Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.

Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet (2009) 7.62

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet (2009) 6.91

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet (2009) 5.65

Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet (2009) 5.06

Validating, augmenting and refining genome-wide association signals. Nat Rev Genet (2009) 4.56

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86

Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet (2009) 3.76

8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A (2010) 3.37

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet (2011) 3.37

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells. Mol Cell Biol (2010) 2.80

Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet (2009) 2.76

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat Genet (2010) 2.56

Evaluation of the 8q24 prostate cancer risk locus and MYC expression. Cancer Res (2009) 2.54

Implications of chimaeric non-co-linear transcripts. Nature (2009) 2.52

Identification of low-frequency variants associated with gout and serum uric acid levels. Nat Genet (2011) 2.48

Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nat Genet (2010) 2.45

Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers. PLoS One (2012) 2.38

Enrichment of sequencing targets from the human genome by solution hybridization. Genome Biol (2009) 2.32

A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. Nat Genet (2012) 2.29

An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer. Genome Res (2010) 2.24

Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14

Architecture of inherited susceptibility to common cancer. Nat Rev Cancer (2010) 2.14

Prostate cancer genomics: towards a new understanding. Nat Rev Genet (2008) 2.08

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med (2014) 2.08

Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms. J Natl Cancer Inst (2015) 2.05

A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. J Natl Cancer Inst (2010) 2.00

Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer. Cancer Res (2013) 1.99

Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet (2010) 1.90

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nat Genet (2010) 1.78

Distinct germ line polymorphisms underlie glioma morphologic heterogeneity. Cancer Genet (2011) 1.77

Genome-wide association studies and beyond. Annu Rev Public Health (2010) 1.73

Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65

A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression. PLoS Genet (2011) 1.60

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene. Hum Mol Genet (2011) 1.58

Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. PLoS Genet (2011) 1.54

Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans. Hum Mol Genet (2011) 1.45

Genome-wide association studies of cancer. J Clin Oncol (2010) 1.45

Recurrent urinary tract infection and risk of bladder cancer in the Nijmegen bladder cancer study. Br J Cancer (2014) 1.42

Genome-wide association studies in cancer--current and future directions. Carcinogenesis (2009) 1.39

Genetics of cleft lip and cleft palate. Am J Med Genet C Semin Med Genet (2013) 1.38

A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. Hum Mol Genet (2011) 1.36

Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk. Proc Natl Acad Sci U S A (2012) 1.36

Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet (2013) 1.34

The 8q24 gene desert: an oasis of non-coding transcriptional activity. Front Genet (2012) 1.28

Translational genomics: the challenge of developing cancer biomarkers. Genome Res (2012) 1.26

A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration. Nat Genet (2013) 1.23

Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis. BMC Cancer (2010) 1.22

Genetic susceptibility to distinct bladder cancer subphenotypes. Eur Urol (2009) 1.19

Therapeutic strategies to inhibit MYC. Cold Spring Harb Perspect Med (2014) 1.19

Identifying disease mutations in genomic medicine settings: current challenges and how to accelerate progress. Genome Med (2012) 1.18

Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk. Carcinogenesis (2009) 1.18

Sequence and structure signatures of cancer mutation hotspots in protein kinases. PLoS One (2009) 1.14

Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis (2010) 1.12

Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers? Genome Med (2010) 1.09

Myc: the beauty and the beast. Genes Cancer (2010) 1.07

Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites. Cancer Epidemiol Biomarkers Prev (2008) 1.06

Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption. Hum Mol Genet (2011) 1.03

Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study. Cancer Res (2011) 1.03

Prostate cancer predisposition loci and risk of metastatic disease and prostate cancer recurrence. Clin Cancer Res (2011) 1.01

Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background. PLoS One (2012) 1.00

Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer. Cancer Res (2010) 1.00

Pooled sample-based GWAS: a cost-effective alternative for identifying colorectal and prostate cancer risk variants in the Polish population. PLoS One (2012) 1.00

Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol (2012) 0.99

Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis. PLoS One (2012) 0.99

Bladder cancer in cancer patients: population-based estimates from a large Swedish study. Br J Cancer (2009) 0.98

Polygenic susceptibility to breast cancer: current state-of-the-art. Future Oncol (2009) 0.98

Regulators of gene expression as biomarkers for prostate cancer. Am J Cancer Res (2012) 0.98

High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLoS Genet (2014) 0.98

Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. Neoplasia (2009) 0.97

Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men. Carcinogenesis (2009) 0.97

Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations. PLoS One (2012) 0.97

Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. Hum Mol Genet (2014) 0.96

The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease. Cancer Res (2014) 0.96

Bladder cancer epidemiology and genetic susceptibility. J Biomed Res (2013) 0.95

Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage. Hum Mol Genet (2009) 0.94

MicroRNA-34a functions as an anti-metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44. J Exp Clin Cancer Res (2014) 0.94

8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. PLoS One (2012) 0.94

Contemporary management of low-risk bladder cancer. Nat Rev Urol (2011) 0.93

Elucidating the role of 8q24 in colorectal cancer. Nat Genet (2009) 0.93

Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study. Cancer Epidemiol Biomarkers Prev (2010) 0.92

Genetic variation at chromosome 8q24 in osteosarcoma cases and controls. Carcinogenesis (2010) 0.92

The evolving discipline of molecular epidemiology of cancer. Carcinogenesis (2009) 0.92

Methylation markers for urine-based detection of bladder cancer: the next generation of urinary markers for diagnosis and surveillance of bladder cancer. Adv Urol (2012) 0.90

Genetic susceptibility to bladder cancer risk and outcome. Per Med (2011) 0.90

Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development. BMC Med Genet (2011) 0.90

Genetic polymorphisms on 8q24.1 and 4p16.3 are not linked with urothelial carcinoma of the bladder in contrast to their association with aggressive upper urinary tract tumours. World J Urol (2012) 0.90

Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Cancer (2014) 0.88

Increased paternal age and the influence on burden of genomic copy number variation in the general population. Hum Genet (2013) 0.88

HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS One (2012) 0.88

Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol (2014) 0.87

Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis (2014) 0.87

Genetic variation in DROSHA 3'UTR regulated by hsa-miR-27b is associated with bladder cancer risk. PLoS One (2013) 0.87

Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. Twin Res Hum Genet (2010) 0.87

What are genome-wide association studies telling us about B-cell tumor development? Oncotarget (2010) 0.87

Genetic variations in colorectal cancer risk and clinical outcome. World J Gastroenterol (2014) 0.86

Urinary bladder cancer susceptibility markers. What do we know about functional mechanisms? Int J Mol Sci (2013) 0.86

Chromosome 4p16.3 variant modify bladder cancer risk in a Chinese population. Carcinogenesis (2011) 0.86

Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. Stroke (2014) 0.85

Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst (1959) 94.48

Genomic control for association studies. Biometrics (1999) 64.39

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17

Genetics of gene expression and its effect on disease. Nature (2008) 21.35

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature (2008) 18.21

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10

Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet (1987) 13.98

A common inversion under selection in Europeans. Nat Genet (2005) 13.66

A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet (2007) 11.62

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet (2007) 10.81

The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am J Surg Pathol (1998) 7.61

The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet (2003) 7.37

Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell (2006) 6.49

Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family. PLoS Med (2004) 2.67

myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res (1991) 2.08

Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. Clin Cancer Res (2003) 1.90

Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol (2002) 1.88

The c-myc insulator element and matrix attachment regions define the c-myc chromosomal domain. Mol Cell Biol (2003) 1.77

Risk of bladder cancer associated with family history of cancer: do low-penetrance polymorphisms account for the increase in risk? Cancer Epidemiol Biomarkers Prev (2007) 1.52

Familial aggregation of urothelial cell carcinoma. Int J Cancer (2002) 1.43

Segregation analysis of urothelial cell carcinoma. Eur J Cancer (2006) 1.21

Genetic alterations in urothelial bladder carcinoma: an updated review. Cancer (2006) 1.20

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Genetics of gene expression and its effect on disease. Nature (2008) 21.35

Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03

A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst (2004) 14.97

Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81

A common inversion under selection in Europeans. Nat Genet (2005) 13.66

A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47

Radical prostatectomy versus watchful waiting in early prostate cancer. N Engl J Med (2011) 13.30

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28