Published in Circulation on September 01, 1991
Long QT Syndrome-Population Genetics and Cardiac Studies (LQTS) | NCT00005176
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10
Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis (2008) 4.09
Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene. Circulation (2007) 2.88
Long QT syndrome: from channels to cardiac arrhythmias. J Clin Invest (2005) 2.71
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation (2010) 2.49
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol (2010) 2.41
Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome. Circulation (2008) 2.40
Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome. J Cardiovasc Electrophysiol (2008) 2.39
Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death Study. Circulation (2009) 2.31
Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol (2007) 2.28
Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol (2011) 2.15
Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. J Am Coll Cardiol (2012) 1.81
Clinical implications for patients with long QT syndrome who experience a cardiac event during infancy. J Am Coll Cardiol (2009) 1.81
Azithromycin as a cause of QT-interval prolongation and torsade de pointes in the absence of other known precipitating factors. J Interv Card Electrophysiol (2007) 1.65
Risk of death in the long QT syndrome when a sibling has died. Heart Rhythm (2008) 1.64
Congenital long QT syndrome. Orphanet J Rare Dis (2008) 1.58
Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace (2007) 1.57
Importance of Knowing the Genotype and the Specific Mutation When Managing Patients with Long QT Syndrome. Circ Arrhythm Electrophysiol (2008) 1.48
Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome. Heart Rhythm (2012) 1.47
Perioperative torsade de pointes: a systematic review of published case reports. Anesth Analg (2013) 1.42
Risk of recurrent cardiac events after onset of menopause in women with congenital long-QT syndrome types 1 and 2. Circulation (2011) 1.41
Heterogeneity and cardiac arrhythmias: an overview. Heart Rhythm (2007) 1.41
Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation. Circ Cardiovasc Genet (2011) 1.40
Autonomic aspects of arrhythmogenesis: the enduring and the new. Curr Opin Cardiol (2004) 1.35
Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. J Clin Invest (2002) 1.31
Mapping of a gene for long QT syndrome to chromosome 4q25-27. Am J Hum Genet (1995) 1.29
Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits. J Physiol (2011) 1.21
Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias. J Clin Invest (2003) 1.18
Sudden cardiac death in young athletes; a literature review and special considerations in Asia. Asian J Sports Med (2011) 1.18
The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. PLoS One (2009) 1.11
Arrhythmia phenotype during fetal life suggests long-QT syndrome genotype: risk stratification of perinatal long-QT syndrome. Circ Arrhythm Electrophysiol (2013) 1.11
Risk stratification for sudden cardiac death: current status and challenges for the future. Eur Heart J (2014) 1.11
Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels. J Biol Chem (2011) 1.10
Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes. J Intern Med (2006) 1.08
Modulation of transmural repolarization. Ann N Y Acad Sci (2005) 1.07
HERG1 channelopathies. Pflugers Arch (2009) 1.06
Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome. Circ Cardiovasc Genet (2013) 1.03
Influence of sex hormones and phytoestrogens on heart disease in men and women. Womens Health (Lond Engl) (2010) 1.02
Current perspectives in genetic cardiovascular disorders: from basic to clinical aspects. Heart Vessels (2013) 1.02
Cardiac repolarization. The long and short of it. Europace (2005) 1.00
Overview of Basic Mechanisms of Cardiac Arrhythmia. Card Electrophysiol Clin (2011) 0.99
Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease. Ann Noninvasive Electrocardiol (2008) 0.98
Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott) (2016) 0.97
The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis. J Cardiovasc Electrophysiol (2006) 0.97
Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia. Anesthesiology (2012) 0.95
Ventricular anti-arrhythmic effects of heptanol in hypokalaemic, Langendorff-perfused mouse hearts. Biomed Rep (2016) 0.95
Drug-induced spatial dispersion of repolarization. Cardiol J (2008) 0.94
KCNQ1 and KCNH2 mutations associated with long QT syndrome in a Chinese population. Hum Mutat (2002) 0.94
Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists. Am J Cardiol (2008) 0.93
Gender and cardiac arrhythmias. Tex Heart Inst J (2001) 0.93
Congenital long-QT syndromes: a clinical and genetic update from infancy through adulthood. Trends Cardiovasc Med (2008) 0.92
Relation between QT duration and maximal wall thickness in familial hypertrophic cardiomyopathy. Heart (2002) 0.92
Age-and sex-dependent mRNA expression of KCNQ1 and HERG in patients with long QT syndrome type 1 and 2. Arch Med Sci (2011) 0.91
Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations. Heart Rhythm (2012) 0.91
Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J Am Heart Assoc (2013) 0.89
Implantable cardioverter defibrillator implantation in children in The Netherlands. Eur J Pediatr (2005) 0.88
A survey of health care practitioners' knowledge of the QT interval. J Gen Intern Med (2005) 0.86
Evidence of a long QT founder gene with varying phenotypic expression in South African families. J Med Genet (1996) 0.86
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients. Circ Cardiovasc Qual Outcomes (2013) 0.86
Analysis of HLA and disease susceptibility: chromosome 6 genes and sex influence long-QT phenotype. Am J Hum Genet (1994) 0.84
Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning. J Biol Chem (2014) 0.84
Effects of sex on the pharmacokinetic and pharmacodynamic properties of quinidine. Br J Clin Pharmacol (2003) 0.84
Effectiveness of a clinical decision support system for reducing the risk of QT interval prolongation in hospitalized patients. Circ Cardiovasc Qual Outcomes (2014) 0.84
Long QT syndrome: a Korean single center study. J Korean Med Sci (2013) 0.84
Long QT syndrome in African-Americans. Ann Noninvasive Electrocardiol (2010) 0.84
Novel genes for QTc interval. How much heritability is explained, and how much is left to find? Genome Med (2010) 0.84
Towards a better understanding of QT interval variability. Ther Adv Drug Saf (2011) 0.83
Long-QT Syndrome and Therapy for Attention Deficit/Hyperactivity Disorder. J Cardiovasc Electrophysiol (2015) 0.82
Cardiac Channelopathies and Sudden Death: Recent Clinical and Genetic Advances. Biology (Basel) (2017) 0.81
Happiness and stress alter susceptibility to cardiac events in Long QT Syndrome. Ann Noninvasive Electrocardiol (2009) 0.81
Transient loss of consciousness with convulsions in two young adults with potentially fatal underlying heart disease: syncope versus seizures. BMJ Case Rep (2009) 0.81
Channel structure and drug-induced cardiac arrhythmias. Proc Natl Acad Sci U S A (2000) 0.80
Prevalence and risk factors for prolonged QT interval and QT dispersion in patients with type 2 diabetes. Acta Diabetol (2016) 0.80
A missense mutation (G604S) in the S5/pore region of HERG causes long QT syndrome in a Chinese family with a high incidence of sudden unexpected death. Eur J Pediatr (2006) 0.79
Long QT Syndromes. Curr Treat Options Cardiovasc Med (2000) 0.79
Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome. Heart Rhythm (2011) 0.78
Pre-participation Cardiovascular Screening of Elderly Wrestlers. Asian J Sports Med (2010) 0.78
Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion. Br Heart J (1993) 0.78
QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome. J Am Heart Assoc (2015) 0.78
Primary cardiac tumor identified as the cause of seizure. West J Emerg Med (2011) 0.78
Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation. J Cardiovasc Electrophysiol (2011) 0.78
Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse. Healthc Inform Res (2011) 0.78
Evaluation of differences in automated QT/QTc measurements between Fukuda Denshi and Nihon Koden systems. PLoS One (2014) 0.77
Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations. Ann Noninvasive Electrocardiol (2008) 0.77
How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation? Europace (2014) 0.77
Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation. Sci Rep (2016) 0.77
Risk stratification in electrical cardiomyopathies. Herz (2009) 0.76
Giant inverted T waves and substantial QT interval prolongation induced by azithromycin in an elderly woman with renal insufficiency. Can Fam Physician (2014) 0.76
Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome. Am J Cardiol (2009) 0.75
Approach to wide complex tachycardias in patients without structural heart disease. Heart (2006) 0.75
QT interval dispersion in the patients with central serous chorioretinopathy. Int J Ophthalmol (2015) 0.75
Management of Patients with Long QT Syndrome. Korean Circ J (2016) 0.75
A 26-year-old woman with recurrent loss of consciousness. J Gen Intern Med (2011) 0.75
Single nucleotide deletion mutation of KCNH2 gene is responsible for LQT syndrome in a 3-generation Korean family. J Korean Med Sci (2013) 0.75
Correlation between seizure in children and prolonged QT interval. ARYA Atheroscler (2013) 0.75
Congenital and drug-induced long-QT syndrome: an update. Neth Heart J (2004) 0.75
Genetic testing for long QT syndrome and the category of cardiac ion channelopathies. PLoS Curr (2012) 0.75
Association of the hERG mutation with long‑QT syndrome type 2, syncope and epilepsy. Mol Med Rep (2016) 0.75
Genetics of inherited arrhythmias in children. Indian Pacing Electrophysiol J (2008) 0.75
Long QT Syndrome: How Effective Therapy in a Single Patient Favorably Influenced the Long-Term Clinical Course and Genetic Understanding of this Hereditary Disorder. Prog Cardiovasc Dis (2015) 0.75
Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med (1996) 15.04
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell (1995) 10.18
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation (2000) 7.50
Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation (2001) 7.47
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet (1996) 7.35
Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. A randomized double-blind study. N Engl J Med (1983) 5.41
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09
Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation (1995) 4.48
Diagnostic criteria for the long QT syndrome. An update. Circulation (1993) 4.48
1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol (1999) 4.15
Comfort care for terminally ill patients. The appropriate use of nutrition and hydration. JAMA (1994) 3.92
ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation (1995) 3.79
Intratribal genetic differentiation among the Yanomama Indians of southern Venezuela. Proc Natl Acad Sci U S A (1967) 3.75
The long Q-T syndrome. Am Heart J (1975) 3.75
Influence of genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. N Engl J Med (1998) 3.41
Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. Science (1991) 3.38
QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation (1978) 3.32
Smooth non-parametric receiver operating characteristic (ROC) curves for continuous diagnostic tests. Stat Med (1997) 3.20
Low penetrance in the long-QT syndrome: clinical impact. Circulation (1999) 3.14
ACC/AHA Guidelines for Exercise Testing. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing). J Am Coll Cardiol (1997) 3.14
Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation (2000) 2.95
Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J (2001) 2.93
Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome. A worldwide report. Circulation (1991) 2.87
Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families. Circulation (2000) 2.81
Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation (1994) 2.79
Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. Circulation (1996) 2.70
Idiopathic long QT syndrome: progress and questions. Am Heart J (1985) 2.59
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Molecular basis of the long-QT syndrome associated with deafness. N Engl J Med (1997) 2.57
Early detection of silent ischaemic heart disease by 24-hour electrocardiographic monitoring of active subjects. Br Heart J (1974) 2.55
Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry. Circulation (1998) 2.53
Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials. Circulation (2001) 2.50
Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. Circ Res (1991) 2.41
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Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum Mol Genet (1995) 2.30
Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circ Res (1996) 2.29
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The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge. Circulation (2000) 1.72
Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: experience in 101 related family members. J Cardiovasc Electrophysiol (2001) 1.71
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