Published in Endocrinology on October 30, 2008
Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL) (EIFFEL) | NCT01745471
WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics (2008) 18.58
The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm Behav (2009) 2.97
Is my network module preserved and reproducible? PLoS Comput Biol (2011) 2.91
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Reframing sexual differentiation of the brain. Nat Neurosci (2011) 2.49
Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol Rev (2010) 2.13
Systems genetics approaches to understand complex traits. Nat Rev Genet (2013) 1.97
A differential wiring analysis of expression data correctly identifies the gene containing the causal mutation. PLoS Comput Biol (2009) 1.96
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet (2012) 1.84
Genome-wide association studies in mice. Nat Rev Genet (2012) 1.75
Sex differences in human adipose tissues - the biology of pear shape. Biol Sex Differ (2012) 1.64
A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice. Int J Obes (Lond) (2010) 1.62
Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. Biol Sex Differ (2013) 1.60
Understanding the sexome: measuring and reporting sex differences in gene systems. Endocrinology (2012) 1.55
Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics (2010) 1.55
DiffCoEx: a simple and sensitive method to find differentially coexpressed gene modules. BMC Bioinformatics (2010) 1.53
Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet (2015) 1.52
Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues. J Neuroendocrinol (2009) 1.50
Modular genetic control of sexually dimorphic behaviors. Cell (2012) 1.50
Disruption of protein kinase A in mice enhances healthy aging. PLoS One (2009) 1.43
When is hub gene selection better than standard meta-analysis? PLoS One (2013) 1.41
The end of gonad-centric sex determination in mammals. Trends Genet (2011) 1.39
Sex differences in primary hypertension. Biol Sex Differ (2012) 1.37
Cardiovascular networks: systems-based approaches to cardiovascular disease. Circulation (2010) 1.30
Gender differences in cancer susceptibility: an inadequately addressed issue. Front Genet (2012) 1.26
DCGL: an R package for identifying differentially coexpressed genes and links from gene expression microarray data. Bioinformatics (2010) 1.23
Link-based quantitative methods to identify differentially coexpressed genes and gene pairs. BMC Bioinformatics (2011) 1.19
Female competition and aggression: interdisciplinary perspectives. Philos Trans R Soc Lond B Biol Sci (2013) 1.14
Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome. BMC Genomics (2010) 1.06
Do sex steroids exert sex-specific and/or opposite effects on gene expression in lacrimal and meibomian glands? Mol Vis (2009) 1.06
Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. PLoS One (2011) 1.06
Systems-based approaches to cardiovascular disease. Nat Rev Cardiol (2012) 1.04
DCGL v2.0: an R package for unveiling differential regulation from differential co-expression. PLoS One (2013) 1.02
Sex-specific modulation of gene expression networks in murine hypothalamus. Front Neurosci (2012) 1.00
Sex-specific gene expression in the BXD mouse liver. Physiol Genomics (2010) 0.98
Systems-level analysis of genome-wide association data. G3 (Bethesda) (2013) 0.95
Identification of causal genes for complex traits. Bioinformatics (2015) 0.94
Sexually-dimorphic targeting of functionally-related genes in COPD. BMC Syst Biol (2014) 0.94
What a difference an X or Y makes: sex chromosomes, gene dose, and epigenetics in sexual differentiation. Handb Exp Pharmacol (2012) 0.92
Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game. Exp Neurol (2014) 0.92
Sex differences in Parkinson's disease. Front Neuroendocrinol (2014) 0.92
Differential C3NET reveals disease networks of direct physical interactions. BMC Bioinformatics (2011) 0.92
Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation. PLoS Genet (2012) 0.91
Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice. Hum Mol Genet (2009) 0.91
Sexual differences of imprinted genes' expression levels. Gene (2013) 0.90
Sex and the basic scientist: is it time to embrace Title IX? Biol Sex Differ (2013) 0.89
A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. Biochim Biophys Acta (2011) 0.88
Differentially expressed genes in major depression reside on the periphery of resilient gene coexpression networks. Front Neurosci (2011) 0.88
Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations. Genetics (2012) 0.86
Systems biology asks new questions about sex differences. Trends Endocrinol Metab (2009) 0.86
Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice. Exp Neurol (2014) 0.84
Promoting the understanding of sex differences to enhance equity and excellence in biomedical science. Biol Sex Differ (2010) 0.84
Sex differences and hormonal effects on gut microbiota composition in mice. Gut Microbes (2016) 0.83
Proximate perspectives on the evolution of female aggression: good for the gander, good for the goose? Philos Trans R Soc Lond B Biol Sci (2013) 0.83
The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res (2016) 0.83
Four core genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels. BMC Res Notes (2015) 0.83
Testosterone affects neural gene expression differently in male and female juncos: a role for hormones in mediating sexual dimorphism and conflict. PLoS One (2013) 0.83
The systems genetics resource: a web application to mine global data for complex disease traits. Front Genet (2013) 0.83
Do these genes make me look fat? Endocrinology (2009) 0.82
Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development. BMC Genomics (2015) 0.82
Male predominance in ketosis-prone diabetes mellitus. Biomed Rep (2015) 0.82
Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. BMC Med Genomics (2014) 0.81
System model network for adipose tissue signatures related to weight changes in response to calorie restriction and subsequent weight maintenance. PLoS Comput Biol (2015) 0.81
Significant association of estrogen receptor binding site variation with bipolar disorder in females. PLoS One (2012) 0.79
Functional Analysis and Characterization of Differential Coexpression Networks. Sci Rep (2015) 0.79
A general theory of sexual differentiation. J Neurosci Res (2017) 0.77
Large Scale Gene Expression Meta-Analysis Reveals Tissue-Specific, Sex-Biased Gene Expression in Humans. Front Genet (2016) 0.77
Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery. BMC Med Genomics (2014) 0.76
Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird. J Exp Biol (2013) 0.76
Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs. Sci Rep (2017) 0.75
Behavioral effects of social challenges and genomic mechanisms of social priming: What's testosterone got to do with it? Curr Zool (2014) 0.75
Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson's Disease. Front Endocrinol (Lausanne) (2011) 0.75
Sex Differences in Human and Animal Toxicology: Toxicokinetics. Toxicol Pathol (2016) 0.75
Sexually dimorphic genetic architecture of complex traits in a large-scale F2 cross in pigs. Genet Sel Evol (2014) 0.75
Sexual Dimorphisms in Genetic Loci Linked to Body Fat Distribution. Biosci Rep (2017) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
Emergence of scaling in random networks Science (1999) 89.38
Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64
DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79
Network biology: understanding the cell's functional organization. Nat Rev Genet (2004) 36.62
Identifying biological themes within lists of genes with EASE. Genome Biol (2003) 31.72
Error and attack tolerance of complex networks Nature (2000) 27.90
The large-scale organization of metabolic networks. Nature (2000) 27.57
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (2006) 25.99
Hierarchical organization of modularity in metabolic networks. Science (2002) 22.47
PANTHER: a library of protein families and subfamilies indexed by function. Genome Res (2003) 21.64
A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol (2005) 17.23
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proc Natl Acad Sci U S A (2006) 5.69
The evolution of sex-biased genes and sex-biased gene expression. Nat Rev Genet (2007) 5.43
The sex-specific genetic architecture of quantitative traits in humans. Nat Genet (2006) 4.93
Molecular and cellular basis of cardiovascular gender differences. Science (2005) 4.37
Gene network interconnectedness and the generalized topological overlap measure. BMC Bioinformatics (2007) 3.83
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci (2002) 3.09
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
VisANT: an integrative framework for networks in systems biology. Brief Bioinform (2008) 2.85
Sexual dimorphism in mammalian gene expression. Trends Genet (2005) 2.31
Sex chromosomes and brain gender. Nat Rev Neurosci (2004) 2.25
Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol (2006) 2.05
The genetics of health. Nat Genet (2006) 2.04
Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genet (2006) 1.93
Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care (2001) 1.90
Are XX and XY brain cells intrinsically different? Trends Endocrinol Metab (2003) 1.86
Obesity and androgens: facts and perspectives. Fertil Steril (2006) 1.78
The biology of human sex differences. N Engl J Med (2006) 1.77
How mammalian sex chromosomes acquired their peculiar gene content. Bioessays (2004) 1.45
Fat cell metabolism in different regions in women. Effect of menstrual cycle, pregnancy, and lactation. J Clin Invest (1985) 1.40
The quantitative genetics of sexual dimorphism: assessing the importance of sex-linkage. Heredity (Edinb) (2006) 1.33
Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci U S A (2001) 1.30
Sexual dimorphism in human lipid metabolism. J Nutr (2005) 1.29
Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiol Genomics (2007) 1.20
Sex and the liver - a journey through five decades. Drug Metab Rev (2006) 1.19
Lessons from studying monogenic disease for common disease. Hum Mol Genet (2006) 1.14
Dissection of multigenic obesity traits in congenic mouse strains. Mamm Genome (2004) 1.07
Wired on hormones: endocrine regulation of hypothalamic development. Curr Opin Neurobiol (2005) 1.04
A thematic review series: systems biology approaches to metabolic and cardiovascular disorders. J Lipid Res (2006) 1.04
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics (2008) 18.58
A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol (2005) 17.23
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med (2005) 15.42
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature (2011) 10.16
The origin of the Haitian cholera outbreak strain. N Engl J Med (2010) 9.85
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med (2011) 9.37
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84
Gene expression profiling of gliomas strongly predicts survival. Cancer Res (2004) 7.79
Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics (2007) 7.72
DNA methylation age of human tissues and cell types. Genome Biol (2013) 7.48
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Global histone modification patterns predict risk of prostate cancer recurrence. Nature (2005) 7.03
Functional organization of the transcriptome in human brain. Nat Neurosci (2008) 7.02
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (2012) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China. N Engl J Med (2009) 6.45
American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum (2011) 6.28
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
The genome of a songbird. Nature (2010) 5.90
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proc Natl Acad Sci U S A (2006) 5.69
PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics (2004) 5.55
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med (2008) 5.54
Strategies and methods for research on sex differences in brain and behavior. Endocrinology (2004) 5.02
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron (2002) 4.77
Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet (2005) 4.56
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
American College of Rheumatology/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Ann Rheum Dis (2011) 4.15
Eigengene networks for studying the relationships between co-expression modules. BMC Syst Biol (2007) 4.06
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med (2004) 4.06
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med (2012) 3.98
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics (2006) 3.87
Gene network interconnectedness and the generalized topological overlap measure. BMC Bioinformatics (2007) 3.83
Identification of molecular subtypes of glioblastoma by gene expression profiling. Oncogene (2003) 3.83
The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study of elderly adults. Ann Intern Med (2005) 3.82
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med (2011) 3.65
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA (2008) 3.64
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51