang, Yao-Li Chen, Hsin-Su Yu

Author Affiliations

1: Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.

Articles cited by this

Global cancer statistics, 2002. CA Cancer J Clin (2005) 119.22

Primary liver cancer: worldwide incidence and trends. Gastroenterology (2004) 11.21

Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer (2006) 10.05

CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J (2002) 6.83

CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol (2004) 5.01

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet (2001) 4.79

C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell (2001) 2.97

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood (2002) 2.71

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem (1996) 2.47

CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol Cell Biol (1997) 2.44

Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma. Cancer Res (2001) 1.78

Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. J Natl Cancer Inst (2006) 1.72

Prognostic molecular markers in hepatocellular carcinoma: a systematic review. Eur J Cancer (2007) 1.55

Down-regulation and antiproliferative role of C/EBPalpha in lung cancer. Cancer Res (2002) 1.53

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells. Blood (2003) 1.51

Histologic prognostic indicators in hepatocellular carcinoma. Cancer (1979) 1.43

Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucleic Acids Res (1995) 1.41

Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade. Cancer Res (2007) 1.40

Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma. Cancer Res (2007) 1.34

C/EBPalpha: a tumour suppressor in multiple tissues? Biochim Biophys Acta (2006) 1.33

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. J Biol Chem (2003) 1.26

Hepatic resection for hepatocellular carcinoma. Am J Surg (1997) 1.17

Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol Clin Exp Res (2006) 1.17

Diminished expression of C/EBPalpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBPalpha in carcinoma cells inhibits proliferation. Cancer Res (2005) 1.16

Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer. Clin Cancer Res (2005) 1.15

An update on the molecular genetics of hepatocellular carcinoma. Semin Liver Dis (2004) 1.15

Predictable factors for estimating prognosis of patients after resection of hepatocellular carcinoma. Cancer (1993) 1.14

Differential patterns of expression of three C/EBP isoforms, HNF-1, and HNF-4 after partial hepatectomy in rats. Exp Cell Res (1993) 1.12

Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes. J Biol Chem (1996) 1.06

CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res (2005) 1.00

Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. Anticancer Res (2003) 0.93

Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: a correlative study of E3590. Lung Cancer (2007) 0.89

A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver. Mod Pathol (2002) 0.88

Immunohistochemical demonstration of CCAAT/enhancer binding protein (C/EBP) in human liver tissues of various origin. Chin Med J (Engl) (1994) 0.82

Articles by these authors

Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization. Heart Rhythm (2013) 2.61

Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis (2005) 2.31

Determinants of bilateral audiometric notches in noise-induced hearing loss. Laryngoscope (2013) 2.04

Deregulated expression of sprouty2 and microRNA-21 in human colon cancer: Correlation with the clinical stage of the disease. Cancer Biol Ther (2011) 1.72

5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells. Ann Neurol (2008) 1.60

Outcomes of hepatectomy for hepatolithiasis. World J Surg (2007) 1.54

DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochem Biophys Res Commun (2010) 1.52

Caffeic Acid phenethyl ester inhibits oral cancer cell metastasis by regulating matrix metalloproteinase-2 and the mitogen-activated protein kinase pathway. Evid Based Complement Alternat Med (2012) 1.47

Percutaneous absorption of inorganic lead compounds. AIHA J (Fairfax, Va) (2003) 1.43

Disturbance of circadian gene expression in hepatocellular carcinoma. Mol Carcinog (2008) 1.27

Does prenatal cadmium exposure affect fetal and child growth? Occup Environ Med (2010) 1.26

Abnormal expression of period 1 (PER1) in endometrial carcinoma. J Pathol (2005) 1.25

Human papillomavirus 16/18 E6 oncoprotein is expressed in lung cancer and related with p53 inactivation. Cancer Res (2007) 1.23

Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan. Atherosclerosis (2005) 1.21

Helium-neon laser irradiation stimulates cell proliferation through photostimulatory effects in mitochondria. J Invest Dermatol (2007) 1.17

Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer Res (2011) 1.15

Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status. Ann Surg Oncol (2008) 1.13

Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers. Int J Mol Med (2004) 1.13

Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. Cancer Res (2003) 1.12

In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age. Environ Res (2013) 1.10

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy. Int J Mol Sci (2013) 1.09

A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer. Clin Cancer Res (2011) 1.09

Sculpting skin appendages out of epidermal layers via temporally and spatially regulated apoptotic events. J Invest Dermatol (2004) 1.09

Multiphoton fluorescence and second harmonic generation imaging of the structural alterations in keratoconus ex vivo. Invest Ophthalmol Vis Sci (2006) 1.08

JunB gene expression is inactivated by methylation in chronic myeloid leukemia. Blood (2002) 1.07

Characterization of a familial case with primary erythromelalgia from Taiwan. J Neurol (2007) 1.05

Association of high levels of Jagged-1 and Notch-1 expression with poor prognosis in head and neck cancer. Ann Surg Oncol (2010) 1.04

Expression of hepcidin and other iron-regulatory genes in human hepatocellular carcinoma and its clinical implications. J Cancer Res Clin Oncol (2009) 1.03

Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. Toxicol Appl Pharmacol (2007) 1.03

High-resolution melting: applications in genetic disorders. Clin Chim Acta (2012) 1.03

Fast simultaneous detection of K-RAS mutations in colorectal cancer. BMC Cancer (2009) 1.02

Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. Cardiology (2010) 1.01

Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib. Cancer Res (2011) 1.01

Temporal change in bimanual interkeypress intervals and self-reported symptoms during continuous typing. J Occup Rehabil (2008) 1.01

MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. Int J Mol Med (2012) 1.01

Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3. Cancer Sci (2006) 1.01

ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations. PLoS One (2012) 0.99

Disturbance of circadian gene expression in breast cancer. Virchows Arch (2009) 0.99

Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. Biochim Biophys Acta (2010) 0.98

Gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma. PLoS One (2012) 0.97

Predicting health-related quality of life in patients with low back pain. Spine (Phila Pa 1976) (2005) 0.97

Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. World J Gastroenterol (2012) 0.97

Effect of TIMP-1 and MMP in pterygium invasion. Invest Ophthalmol Vis Sci (2010) 0.97

Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia. Br J Haematol (2003) 0.96

Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer. BMC Cancer (2006) 0.96

Glutathione S-transferase M1 gene polymorphisms are associated with cardiac iron deposition in patients with beta-thalassemia major. Hemoglobin (2006) 0.96

The effect of hydroxyurea in spinal muscular atrophy cells and patients. J Neurol Sci (2007) 0.96

Novel heteroplasmic frameshift and missense somatic mitochondrial DNA mutations in oral cancer of betel quid chewers. Genes Chromosomes Cancer (2003) 0.96

Arsenic induces human keratinocyte apoptosis by the FAS/FAS ligand pathway, which correlates with alterations in nuclear factor-kappa B and activator protein-1 activity. J Invest Dermatol (2004) 0.96

A polymorphism of the ORAI1 gene is associated with the risk and recurrence of calcium nephrolithiasis. J Urol (2011) 0.96

Low concentrations of arsenic induce vascular endothelial growth factor and nitric oxide release and stimulate angiogenesis in vitro. Chem Res Toxicol (2003) 0.95

Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol (2011) 0.95

Rapid identification of HBB gene mutations by high-resolution melting analysis. Clin Biochem (2009) 0.94

High expression of interleukin 10 might predict poor prognosis in early stage oral squamous cell carcinoma patients. Clin Chim Acta (2012) 0.94

The mechanisms of action of Tianhua(™) on antitumor activity in lung cancer cells. Pharm Biol (2010) 0.94

Effect of gestational smoke exposure on atopic dermatitis in the offspring. Pediatr Allergy Immunol (2008) 0.94

Characteristics and prevalence of KRAS, BRAF, and PIK3CA mutations in colorectal cancer by high-resolution melting analysis in Taiwanese population. Clin Chim Acta (2012) 0.94

Synthesis and biological evaluation of thiobenzanilides as anticancer agents. Bioorg Med Chem (2008) 0.93

Possible association between nickel and chromium and oral cancer: a case-control study in central Taiwan. Sci Total Environ (2010) 0.93

Overexpression of Thy1/CD90 in human hepatocellular carcinoma is associated with HBV infection and poor prognosis. Acta Histochem (2011) 0.93

Cardiopulmonary toxicity of pulmonary exposure to occupationally relevant zinc oxide nanoparticles. Nanotoxicology (2013) 0.93

Elucidating the underlying causes of oral cancer through spatial clustering in high-risk areas of Taiwan with a distinct gender ratio of incidence. Geospat Health (2010) 0.92

Promoter CpG methylation of caveolin-1 in sporadic colorectal cancer. Anticancer Res (2004) 0.92

Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma. Nucleic Acids Res (2013) 0.92

A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy. Prenat Diagn (2008) 0.92

Acupuncture, electrostimulation, and reflex therapy in dermatology. Dermatol Ther (2003) 0.92

Relationships between the level of matrix metalloproteinase-2 and tumor size of breast cancer. Clin Chim Acta (2006) 0.91

Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis. Chem Biol Interact (2010) 0.91

The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma. Anticancer Res (2003) 0.91

Biomarkers for itch and disease severity in atopic dermatitis. Curr Probl Dermatol (2011) 0.91

Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells. J Cell Biochem (2011) 0.90

The change of beta-adrenergic system after cessation of lead exposure. Toxicology (2005) 0.90

Effect of linear polarized light irradiation near the stellate ganglion in skin blood flow of fingers in patients with progressive systemic sclerosis. Photomed Laser Surg (2006) 0.90

Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells. Chem Biol Interact (2009) 0.90

Prevalence of adult atopic dermatitis among nursing staff in a Taiwanese medical center: a pilot study on validation of diagnostic questionnaires. J Am Acad Dermatol (2009) 0.90

ALPK1 genetic regulation and risk in relation to gout. Int J Epidemiol (2013) 0.90

Clinical implications of deregulated CDK4 and Cyclin D1 expression in patients with human hepatocellular carcinoma. Med Oncol (2013) 0.90

Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. Oncol Rep (2004) 0.90

The Taiwanese Dermatological Association and the Taiwanese Society for Investigative Dermatology: brief history and current status. J Invest Dermatol (2009) 0.90

Differential impact of IL-10 expression on survival and relapse between HPV16-positive and -negative oral squamous cell carcinomas. PLoS One (2012) 0.90

Detection of the JAK2 V617F missense mutation by high resolution melting analysis and its validation. Clin Chim Acta (2009) 0.90

Heat shock induces apoptosis through reactive oxygen species involving mitochondrial and death receptor pathways in corneal cells. Exp Eye Res (2011) 0.90

Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells. Toxicology (2008) 0.89