Published in Nutrition on September 01, 2008
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Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides (2009) 0.96
Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay. Peptides (2009) 0.91
The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction. Aging Cell (2011) 0.84
Expression levels of obesity-related genes are associated with weight change in kidney transplant recipients. PLoS One (2013) 0.82
Long-term correction of type 1 and 2 diabetes by central leptin gene therapy independent of effects on appetite and energy expenditure. Indian J Endocrinol Metab (2012) 0.77
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Circulating ghrelin levels are decreased in human obesity. Diabetes (2001) 4.28
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Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology (1984) 2.89
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Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes (1999) 1.79
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Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides (1999) 1.26
Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels. Diabetes (2002) 1.11
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Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regul Pept (2001) 1.08
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Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice. Peptides (2006) 1.03
Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes. Pediatr Res (2002) 0.99
Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin. Neurobiol Aging (2006) 0.99
Hypothalamic clamp on insulin release by leptin-transgene expression. Peptides (2006) 0.99
Suppression of fat deposition for the life time with gene therapy. Peptides (2005) 0.97
Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin. Obes Res (2003) 0.97
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Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides (2008) 0.95
Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology (2002) 0.95
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Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change. Regul Pept (2000) 0.90
Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity. Endocrinology (2006) 0.88
High-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats. Obes Res (2005) 0.87
Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight. Peptides (2005) 0.85
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Low abundance of NPY in the hypothalamus can produce hyperphagia and obesity. Peptides (2007) 0.83
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To subjugate NPY is to improve the quality of life and live longer. Peptides (2007) 0.78