Published in Annu Rev Genet on January 01, 2008
The hallmarks of aging. Cell (2013) 14.29
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell (2009) 5.74
How telomeres solve the end-protection problem. Science (2009) 4.54
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28
Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet (2010) 4.26
Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol (2010) 4.23
The telomere syndromes. Nat Rev Genet (2012) 4.01
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2011) 3.29
Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07
Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94
Removal of shelterin reveals the telomere end-protection problem. Science (2012) 2.87
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell (2009) 2.76
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell (2012) 2.74
Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol Cell (2009) 2.62
TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol Cell (2009) 2.60
Syndromes of telomere shortening. Annu Rev Genomics Hum Genet (2009) 2.60
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell (2010) 2.43
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol (2011) 2.41
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol (2010) 2.39
Cellular senescence and its effector programs. Genes Dev (2014) 2.37
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature (2012) 2.33
Multiple roles for MRE11 at uncapped telomeres. Nature (2009) 2.18
Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18
In vivo stoichiometry of shelterin components. J Biol Chem (2009) 2.12
Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet (2014) 2.08
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat Struct Mol Biol (2009) 2.08
Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett (2010) 1.99
Apollo contributes to G overhang maintenance and protects leading-end telomeres. Mol Cell (2010) 1.97
Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct (2011) 1.94
TERRA: telomeric repeat-containing RNA. EMBO J (2009) 1.94
Architecture of human telomerase RNA. Proc Natl Acad Sci U S A (2011) 1.93
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc (2008) 1.91
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods (2013) 1.88
Functional dissection of human and mouse POT1 proteins. Mol Cell Biol (2008) 1.87
Control of telomere length by a trimming mechanism that involves generation of t-circles. EMBO J (2009) 1.85
The genetics and clinical manifestations of telomere biology disorders. Genet Med (2010) 1.83
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell (2014) 1.82
Evolution of CST function in telomere maintenance. Cell Cycle (2010) 1.81
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J (2010) 1.80
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell (2013) 1.79
Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression. Nat Cell Biol (2016) 1.78
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Cell (2012) 1.77
53BP1: pro choice in DNA repair. Trends Cell Biol (2013) 1.75
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J (2012) 1.73
Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol (2013) 1.73
Engineered telomere degradation models dyskeratosis congenita. Genes Dev (2008) 1.72
ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres. EMBO J (2012) 1.69
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
CpG-island promoters drive transcription of human telomeres. RNA (2009) 1.66
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov (2012) 1.62
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol (2014) 1.62
Telomere length and genetic analyses in population-based studies of endometrial cancer risk. Cancer (2010) 1.61
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol (2009) 1.60
Interchromosomal homology searches drive directional ALT telomere movement and synapsis. Cell (2014) 1.60
Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest (2013) 1.58
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutat Res (2011) 1.56
A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J (2009) 1.56
Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J (2009) 1.54
Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins. Structure (2014) 1.54
The association of telomere length and genetic variation in telomere biology genes. Hum Mutat (2010) 1.53
The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett (2010) 1.53
Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell (2015) 1.52
Telomere dysfunction and chromosome instability. Mutat Res (2011) 1.51
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev (2009) 1.51
A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol (2009) 1.51
The genetics of dyskeratosis congenita. Cancer Genet (2011) 1.50
Human RAP1 inhibits non-homologous end joining at telomeres. EMBO J (2009) 1.49
DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat Cell Biol (2011) 1.49
Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO J (2009) 1.49
Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol (2008) 1.46
A system-level pathway-phenotype association analysis using synthetic feature random forest. Genet Epidemiol (2014) 1.46
STN1 protects chromosome ends in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2008) 1.46
Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol (2009) 1.45
Mutations in the telomere capping complex in bone marrow failure and related syndromes. Haematologica (2012) 1.45
Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Rep (2011) 1.45
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol (2010) 1.44
Chromothripsis: chromosomes in crisis. Dev Cell (2012) 1.40
An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance. Mol Cell (2009) 1.39
Epidemiologic evidence for a role of telomere dysfunction in cancer etiology. Mutat Res (2011) 1.37
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem (2010) 1.37
Dyskeratosis congenita as a disorder of telomere maintenance. Mutat Res (2011) 1.35
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J (2010) 1.32
Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast. Nat Struct Mol Biol (2011) 1.31
Double strand break repair functions of histone H2AX. Mutat Res (2013) 1.31
Human telomeric proteins occupy selective interstitial sites. Cell Res (2011) 1.30
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol (2010) 1.30
Rif1 supports the function of the CST complex in yeast telomere capping. PLoS Genet (2011) 1.30
Conservation of telomere protein complexes: shuffling through evolution. Crit Rev Biochem Mol Biol (2009) 1.29
53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell (2015) 1.29
Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep (2012) 1.29
Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol (2009) 1.29
DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature (2007) 6.82
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell (2009) 5.74
Regulation of telomerase by telomeric proteins. Annu Rev Biochem (2004) 5.69
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol (2005) 5.49
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature (2008) 5.11
Homologous recombination generates T-loop-sized deletions at human telomeres. Cell (2004) 4.85
Senescence induced by altered telomere state, not telomere loss. Science (2002) 4.17
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell (2006) 4.11
53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science (2013) 4.00
DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol (2002) 3.95
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev (2004) 3.25
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nat Cell Biol (2006) 3.08
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell (2003) 3.01
Removal of shelterin reveals the telomere end-protection problem. Science (2012) 2.87
Different telomere damage signaling pathways in human and mouse cells. EMBO J (2002) 2.87
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol (2011) 2.54
Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell (2010) 2.45
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem (2004) 2.36
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr Biol (2006) 2.36
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev (2004) 2.33
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science (2008) 2.30
Tel2 regulates the stability of PI3K-related protein kinases. Cell (2007) 2.30
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science (2010) 2.23
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell (2012) 2.21
In vivo stoichiometry of shelterin components. J Biol Chem (2009) 2.12
Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nat Struct Mol Biol (2007) 2.09
Apollo contributes to G overhang maintenance and protects leading-end telomeres. Mol Cell (2010) 1.97
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet (2004) 1.91
Functional dissection of human and mouse POT1 proteins. Mol Cell Biol (2008) 1.87
DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J Biol Chem (2004) 1.83
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev (2006) 1.81
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev (2008) 1.80
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Cell (2012) 1.77
Engineered telomere degradation models dyskeratosis congenita. Genes Dev (2008) 1.72
Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol (2003) 1.69
Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol (2009) 1.66
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol Cell (2011) 1.62
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol (2009) 1.60
Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell (2003) 1.59
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev (2010) 1.55
Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol (2004) 1.55
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell (2010) 1.51
Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes Dev (2006) 1.42
A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol Cell (2010) 1.24
p16INK4a as a second effector of the telomere damage pathway. Cell Cycle (2005) 1.18
The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex. J Biol Chem (2007) 1.10
Role of 53BP1 oligomerization in regulating double-strand break repair. Proc Natl Acad Sci U S A (2013) 1.09
No overt nucleosome eviction at deprotected telomeres. Mol Cell Biol (2008) 0.98
Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma (2010) 0.94
TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. Mol Cell Biol (2014) 0.93
A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes Dev (2014) 0.91
A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma (2012) 0.89
Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle (2010) 0.86
Telomerase regulation at the telomere: a binary switch. Cell (2004) 0.76
Human telomerase caught in the act. Cell (2009) 0.75
TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell (2017) 0.75
Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol Cell (2017) 0.75