Published in PLoS One on September 18, 2008
Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity. J Biol Chem (2010) 1.07
Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem (2012) 1.05
Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics. Alzheimers Res Ther (2014) 0.86
Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. PLoS One (2014) 0.85
Amyloid Beta peptides differentially affect hippocampal theta rhythms in vitro. Int J Pept (2013) 0.81
Axon degeneration is key component of neuronal death in amyloid-β toxicity. Neurochem Int (2013) 0.80
WIN 55,212-2, agonist of cannabinoid receptors, prevents amyloid β1-42 effects on astrocytes in primary culture. PLoS One (2015) 0.79
Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies. Acta Neuropathol Commun (2014) 0.79
Therapeutic Effect of Yi-Chi-Tsung-Ming-Tang on Amyloid β-Induced Alzheimer's Disease-Like Phenotype via an Increase of Acetylcholine and Decrease of Amyloid β. Evid Based Complement Alternat Med (2012) 0.77
A structure-toxicity study of Aß42 reveals a new anti-parallel aggregation pathway. PLoS One (2013) 0.77
β-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition. Neuron (2014) 0.76
Effects of Ranolazine on Astrocytes and Neurons in Primary Culture. PLoS One (2016) 0.75
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (2003) 18.18
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci (2004) 9.73
A beta oligomers - a decade of discovery. J Neurochem (2007) 8.88
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci (2007) 8.27
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science (1990) 6.03
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem (1999) 4.64
Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem (2005) 3.06
Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans (2002) 2.55
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging (2006) 2.50
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med (1998) 2.32
The late maintenance of hippocampal LTP: requirements, phases, 'synaptic tagging', 'late-associativity' and implications. Neuropharmacology (2006) 1.88
The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans (2005) 1.84
Microglia provide neuroprotection after ischemia. FASEB J (2006) 1.82
Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proc Natl Acad Sci U S A (1994) 1.79
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci U S A (2007) 1.68
Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue. J Neurochem (1995) 1.65
Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair. Curr Drug Targets CNS Neurol Disord (2005) 1.64
Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death. J Neurosci (2005) 1.56
Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis. J Neurochem (1997) 1.46
Appraisal of the MTT-based assay as a useful tool for predicting drug chemosensitivity in leukemia. Leuk Lymphoma (2003) 1.35
Mitochondrial energy metabolism is markedly impaired by D-2-hydroxyglutaric acid in rat tissues. Mol Genet Metab (2005) 1.32
On the structural definition of amyloid fibrils and other polypeptide aggregates. Cell Mol Life Sci (2007) 1.29
ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem (2006) 1.28
Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism. FASEB J (2007) 1.24
Organotypic cultures as tools for functional screening in the CNS. Drug Discov Today (2005) 1.23
Studies on succinate dehydrogenase. 13. Reversible activation of the mammalian enzyme. J Biol Chem (1967) 1.15
Why Alzheimer's is a disease of memory: the attack on synapses by A beta oligomers (ADDLs). J Nutr Health Aging (2008) 1.13
Synaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction. Biochem Soc Trans (2007) 1.13
PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J Neurochem (2006) 1.12
Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease. J Lipid Res (2005) 1.12
Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation. Neurobiol Aging (2007) 1.11
Amyloid beta protein inhibits cellular MTT reduction not by suppression of mitochondrial succinate dehydrogenase but by acceleration of MTT formazan exocytosis in cultured rat cortical astrocytes. Neurosci Res (1998) 1.06
Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide. Protein Sci (2005) 1.06
Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder. J Cell Biol (1981) 0.97
Early phase of amyloid beta42-induced cytotoxicity in neuronal cells is associated with vacuole formation and enhancement of exocytosis. Exp Mol Med (2005) 0.92
Influence of EGF/bFGF treatment on proliferation, early neurogenesis and infarct volume after transient focal ischemia. Brain Res (2005) 0.91
Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Biochemistry (2007) 0.90
Inhibition of different pathways influencing Na(+) homeostasis protects organotypic hippocampal slice cultures from hypoxic/hypoglycemic injury. Neuropharmacology (2000) 0.89
Protective effect of Rosa laevigata against amyloid beta peptide-induced oxidative stress. Amyloid (2006) 0.87
Metabolic activity of cultured rat brainstem, hippocampal and spinal cord slices. J Neurosci Methods (2000) 0.86
Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning. Eur J Pharmacol (2007) 0.84
Glial fibrillary acidic protein is necessary for mature astrocytes to react to beta-amyloid. Glia (1999) 0.83
Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35). Brain Res (2001) 0.81
Differential regulation by beta-amyloid peptides of intracellular free Ca2+ concentration in cultured rat microglia. Eur J Pharmacol (1995) 0.81
Modelling of amyloid beta-peptide induced lesions using roller-drum incubation of hippocampal slice cultures from neonatal rats. Exp Brain Res (2005) 0.80
The ATP-regulated K+-channel inhibitor HMR-1372 affects synaptic plasticity in hippocampal slices. Eur J Pharmacol (2004) 0.80
Understanding the biological activity of amyloid proteins in vitro: from inhibited cellular MTT reduction to altered cellular cholesterol homeostatis. Prog Neuropsychopharmacol Biol Psychiatry (1999) 0.80
Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background. Exp Brain Res (2006) 0.79
Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity. Am J Pathol (1993) 0.79
Preparation of a tissue-like cortical primary culture from embryonic rats using Matrigel and serum free Start V Medium. J Neurosci Methods (2006) 0.78
Endomorphin-2, an endogenous tetrapeptide, protects against Abeta1-42 in vitro and in vivo. FASEB J (2006) 0.78
Role of caspase-12 in amyloid beta-peptide-induced toxicity in organotypic hippocampal slices cultured for long periods. J Pharmacol Sci (2007) 0.78
Temperature and PMA affect different phases of exocytosis in bovine chromaffin cells. Eur J Neurosci (2001) 0.77
A three amino acid peptide, Gly-Pro-Arg, protects and rescues cell death induced by amyloid beta-peptide. Exp Neurol (2003) 0.77
Amyloid beta-protein potentiates tunicamycin-induced neuronal death in organotypic hippocampal slice cultures. Neuroscience (2007) 0.77
Nanomolar amyloid beta protein-induced inhibition of cellular redox activity in cultured astrocytes. J Neurochem (1997) 0.77
Neurotoxicity induced by amyloid beta-peptide and ibotenic acid in organotypic hippocampal cultures: protection by S-allyl-L-cysteine, a garlic compound. Brain Res (2003) 0.77
Morphological and functional changes in rat hippocampal slice cultures after short-term oxygen-glucose deprivation. J Cell Mol Med (2004) 0.76
Different effects of monocarboxylates on neuronal survival and beta-amyloid toxicity. Eur J Neurosci (2007) 0.76
Congo red reverses amyloid beta protein-induced cellular stress in astrocytes. Neurosci Res (1997) 0.76
High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. J Mol Biol (2007) 2.67
FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci (2004) 2.31
Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Proc Natl Acad Sci U S A (2008) 1.89
Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. J Mol Biol (2008) 1.86
Microglia provide neuroprotection after ischemia. FASEB J (2006) 1.82
The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation. Protein Sci (2005) 1.74
Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J Neurosci (2008) 1.73
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci U S A (2007) 1.68
Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A (2009) 1.61
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci (2004) 1.45
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci U S A (2010) 1.42
Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils. J Mol Biol (2007) 1.39
Raft lipids as common components of human extracellular amyloid fibrils. Proc Natl Acad Sci U S A (2005) 1.38
Structural polymorphism of Alzheimer Abeta and other amyloid fibrils. Prion (2009) 1.35
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiol Aging (2010) 1.32
Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain (2006) 1.29
Solid-state NMR spectroscopic investigation of Aβ protofibrils: implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils. Angew Chem Int Ed Engl (2011) 1.24
Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. J Mol Med (Berl) (2008) 1.23
The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? J Cereb Blood Flow Metab (2011) 1.20
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides. Protein Sci (2007) 1.16
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A (2012) 1.11
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. J Neurosci (2011) 1.08
Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide. J Mol Biol (2006) 1.07
Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide. Protein Sci (2005) 1.06
An asymmetric dimer as the basic subunit in Alzheimer's disease amyloid β fibrils. Angew Chem Int Ed Engl (2012) 1.03
ALys amyloidosis caused by compound heterozygosity in exon 2 (Thr70Asn) and exon 4 (Trp112Arg) of the lysozyme gene. Hum Mutat (2006) 1.02
The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology (2008) 1.01
Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. Eur J Pharmacol (2008) 0.99
The neuroprotective effect of bone marrow stem cells is not dependent on direct cell contact with hypoxic injured tissue. Exp Neurol (2008) 0.99
Hereditary lattice corneal dystrophy is associated with corneal amyloid deposits enclosing C-terminal fragments of keratoepithelin. Invest Ophthalmol Vis Sci (2005) 0.98
Protease-activated receptors in neuronal development, neurodegeneration, and neuroprotection: thrombin as signaling molecule in the brain. Neuroscientist (2004) 0.98
Determination of the therapeutic time window for human umbilical cord blood mononuclear cell transplantation following experimental stroke in rats. Cell Transplant (2011) 0.97
A population of serum deprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells. Exp Cell Res (2008) 0.97
Structural basis of β-amyloid-dependent synaptic dysfunctions. Angew Chem Int Ed Engl (2012) 0.96
Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol (2010) 0.96
AA amyloidosis: pathogenesis and targeted therapy. Annu Rev Pathol (2014) 0.94
Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease. Acta Neuropathol (2014) 0.94
Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions. J Mol Biol (2010) 0.94
Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia. Neurosci Lett (2002) 0.93
Stases are associated with blood-brain barrier damage and a restricted activation of coagulation in SHRSP. J Neurol Sci (2012) 0.92
Assessment of neuroprotective effects of human umbilical cord blood mononuclear cell subpopulations in vitro and in vivo. Cell Transplant (2011) 0.92
High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain. J Cell Mol Med (2012) 0.92
Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy. Angew Chem Int Ed Engl (2010) 0.91
Influence of EGF/bFGF treatment on proliferation, early neurogenesis and infarct volume after transient focal ischemia. Brain Res (2005) 0.91
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment. Proc Natl Acad Sci U S A (2012) 0.91
Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease. J Biol Chem (2003) 0.91
Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin. J Mol Biol (2006) 0.91
Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice. Neurobiol Aging (2012) 0.90
Time-dependent segmentation of BrdU-signal leads to late detection problems in studies using BrdU as cell label or proliferation marker. J Neurosci Methods (2008) 0.89
Anti-inflammatory treatment in oxygen-glucose-deprived hippocampal slice cultures is neuroprotective and associated with reduced cell proliferation and intact neurogenesis. Neurobiol Dis (2006) 0.88
Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra. Brain Res (2006) 0.88
Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods? J Alzheimers Dis (2008) 0.88
Thermodynamic analysis of the aggregation propensity of oxidized Alzheimer's beta-amyloid variants. Protein Sci (2005) 0.87
Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils. J Mol Biol (2011) 0.86
Neurovascular pathophysiology in cerebral ischemia, dementia and the ageing brain - current trends in basic, translational and clinical research. Exp Transl Stroke Med (2012) 0.86
Mutagenic exploration of the cross-seeding and fibrillation propensity of Alzheimer's beta-amyloid peptide variants. Protein Sci (2006) 0.85
Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke. Acta Neuropathol (2014) 0.84
Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction. J Pharmacol Exp Ther (2008) 0.84
Combining independent drug classes into superior, synergistically acting hybrid molecules. Angew Chem Int Ed Engl (2010) 0.84
7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro. Eur J Neurosci (2003) 0.84
Kidney pathology precedes and predicts the pathological cascade of cerebrovascular lesions in stroke prone rats. PLoS One (2011) 0.84
Effects of transient global ischaemia on freezing behaviour and activity in a context-dependent fear conditioning task--implications for memory investigations. Brain Res Bull (2011) 0.83
bFGF and EGF modulate trauma-induced proliferation and neurogenesis in juvenile organotypic hippocampal slice cultures. Brain Res (2005) 0.83
Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia. Neuropharmacology (2009) 0.81
P2 receptor antagonist trinitrophenyl-adenosine-triphosphate protects hippocampus from oxygen and glucose deprivation cell death. J Pharmacol Exp Ther (2007) 0.81
Pattern of time-dependent reduction of histologically determined infarct volume after focal ischaemia in mice. Neurosci Lett (2007) 0.81
Detection of chronic sensorimotor impairments in the ladder rung walking task in rats with endothelin-1-induced mild focal ischemia. J Neurosci Methods (2004) 0.81
Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.81
Protease-activated receptor-1 induces generation of new microglia in the dentate gyrus of traumatised hippocampal slice cultures. Neurosci Lett (2007) 0.81
The ATP-regulated K+-channel inhibitor HMR-1372 affects synaptic plasticity in hippocampal slices. Eur J Pharmacol (2004) 0.80
Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. Altern Lab Anim (2002) 0.80
Preconditioning with thrombin can be protective or worsen damage after endothelin-1-induced focal ischemia in rats. J Neurosci Res (2006) 0.80
Inhibitors of cation-chloride-cotransporters affect hypoxic/hypoglycemic injury in hippocampal slices. Brain Res (2005) 0.80
Neural regeneration protein is a novel chemoattractive and neuronal survival-promoting factor. Exp Cell Res (2006) 0.79
Structure and biomedical applications of amyloid oligomer nanoparticles. ACS Nano (2014) 0.79
Neuroprotective effects of the survival promoting peptide Y-P30. Eur J Pharmacol (2009) 0.79
Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies. Acta Neuropathol Commun (2014) 0.79
Preparation of a tissue-like cortical primary culture from embryonic rats using Matrigel and serum free Start V Medium. J Neurosci Methods (2006) 0.78
Phosphate and HEPES buffers potently affect the fibrillation and oligomerization mechanism of Alzheimer's Aβ peptide. Biochem Biophys Res Commun (2011) 0.78
The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.78
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion. J Neurosci Res (2011) 0.77