Published in Circulation on August 25, 2008
Intermittent Hypoxia 2: Cardiovascular and Metabolism (IH2) | NCT02058823
Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep (2008) 8.69
Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med (2010) 7.03
Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation (2010) 5.70
Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA (2012) 2.85
CPAP versus oxygen in obstructive sleep apnea. N Engl J Med (2014) 2.75
Screening for severe obstructive sleep apnea syndrome in hypertensive outpatients. J Clin Hypertens (Greenwich) (2013) 2.65
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24
Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ (2009) 2.06
Increased dietary sodium is related to severity of obstructive sleep apnea in patients with resistant hypertension and hyperaldosteronism. Chest (2013) 1.88
Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest (2010) 1.79
Cross-cultural comparison of the sleep-disordered breathing prevalence among Americans and Japanese. Eur Respir J (2010) 1.79
Advancing respiratory research. Chest (2011) 1.79
Triggering of nocturnal arrhythmias by sleep-disordered breathing events. J Am Coll Cardiol (2009) 1.78
Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med (2011) 1.71
Obstructive sleep apnea during REM sleep and hypertension. results of the Wisconsin Sleep Cohort. Am J Respir Crit Care Med (2014) 1.68
Objectively measured sleep characteristics and prevalence of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis Sleep study. Thorax (2015) 1.64
Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort. J Clin Sleep Med (2014) 1.58
Sleep duration, insomnia, and coronary heart disease among postmenopausal women in the Women's Health Initiative. J Womens Health (Larchmt) (2013) 1.57
The effects of simulated obstructive apnea and hypopnea on arrhythmic potential in healthy subjects. Eur J Appl Physiol (2012) 1.54
Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers. Neurology (2009) 1.54
Metabolic activity of the tongue in obstructive sleep apnea. A novel application of FDG positron emission tomography imaging. Am J Respir Crit Care Med (2014) 1.43
Hypertension, snoring, and obstructive sleep apnoea during pregnancy: a cohort study. BJOG (2014) 1.41
Vascular inflammation in obesity and sleep apnea. Circulation (2010) 1.38
Sleep and cardiovascular disease: an overview. Prog Cardiovasc Dis (2008) 1.36
Impact of sleep on arrhythmogenesis. Circ Arrhythm Electrophysiol (2009) 1.34
Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea. Am J Respir Crit Care Med (2010) 1.32
Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. Sleep (2013) 1.19
Severity of obstructive sleep apnea is related to aldosterone status in subjects with resistant hypertension. J Clin Sleep Med (2010) 1.15
Effect of sleep apnea and continuous positive airway pressure on cardiac structure and recurrence of atrial fibrillation. J Am Heart Assoc (2013) 1.13
Association between sleep disorders, obesity, and exercise: a review. Nat Sci Sleep (2013) 1.10
Tongue fat and its relationship to obstructive sleep apnea. Sleep (2014) 1.10
Association between self-reported global sleep status and prevalence of hypertension in Chinese adults: data from the Kailuan community. Int J Environ Res Public Health (2015) 1.09
Obstructive sleep apnea, inflammation, and the metabolic syndrome. Metab Syndr Relat Disord (2009) 1.08
Consequences of comorbid sleep apnea in the metabolic syndrome--implications for cardiovascular risk. Sleep (2010) 1.08
Cerebrovascular consequences of obstructive sleep apnea. J Am Heart Assoc (2012) 1.07
Leukotriene B4 receptor-1 mediates intermittent hypoxia-induced atherogenesis. Am J Respir Crit Care Med (2011) 1.06
TNF-α gene polymorphisms and excessive daytime sleepiness in pediatric obstructive sleep apnea. J Pediatr (2010) 1.06
Sleep and biomarkers of atherosclerosis in elderly Alzheimer caregivers and controls. Gerontology (2009) 1.06
Obstructive sleep apnea, immuno-inflammation, and atherosclerosis. Semin Immunopathol (2009) 1.06
The relationship among restless legs syndrome (Willis-Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular disease. J Neurol (2013) 1.05
Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function. J Pediatr (2013) 1.05
Obstructive sleep apnea and depression: a review. Innov Clin Neurosci (2011) 1.04
Snoring is not associated with all-cause mortality, incident cardiovascular disease, or stroke in the Busselton Health Study. Sleep (2012) 1.04
Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans. J Physiol (2009) 1.03
Obstructive sleep apnea and cardiac arrhythmias. Ann Thorac Med (2010) 1.03
Rationale, design and findings from the Wisconsin Sleep Cohort Study: Toward understanding the total societal burden of sleep disordered breathing. Sleep Med Clin (2009) 1.02
Increased circulating endothelial microparticles and carotid atherosclerosis in obstructive sleep apnea. J Clin Neurol (2010) 0.98
Management of hypertension in the elderly. Nat Rev Cardiol (2012) 0.98
The National Veteran Sleep Disorder Study: Descriptive Epidemiology and Secular Trends, 2000-2010. Sleep (2016) 0.98
Associations between obstructive sleep apnea, metabolic syndrome, and sleep duration, as measured with an actigraph, in an urban male working population in Japan. Sleep (2010) 0.98
Prognosis and cardiovascular morbidity and mortality in prospective study of hypertensive patients with obstructive sleep apnea syndrome in St Petersburg, Russia. Med Sci Monit (2011) 0.97
Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apnea. Chest (2010) 0.97
Mechanisms of intermittent hypoxia induced hypertension. J Cell Mol Med (2009) 0.95
Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan Study. Int J Stroke (2010) 0.95
Sleep disorders and stroke. Int J Stroke (2012) 0.95
Endothelial dysfunction in children with obstructive sleep apnea is associated with epigenetic changes in the eNOS gene. Chest (2013) 0.94
Endothelial dysfunction and circulating microparticles from patients with obstructive sleep apnea. Am J Pathol (2010) 0.94
Obstructive sleep apnea: its prevention and screening may contribute to the prevention of hypertension, diabetes and cardiovascular diseases. EPMA J (2011) 0.94
Sleep-related breathing disorders in acute lacunar stroke. J Neurol (2009) 0.94
Short-term complexity of cardiac autonomic control during sleep: REM as a potential risk factor for cardiovascular system in aging. PLoS One (2011) 0.93
Short sleep duration is associated with carotid intima-media thickness among men in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Stroke (2012) 0.93
Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome. PLoS One (2009) 0.93
High prevalence of obstructive sleep apnea in patients with resistant paroxysmal atrial fibrillation after pulmonary vein isolation. J Interv Card Electrophysiol (2010) 0.92
Risk factor management to prevent first stroke. Neurol Clin (2008) 0.92
Poor sleep and impaired self-care: towards a comprehensive model linking sleep, cognition, and heart failure outcomes. Eur J Cardiovasc Nurs (2009) 0.92
Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. J Physiol (2016) 0.92
Association of sleep disordered breathing and cognitive deficit in APOE ε4 carriers. Sleep (2013) 0.92
High baseline insulin levels associated with 6-year incident observed sleep apnea. Diabetes Care (2010) 0.92
Symptoms of sleep disordered breathing and risk of cancer: a prospective cohort study. Sleep (2013) 0.91
Noise in the signal or bad vibrations? Sleep (2012) 0.91
Sleep Apnea Cardiovascular Clinical Trials-Current Status and Steps Forward: The International Collaboration of Sleep Apnea Cardiovascular Trialists. Sleep (2013) 0.91
A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol (2013) 0.91
Subjective and objective appraisal of activity in adults with obstructive sleep apnea. J Aging Res (2011) 0.90
Effect of treatment of obstructive sleep apnea on depressive symptoms: systematic review and meta-analysis. PLoS Med (2014) 0.89
Transvenous phrenic nerve stimulation for the treatment of central sleep apnoea in heart failure. Eur Heart J (2011) 0.89
The Sleep Apnea cardioVascular Endpoints (SAVE) Trial: Rationale, Ethics, Design, and Progress. Sleep (2015) 0.89
Obstructive sleep apnea affects hospital outcomes of patients with non-ST-elevation acute coronary syndromes. Sleep (2012) 0.89
Sleep apnea and atrial fibrillation; 2012 update. Curr Cardiol Rev (2012) 0.88
Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia. Front Physiol (2014) 0.88
Hippocampal hypertrophy and sleep apnea: a role for the ischemic preconditioning? PLoS One (2013) 0.88
Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension. Hypertension (2015) 0.88
P2Y1 receptors expressed by C1 neurons determine peripheral chemoreceptor modulation of breathing, sympathetic activity, and blood pressure. Hypertension (2013) 0.88
Plasma ghrelin and pro-inflammatory markers in patients with obstructive sleep apnea and stable coronary heart disease. Med Sci Monit (2013) 0.88
Ischemic heart disease in women: a focus on risk factors. Trends Cardiovasc Med (2014) 0.87
Severity of obstructive sleep apnea is associated with cardiac troponin I concentrations in a community-based sample: data from the Akershus Sleep Apnea Project. Sleep (2014) 0.87
Etiopathogenetic mechanisms of pulmonary hypertension in sleep-related breathing disorders. Pulm Med (2012) 0.87
Obstructive sleep apnea, hypertension and cardiovascular diseases. J Hum Hypertens (2015) 0.87
Severity of obstructive sleep apnea is associated with elevated plasma fibrinogen in otherwise healthy patients. Sleep Breath (2014) 0.87
Toll-like receptor-4 mediated inflammation is involved in the cardiometabolic alterations induced by intermittent hypoxia. Mediators Inflamm (2015) 0.87
Chemoreflexes, sleep apnea, and sympathetic dysregulation. Curr Hypertens Rep (2014) 0.86
Obstructive sleep apnea syndrome (OSAS) and hypertension: pathogenic mechanisms and possible therapeutic approaches. Ups J Med Sci (2012) 0.86
Role of sleep quality in the metabolic syndrome. Diabetes Metab Syndr Obes (2016) 0.86
Cardiac autonomic control in Brugada syndrome patients during sleep: the effects of sleep disordered breathing. Int J Cardiol (2013) 0.86
Use of a level 3 portable monitor for the diagnosis and management of sleep disordered breathing in an inpatient tertiary care setting. Can Respir J (2013) 0.85
Upper airway collapsibility evaluated by a negative expiratory pressure test in severe obstructive sleep apnea. Clinics (Sao Paulo) (2011) 0.85
Effects of the Mueller maneuver on functional mitral regurgitation and implications for obstructive sleep apnea. Am J Cardiol (2015) 0.85
The Na+/Ca2+ exchanger-1 mediates left ventricular dysfunction in mice with chronic intermittent hypoxia. J Appl Physiol (1985) (2010) 0.85
Cardiovascular risk factors for acute stroke: Risk profiles in the different subtypes of ischemic stroke. World J Clin Cases (2015) 0.85
Obstructive sleep apnea syndrome: blood viscosity, blood coagulation abnormalities, and early atherosclerosis. Lung (2012) 0.85
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation (2005) 43.74
Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation (2004) 23.07
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation (2010) 13.28
Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med (2002) 12.95
2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 11.88
Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation (2006) 11.65
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med (2004) 11.17
Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet (2009) 10.53
Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med (2011) 10.29
A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med (2003) 9.24
Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey. Hypertension (2006) 8.72
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet (2006) 8.61
Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med (2015) 8.61
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol (2007) 7.79
Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation (2003) 7.68
2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2010) 7.54
An open letter to The BMJ editors on qualitative research. BMJ (2016) 7.49
A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care (2003) 7.40
Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med (2013) 7.35
Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol (2013) 7.31
Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation (2008) 7.11
Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2010) 6.93
Effect of altitude on leptin levels, does it go up or down? J Appl Physiol (1985) (2008) 6.68
Obstructive sleep apnoea. Lancet (2002) 6.37
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol (2011) 6.35
Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis. JAMA (2005) 6.32
Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med (2005) 6.20
A prospective study of sleep duration and mortality risk in women. Sleep (2004) 6.11
A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med (2013) 5.99
Correlates of long sleep duration. Sleep (2006) 5.67
Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA (2003) 5.39
Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial. JAMA (2003) 5.30
Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. J Am Coll Cardiol (2008) 5.09
Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation (2002) 4.77
Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation (2006) 4.61
Association between performance measures and clinical outcomes for patients hospitalized with heart failure. JAMA (2007) 4.59
Association between reduced sleep and weight gain in women. Am J Epidemiol (2006) 4.59
Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA (2006) 4.30
Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care (2007) 4.30
History of the development of sleep medicine in the United States. J Clin Sleep Med (2005) 4.22
Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med (2003) 4.16
Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation (2007) 4.16
Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure. J Am Coll Cardiol (2004) 4.14
Sleep duration as a risk factor for diabetes incidence in a large U.S. sample. Sleep (2007) 4.14
Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med (2013) 3.98
Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry. J Am Coll Cardiol (2007) 3.92
Day-night pattern of sudden death in obstructive sleep apnea. N Engl J Med (2005) 3.84
Sleep-disordered breathing and cancer mortality: results from the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med (2012) 3.83
Childhood blood pressure trends and risk factors for high blood pressure: the NHANES experience 1988-2008. Hypertension (2013) 3.81
Association of atrial fibrillation and obstructive sleep apnea. Circulation (2004) 3.81
Obstructive sleep apnoea and its cardiovascular consequences. Lancet (2008) 3.73
Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med (2005) 3.73
Restless legs syndrome and daytime sleepiness are prominent in myotonic dystrophy type 2. Neurology (2013) 3.70
Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care (2008) 3.65
An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2013) 3.60
Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure. Circulation (2003) 3.56
Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 3.48
Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents. N Engl J Med (2002) 3.43
Association of sleep apnea and type II diabetes: a population-based study. Am J Respir Crit Care Med (2005) 3.42
Relationship between heart failure treatment and development of worsening renal function among hospitalized patients. Am Heart J (2004) 3.37
Impaired endothelial function in persons with obstructive sleep apnoea: impact of obesity. Heart (2012) 3.36
Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33