Published in PLoS One on August 06, 2008
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Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells. Stem Cells Dev (2011) 0.81
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Cardiomyocyte regeneration. Cells (2013) 0.80
Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells. PLoS One (2014) 0.79
Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem J (2014) 0.79
Prospective in vitro models of channelopathies and cardiomyopathies. Stem Cells Int (2012) 0.79
Link protein N-terminal peptide binds to bone morphogenetic protein (BMP) type II receptor and drives matrix protein expression in rabbit intervertebral disc cells. J Biol Chem (2013) 0.79
Human cardiomyogenesis and the need for systems biology analysis. Wiley Interdiscip Rev Syst Biol Med (2010) 0.78
RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish. PLoS One (2012) 0.78
Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS One (2015) 0.78
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Proteins and small molecules for cellular regenerative medicine. Physiol Rev (2013) 0.77
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Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule. PLoS One (2013) 0.76
Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors. PLoS One (2013) 0.76
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Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts. Sci Rep (2016) 0.75
A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives. Stem Cells Int (2016) 0.75
A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Res (2017) 0.75
The acceleration of cardiomyogenesis in embryonic stem cells in vitro by serum depletion does not increase the number of developed cardiomyocytes. PLoS One (2017) 0.75
NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells. Immune Netw (2011) 0.75
Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways. Sci Rep (2017) 0.75
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Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
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Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol (2007) 14.48
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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol (2007) 8.08
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell (2006) 7.21
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell (2006) 6.19
Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev (2001) 4.41
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Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nat Biotechnol (2005) 2.34
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Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.75
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Tgf-Beta signaling in development. Sci STKE (2007) 1.70
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A chemical approach to stem cell biology. Curr Opin Chem Biol (2007) 1.01
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Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol (2013) 21.32
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods (2010) 8.86
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol (2007) 8.08
Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat Biotechnol (2011) 7.05
Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One (2009) 6.67
In vivo drug discovery in the zebrafish. Nat Rev Drug Discov (2005) 6.56
BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med (2008) 4.20
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (2010) 3.60
Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic Acids Res (2012) 3.41
Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol (2010) 2.87
Heritable and precise zebrafish genome editing using a CRISPR-Cas system. PLoS One (2013) 2.74
Targeted mutagenesis in zebrafish using customized zinc-finger nucleases. Nat Protoc (2009) 2.67
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol (2004) 2.57
Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett (2008) 2.51
Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation (2003) 2.42
In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol (2010) 2.29
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol (2004) 2.12
Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (2006) 2.00
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell (2004) 2.00
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem (2008) 1.88
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol (2005) 1.80
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation (2008) 1.77
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res (2006) 1.77
Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst (2013) 1.69
Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Curr Biol (2006) 1.68
Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circ Res (2007) 1.65
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol (2004) 1.64
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood (2011) 1.63
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood (2011) 1.61
Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem (2009) 1.59
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nat Chem Biol (2009) 1.58
Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis. J Exp Med (2003) 1.58
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res (2010) 1.54
Zebrafish-based small molecule discovery. Chem Biol (2003) 1.53
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol (2011) 1.52
LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction. Tex Heart Inst J (2010) 1.52
Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem Biol (2010) 1.51
Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva. J Bone Joint Surg Am (2010) 1.51
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood (2011) 1.49
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest (2009) 1.48
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol (2012) 1.46
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem (2007) 1.45
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J Clin Invest (2010) 1.45
AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development (2008) 1.44
Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nat Cell Biol (2011) 1.43
Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A (2013) 1.42
Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation (2009) 1.41
Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis Model Mech (2011) 1.40
Chemical informatics and target identification in a zebrafish phenotypic screen. Nat Chem Biol (2011) 1.37
Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J Biol Chem (2007) 1.36
A new class of small molecule inhibitor of BMP signaling. PLoS One (2013) 1.36
Unraveling tissue regeneration pathways using chemical genetics. J Biol Chem (2007) 1.35
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Embryonic endothelial progenitor cells expressing a broad range of proangiogenic and remodeling factors enhance vascularization and tissue recovery in acute and chronic ischemia. FASEB J (2005) 1.33
The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Dev Dyn (2006) 1.31
Identification of a novel retinoid by small molecule screening with zebrafish embryos. PLoS One (2008) 1.30
Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res (2011) 1.28
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Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arterioscler Thromb Vasc Biol (2011) 1.23
Biologic properties of endothelial progenitor cells and their potential for cell therapy. Prog Cardiovasc Dis (2007) 1.22
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood (2011) 1.19
sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair. J Biol Chem (2010) 1.18
Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mech Dev (2009) 1.17
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival. Blood (2008) 1.16
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The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One (2009) 1.15
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Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro. Circ Res (2005) 1.14
DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci (2012) 1.11
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Mol Biol Cell (2007) 1.10
Small molecule screening in zebrafish. J Cardiovasc Transl Res (2010) 1.10
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Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. Nucleic Acids Res (2006) 1.08
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Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Brief Funct Genomic Proteomic (2008) 1.06
The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.05
Participation of bone marrow-derived cells in long-term repair processes after experimental stroke. J Cereb Blood Flow Metab (2003) 1.05
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem (2009) 1.04
DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. PLoS One (2012) 1.04
Identification of nonvisual photomotor response cells in the vertebrate hindbrain. J Neurosci (2013) 1.04
Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke. Am J Pathol (2008) 1.03
Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods Cell Biol (2011) 1.02
Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice. J Bone Miner Res (2013) 1.01
Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen. Circulation (2010) 1.01
Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Dev Biol (2011) 1.01
Using the zebrafish photomotor response for psychotropic drug screening. Methods Cell Biol (2011) 1.01
In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res (2011) 1.01