Published in Shock on July 01, 2009
Mediators of inflammation in acute kidney injury. Mediators Inflamm (2010) 2.05
Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal (2010) 2.04
NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. Gut Liver (2012) 1.70
Sensing damage by the NLRP3 inflammasome. Immunol Rev (2011) 1.69
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener (2011) 1.48
The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci (2011) 1.46
Endogenous toll-like receptor ligands and their biological significance. J Cell Mol Med (2010) 1.41
Innate and adaptive immune responses to cell death. Immunol Rev (2011) 1.40
Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation (2012) 1.40
Pretreatment with ALDH2 agonist Alda-1 reduces intestinal injury induced by ischemia and reperfusion in mice. Clin Sci (Lond) (2017) 1.38
Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.29
Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4. Cancer Res (2010) 1.18
TLR2 and TLR4 in the brain injury caused by cerebral ischemia and reperfusion. Mediators Inflamm (2013) 1.18
Human intestinal ischemia-reperfusion-induced inflammation characterized: experiences from a new translational model. Am J Pathol (2010) 1.16
Ischemia/Reperfusion injury in liver surgery and transplantation: pathophysiology. HPB Surg (2012) 1.12
Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury. Hepatology (2011) 1.12
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J Immunol (2013) 1.11
Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol (2010) 1.11
Toll-like receptors in cerebral ischemic inflammatory injury. J Neuroinflammation (2011) 1.06
Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response. Neural Regen Res (2014) 1.06
Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury. Hepatology (2010) 1.05
Toll-like receptors: new players in myocardial ischemia/reperfusion injury. Antioxid Redox Signal (2011) 1.04
Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis. J Am Soc Nephrol (2014) 1.03
TIPE2, a novel regulator of immunity, protects against experimental stroke. J Biol Chem (2012) 1.02
Hyaluronan regulation of vascular integrity. Am J Cardiovasc Dis (2011) 1.00
Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. Shock (2010) 1.00
Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion. Mol Immunol (2010) 0.99
Enhancing the efficacy of mesenchymal stem cell therapy. World J Stem Cells (2014) 0.99
Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood-spinal cord barrier following ischemia/reperfusion injury in rats. Mol Brain (2014) 0.97
Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury. J Neuroinflammation (2012) 0.96
TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons. Proc Natl Acad Sci U S A (2013) 0.95
Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol (2014) 0.93
Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation. J Am Heart Assoc (2013) 0.92
The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review. Aging Dis (2014) 0.90
Toll-like receptors in ischaemia and its potential role in the pathophysiology of muscle damage in critical limb ischaemia. Cardiol Res Pract (2012) 0.89
Drugs to cure avian influenza infection--multiple ways to prevent cell death. Cell Death Dis (2013) 0.88
Putative role of protein kinase C in neurotoxic inflammation mediated by extracellular heat shock protein 70 after ischemia-reperfusion. J Neuroinflammation (2014) 0.88
Ischemic transient neurological events identified by immune response to cerebral ischemia. Stroke (2012) 0.87
Domain V peptides inhibit beta2-glycoprotein I-mediated mesenteric ischemia/reperfusion-induced tissue damage and inflammation. J Immunol (2010) 0.86
It's all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection. Future Neurol (2009) 0.86
An adipoinductive role of inflammation in adipose tissue engineering: key factors in the early development of engineered soft tissues. Stem Cells Dev (2013) 0.85
Ischemic Preconditioning-Induced SOCS-1 Protects Rat Intestinal Ischemia Reperfusion Injury via Degradation of TRAF6. Dig Dis Sci (2016) 0.84
Comparison of the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery. Yonsei Med J (2011) 0.83
Perioperative infliximab application has marginal effects on ischemia-reperfusion injury in experimental small bowel transplantation in rats. Langenbecks Arch Surg (2011) 0.83
Downstream Toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia. J Neuroinflammation (2012) 0.83
Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury. PLoS One (2010) 0.83
Retracted Pterostilbene attenuates inflammation in rat heart subjected to ischemia-reperfusion: role of TLR4/NF-κB signaling pathway. Int J Clin Exp Med (2015) 0.82
Effect of dexmedetomidine on lung ischemia‑reperfusion injury. Mol Med Rep (2013) 0.82
Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway. Cell Stress Chaperones (2014) 0.81
Toll-like receptor 9 mediated responses in cardiac fibroblasts. PLoS One (2014) 0.81
Enteral arginine modulates inhibition of AP-1/c-Jun by SP600125 in the postischemic gut. Mol Cell Biochem (2010) 0.81
The effect of dexmedetomidine on inflammatory response of septic rats. BMC Anesthesiol (2015) 0.79
The innate immune system and transplantation. Cold Spring Harb Perspect Med (2013) 0.79
TLR4/NF-κB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury. Biomed Res Int (2015) 0.79
Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia. J Neuroinflammation (2015) 0.78
Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension. PLoS One (2014) 0.78
Association between plasma levels of hyaluronic acid and functional outcome in acute stroke patients. J Neuroinflammation (2014) 0.78
Hyaluronan-phosphatidylethanolamine polymers form pericellular coats on keratinocytes and promote basal keratinocyte proliferation. Biomed Res Int (2014) 0.78
Toll-like receptor 2 mediates ischemia-reperfusion injury of the small intestine in adult mice. PLoS One (2014) 0.78
Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation. Circ Cardiovasc Genet (2014) 0.77
Down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 translocation and release and protects against liver ischemia-reperfusion injury. Sci Rep (2017) 0.77
Infiltrating monocytes in liver injury and repair. Clin Transl Immunology (2016) 0.76
TLR4 signaling is involved in brain vascular toxicity of PCB153 bound to nanoparticles. PLoS One (2013) 0.76
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets. J Leukoc Biol (2016) 0.75
Mesenchymal stromal cell therapy for the treatment of intestinal ischemia: Defining the optimal cell isolate for maximum therapeutic benefit. Cytotherapy (2016) 0.75
The role of Toll-like receptors in retinal ischemic diseases. Int J Ophthalmol (2016) 0.75
A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system. J Neuroinflammation (2016) 0.75
Postinjury Inflammation and Organ Dysfunction. Crit Care Clin (2017) 0.75
The Receptor for Advanced Glycation Endproducts Does Not Contribute to Pathology in a Mouse Mesenteric Ischemia/Reperfusion-Induced Injury Model. Front Immunol (2015) 0.75
TLR2-deficiency of cKit+ bone marrow cells is associated with augmented potency to stimulate angiogenic processes. Int J Clin Exp Pathol (2013) 0.75
Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination. Cell Death Differ (2017) 0.75
Intestinal Ischemia-Reperfusion: Rooting for the SOCS? Dig Dis Sci (2016) 0.75
Down-regulation of toll-like receptor 4 alleviates intestinal ischemia reperfusion injury and acute lung injury in mice. Oncotarget (2017) 0.75
Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach. J Transl Med (2016) 0.75
Octreotide Attenuates Acute Kidney Injury after Hepatic Ischemia and Reperfusion by Enhancing Autophagy. Sci Rep (2017) 0.75
Enhanced bleaching treatment: opportunities for immune-assisted melanocyte suicide in vitiligo. Exp Dermatol (2014) 0.75
Cellular Stress Response and Immune Signaling in Retinal Ischemia-Reperfusion Injury. Front Immunol (2016) 0.75
Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue. Iran J Basic Med Sci (2016) 0.75
Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15
The role of the complement system in ischemia-reperfusion injury. Shock (2004) 1.82
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med (2006) 1.82
Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol (2009) 1.66
beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol (2009) 1.57
Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci (2008) 1.55
The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol (2008) 1.52
Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. Cardiovasc Res (2012) 1.49
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener (2011) 1.48
Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A (2007) 1.46
A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney Int (2003) 1.41
A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. J Immunol (2003) 1.40
Involvement of notch signaling in wound healing. PLoS One (2007) 1.35
Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration. FASEB J (2006) 1.33
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging (2012) 1.32
Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes. J Neurosci Res (2007) 1.31
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat Commun (2012) 1.29
C5L2: a controversial receptor of complement anaphylatoxin, C5a. FASEB J (2012) 1.28
The role of the complement system and the activation fragment C5a in the central nervous system. Neuromolecular Med (2009) 1.27
Complement component 5a (C5a). Int J Biochem Cell Biol (2009) 1.24
Dendritic cell function in allostimulation is modulated by C5aR signaling. J Immunol (2009) 1.24
Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. FASEB J (2012) 1.21
Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis. J Neuroinflammation (2013) 1.21
The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proc Natl Acad Sci U S A (2013) 1.21
Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing. Biomaterials (2012) 1.20
Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease. J Neurochem (2010) 1.16
GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons. Cardiovasc Res (2010) 1.14
Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. Br J Pharmacol (2004) 1.11
Complement activation in the injured central nervous system: another dual-edged sword? J Neuroinflammation (2012) 1.11
Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation. J Immunol (2007) 1.10
Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats. J Surg Res (2004) 1.09
Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine. J Surg Res (2002) 1.08
Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. Br J Pharmacol (2003) 1.05
Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol (2011) 1.04
Hormesis/preconditioning mechanisms, the nervous system and aging. Ageing Res Rev (2006) 1.04
De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation. J Med Chem (2012) 1.04
Complement mediators in ischemia-reperfusion injury. Clin Chim Acta (2006) 1.03
Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis Rheum (2002) 1.03
Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease. Neurobiol Aging (2008) 1.02
Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. J Hepatol (2004) 1.01
Incidence and etiologies of stroke during pregnancy and puerperium as evidenced in Taiwanese women. Cerebrovasc Dis (2004) 1.01
Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J (2011) 1.00
Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol Pharmacol (2004) 1.00
Eph/Ephrin signaling in injury and inflammation. Am J Pathol (2012) 1.00
The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice. J Neurochem (2007) 0.96
Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice. Neuromolecular Med (2007) 0.96
Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. J Biol Chem (2005) 0.95
The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. J Biol Chem (2006) 0.95
Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats. J Immunol (2006) 0.95
Complement in pregnancy: a delicate balance. Am J Reprod Immunol (2012) 0.94
The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair. Neuromolecular Med (2009) 0.92
The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis. Mol Immunol (2007) 0.92
Dysphagia screening decreases pneumonia in acute stroke patients admitted to the stroke intensive care unit. J Neurol Sci (2011) 0.90
Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease. J Pharmacol Exp Ther (2005) 0.90
A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. J Org Chem (2003) 0.90
Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. J Neurochem (2012) 0.89
The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice. J Cereb Blood Flow Metab (2012) 0.89
Predictors of survival and functional outcome in acute stroke patients admitted to the stroke intensive care unit. J Neurol Sci (2008) 0.89
Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. Int Immunopharmacol (2006) 0.89
Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats. Br J Pharmacol (2002) 0.89
Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan. J Biomed Sci (2012) 0.88
Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Exp Transl Stroke Med (2010) 0.88
Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis. PLoS One (2013) 0.88
Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. J Cardiovasc Pharmacol (2011) 0.88
A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. Int Immunopharmacol (2005) 0.88
Stroke in women of reproductive age: comparison between stroke related and unrelated to pregnancy. J Neurol Sci (2004) 0.88
Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease. Aging Cell (2012) 0.88
Targeting ischemic brain injury with intravenous immunoglobulin. Expert Opin Ther Targets (2008) 0.87
Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease. Neurobiol Aging (2011) 0.87
Epidemiology, diagnosis and management of intracranial atherosclerotic disease. Expert Rev Cardiovasc Ther (2010) 0.86