A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis.

PubWeight™: 2.15‹?› | Rank: Top 2%

🔗 View Article (PMID 18835860)

Published in J Med Genet on October 01, 2008

Authors

T Mushiroda1, S Wattanapokayakit, A Takahashi, T Nukiwa, S Kudoh, T Ogura, H Taniguchi, M Kubo, N Kamatani, Y Nakamura, Pirfenidone Clinical Study Group

Author Affiliations

1: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Articles citing this

Telomere diseases. N Engl J Med (2009) 5.68

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62

Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet (2009) 5.13

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35

Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst (2010) 3.18

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med (2013) 2.86

Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96

Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation. Lancet Respir Med (2014) 1.91

The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90

A subset-based approach improves power and interpretation for the combined analysis of genetic association studies of heterogeneous traits. Am J Hum Genet (2012) 1.57

Transcriptome analysis reveals differential splicing events in IPF lung tissue. PLoS One (2014) 1.45

Genome-wide association studies in cancer--current and future directions. Carcinogenesis (2009) 1.39

Idiopathic pulmonary fibrosis: update on genetic discoveries. Proc Am Thorac Soc (2011) 1.23

Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 1.23

Epidemiology of idiopathic pulmonary fibrosis. Clin Epidemiol (2013) 1.17

Biomarkers in idiopathic pulmonary fibrosis. Curr Opin Pulm Med (2012) 1.09

New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses. Am J Respir Crit Care Med (2014) 1.02

Genetics and early detection in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2014) 1.01

Diseases of pulmonary surfactant homeostasis. Annu Rev Pathol (2015) 1.01

Association between MUC5B and TERT polymorphisms and different interstitial lung disease phenotypes. Transl Res (2013) 0.93

The state of genome-wide association studies in pulmonary disease: a new perspective. Am J Respir Crit Care Med (2011) 0.91

Evolving genomic approaches to idiopathic pulmonary fibrosis: moving beyond genes. Clin Transl Sci (2011) 0.91

The genetic basis of idiopathic pulmonary fibrosis. Eur Respir J (2015) 0.91

Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. J Cancer Epidemiol (2010) 0.90

Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: an association study. Sci Rep (2014) 0.87

Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies. Curr Pharmacogenomics Person Med (2010) 0.87

Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases. BMC Genomics (2012) 0.85

A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One (2013) 0.85

Personalized medicine: applying 'omics' to lung fibrosis. Biomark Med (2012) 0.84

A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest (2014) 0.83

The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. Am J Respir Crit Care Med (2014) 0.83

Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme. Aging Cell (2011) 0.82

Medical genetics and epigenetics of telomerase. J Cell Mol Med (2011) 0.82

Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry. Breast Cancer Res Treat (2011) 0.81

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression. BMC Pulm Med (2010) 0.81

A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome. BMC Med Genet (2014) 0.81

Genetics of Interstitial Lung Disease: Vol de Nuit (Night Flight). Clin Med Insights Circ Respir Pulm Med (2015) 0.81

Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis. Lung (2010) 0.80

Angiotensin-converting enzyme (ACE) gene polymorphisms are associated with idiopathic pulmonary fibrosis. Lung (2013) 0.80

Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis. Patient Prefer Adherence (2014) 0.79

Getting from genes to function in lung disease: a National Heart, Lung, and Blood Institute workshop report. Am J Respir Crit Care Med (2010) 0.79

Comparison of gene expression profiling between lung fibrotic and emphysematous tissues sampled from patients with combined pulmonary fibrosis and emphysema. Fibrogenesis Tissue Repair (2012) 0.79

Genetic susceptibility and pulmonary fibrosis. Curr Opin Pulm Med (2014) 0.78

Smoking-related interstitial lung disease. Dtsch Arztebl Int (2015) 0.78

The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema. Pulm Med (2012) 0.77

Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet (2015) 0.76

Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing. Transl Res (2015) 0.76

Candidate genes of idiopathic pulmonary fibrosis: current evidence and research. Appl Clin Genet (2016) 0.76

Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet (2016) 0.76

Analysis of heat shock protein 70 gene polymorphisms Mexican patients with idiopathic pulmonary fibrosis. BMC Pulm Med (2015) 0.76

The GG genotype of telomerase reverse transcriptase at genetic locus rs2736100 is associated with human atherosclerosis risk in the Han Chinese population. PLoS One (2014) 0.76

ADAM33 gene polymorphisms are associated with the risk of idiopathic pulmonary fibrosis. Lung (2014) 0.76

Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations. Front Immunol (2016) 0.76

Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice. Environ Health Perspect (2016) 0.75

Idiopathic pulmonary fibrosis: a paradigm of late-onset, single-gene human disease? BMJ Open Respir Res (2014) 0.75

Pharmacogenetics and interstitial lung disease. Curr Opin Pulm Med (2016) 0.75

A first glimpse at the early origins of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2015) 0.75

Familial Interstitial Pneumonia (FIP). Clin Pulm Med (2014) 0.75

Understanding Idiopathic Interstitial Pneumonia: A Gene-Based Review of Stressed Lungs. Biomed Res Int (2015) 0.75

Using omics approaches to understand pulmonary diseases. Respir Res (2017) 0.75

Articles by these authors

Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res (1996) 28.37

Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82

Variable number of tandem repeat (VNTR) markers for human gene mapping. Science (1987) 25.71

Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med (1998) 23.22

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66

Quantum computers. Nature (2010) 6.79

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature (2000) 6.01

When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain (1995) 5.97

Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol (1999) 5.65

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64

Allelotype of colorectal carcinomas. Science (1989) 5.54

Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells. J Bacteriol (1989) 5.43

The action of tetrodotoxin on electrogenic components of squid giant axons. J Gen Physiol (1965) 5.42

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14

Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94

Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J (2009) 4.63

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62

The gene for familial polyposis coli maps to the long arm of chromosome 5. Science (1987) 4.48

Partition mechanism of F plasmid: two plasmid gene-encoded products and a cis-acting region are involved in partition. Cell (1983) 4.39

Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38

Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA. Nucleic Acids Res (1986) 4.36

Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27

A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res (1992) 4.21

Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res (2000) 4.11

Mini-F plasmid genes that couple host cell division to plasmid proliferation. Proc Natl Acad Sci U S A (1983) 4.07

Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03

Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature (1988) 3.96

An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature (1998) 3.86

The new gene mukB codes for a 177 kd protein with coiled-coil domains involved in chromosome partitioning of E. coli. EMBO J (1991) 3.86

Antibacterial activity of apalcillin (PC-904) against gram-negative bacilli, especially ampicillin-, carbenicillin-, and gentamicin-resistant clinical isolates. Antimicrob Agents Chemother (1978) 3.65

Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47

Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42

Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci (2002) 3.28

Rapid confirmation of single copy lambda prophage integration by PCR. Nucleic Acids Res (1994) 3.19

Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18

A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18

Isolation and mapping of a polymorphic DNA sequence (pTHH22) on chromosome 9 [D9S12]. Nucleic Acids Res (1988) 3.17

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet (2001) 3.14

IL-6 is produced by osteoblasts and induces bone resorption. J Immunol (1990) 3.14

Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome. J Mol Biol (1992) 3.11

Effects of the ccd function of the F plasmid on bacterial growth. J Bacteriol (1985) 3.10

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05

Editorial: The First Specialist Qualification Examination of the Japanese Society of Intravascular Neurosurgery (JSIN). Interv Neuroradiol (2004) 3.03

Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome. Am J Hum Genet (1988) 2.97

Mapping of mutation causing Friedreich's ataxia to human chromosome 9. Nature (1988) 2.96

A tripeptide 'anticodon' deciphers stop codons in messenger RNA. Nature (2000) 2.90

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A (1995) 2.89

Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet (1993) 2.88

Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun (2001) 2.86

Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell (1995) 2.81

A mapped set of genetic markers for human chromosome 9. Genomics (1988) 2.80

Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: identification of new linked markers on chromosome 17. Am J Hum Genet (1990) 2.77

Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet (1998) 2.77

Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75

Electrophysiological end point for catheter ablation of atrial fibrillation initiated from multiple pulmonary venous foci. Circulation (2000) 2.72

Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum (2000) 2.72

Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res (1992) 2.72

A primary genetic linkage map for human chromosome 12. Genomics (1987) 2.72

Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65

Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res (1987) 2.65

Complete structure of the chloroplast genome of Arabidopsis thaliana. DNA Res (1999) 2.63

Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat (1993) 2.63

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol (1994) 2.62

Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62

Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res (1990) 2.57

A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54

Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54

Structure and function of the F plasmid genes essential for partitioning. J Mol Biol (1986) 2.53

Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene. Hum Genet (2000) 2.50

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell (2001) 2.47

Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res (1995) 2.47

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44

Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology (2000) 2.43

Helium-3 emission related to volcanic activity. Science (1984) 2.43

Modulation of cell death by Bcl-XL through caspase interaction. Proc Natl Acad Sci U S A (1998) 2.42

Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res (1998) 2.42

A pitfall in the surgery of a recurrent aneurysm after coil embolization and its histological observation: technical case report. Neurosurgery (1996) 2.40

Molecular basis of alpha-1-antitrypsin deficiency. Am J Med (1988) 2.40

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci U S A (2000) 2.38

Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase. Nature (1978) 2.37

Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci (2000) 2.36

A large scale analysis of cDNA in Arabidopsis thaliana: generation of 12,028 non-redundant expressed sequence tags from normalized and size-selected cDNA libraries. DNA Res (2000) 2.33

Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. N Engl J Med (1990) 2.32

The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. Mol Cell Biol (1991) 2.30

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]. JAMA (1989) 2.29

Biochemical and genetic analysis of the effects of amylose-extender mutation in rice endosperm. Plant Physiol (2001) 2.28

Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene. J Clin Microbiol (1998) 2.28

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts. Oncogene (1999) 2.27

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene (2001) 2.25

A new technique for monitoring the behaviour of free-ranging Adélie penguins. J Exp Biol (2001) 2.24

Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell (1994) 2.20

Nanometre-scale thermometry in a living cell. Nature (2013) 2.20