Published in Curr Opin Pulm Med on January 01, 2009
The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev (2011) 2.44
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
Asthma genetics and personalised medicine. Lancet Respir Med (2014) 1.17
Genome-wide expression profiling deciphers host responses altered during dengue shock syndrome and reveals the role of innate immunity in severe dengue. PLoS One (2010) 1.08
Identifying predictors, moderators, and mediators of antidepressant response in major depressive disorder: neuroimaging approaches. Am J Psychiatry (2015) 1.04
Clinical patterns in asthma based on proximal and distal airway nitric oxide categories. Respir Res (2010) 0.97
Emerging role of alternative splicing of CRF1 receptor in CRF signaling. Acta Biochim Pol (2010) 0.97
Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. J Biol Chem (2014) 0.94
Proteomic Analysis of Anti-inflammatory Effects of a Kampo (Japanese Herbal) Medicine "Shoseiryuto (Xiao-Qing-Long-Tang)" on Airway Inflammation in a Mouse Model. Evid Based Complement Alternat Med (2011) 0.92
Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics (2012) 0.81
ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos. J Allergy Clin Immunol (2010) 0.81
Genome-wide association study of leukotriene modifier response in asthma. Pharmacogenomics J (2015) 0.80
Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities. Pharmacogenomics (2010) 0.80
Genetics of asthma susceptibility and severity. Clin Chest Med (2012) 0.78
Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma. PLoS One (2015) 0.77
Exercise-induced bronchoconstriction: The effects of montelukast, a leukotriene receptor antagonist. Ther Clin Risk Manag (2009) 0.77
Chronic obstructive pulmonary disease: towards pharmacogenetics. Genome Med (2009) 0.75
The role of CD23 in IgE dependent signaling: implications from pharmacogenetics. Trans Am Clin Climatol Assoc (2011) 0.75
Rise and fall of asthma mortality in England and Wales in relation to use of pressurised aerosols. Lancet (1969) 12.03
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A (2000) 10.27
Regular inhaled beta-agonist treatment in bronchial asthma. Lancet (1990) 9.93
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Leukotrienes. N Engl J Med (2007) 5.00
End of the New Zealand asthma mortality epidemic. Lancet (1995) 4.88
Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol (2005) 4.50
Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/Beclomethasone Study Group. Ann Intern Med (1999) 4.45
Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. Am J Respir Crit Care Med (2006) 4.35
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry (1994) 4.33
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med (1996) 4.03
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91
Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol (1995) 3.27
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med (2000) 3.08
Heterogeneity of therapeutic responses in asthma. Br Med Bull (2000) 2.86
Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest (1997) 2.85
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol (2006) 2.49
beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med (2005) 2.45
Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet (2007) 2.41
Regular treatment with salmeterol for chronic asthma: serious adverse events. Cochrane Database Syst Rev (2008) 2.38
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet (1999) 2.37
Integrating patient preferences into health outcomes assessment: the multiattribute Asthma Symptom Utility Index. Chest (1998) 2.28
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax (2000) 2.10
Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest (1998) 1.94
Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics. Clin Pharmacol Ther (1999) 1.93
Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study. Lancet (2006) 1.84
Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. Am J Physiol Lung Cell Mol Physiol (2007) 1.66
Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med (2006) 1.59
Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med (2005) 1.58
Beta 2-adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics. Hum Genet (2006) 1.43
Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev (2006) 1.42
FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma. J Allergy Clin Immunol (2007) 1.40
The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol. Br J Clin Pharmacol (2004) 1.38
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med (2008) 1.34
Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol (2003) 1.34
Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc Natl Acad Sci U S A (2005) 1.31
TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A (2004) 1.30
Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast. Thorax (2000) 1.20
Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast. Pharmacogenet Genomics (2007) 1.17
Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma. Eur Respir J (1998) 1.16
Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma. Pharmacogenetics (2002) 1.11
Asthma control during long-term treatment with regular inhaled salbutamol and salmeterol. Thorax (1998) 1.11
Treatment heterogeneity in asthma: genetics of response to leukotriene modifiers. Mol Diagn Ther (2007) 1.04
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma. Respir Med (2008) 1.02
Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma. Pharmacogenet Genomics (2008) 0.98
Bronchodilator response in relation to beta2-adrenoceptor haplotype in patients with asthma. Am J Respir Crit Care Med (2005) 0.96
Effect of montelukast on time-course of exhaled nitric oxide in asthma: influence of LTC4 synthase A(-444)C polymorphism. Pediatr Pulmonol (2003) 0.86
Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma. J Asthma (2008) 0.85
Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms. J Allergy Clin Immunol (2008) 0.81
Population pharmacodynamic model of bronchodilator response to inhaled albuterol in children and adults with asthma. Chest (2008) 0.81
Relationships between asthma mortality and treatment. Ann Allergy (1993) 0.77
Present state of the controversy about regular inhaled beta-agonists in asthma. Eur Respir J (1995) 0.77
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med (2009) 4.64
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol (2004) 4.17
Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol (2007) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr (2007) 3.89
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr (2007) 3.40
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med (2008) 2.61
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Uric acid and the development of hypertension: the normative aging study. Hypertension (2006) 2.45
Obesity and asthma. Am J Respir Crit Care Med (2006) 2.43
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med (2013) 2.36
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet (2009) 2.27
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23
Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J Am Med Inform Assoc (2009) 2.20
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol (2005) 2.16
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy. J Allergy Clin Immunol (2004) 2.11
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med (2009) 2.10
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort study. Am J Respir Crit Care Med (2002) 2.02
Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med (2003) 1.98
Pharmacogenomics: challenges and opportunities. Ann Intern Med (2006) 1.96
Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma. J Allergy Clin Immunol (2007) 1.93
The burden of asthma in the United States: level and distribution are dependent on interpretation of the national asthma education and prevention program guidelines. Am J Respir Crit Care Med (2002) 1.92
A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered (2003) 1.89
Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am J Respir Crit Care Med (2012) 1.88
Transcriptomic analysis of human lung development. Am J Respir Crit Care Med (2009) 1.87
Asthma in Hispanics. Am J Respir Crit Care Med (2005) 1.84
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. J Allergy Clin Immunol (2008) 1.80
Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut. Chest (2004) 1.79
Cost-effectiveness of omalizumab in adults with severe asthma: results from the Asthma Policy Model. J Allergy Clin Immunol (2007) 1.73
Perinatal predictors of atopic dermatitis occurring in the first six months of life. Pediatrics (2004) 1.72
Maternal diet vs lack of exposure to sunlight as the cause of the epidemic of asthma, allergies and other autoimmune diseases. Thorax (2007) 1.67
Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. Am J Physiol Lung Cell Mol Physiol (2007) 1.66
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol (2011) 1.65
Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev (2002) 1.65
A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets. J Allergy Clin Immunol (2002) 1.65
IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol (2004) 1.64
Beta 2-adrenergic receptor polymorphisms and haplotypes are associated with airways hyperresponsiveness among nonsmoking men. Chest (2004) 1.63
On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. Genet Epidemiol (2009) 1.62
Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med (2006) 1.59
Apolipoprotein E genotype predicts 24-month bayley scales infant development score. Pediatr Res (2003) 1.59
Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med (2005) 1.58
Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. Am J Respir Crit Care Med (2015) 1.58
Variation in total and specific IgE: effects of ethnicity and socioeconomic status. J Allergy Clin Immunol (2005) 1.56
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol (2012) 1.54
Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma. J Allergy Clin Immunol (2006) 1.54
Global analysis of the impact of environmental perturbation on cis-regulation of gene expression. PLoS Genet (2011) 1.51
The role of indoor allergen sensitization and exposure in causing morbidity in women with asthma. Am J Respir Crit Care Med (2002) 1.50
Real-world Evaluation of Asthma Control and Treatment (REACT): findings from a national Web-based survey. J Allergy Clin Immunol (2007) 1.49
Association of lung perfusion disparity and mortality in patients with cystic fibrosis awaiting lung transplantation. J Heart Lung Transplant (2002) 1.47
Eat dirt--the hygiene hypothesis and allergic diseases. N Engl J Med (2002) 1.47
ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med (2003) 1.47
On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol (2008) 1.47
Mild to moderate asthma affects lung growth in children and adolescents. J Allergy Clin Immunol (2006) 1.44
Genome-wide interrogation of longitudinal FEV1 in children with asthma. Am J Respir Crit Care Med (2014) 1.44
Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits. Curr Med Res Opin (2013) 1.44
Lead exposure biomarkers and mini-mental status exam scores in older men. Epidemiology (2003) 1.44
ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol (2004) 1.43
Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. Genet Epidemiol (2006) 1.43
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42
Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. Am J Respir Crit Care Med (2015) 1.42
FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma. J Allergy Clin Immunol (2007) 1.40
On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet (2009) 1.39
Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol (2010) 1.39
Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol (2009) 1.38
Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutr (2006) 1.38
Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program. J Allergy Clin Immunol (2008) 1.36