Published in PLoS Genet on December 05, 2008
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol (2013) 3.13
Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08
Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell (2011) 2.84
Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol (2010) 1.85
Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clin Cancer Res (2011) 1.84
Autophagy is essential for mouse sense of balance. J Clin Invest (2010) 1.81
Amyloids, melanins and oxidative stress in melanomagenesis. Exp Dermatol (2014) 1.50
Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation. Trends Cell Biol (2012) 1.39
Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet (2012) 1.31
Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLoS Genet (2011) 1.27
Signaling pathways in melanosome biogenesis and pathology. Int J Biochem Cell Biol (2010) 1.27
Blood vitamin d levels in relation to genetic estimation of African ancestry. Cancer Epidemiol Biomarkers Prev (2010) 1.22
Mechanisms of protein delivery to melanosomes in pigment cells. Physiology (Bethesda) (2012) 1.19
Systems-level cancer gene identification from protein interaction network topology applied to melanogenesis-related functional genomics data. J R Soc Interface (2009) 1.19
Comprehensive mapping of the human kinome to epidermal growth factor receptor signaling. J Biol Chem (2010) 1.14
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nat Med (2013) 1.13
Atg7 is required for acrosome biogenesis during spermatogenesis in mice. Cell Res (2014) 1.05
ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane. Traffic (2009) 1.05
RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage. Cancer Res (2012) 1.00
WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem (2011) 0.99
Protein interaction network topology uncovers melanogenesis regulatory network components within functional genomics datasets. BMC Syst Biol (2010) 0.98
Suppression of autophagy dysregulates the antioxidant response and causes premature senescence of melanocytes. J Invest Dermatol (2014) 0.92
Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma. Pigment Cell Melanoma Res (2013) 0.91
Suppression of dendritic cell-mediated responses by genes in calcium and cysteine protease pathways during Mycobacterium tuberculosis infection. J Biol Chem (2012) 0.89
Identification of secreted proteins that reflect autophagy dynamics within tumor cells. Autophagy (2015) 0.88
Reactions of HNO with heme proteins: new routes to HNO-heme complexes and insight into physiological effects. Inorg Chem (2010) 0.88
ULK1 regulates melanin levels in MNT-1 cells independently of mTORC1. PLoS One (2013) 0.87
Networks and pathways in pigmentation, health, and disease. Wiley Interdiscip Rev Syst Biol Med (2010) 0.86
Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res (2013) 0.86
RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. Am J Physiol Cell Physiol (2010) 0.83
Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects. J Biomed Sci (2011) 0.82
Symplekin specifies mitotic fidelity by supporting microtubule dynamics. Mol Cell Biol (2010) 0.82
[6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway. Acta Pharmacol Sin (2012) 0.82
9-cis retinoic acid is the ALDH1A1 product that stimulates melanogenesis. Exp Dermatol (2013) 0.82
Selective autophagy against membranous compartments: Canonical and unconventional purposes and mechanisms. Autophagy (2014) 0.81
A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol (2015) 0.80
Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes. Sci Rep (2016) 0.79
A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices. Fibrogenesis Tissue Repair (2011) 0.79
Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle. PLoS One (2015) 0.77
Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish. PLoS One (2013) 0.76
Autophagy as a melanocytic self-defense mechanism. J Invest Dermatol (2015) 0.76
Organelle biogenesis and interorganellar connections: Better in contact than in isolation. Commun Integr Biol (2014) 0.76
Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster. PLoS One (2015) 0.75
Evolutionary history inferred from the de novo assembly of a nonmodel organism, the blue-eyed black lemur. Mol Ecol (2015) 0.75
Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma. Front Oncol (2016) 0.75
Targeting ALDH1A1 to treat pigmentary disorders. Exp Dermatol (2013) 0.75
Dysfunction of Autophagy: A Possible Mechanism Involved in the Pathogenesis of Vitiligo by Breaking the Redox Balance of Melanocytes. Oxid Med Cell Longev (2016) 0.75
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science (2005) 12.02
Genetic determinants of hair, eye and skin pigmentation in Europeans. Nat Genet (2007) 8.79
Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev (2004) 5.89
Statistical practice in high-throughput screening data analysis. Nat Biotechnol (2006) 5.85
Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science (2002) 5.08
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature (2007) 4.70
MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med (2006) 4.60
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health (2007) 3.67
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res (2004) 3.64
The color loci of mice--a genetic century. Pigment Cell Res (2003) 3.47
Autophagy and human disease. Cell Cycle (2007) 3.22
Melanosomes--dark organelles enlighten endosomal membrane transport. Nat Rev Mol Cell Biol (2007) 3.19
WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. Oncogene (2004) 2.86
Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J (2007) 2.62
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell (2005) 2.56
BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell (2006) 2.37
A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev Cell (2006) 2.29
Lysosome-related organelles: driving post-Golgi compartments into specialisation. Curr Opin Cell Biol (2007) 2.11
A model for melanosome biogenesis based on the purification and analysis of early melanosomes. Proc Natl Acad Sci U S A (2001) 2.06
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cell Mol Life Sci (2005) 2.03
The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function. J Biol Chem (1994) 1.65
Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase. J Invest Dermatol (2007) 1.37
Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson's disease. Prog Neurobiol (2005) 1.37
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res (2003) 1.31
Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. J Biol Chem (2003) 1.27
What controls variation in human skin color? PLoS Biol (2003) 1.27
Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-Kit expression. J Histochem Cytochem (2002) 1.26
Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide. Biochem Pharmacol (1998) 1.21
Spectrophotometric characterization of eumelanin and pheomelanin in hair. Pigment Cell Res (1996) 1.19
Disulfiram induces apoptosis in human melanoma cells: a redox-related process. Mol Cancer Ther (2002) 1.19
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. Neurology (2006) 1.07
Sound needs sound melanocytes to be heard. Pigment Cell Res (1999) 1.05
Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation. Pigment Cell Res (2005) 0.99
Membranous complexes characteristic of melanocytes derived from patients with Hermansky-Pudlak syndrome type 1 are macroautophagosomal entities of the lysosomal compartment. Pigment Cell Res (2005) 0.90
Melanization and phagocytosis: implications for age related macular degeneration. Mol Vis (2005) 0.88
Melanosome biogenesis: shedding light on the origin of an obscure organelle. Trends Cell Biol (2003) 0.86
The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register. J Am Acad Dermatol (2007) 0.84
Variations in melanin formation by cultured melanocytes from different skin types. Arch Dermatol Res (1998) 0.81
Melanogenesis in cultured melanocytes can be substantially influenced by L-tyrosine and L-cysteine. J Invest Dermatol (1997) 0.80
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell (2005) 6.47
Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev (2005) 6.14
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell (2006) 5.08
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature (2007) 4.70
Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell (2003) 3.75
The exocyst is a Ral effector complex. Nat Cell Biol (2002) 3.33
Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophys J (2006) 2.71
RNA interference in mammalian cells by chemically-modified RNA. Biochemistry (2003) 2.62
Laparoendoscopic single-site surgery in urology: worldwide multi-institutional analysis of 1076 cases. Eur Urol (2011) 2.46
Ral GTPases and cancer: linchpin support of the tumorigenic platform. Nat Rev Cancer (2008) 2.39
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23
Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts. J Cell Biol (2003) 2.22
In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. J Exp Med (2005) 2.21
The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol Cell Biol (2002) 2.19
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell (2011) 2.13
RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival. EMBO Rep (2003) 2.02
Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties. Biophys J (2007) 1.96
RalB mobilizes the exocyst to drive cell migration. Mol Cell Biol (2006) 1.91
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature (2004) 1.87
Novel robotic da Vinci instruments for laparoendoscopic single-site surgery. Urology (2010) 1.83
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem (2004) 1.75
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2005) 1.73
Compact scanning laser ophthalmoscope with high-speed retinal tracker. Appl Opt (2003) 1.69
Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. J Cell Biol (2003) 1.63
Towards patient-based cancer therapeutics. Nat Biotechnol (2010) 1.63
Robotic versus laparoscopic partial nephrectomy: single-surgeon matched cohort study of 150 patients. Urology (2010) 1.61
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell (2013) 1.60
Broad spectrum identification of cellular small ubiquitin-related modifier (SUMO) substrate proteins. J Biol Chem (2004) 1.59
Ral GTPases: corrupting the exocyst in cancer cells. Trends Cell Biol (2005) 1.58
Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1. J Biol Chem (2004) 1.56
Variations in atmospheric CO2 growth rates coupled with tropical temperature. Proc Natl Acad Sci U S A (2013) 1.54
CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell (2013) 1.53
Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data. PLoS Comput Biol (2010) 1.47
Testicular compartment syndrome: a new approach to conceptualizing and managing testicular torsion. Urology (2008) 1.46
A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin Cancer Res (2013) 1.46
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Mol Cell Biol (2004) 1.45
[Robot assisted laparoscopic partial nephrectomy: techniques and outcomes]. Arch Esp Urol (2011) 1.40
Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J Biol Chem (2002) 1.39
Working as second-class citizens. Nurs N Z (2012) 1.38
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J Exp Med (2012) 1.35
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol Biol Cell (2003) 1.29
In vivo multiphoton fluorescence imaging: a novel approach to oral malignancy. Lasers Surg Med (2004) 1.26
A polarity dependent fluorescence "switch" in live cells. J Photochem Photobiol B (2004) 1.26
The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity. Sci Signal (2011) 1.21
Image guided percutaneous probe ablation for renal tumors in 65 solitary kidneys: functional and oncological outcomes. J Urol (2011) 1.20
RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Curr Biol (2009) 1.16
Critical contribution of linker proteins to Raf kinase activation. J Biol Chem (2001) 1.15
Comprehensive mapping of the human kinome to epidermal growth factor receptor signaling. J Biol Chem (2010) 1.14
Photothermal treatment of glioma; an in vitro study of macrophage-mediated delivery of gold nanoshells. J Neurooncol (2011) 1.13
Laparoendoscopic single site reconstructive procedures in urology: medium term results. J Urol (2012) 1.12
Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors. Mol Biol Cell (2005) 1.11
Bayesian optimal discovery procedure for simultaneous significance testing. BMC Bioinformatics (2009) 1.10
Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation. Cancer Res (2010) 1.09
Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps. Genome Res (2010) 1.09
Affinity enrichment of plasma membrane for proteomics analysis. Electrophoresis (2003) 1.08
CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation. Curr Biol (2004) 1.08
Noninvasive imaging of oral premalignancy and malignancy. J Biomed Opt (2005) 1.07
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized. Cancer Res (2007) 1.05
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol (2011) 1.04
Randomized clinical trials presented at the World Congress of Endourology: how is the quality of reporting? J Endourol (2010) 1.04
A case of simultaneously occurring lichen sclerosus and segmental vitiligo: connecting the underlying autoimmune pathogenesis. Int J Dermatol (2008) 1.04
Current status and future perspectives in laparoendoscopic single-site and natural orifice transluminal endoscopic urological surgery. Int J Urol (2010) 1.03
Macrophages as cell-based delivery systems for nanoshells in photothermal therapy. Ann Biomed Eng (2011) 1.03
sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database. BMC Bioinformatics (2007) 1.02
The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells. Mol Cell Biol (2008) 1.02
Casein kinase I regulates membrane binding by ARF GAP1. Mol Biol Cell (2002) 1.01
Capillary high-performance liquid chromatography/mass spectrometric analysis of proteins from affinity-purified plasma membrane. Anal Chem (2003) 1.00
RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage. Cancer Res (2012) 1.00
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide. Bioorg Med Chem Lett (2008) 0.99
Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis. J Am Chem Soc (2013) 0.99
Protein interaction network topology uncovers melanogenesis regulatory network components within functional genomics datasets. BMC Syst Biol (2010) 0.98
Broad spectrum identification of SUMO substrates in melanoma cells. Proteomics (2007) 0.98
A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle (2008) 0.97
Phosphodiesterase-Ialpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization. Mol Cell Neurosci (2007) 0.97
Laparoendoscopic single-site radical cystectomy and pelvic lymph node dissection: initial experience and 2-year follow-up. Urology (2010) 0.97
Features of influenza HA required for apical sorting differ from those required for association with DRMs or MAL. Traffic (2003) 0.96
Retraction. Science (2005) 0.96
GWAS meets TCGA to illuminate mechanisms of cancer predisposition. Cell (2013) 0.96
Relative abundance and the species-specific reinforcement of male mating preference in the Chrysochus (Coleoptera: Chrysomelidae) hybrid zone. Evolution (2005) 0.95
SPIDER surgical system for urologic procedures with laparoendoscopic single-site surgery: from initial laboratory experience to first clinical application. Eur Urol (2011) 0.94
The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic. Dev Cell (2012) 0.94
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol (2012) 0.94
Using functional signature ontology (FUSION) to identify mechanisms of action for natural products. Sci Signal (2013) 0.94
Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth. Cancer Res (2011) 0.94
Laparoendoscopic single-site repair of retrocaval ureter: first case report. Urology (2010) 0.92
Correlation of the RENAL nephrometry score with warm ischemia time after robotic partial nephrectomy. World J Urol (2012) 0.91
Host modulators of H1N1 cytopathogenicity. PLoS One (2012) 0.91
Skin-derived precursors as a source of progenitors for cutaneous nerve regeneration. Stem Cells (2012) 0.91
Demographic history of a recent invasion of house mice on the isolated Island of Gough. Mol Ecol (2014) 0.90
Robotic bladder diverticulectomy: technique and surgical outcomes. Int J Urol (2011) 0.90