Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.

PubWeight™: 0.93‹?›

🔗 View Article (PMID 19027755)

Published in Mutat Res on November 06, 2008

Authors

Philip Thomas1, Yan-Jiang Wang, Jin-Hua Zhong, Shantha Kosaraju, Nathan J O'Callaghan, Xin-Fu Zhou, Michael Fenech

Author Affiliations

1: CSIRO Human Nutrition, PO Box 10041, Adelaide BC, Adelaide, SA 5000, Australia.

Articles citing this

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch Toxicol (2010) 2.36

Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem (2010) 1.14

Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev (2013) 0.98

Telomerase deficiency does not alter bleomycin-induced fibrosis in mice. Exp Lung Res (2012) 0.93

Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y. Am J Clin Nutr (2015) 0.90

A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization. PLoS One (2012) 0.86

Grape powder prevents cognitive, behavioral, and biochemical impairments in a rat model of posttraumatic stress disorder. Nutr Res (2014) 0.85

Effects of (-)Epicatechin on the Pathology of APP/PS1 Transgenic Mice. Front Neurol (2014) 0.85

Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications. Front Aging Neurosci (2014) 0.85

Therapeutic targeting of replicative immortality. Semin Cancer Biol (2015) 0.83

Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells. Exp Ther Med (2011) 0.80

Recent advances on the neuroprotective potential of antioxidants in experimental models of Parkinson's disease. Int J Mol Sci (2012) 0.80

Nutrition and lifestyle in healthy aging: the telomerase challenge. Aging (Albany NY) (2016) 0.80

Association between the Dietary Inflammatory Index (DII) and telomere length and C-reactive protein from the National Health and Nutrition Examination Survey-1999-2002. Mol Nutr Food Res (2016) 0.76

Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease. Int J Mol Sci (2017) 0.75

Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer's disease: a prospective, open-label pilot study. Clin Interv Aging (2016) 0.75

Articles by these authors

An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis (2006) 2.45

The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps. Mutat Res (2008) 2.13

A quantitative real-time PCR method for absolute telomere length. Biotechniques (2008) 1.77

Health benefits of herbs and spices: the past, the present, the future. Med J Aust (2006) 1.76

Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech Ageing Dev (2008) 1.69

A quantitative PCR method for measuring absolute telomere length. Biol Proced Online (2011) 1.62

Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms--the Beyond Ageing Project: a randomized controlled trial. Am J Clin Nutr (2011) 1.57

Report from the in vitro micronucleus assay working group. Mutat Res (2003) 1.47

Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway. J Neurochem (2013) 1.46

Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis (2011) 1.43

The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure. Mutagenesis (2011) 1.40

Buccal micronucleus cytome assay. Nat Protoc (2009) 1.36

γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies. Mutat Res (2013) 1.30

Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today (2006) 1.28

Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat Res (2003) 1.25

The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr (2005) 1.24

Isolation and characterization of neural crest progenitors from adult dorsal root ganglia. Stem Cells (2007) 1.24

CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. Cancer Res (2002) 1.24

Folate and methionine metabolism in autism: a systematic review. Am J Clin Nutr (2010) 1.23

Suppression of p75NTR does not promote regeneration of injured spinal cord in mice. J Neurosci (2004) 1.18

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain. J Neurosci (2011) 1.17

Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse. Neurotox Res (2009) 1.11

ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS One (2012) 1.11

Multiple origins of spontaneously arising micronuclei in HeLa cells: direct evidence from long-term live cell imaging. Mutat Res (2008) 1.10

Effects of surface chemistry on cytotoxicity, genotoxicity, and the generation of reactive oxygen species induced by ZnO nanoparticles. Langmuir (2010) 1.10

Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat. J Physiol (2005) 1.08

Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J Nutr (2004) 1.07

Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei. Mutat Res (2005) 1.06

Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. Mutagenesis (2007) 1.06

RE: Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture (Mutagenesis, 27, 743-747, 2012). Mutagenesis (2013) 1.06

DNA repair gene polymorphisms and prostate cancer risk in South Australia--results of a pilot study. Urol Oncol (2009) 1.06

The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research. Genes Nutr (2010) 1.06

Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa. Rejuvenation Res (2009) 1.05

Immunotherapy for Alzheimer disease: the challenge of adverse effects. Nat Rev Neurol (2012) 1.05

Knockout of p75(NTR) impairs re-myelination of injured sciatic nerve in mice. J Neurochem (2005) 1.04

TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats. J Bone Miner Res (2006) 1.02

The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol. Mutat Res (2011) 1.02

Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord (2013) 1.01

Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes. Mutat Res (2006) 1.01

Metabolic syndrome increases the risk of stroke: a 5-year follow-up study in a Chinese population. J Neurol (2009) 1.00

PPARγ attenuates intimal hyperplasia by inhibiting TLR4-mediated inflammation in vascular smooth muscle cells. Cardiovasc Res (2011) 0.99

The HUMNxl scoring criteria for different cell types and nuclear anomalies in the buccal micronucleus cytome assay - an update and expanded photogallery. Mutat Res (2013) 0.99

In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models. Mutagenesis (2011) 0.98

Distribution and localization of pro-brain-derived neurotrophic factor-like immunoreactivity in the peripheral and central nervous system of the adult rat. J Neurochem (2004) 0.98

Genome-health nutrigenomics and nutrigenetics: nutritional requirements or 'nutriomes' for chromosomal stability and telomere maintenance at the individual level. Proc Nutr Soc (2008) 0.97

Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. J Neurochem (2012) 0.96

Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem (2009) 0.96

Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay. Mutagenesis (2003) 0.95

Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease. Neurobiol Aging (2007) 0.95

Effect of lumbar 5 ventral root transection on pain behaviors: a novel rat model for neuropathic pain without axotomy of primary sensory neurons. Exp Neurol (2002) 0.95

Primary sensory neuron addition in the adult rat trigeminal ganglion: evidence for neural crest glio-neuronal precursor maturation. J Neurosci (2007) 0.95

Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Anal Biochem (2004) 0.94

Mental health literacy, folic acid and vitamin B12, and physical activity for the prevention of depression in older adults: randomised controlled trial. Br J Psychiatry (2010) 0.94

Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. PLoS One (2008) 0.93

hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo. Mutagenesis (2007) 0.93

Association of micronucleus frequency with neurodegenerative diseases. Mutagenesis (2011) 0.92

Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers. Cancer Epidemiol Biomarkers Prev (2008) 0.92

Huntingtin associated protein 1 and its functions. Cell Adh Migr (2009) 0.92

Human population studies with the exfoliated buccal micronucleus assay: statistical and epidemiological issues. Mutat Res (2009) 0.92

The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls. Mutat Res (2007) 0.92

The role of zinc in genomic stability. Mutat Res (2011) 0.92

A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro. Mutagenesis (2003) 0.92

Association between bone mineral density and the risk of Alzheimer's disease. J Alzheimers Dis (2011) 0.92

Folate, vitamin B12, vitamin B6 and homocysteine: impact on pregnancy outcome. Matern Child Nutr (2011) 0.92

A possible link between iron deficiency and gastrointestinal carcinogenesis. Nutr Cancer (2009) 0.91

EGF family of growth factors: essential roles and functional redundancy in the nerve system. Front Biosci (2004) 0.91

Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells. Cancer Prev Res (Phila) (2013) 0.91

ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro Oncol (2013) 0.91

Estimating the lowest detectable dose of ionizing radiation by the cytokinesis-block micronucleus assay. Radiat Res (2013) 0.90

Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats. Eur J Neurosci (2008) 0.90

ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury. Brain Behav Immun (2010) 0.90

Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. Eur J Pharmacol (2010) 0.90

Telomere dynamics: the influence of folate and DNA methylation. Ann N Y Acad Sci (2011) 0.90

Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical hypersensitivity in rats after incision. Anesthesiology (2011) 0.89

Autoreactive-Aβ antibodies promote APP β-secretase processing. J Neurochem (2012) 0.89

Roles of p75NTR in the pathogenesis of Alzheimer's disease: a novel therapeutic target. Biochem Pharmacol (2011) 0.89

Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life. Genes Nutr (2013) 0.88

Telomere length in lymphocytes of older South Australian men may be inversely associated with plasma homocysteine. Rejuvenation Res (2009) 0.88

Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism. Neurotox Res (2009) 0.87

Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain. Mol Cell Neurosci (2003) 0.87

Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21. Mutat Res (2004) 0.87

The fate of micronucleated cells post X-irradiation detected by live cell imaging. DNA Repair (Amst) (2011) 0.87

SNAP25 ameliorates sensory deficit in rats with spinal cord transection. Mol Neurobiol (2014) 0.87