Published in Am J Physiol Cell Physiol on October 22, 2008
The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder. J Physiol (2015) 1.59
P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci (2010) 1.55
Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal (2012) 1.49
Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. J Biol Chem (2012) 1.44
Intercellular Ca(2+) waves: mechanisms and function. Physiol Rev (2012) 1.32
Alpha-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis. Proc Natl Acad Sci U S A (2009) 1.30
SCAM analysis of Panx1 suggests a peculiar pore structure. J Gen Physiol (2010) 1.25
Pannexin: from discovery to bedside in 11±4 years? Brain Res (2012) 1.24
The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice. J Clin Invest (2011) 1.21
Release of adenosine and ATP during ischemia and epilepsy. Curr Neuropharmacol (2009) 1.21
Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury. J Cereb Blood Flow Metab (2014) 1.20
Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol (2012) 1.17
The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable. J Cell Sci (2012) 1.16
Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. J Neurosci (2011) 1.15
Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. J Biol Chem (2013) 1.10
A comparative antibody analysis of pannexin1 expression in four rat brain regions reveals varying subcellular localizations. Front Pharmacol (2013) 1.09
Physiological mechanisms for the modulation of pannexin 1 channel activity. J Physiol (2012) 1.07
Pannexin1 stabilizes synaptic plasticity and is needed for learning. PLoS One (2012) 1.07
Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP". Am J Physiol Cell Physiol (2009) 1.06
Brilliant blue FCF as an alternative dye for saphenous vein graft marking: effect on conduit function. JAMA Surg (2014) 1.04
Homeostasis of extracellular ATP in human erythrocytes. J Biol Chem (2011) 1.04
The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation. Sci Signal (2014) 1.03
Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells. Front Physiol (2013) 1.03
Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS Lett (2014) 1.01
The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol (2013) 1.01
Pannexin 1 constitutes the large conductance cation channel of cardiac myocytes. J Biol Chem (2010) 1.00
Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett (2011) 1.00
Functional characterization of intracellular Dictyostelium discoideum P2X receptors. J Biol Chem (2009) 1.00
Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol (2013) 0.97
Expression of pannexin isoforms in the systemic murine arterial network. J Vasc Res (2012) 0.95
The bizarre pharmacology of the ATP release channel pannexin1. Neuropharmacology (2013) 0.93
Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity. Purinergic Signal (2011) 0.93
Pannexin 1 in the regulation of vascular tone. Trends Cardiovasc Med (2012) 0.92
ATP release through pannexon channels. Philos Trans R Soc Lond B Biol Sci (2015) 0.92
A taste for ATP: neurotransmission in taste buds. Front Cell Neurosci (2013) 0.92
Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism. J Biol Chem (2014) 0.89
Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction. Acta Pharmacol Sin (2012) 0.89
Haemolysis induced by α-toxin from Staphylococcus aureus requires P2X receptor activation. Pflugers Arch (2011) 0.89
C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal (2011) 0.89
Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes. Biochim Biophys Acta (2013) 0.88
ATP and potassium ions: a deadly combination for astrocytes. Sci Rep (2014) 0.88
Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton. J Biol Chem (2012) 0.88
5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) stimulates cellular ATP release through exocytosis of ATP-enriched vesicles. J Biol Chem (2009) 0.87
Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. PLoS One (2011) 0.86
Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling. PLoS One (2014) 0.86
Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels. Gen Comp Endocrinol (2011) 0.86
Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis. Protein Sci (2012) 0.86
Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons. Front Cell Neurosci (2014) 0.85
Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS One (2013) 0.83
Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases. Front Physiol (2014) 0.83
Pannexin1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated free fatty acids in liver cells. Am J Physiol Cell Physiol (2012) 0.83
Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels. J Biol Chem (2014) 0.83
Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain. J Biol Chem (2011) 0.82
Intrinsic properties and regulation of Pannexin 1 channel. Channels (Austin) (2014) 0.82
Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nat Commun (2015) 0.81
Emerging functions of pannexin 1 in the eye. Front Cell Neurosci (2014) 0.81
Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury. Dev Neurobiol (2013) 0.80
Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells. Neurochem Res (2012) 0.79
Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death. Channels (Austin) (2014) 0.79
Investigation of olfactory function in a Panx1 knock out mouse model. Front Cell Neurosci (2014) 0.79
Possible role of hemichannels in cancer. Front Physiol (2014) 0.78
Emerging concepts regarding pannexin 1 in the vasculature. Biochem Soc Trans (2015) 0.78
Suppression of cell membrane permeability by suramin: involvement of its inhibitory actions on connexin 43 hemichannels. Br J Pharmacol (2014) 0.78
A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus. Channels (Austin) (2014) 0.78
Mechanosensitive unpaired innexin channels in C. elegans touch neurons. Am J Physiol Cell Physiol (2014) 0.77
Pannexin 1 channels in skeletal muscles. Front Physiol (2014) 0.76
Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop. J Gen Physiol (2016) 0.76
Interactions of Pannexin1 channels with purinergic and NMDA receptor channels. Biochim Biophys Acta (2017) 0.75
Purinergic Signaling in Gut Inflammation: The Role of Connexins and Pannexins. Front Neurosci (2016) 0.75
Brilliant Blue Dyes in Daily Food: How Could Purinergic System Be Affected? Int J Food Sci (2016) 0.75
Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins? Stem Cells Int (2012) 0.75
Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production. J Biol Chem (2016) 0.75
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions. Front Mol Neurosci (2016) 0.75
CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells. Sci Rep (2017) 0.75
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics. Neurochem Res (2017) 0.75
The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition. Elife (2017) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12
Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73
Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03
The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A (2007) 4.01
Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci U S A (2003) 3.96
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem (2005) 3.87
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett (2007) 3.19
P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci (2006) 3.14
Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res (1992) 2.86
Deformation-induced ATP release from red blood cells requires CFTR activity. Am J Physiol (1998) 2.85
Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol (2008) 2.79
A ubiquitous family of putative gap junction molecules. Curr Biol (2000) 2.77
The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics (2004) 2.54
P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol (2008) 2.49
Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol (2000) 2.47
Nucleotide receptors. Curr Opin Neurobiol (1997) 2.44
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci (2007) 2.41
Regulation of presynaptic Ca(V)2.1 channels by Ca2+ sensor proteins mediates short-term synaptic plasticity. Neuron (2008) 2.30
Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor. J Biol Chem (2000) 2.08
Pannexin: to gap or not to gap, is that a question? IUBMB Life (2006) 2.05
Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem (2007) 2.05
Pannexin1 is expressed by neurons and glia but does not form functional gap junctions. Glia (2007) 1.92
Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol (2007) 1.86
Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol (2007) 1.77
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol (2007) 1.60
Site-specific and developmental expression of pannexin1 in the mouse nervous system. Eur J Neurosci (2005) 1.46
Function of the voltage gate of gap junction channels: selective exclusion of molecules. Proc Natl Acad Sci U S A (2002) 1.40
Brefeldin A block of integrin-dependent mechanosensitive ATP release from Xenopus oocytes reveals a novel mechanism of mechanotransduction. J Biol Chem (2001) 1.35
Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus. Neuroscience (2007) 1.33
Current state of purinoceptor research. Pharm Acta Helv (1995) 1.04
Coupling gating with ion permeation in ClC channels. Sci STKE (2003) 1.03
Mutagenesis to study channel structure. Methods Mol Biol (2001) 0.98
The role of positively charged amino acids in ATP recognition by human P2X1 receptors J Biol Chem (2000) 0.88
Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73
Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett (2007) 3.19
The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90
Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol (2008) 2.79
Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci (2009) 2.48
Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem (2007) 2.05
Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89
Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol (2007) 1.86
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol (2007) 1.60
Connexins are mechanosensitive. Am J Physiol Cell Physiol (2004) 1.46
Function of the voltage gate of gap junction channels: selective exclusion of molecules. Proc Natl Acad Sci U S A (2002) 1.40
Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. J Biol Chem (2010) 1.39
SCAM analysis of Panx1 suggests a peculiar pore structure. J Gen Physiol (2010) 1.25
ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes. Glia (2012) 1.22
Trafficking dynamics of glycosylated pannexin 1 proteins. Cell Commun Adhes (2008) 1.20
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J (2009) 1.07
Innexins form two types of channels. FEBS Lett (2007) 1.05
The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol (2013) 1.01
Conductance of connexin hemichannels segregates with the first transmembrane segment. Biophys J (2005) 1.00
Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett (2011) 1.00
Neuroglial ATP release through innexin channels controls microglial cell movement to a nerve injury. J Gen Physiol (2010) 0.95
Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity. Purinergic Signal (2011) 0.93
Cosegregation of permeability and single-channel conductance in chimeric connexins. Biophys J (2005) 0.88
Accessibility of cx46 hemichannels for uncharged molecules and its modulation by voltage. Biophys J (2004) 0.84
Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury. Dev Neurobiol (2013) 0.80
Assessing a potential role of host Pannexin 1 during Chlamydia trachomatis infection. PLoS One (2013) 0.78