Published in J Biol Chem on August 18, 2008
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest (2011) 1.32
Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer. Clin Cancer Res (2009) 1.05
Epithelial phosphatidylinositol-3-kinase signaling is required for β-catenin activation and host defense against Citrobacter rodentium infection. Infect Immun (2011) 1.02
TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol (2011) 0.96
Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation. Front Cell Infect Microbiol (2013) 0.96
TNF-α induces vectorial secretion of IL-8 in Caco-2 cells. J Gastrointest Surg (2010) 0.92
TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2011) 0.87
Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia. J Cereb Blood Flow Metab (2015) 0.84
Gemifloxacin, a fluoroquinolone antimicrobial drug, inhibits migration and invasion of human colon cancer cells. Biomed Res Int (2013) 0.82
Redeeming an old foe: protective as well as pathophysiological roles for tumor necrosis factor in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol (2014) 0.81
The dual role of TLR3 in metastatic cell line. Clin Exp Metastasis (2011) 0.80
Tumor necrosis factor receptor 1 functions as a tumor suppressor. Am J Physiol Gastrointest Liver Physiol (2011) 0.80
Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases. Prz Gastroenterol (2014) 0.77
NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury. Mucosal Immunol (2016) 0.77
TNFR-1 on tumor cells contributes to the sensitivity of fibrosarcoma to chemotherapy. Protein Cell (2013) 0.75
Cerebral ischemia-induced angiogenesis is dependent on tumor necrosis factor receptor 1-mediated upregulation of α5β1 and αVβ3 integrins. J Neuroinflammation (2016) 0.75
Activation of TGF-β activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease. Physiol Rep (2017) 0.75
Death receptors: signaling and modulation. Science (1998) 16.95
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell (2004) 15.82
Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene (1999) 13.46
The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell (2001) 12.59
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene (2007) 11.85
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med (1997) 10.67
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity (1999) 7.34
Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature (2007) 7.17
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell (1998) 7.03
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell (2002) 5.84
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest (2008) 5.26
Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology (1995) 4.39
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J (2003) 4.22
Transcriptional regulation via the NF-kappaB signaling module. Oncogene (2006) 3.92
Two tumour necrosis factor receptors: structure and function. Trends Cell Biol (1995) 3.67
Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B. Genes Dev (1992) 3.47
Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. Proc Natl Acad Sci U S A (1993) 3.45
C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Immunity (2007) 3.32
The complexity of Raf-1 regulation. Curr Opin Cell Biol (1997) 3.25
Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology (1994) 2.85
Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78
Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP. Mol Cell Biol (1991) 2.76
Identification of the major phosphorylation sites of the Raf-1 kinase. J Biol Chem (1993) 2.70
Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem (1995) 2.60
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J (2001) 2.32
Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J Biol Chem (1993) 2.29
Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J Biol Chem (1999) 2.27
Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines. J Biol Chem (1999) 2.15
FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell (1996) 2.15
Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J Biol Chem (1996) 2.14
Kinase suppressor of Ras is ceramide-activated protein kinase. Cell (1997) 2.05
Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea. J Clin Pathol (1993) 1.96
Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun (2003) 1.91
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest (2004) 1.79
The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr Biol (1997) 1.73
NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet (1999) 1.63
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J (1999) 1.59
Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice. J Gastroenterol Hepatol (2003) 1.58
Phosphorylation of Raf by ceramide-activated protein kinase. Nature (1995) 1.58
Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line. Gastroenterology (1997) 1.58
Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am J Physiol Cell Physiol (2002) 1.50
Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis. J Biol Chem (2000) 1.49
Second nature: biological functions of the Raf-1 "kinase". FEBS Lett (2005) 1.49
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology (2002) 1.45
Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis. J Biol Chem (2002) 1.45
cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B. J Biol Chem (2004) 1.44
Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem (2005) 1.41
Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest (2004) 1.40
p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. J Biol Chem (2005) 1.34
Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity (2000) 1.30
Tumor necrosis factor family members and inflammatory bowel disease. Immunol Rev (2005) 1.29
Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol Cell Biol (1995) 1.29
Raised pro-inflammatory cytokines interleukin 6 and tumour necrosis factor alpha in coeliac disease mucosa detected by immunohistochemistry. Gut (1994) 1.28
Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. Cancer Res (2001) 1.23
Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation. J Biol Chem (2000) 1.22
A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway. J Biol Chem (1996) 1.21
Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J Cell Biol (2005) 1.20
Protective role of Raf-1 in Salmonella-induced macrophage apoptosis. J Exp Med (2001) 1.19
Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. J Biol Chem (2000) 1.18
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. J Biol Chem (2008) 1.13
Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells. Cancer Res (2001) 1.10
Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha-induced vascular permeability. Am J Physiol Cell Physiol (2001) 1.06
Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology (2008) 1.05
Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75. J Immunol (1998) 1.02
Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase. EMBO J (1995) 1.00
Conversion of TNF alpha from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase. Exp Cell Res (1999) 1.00
Retracted Kinase suppressor of Ras signals through Thr269 of c-Raf-1. J Biol Chem (2000) 0.99
Overexpression of tumor necrosis factor- alpha activates both anti- and pro-apoptotic pathways in the myocardium. J Mol Cell Cardiol (2001) 0.99
Evidence that neutral sphingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane. Biochim Biophys Acta (1984) 0.99
Molecular steps of tumor necrosis factor receptor-mediated apoptosis. Curr Mol Med (2001) 0.98
Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras. J Biol Chem (2000) 0.97
Phosphodiesterase inhibitors prevent NSAID enteropathy independently of effects on TNF-alpha release. Am J Physiol (1999) 0.90
Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol (2008) 0.88
Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors. J Cell Sci (2005) 0.88
Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity. J Biol Chem (1998) 0.84
Long-term functional outcomes after treatment for localized prostate cancer. N Engl J Med (2013) 7.95
Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology (2006) 3.96
Mortality after radical prostatectomy or external beam radiotherapy for localized prostate cancer. J Natl Cancer Inst (2013) 3.81
Effect of age, tumor risk, and comorbidity on competing risks for survival in a U.S. population-based cohort of men with prostate cancer. Ann Intern Med (2013) 3.74
Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. J Immunol (2013) 2.96
Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem (2002) 2.59
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40
Recurrent abdominal pain: symptom subtypes based on the Rome II Criteria for pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr (2004) 2.26
Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest (2009) 2.17
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest (2011) 2.16
Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2008) 1.83
Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure. Dig Dis Sci (2010) 1.78
Spiny frogs (Paini) illuminate the history of the Himalayan region and Southeast Asia. Proc Natl Acad Sci U S A (2010) 1.73
Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A (2008) 1.58
Association between physical activity, lower urinary tract symptoms (LUTS) and prostate volume. BJU Int (2012) 1.52
Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm Bowel Dis (2006) 1.51
Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma (2010) 1.51
Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am J Physiol Cell Physiol (2002) 1.50
Chronic disease prevalence and care among the elderly in urban and rural Beijing, China - a 10/66 Dementia Research Group cross-sectional survey. BMC Public Health (2009) 1.47
Racial variation in the quality of surgical care for bladder cancer. Cancer (2013) 1.45
Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis (2008) 1.45
Acetic Acid Acts as a Volatile Signal To Stimulate Bacterial Biofilm Formation. MBio (2015) 1.44
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology (2011) 1.41
Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol (2007) 1.40
Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest (2004) 1.40
Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut Microbes (2012) 1.40
Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol (2007) 1.37
p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J (2006) 1.36
Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Gastroenterology (2006) 1.33
Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling. J Biol Chem (2004) 1.32
Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer (2008) 1.32
Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis (2009) 1.29
Commensal bacteria in the gut: learning who our friends are. Curr Opin Gastroenterol (2004) 1.29
The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology (2008) 1.29
Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology (2009) 1.28
Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care (2013) 1.26
Probiotics as functional food in the treatment of diarrhea. Curr Opin Clin Nutr Metab Care (2006) 1.24
Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res (2009) 1.17
Functional analysis of the p40 and p75 proteins from Lactobacillus casei BL23. J Mol Microbiol Biotechnol (2010) 1.16
Optimal two-stage designs allowing flexibility in number of subjects for phase II clinical trials. J Biopharm Stat (2009) 1.15
Body mass index and blood pressure changes over the course of treatment of pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer (2011) 1.15
STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis (2011) 1.13
Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol (2011) 1.12
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One (2012) 1.12
Antitumor effects of curcin from seeds of Jatropha curcas. Acta Pharmacol Sin (2003) 1.09
Psychosocial factors associated with reports of physical dating violence among U.S. adolescent females. Adolescence (2007) 1.07
Bmp signaling is required for intestinal growth and morphogenesis. Dev Dyn (2006) 1.07
Two-dimensional liquid separations-mass mapping of proteins from human cancer cell lysates. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 1.06
Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol (2011) 1.06
Accuracy and reproducibility of a multiplex immunoassay platform: a validation study. J Immunol Methods (2011) 1.05
Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem Biophys Res Commun (2006) 1.05
Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology (2008) 1.05
Validation of a fully automatic method for the routine selection of the anterior and posterior commissures in magnetic resonance images. Stereotact Funct Neurosurg (2009) 1.04
Expression, purification and anti-tumor activity of curcin. Acta Biochim Biophys Sin (Shanghai) (2006) 1.03
Serum methionine metabolites are risk factors for metastatic prostate cancer progression. PLoS One (2011) 1.03
Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat Med (2011) 1.02
Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest (2012) 1.01
Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin Cancer Res (2008) 1.01
Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. Dis Model Mech (2012) 1.01
Quantitative effects of using compressed sensing in dynamic contrast enhanced MRI. Phys Med Biol (2011) 0.99
Using a population-based observational cohort study to address difficult comparative effectiveness research questions: the CEASAR study. J Comp Eff Res (2013) 0.99
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett (2008) 0.99
Transactivation of EGFR by LPS induces COX-2 expression in enterocytes. PLoS One (2012) 0.99
Racial and ethnic differences in pediatric obesity-prevention counseling: national prevalence of clinician practices. Obesity (Silver Spring) (2008) 0.98
Genetic diversity and genetic structure of an endangered species, Trillium tschonoskii. Biochem Genet (2005) 0.97
Identification of a novel intracellular interaction domain essential for Bves function. PLoS One (2008) 0.97
STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol (2013) 0.96
Overexpression of SPINDLIN1 induces cellular senescence, multinucleation and apoptosis. Gene (2007) 0.96
Gender, race, and variation in the evaluation of microscopic hematuria among Medicare beneficiaries. J Gen Intern Med (2014) 0.96
The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J Biol Chem (2006) 0.95
Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2008) 0.95
Red blood cell alloimmunization is influenced by recipient inflammatory state at time of transfusion in patients with sickle cell disease. Br J Haematol (2014) 0.94
Ontogeny of FOXP3(+) regulatory T cells in the postnatal human small intestinal and large intestinal lamina propria. Pediatr Dev Pathol (2010) 0.94
Self-Reported Health Status Predicts Other-Cause Mortality in Men with Localized Prostate Cancer: Results from the Prostate Cancer Outcomes Study. J Gen Intern Med (2015) 0.94
Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis. Surgery (2010) 0.94
Initial vancomycin dosing in pediatric oncology and stem cell transplant patients. J Pediatr Hematol Oncol (2009) 0.93
Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessed in vitro by everted gut sac and in situ by improved intestinal perfusion. Int J Pharm (2010) 0.93
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. PLoS One (2013) 0.93
Resveratrol-induced mitochondrial dysfunction and apoptosis are associated with Ca2+ and mCICR-mediated MPT activation in HepG2 cells. Mol Cell Biochem (2007) 0.92
A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem (2013) 0.92
Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution. Am J Physiol Gastrointest Liver Physiol (2011) 0.91