Published in PLoS Biol on December 02, 2008
A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet (2010) 7.96
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11
Modification of enhancer chromatin: what, how, and why? Mol Cell (2013) 3.62
Open chromatin in pluripotency and reprogramming. Nat Rev Mol Cell Biol (2011) 2.69
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev (2015) 2.51
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Functional implications of genome topology. Nat Struct Mol Biol (2013) 2.13
Chromatin higher-order structures and gene regulation. Curr Opin Genet Dev (2011) 2.08
A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res (2012) 1.92
Integrating one-dimensional and three-dimensional maps of genomes. J Cell Sci (2010) 1.92
Chromosome crosstalk in three dimensions. Nature (2009) 1.91
Interactions among Polycomb domains are guided by chromosome architecture. PLoS Genet (2011) 1.76
Spatial epigenetic control of mono- and bistable gene expression. PLoS Biol (2010) 1.71
Environmental epigenetics of asthma: an update. J Allergy Clin Immunol (2010) 1.53
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One (2009) 1.47
Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods? Bioessays (2013) 1.45
Oncogene-mediated alterations in chromatin conformation. Proc Natl Acad Sci U S A (2012) 1.40
Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. Genome Biol (2010) 1.38
Epigenetics and colorectal cancer pathogenesis. Cancers (Basel) (2013) 1.33
Epigenetics meets endocrinology. J Mol Endocrinol (2011) 1.30
EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. Mol Cancer Res (2011) 1.30
In the loop: long range chromatin interactions and gene regulation. Brief Funct Genomics (2011) 1.30
Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP. PLoS Pathog (2010) 1.27
Chromatin and epigenetic features of long-range gene regulation. Nucleic Acids Res (2013) 1.26
Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini. Nat Chem Biol (2010) 1.25
3D shortcuts to gene regulation. Curr Opin Cell Biol (2010) 1.25
The complex transcription regulatory landscape of our genome: control in three dimensions. EMBO J (2011) 1.22
Nuclear organization and genome function. Annu Rev Cell Dev Biol (2012) 1.21
A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization. EMBO J (2012) 1.17
Coordination of KSHV latent and lytic gene control by CTCF-cohesin mediated chromosome conformation. PLoS Pathog (2011) 1.16
PcG complexes set the stage for epigenetic inheritance of gene silencing in early S phase before replication. PLoS Genet (2011) 1.15
Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nat Rev Genet (2010) 1.13
Gene positioning. Cold Spring Harb Perspect Biol (2010) 1.12
Do chromatin loops provide epigenetic gene expression states? Curr Opin Genet Dev (2010) 1.12
Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J (2012) 1.10
EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence. Epigenetics Chromatin (2009) 1.05
Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements. J Biol Chem (2009) 1.01
Origins of aberrant DNA methylation in acute myeloid leukemia. Leukemia (2013) 1.00
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities. Genome Biol (2012) 1.00
A repetitive elements perspective in Polycomb epigenetics. Front Genet (2012) 0.97
Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons. Front Aging Neurosci (2010) 0.96
The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes. Nucleic Acids Res (2011) 0.94
Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc. Oncogene (2010) 0.92
Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. BMC Cancer (2011) 0.92
Hox in motion: tracking HoxA cluster conformation during differentiation. Nucleic Acids Res (2013) 0.90
The BAF60 subunit of the SWI/SNF chromatin-remodeling complex directly controls the formation of a gene loop at FLOWERING LOCUS C in Arabidopsis. Plant Cell (2014) 0.89
EZH2: a pivotal regulator in controlling cell differentiation. Am J Transl Res (2012) 0.89
Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications. Med Res Rev (2015) 0.88
Cancer stem cells: potential target for bioactive food components. J Nutr Biochem (2012) 0.86
Throwing transcription for a loop: expression of the genome in the 3D nucleus. Chromosoma (2011) 0.86
Epigenetic repression of RARRES1 is mediated by methylation of a proximal promoter and a loss of CTCF binding. PLoS One (2012) 0.86
High-resolution analysis of cis-acting regulatory networks at the α-globin locus. Philos Trans R Soc Lond B Biol Sci (2013) 0.83
Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping. Nucleic Acids Res (2014) 0.83
Polycomb repressive complex 2 in embryonic stem cells: an overview. Protein Cell (2011) 0.83
Novel cis-regulatory modules control expression of the Hairy and Enhancer of Split-1 (HES1) transcription factor in myoblasts. J Biol Chem (2011) 0.82
Minireview: Switching on progesterone receptor expression with duplex RNA. Mol Endocrinol (2010) 0.81
Breaching the boundaries that safeguard against repression. Mol Cell (2009) 0.81
PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C. PLoS Genet (2013) 0.81
EZH2: novel therapeutic target for human cancer. Biomedicine (Taipei) (2014) 0.79
Structural dynamics and epigenetic modifications of Hoxc loci along the anteroposterior body axis in developing mouse embryos. Int J Biol Sci (2012) 0.79
ConteXt of change--X inactivation and disease. EMBO Mol Med (2010) 0.79
EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells. PLoS Pathog (2016) 0.79
Loopy chromatin brings distant DNA to bear on silencing promoter genes. PLoS Biol (2008) 0.78
Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus. Nucleic Acids Res (2013) 0.78
One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation. Genes (Basel) (2015) 0.77
Epigenetic alterations in muscular disorders. Comp Funct Genomics (2012) 0.77
Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma. Epigenetics (2010) 0.76
Gene dates, parties and galas. Symposium on Chromatin Dynamics and Higher Order Organization. EMBO Rep (2009) 0.76
Linking Chromatin Fibers to Gene Folding by Hierarchical Looping. Biophys J (2017) 0.75
Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation. Sci Rep (2016) 0.75
DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects. Genes (Basel) (2017) 0.75
Study of distant interactions of LCR from the Drosophila melanogaster locus CUT. Dokl Biochem Biophys (2010) 0.75
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
The epigenomics of cancer. Cell (2007) 30.91
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A (1996) 29.54
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Genomic maps and comparative analysis of histone modifications in human and mouse. Cell (2005) 18.96
Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell (2006) 15.24
Genome-wide map of nucleosome acetylation and methylation in yeast. Cell (2005) 15.08
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48
Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell (2002) 11.35
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat Genet (2006) 11.02
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet (2006) 8.99
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. Science (2006) 7.68
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet (2007) 7.61
Interchromosomal associations between alternatively expressed loci. Nature (2005) 7.45
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48
Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov (2006) 6.39
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat Protoc (2007) 6.28
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Stem cells and cancer: two faces of eve. Cell (2006) 6.13
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene (2002) 5.96
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet (2006) 5.62
The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet (2003) 5.54
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet (2004) 5.47
DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol (2005) 5.02
An evaluation of 3C-based methods to capture DNA interactions. Nat Methods (2007) 4.94
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet (2006) 4.86
RNAi components are required for nuclear clustering of Polycomb group response elements. Cell (2006) 4.70
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol (2004) 4.67
Looping versus linking: toward a model for long-distance gene activation. Genes Dev (1999) 4.63
Spatial organization of gene expression: the active chromatin hub. Chromosome Res (2003) 3.91
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet (2006) 3.83
Hierarchical recruitment of polycomb group silencing complexes. Mol Cell (2004) 3.73
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
The ENCODE Project at UC Santa Cruz. Nucleic Acids Res (2006) 3.57
Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol (2006) 3.41
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96
Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev (1997) 2.96
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93
Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex. Nat Cell Biol (2007) 2.72
Division of labor in polycomb group repression. Trends Biochem Sci (2004) 2.66
Identification of higher-order functional domains in the human ENCODE regions. Genome Res (2007) 2.62
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol (2003) 2.42
Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes. Mol Cell (2004) 2.40
The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain. J Cell Biol (1998) 2.29
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1. Mol Cell Biol (2005) 2.27
DNA methylation, chromatin inheritance, and cancer. Oncogene (2001) 2.26
polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes Dev (1993) 2.13
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. Genome Res (2008) 2.10
Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol (2004) 2.09
Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev (2003) 2.07
Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobases. Mol Cell Biol (2005) 2.06
Methyl CpG-binding proteins and transcriptional repression. Bioessays (2001) 2.03
The active FMR1 promoter is associated with a large domain of altered chromatin conformation with embedded local histone modifications. Proc Natl Acad Sci U S A (2006) 2.00
Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region. Genetics (1994) 1.98
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res (2007) 1.96
Polycomb complexes and the propagation of the methylation mark at the Drosophila ubx gene. J Biol Chem (2006) 1.78
Polycomb comes of age: genome-wide profiling of target sites. Curr Opin Cell Biol (2007) 1.72
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells. Cancer Res (2008) 1.69
Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification. Nat Genet (2006) 1.68
Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced. Genetics (1995) 1.67
ChIP-chip comes of age for genome-wide functional analysis. Cancer Res (2006) 1.55
Genome-wide profiling of promoter methylation in human. Oncogene (2006) 1.55
The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2. Oncogene (2007) 1.54
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet (2002) 1.48
The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. J Cell Biol (1998) 1.46
High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid. Stem Cells (2007) 1.32
PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter. Dev Cell (2006) 1.31
High-resolution mapping of DNA methylation in human genome using oligonucleotide tiling array. Hum Genet (2006) 1.31
Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nat Clin Pract Oncol (2007) 1.24
The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing. Oncogene (2007) 1.23
Optimal primer design using the novel primer design program: MSPprimer provides accurate methylation analysis of the ATM promoter. Oncogene (2007) 1.23
The epigenomics of cancer. Cell (2007) 30.91
The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med (2003) 18.04
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet (2005) 15.37
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer (2006) 11.22
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature (2002) 9.40
DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell (2008) 7.68
RefSeq: an update on mammalian reference sequences. Nucleic Acids Res (2013) 7.29
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med (2008) 5.87
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med (2006) 5.80
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet (2002) 5.38
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov (2011) 4.60
Global reorganization of replication domains during embryonic stem cell differentiation. PLoS Biol (2008) 4.50
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol (2008) 4.32
Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet (2010) 4.27
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res (2006) 4.15
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res (2005) 3.98
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell (2012) 3.82
Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat Genet (2005) 3.66
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell (2010) 3.57
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
Genomic patterns of DNA methylation: targets and function of an epigenetic mark. Curr Opin Cell Biol (2007) 3.54
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53
The cancer epigenome--components and functional correlates. Genes Dev (2006) 3.40
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet (2007) 3.39
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Determinants and dynamics of genome accessibility. Nat Rev Genet (2011) 3.15
A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol (2003) 3.09
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol (2010) 3.07
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell (2011) 3.07
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res (2006) 3.05
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol (2002) 3.00
Low-level microsatellite instability in most colorectal carcinomas. Cancer Res (2002) 2.87
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res (2002) 2.84
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J (2008) 2.81
A systematic profile of DNA methylation in human cancer cell lines. Cancer Res (2003) 2.75
DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states. Proc Natl Acad Sci U S A (2004) 2.66
Genetics and epigenetics: stability and plasticity during cellular differentiation. Trends Genet (2009) 2.57
Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle (2007) 2.55
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet (2008) 2.55
Adoption of gene expression profile testing and association with use of chemotherapy among women with breast cancer. J Clin Oncol (2012) 2.53
Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol (2003) 2.42
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol (2003) 2.42
Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol (2004) 2.41
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J Natl Cancer Inst (2002) 2.38
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell (2003) 2.38
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood (2002) 2.34
Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med (2011) 2.33
Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res (2003) 2.28
Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Genes Dev (2005) 2.26
N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer. J Natl Cancer Inst (2009) 2.22
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J (2007) 2.19
Current status and new features of the Consensus Coding Sequence database. Nucleic Acids Res (2013) 2.19
BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. J Clin Oncol (2010) 2.18
Methylated DNA immunoprecipitation (MeDIP). Methods Mol Biol (2009) 2.17
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. Cancer Res (2008) 2.16
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A (2007) 2.11
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. Genome Res (2008) 2.10
Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome. Genes Dev (2009) 2.08
Genomic and epigenomic integration identifies a prognostic signature in colon cancer. Clin Cancer Res (2011) 2.06