Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation.

PubWeight™: 1.39‹?› | Rank: Top 5%

🔗 View Article (PMC 2597127)

Published in Blood on September 23, 2008

Authors

Spencer W Stonier1, Lisa J Ma, Eliseo F Castillo, Kimberly S Schluns

Author Affiliations

1: Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Articles citing this

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity (2011) 5.43

Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol Rev (2012) 2.03

Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum. Blood (2012) 1.90

Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett (2009) 1.64

Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells. J Immunol (2010) 1.48

Memory CD8+ T cell differentiation. Ann N Y Acad Sci (2010) 1.47

Once a killer, always a killer: from cytotoxic T cell to memory cell. Immunol Rev (2010) 1.46

Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol (2010) 1.42

IL-15: a central regulator of celiac disease immunopathology. Immunol Rev (2014) 1.14

Regulating the immune system via IL-15 transpresentation. Cytokine (2012) 1.08

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes. Proc Natl Acad Sci U S A (2010) 1.07

A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. J Immunol (2010) 1.05

CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol (2013) 1.05

Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. J Nutr (2010) 1.04

Cutting edge: the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression in vivo. J Immunol (2012) 1.03

Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation. Blood (2010) 1.00

Monocytes differentiated with GM-CSF and IL-15 initiate Th17 and Th1 responses that are contact-dependent and mediated by IL-15. J Leukoc Biol (2011) 0.96

Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo. Clin Cancer Res (2011) 0.92

IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo. Blood (2009) 0.88

Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen. J Leukoc Biol (2012) 0.87

The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria. J Immunol (2013) 0.86

Pulmonary dendritic cells: thinking globally, acting locally. J Exp Med (2010) 0.86

Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun (2015) 0.85

Transcriptional regulation of IL-15 expression during hematopoiesis. J Immunol (2013) 0.83

Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations. PLoS One (2015) 0.82

Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types. J Leukoc Biol (2010) 0.82

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. Proc Natl Acad Sci U S A (2016) 0.81

Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer. Am J Immunol (2009) 0.81

Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency. Oncoimmunology (2014) 0.80

Overlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functions. ScientificWorldJournal (2011) 0.78

Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways. PLoS One (2015) 0.78

Chemotherapy and immunotherapy: A close interplay to fight cancer? Oncoimmunology (2016) 0.78

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins. Cell Death Differ (2014) 0.77

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells. Proc Natl Acad Sci U S A (2016) 0.76

High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner. Sci Rep (2016) 0.75

IL-15, in synergy with RAE-1ɛ, stimulates TCR-independent proliferation and activation of CD8(+) T cells. Oncol Lett (2011) 0.75

Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion. J Immunol (2016) 0.75

Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use. J Immunol Res (2017) 0.75

IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues. J Immunol (2017) 0.75

Articles cited by this

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol (2003) 15.51

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

Preferential localization of effector memory cells in nonlymphoid tissue. Science (2001) 14.22

Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity (2007) 12.98

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med (2000) 9.78

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol (2001) 9.23

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity (1998) 9.02

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity (1998) 8.29

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity (2002) 6.10

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med (2002) 5.64

Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity (2007) 5.50

Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol (2002) 4.36

Dynamic programming of CD8+ T lymphocyte responses. Nat Immunol (2003) 3.73

Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity (2005) 3.39

Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. J Exp Med (2007) 3.09

Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J Exp Med (2004) 2.78

IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J Immunol (2001) 2.65

The role of programming in memory T-cell development. Curr Opin Immunol (2004) 2.41

IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med (2008) 2.33

IL-15 promotes the survival of naive and memory phenotype CD8+ T cells. J Immunol (2003) 2.28

Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo. J Immunol (1995) 2.18

IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory. Proc Natl Acad Sci U S A (2003) 2.07

Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells. Blood (2003) 2.00

Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs. Immunity (2006) 1.95

Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. J Immunol (2005) 1.95

Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem (1995) 1.90

IL-15 regulates CD8+ T cell contraction during primary infection. J Immunol (2006) 1.88

Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. J Immunol (2004) 1.87

Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15. Blood (1999) 1.71

Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression. Proc Natl Acad Sci U S A (2004) 1.68

CD8 cell division maintaining cytotoxic memory occurs predominantly in the bone marrow. J Immunol (2005) 1.49

Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity. J Biol Chem (2007) 1.47

Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses. Eur J Immunol (2003) 1.16

Articles by these authors

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26

Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56

Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J Immunol (2006) 2.69

Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion. Nat Med (2013) 2.65

Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. J Immunol (2004) 1.87

Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett (2009) 1.64

Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J Immunol (2002) 1.58

IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J Immunol (2009) 1.43

Functions of γC cytokines in immune homeostasis: current and potential clinical applications. Clin Immunol (2009) 1.22

Nfil3-independent lineage maintenance and antiviral response of natural killer cells. J Exp Med (2013) 1.21

Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation. J Immunol (2009) 1.20

Autophagy as an immune effector against tuberculosis. Curr Opin Microbiol (2013) 1.19

Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity (2012) 1.18

Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J Immunol (2009) 1.16

Regulating the immune system via IL-15 transpresentation. Cytokine (2012) 1.08

Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation. Blood (2010) 1.00

Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators. J Innate Immun (2013) 1.00

Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res (2011) 0.88

Window of opportunity for daclizumab. Nat Med (2011) 0.83

Transcriptional regulation of IL-15 expression during hematopoiesis. J Immunol (2013) 0.83

Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types. J Leukoc Biol (2010) 0.82

Migration of primary and memory CD8 T cells. Adv Exp Med Biol (2002) 0.80

Procedures for mucosal immunization and analyses of cellular immune response to candidate HIV vaccines in murine and nonhuman primate models. Methods Mol Biol (2014) 0.78

Pasteurized whole milk confers reduced susceptibilities to the antimicrobial agents trimethoprim, gatifloxacin, cefotaxime and tetracycline via the marRAB locus in Escherichia coli. J Dairy Res (2008) 0.77

The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol (2013) 0.77