PubRank

N G McElvaney

Author PubWeight™ 53.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat Genet 1994 4.40
2 Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 1992 2.62
3 A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosis. N Engl J Med 1992 2.57
4 Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am J Respir Crit Care Med 1994 2.26
5 Systemic deficiency of glutathione in cystic fibrosis. J Appl Physiol (1985) 1993 1.88
6 Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. J Biol Chem 2000 1.82
7 Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Eur Respir J 2004 1.54
8 Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium. J Biol Chem 2001 1.41
9 Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector. Hum Gene Ther 1995 1.34
10 Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor. J Biol Chem 2001 1.30
11 Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 2003 1.28
12 Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis. J Immunol 2000 1.17
13 Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils. J Leukoc Biol 2002 1.11
14 Quantitative assessment of the epithelial and inflammatory cell populations in large airways of normals and individuals with cystic fibrosis. Am J Respir Crit Care Med 1996 1.07
15 Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8. Am J Physiol Lung Cell Mol Physiol 2000 1.03
16 Recombinant secretory leukoprotease inhibitor augments glutathione levels in lung epithelial lining fluid. J Appl Physiol (1985) 1993 1.02
17 Two case reports of pneumomediastinum. Ir J Med Sci 2007 1.02
18 Prediction of heart rate and oxygen uptake during incremental and maximal exercise in healthy adults. Chest 1994 1.02
19 A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung. Hum Gene Ther 1995 0.98
20 IL-6 release and airway administration of human CFR cDNA adenovirus vector. Nat Med 1995 0.98
21 Alpha1-antitrypsin deficiency: biological answers to clinical questions. Am J Med Sci 2001 0.97
22 Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis. J Cyst Fibros 2011 0.96
23 The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses. Biochem Soc Trans 2007 0.95
24 Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations. J Inherit Metab Dis 2008 0.95
25 Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis. J Appl Physiol (1985) 1999 0.93
26 Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency. J Clin Invest 1989 0.91
27 Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells. Eur Respir J 2009 0.89
28 Intravenous recombinant secretory leukoprotease inhibitor augments antineutrophil elastase defense. J Appl Physiol (1985) 1992 0.89
29 High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations. Thorax 2010 0.88
30 Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes. Blood 1996 0.87
31 Normal values and ranges for ventilation and breathing pattern at maximal exercise. Chest 1991 0.86
32 Heritability of lung function in severe alpha-1 antitrypsin deficiency. Hum Hered 2008 0.86
33 Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro. Thorax 2008 0.86
34 Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency. Am J Epidemiol 2009 0.86
35 Team Objective Structured Bedside Assessment (TOSBA): a novel and feasible way of providing formative teaching and assessment. Med Teach 2007 0.83
36 A case of dapsone induced methaemoglobinaemia. Ir J Med Sci 2008 0.82
37 Pleural fluid analysis: standstill or a work in progress? Pulm Med 2012 0.81
38 Persistant right lower lobe consolidation. Chest 2000 0.81
39 Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin. Am J Respir Cell Mol Biol 2001 0.81
40 An outreach programme for patients with an exacerbation of chronic obstructive pulmonary disease. Ir Med J 2003 0.80
41 Altered intracellular pH regulation in neutrophils from patients with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 2000 0.80
42 Demodex-associated bacterial proteins induce neutrophil activation. Br J Dermatol 2012 0.79
43 Radiological abnormalities associated with Aspergillus colonization in a cystic fibrosis population. Eur J Radiol 2011 0.78
44 Gene therapy for the respiratory manifestations of cystic fibrosis. Am J Respir Crit Care Med 1995 0.78
45 Alpha 1-antitrypsin deficiency and liver disease. J Inherit Metab Dis 1991 0.76
46 Interstitial pneumonitis is a frequent complication in liver transplant recipients treated with sirolimus. Ir J Med Sci 2012 0.76
47 Male fertility in cystic fibrosis. Ir Med J 2009 0.75
48 Thrombolysis for indwelling catheter related thrombosis and superior vena cava obstruction in cystic fibrosis: a case series. Ir J Med Sci 2010 0.75
49 Alopecia as a presenting complaint in non-Hodgkin's lymphoma with hair regrowth on chemotherapy. Ir J Med Sci 1988 0.75
50 A platelet dense-granule secretion defect may lead to a muted inflammatory cell mobilization response in cystic fibrosis patients. J Thromb Haemost 2013 0.75
51 Alpha 1-antitrypsin deficiency. Ir Med J 1999 0.75
52 Life-saving thrombus. Emerg Med J 2008 0.75
53 Cystic fibrosis, common variable immunodeficiency and Aspergers syndrome: an immunological and behavioural challenge. Ir J Med Sci 2009 0.75
54 A survey of the prevalence of smoking and smoking cessation advice received by inpatients in a large teaching hospital in Ireland. Ir J Med Sci 2012 0.75