| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
General synthesis of persistent trityl radicals for EPR imaging of biological systems.
|
J Org Chem
|
2002
|
2.06
|
|
2
|
An efficient approach to Aspidosperma alkaloids via [4 + 2] cycloadditions of aminosiloxydienes: stereocontrolled total synthesis of (+/-)-tabersonine. Gram-scale catalytic asymmetric syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric syntheses of (+)-aspidospermidine and (-)-quebrachamine.
|
J Am Chem Soc
|
2002
|
2.00
|
|
3
|
Hydrogen bonding: single enantiomers from a chiral-alcohol catalyst.
|
Nature
|
2003
|
1.79
|
|
4
|
Chiral squaramide derivatives are excellent hydrogen bond donor catalysts.
|
J Am Chem Soc
|
2008
|
1.67
|
|
5
|
Rapid synthesis of the N-methylwelwitindolinone skeleton.
|
Org Lett
|
2005
|
1.66
|
|
6
|
Broadly effective enantioselective Diels-Alder reactions of 1-amino-substituted-1,3-butadienes.
|
Org Lett
|
2002
|
1.56
|
|
7
|
Total synthesis of N-methylwelwitindolinone D isonitrile.
|
J Am Chem Soc
|
2011
|
1.23
|
|
8
|
Total synthesis of mycalamide A.
|
J Am Chem Soc
|
2005
|
1.12
|
|
9
|
Highly diastereo- and enantioselective Mukaiyama aldol reactions catalyzed by hydrogen bonding.
|
Angew Chem Int Ed Engl
|
2006
|
1.12
|
|
10
|
Hydrogen-bond-promoted hetero-Diels-Alder reactions of unactivated ketones.
|
J Am Chem Soc
|
2002
|
1.12
|
|
11
|
Axially chiral biaryl diols catalyze highly enantioselective hetero-Diels-Alder reactions through hydrogen bonding.
|
J Am Chem Soc
|
2005
|
1.11
|
|
12
|
Enantioselective Diels-Alder reactions catalyzed by hydrogen bonding.
|
Proc Natl Acad Sci U S A
|
2004
|
1.06
|
|
13
|
Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles.
|
Org Lett
|
2008
|
1.04
|
|
14
|
Palladium-catalyzed C3-benzylation of indoles.
|
J Am Chem Soc
|
2011
|
1.03
|
|
15
|
Facile synthesis of the indeno-tetrahydropyridine core of haouamine A.
|
Org Lett
|
2005
|
1.02
|
|
16
|
Design and development of highly effective Lewis acid catalysts for enantioselective Diels-Alder reactions.
|
J Am Chem Soc
|
2002
|
1.01
|
|
17
|
Squaramide-catalyzed enantioselective Michael addition of diphenyl phosphite to nitroalkenes.
|
Angew Chem Int Ed Engl
|
2010
|
1.00
|
|
18
|
A unified route to the welwitindolinone alkaloids: total syntheses of (-)-N-methylwelwitindolinone C isothiocyanate, (-)-N-methylwelwitindolinone C isonitrile, and (-)-3-hydroxy-N-methylwelwitindolinone C isothiocyanate.
|
J Am Chem Soc
|
2012
|
0.99
|
|
19
|
Total synthesis of pederin.
|
Angew Chem Int Ed Engl
|
2007
|
0.98
|
|
20
|
A general strategy to elisabethane diterpenes: stereocontrolled synthesis of elisapterosin B via oxidative cyclization of an elisabethin precursor.
|
J Am Chem Soc
|
2003
|
0.97
|
|
21
|
Silver-catalyzed formal inverse electron-demand Diels-Alder reaction of 1,2-diazines and siloxy alkynes.
|
J Am Chem Soc
|
2012
|
0.96
|
|
22
|
Stereospecific synthesis of highly substituted skipped dienes through multifunctional palladium catalysis.
|
Org Lett
|
2002
|
0.95
|
|
23
|
Enantioselective alpha-amination of 1,3-dicarbonyl compounds using squaramide derivatives as hydrogen bonding catalysts.
|
Org Lett
|
2010
|
0.95
|
|
24
|
Stereocontrolled synthesis of 20,21-dihydro N-methylwelwitindolinone B isothiocyanate.
|
Chem Commun (Camb)
|
2011
|
0.94
|
|
25
|
Diastereoselective and enantioselective synthesis of tertiary alpha-hydroxy phosphonates through hydrogen-bond catalysis.
|
Angew Chem Int Ed Engl
|
2009
|
0.93
|
|
26
|
Electronic and steric tuning of chiral diene ligands for rhodium-catalyzed asymmetric arylation of imines.
|
Chem Commun (Camb)
|
2009
|
0.92
|
|
27
|
Directed oxidative cyclizations to C2- or C4-positions of indole: efficient construction of the bicyclo[4.3.1]decane core of welwitindolinones.
|
Org Lett
|
2011
|
0.92
|
|
28
|
Total synthesis of (+/-)-platencin.
|
Angew Chem Int Ed Engl
|
2008
|
0.91
|
|
29
|
Highly enantioselective carbonyl-ene reactions catalyzed by a hindered silyl-salen-cobalt complex.
|
Org Lett
|
2007
|
0.91
|
|
30
|
Squaramide-catalyzed enantioselective Michael addition of masked acyl cyanides to substituted enones.
|
J Am Chem Soc
|
2013
|
0.90
|
|
31
|
Palladium-catalyzed decarboxylative allylation and benzylation of N-alloc and N-Cbz indoles.
|
Org Lett
|
2013
|
0.87
|
|
32
|
Total synthesis of (+/-)-bipinnatin J.
|
Org Lett
|
2006
|
0.87
|
|
33
|
Palladium-catalyzed regiocontrolled alpha-arylation of trimethylsilyl enol ethers with aryl halides.
|
Org Lett
|
2006
|
0.86
|
|
34
|
Enantioselective total syntheses of (+)-arborescidine A, (-)-arborescidine B, and (-)-arborescidine C.
|
J Org Chem
|
2004
|
0.86
|
|
35
|
Synthesis of C-15 vindoline analogues by palladium-catalyzed cross-coupling reactions.
|
J Org Chem
|
2006
|
0.86
|
|
36
|
Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B.
|
RNA
|
2011
|
0.85
|
|
37
|
Synthesis of α-amino acid derivatives and peptides via enantioselective addition of masked acyl cyanides to imines.
|
J Am Chem Soc
|
2014
|
0.84
|
|
38
|
Hydrogen bond catalyzed enantioselective vinylogous Mukaiyama aldol reaction.
|
Org Lett
|
2005
|
0.83
|
|
39
|
Non-precious metals catalyze formal [4 + 2] cycloaddition reactions of 1,2-diazines and siloxyalkynes under ambient conditions.
|
Org Lett
|
2014
|
0.83
|
|
40
|
Simple chiral diene ligands provide high enantioselectivities in transition-metal-catalyzed conjugate addition reactions.
|
Org Lett
|
2008
|
0.82
|
|
41
|
Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin.
|
Life Sci
|
2003
|
0.82
|
|
42
|
Lessons Learned while Traversing the Welwitindolinone Alkaloids Obstacle Course.
|
Tetrahedron
|
2011
|
0.81
|
|
43
|
Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.
|
Chem Commun (Camb)
|
2010
|
0.80
|
|
44
|
Exploring the potential of diarylacetylenediols as hydrogen bonding catalysts.
|
J Org Chem
|
2013
|
0.79
|
|
45
|
Rapid access to spirocyclized indolenines via palladium-catalyzed cascade reactions of tryptamine derivatives and propargyl carbonate.
|
Org Lett
|
2014
|
0.78
|
|
46
|
Multifunctional palladium catalysis. 2. Tandem haloallylation followed by Wacker-Tsuji oxidation or sonogashira cross-coupling.
|
Org Lett
|
2002
|
0.78
|
|
47
|
Temporary restraints to overcome steric obstacles: an efficient strategy for the synthesis of mycalamide B.
|
Angew Chem Int Ed Engl
|
2010
|
0.77
|
|
48
|
Salen promoted enantioselective Nazarov cyclizations of activated and unactivated dienones.
|
J Am Chem Soc
|
2013
|
0.77
|
|
49
|
[2+2+2] Cycloadditions of siloxy alkynes with 1,2-diazines: from reaction discovery to identification of an antiglycolytic chemotype.
|
Angew Chem Int Ed Engl
|
2013
|
0.77
|
|
50
|
Diastereoselective and enantioselective Mukaiyama aldol reactions of alpha-ketoesters using hydrogen bond catalysis.
|
Chem Commun (Camb)
|
2010
|
0.76
|
|
51
|
Studies toward the asymmetric synthesis of the right part of the mycalamides.
|
J Org Chem
|
2007
|
0.75
|
|
52
|
Expedient, high-yielding synthesis of silyl-substituted salen ligands.
|
Org Lett
|
2007
|
0.75
|