Published in Future Neurol on May 01, 2008
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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem (2005) 5.89
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Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
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Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A (2007) 3.92
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
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Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39
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Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol (2007) 3.29
A block of autophagy in lysosomal storage disorders. Hum Mol Genet (2007) 3.28
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol (2007) 3.27
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Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest (2008) 3.23
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Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proc Natl Acad Sci U S A (2005) 2.69
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Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol (2008) 2.57
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol (2007) 2.46
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
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Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem (2006) 2.34
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J Neurosci (2002) 2.31
Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol (2006) 2.17
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet (2007) 2.03
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Mitochondrial movement and positioning in axons: the role of growth factor signaling. J Exp Biol (2003) 1.92
Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell (2006) 1.85
Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ (2007) 1.80
Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol (2006) 1.80
Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy (2007) 1.79
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol (2003) 1.75
Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Hum Mol Genet (2007) 1.73
Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med (2006) 1.73
Peroxisome turnover by micropexophagy: an autophagy-related process. Trends Cell Biol (2004) 1.69
Mitochondrial aberrations in mucolipidosis Type IV. J Biol Chem (2006) 1.61
Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy (2007) 1.61
Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau. J Neurocytol (2003) 1.58
Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis. Mol Pharmacol (2008) 1.56
Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy (2007) 1.55
Apoptosis and autophagy in photoreceptors exposed to oxidative stress. Autophagy (2007) 1.55
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J Neurosci (2007) 1.52
Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain. Am J Pathol (2007) 1.46
Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci (2007) 1.45
Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res (2007) 1.45
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res (2007) 1.43
Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration. Hum Mol Genet (2001) 1.42
Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy (2007) 1.40
Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Autophagy (2007) 1.39
Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab (2007) 1.33
Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J Neurosci (2004) 1.32
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Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett (2006) 1.07
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Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies. J Biol Chem (2007) 1.01
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Regulation of the autophagy protein LC3 by phosphorylation. J Cell Biol (2010) 1.86
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol (2003) 1.75
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy (2008) 1.74
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Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab (2007) 1.33
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The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons. J Neurosci (2004) 1.21
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Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am J Pathol (2012) 1.16
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Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy (2007) 1.12
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A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis (2009) 1.11
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Monitoring mitophagy in neuronal cell cultures. Methods Mol Biol (2011) 0.93
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Mitochondrial autophagy as a compensatory response to PINK1 deficiency. Autophagy (2009) 0.89
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Altered transcription factor trafficking in oxidatively-stressed neuronal cells. Biochim Biophys Acta (2012) 0.78
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