Published in Adv Immunol on January 01, 2008
Development and migration of plasma cells in the mouse lymph node. Immunity (2010) 2.44
The proteasome: overview of structure and functions. Proc Jpn Acad Ser B Phys Biol Sci (2009) 1.82
Roles of the NF-kappaB pathway in lymphocyte development and function. Cold Spring Harb Perspect Biol (2009) 1.63
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis. J Clin Invest (2013) 1.57
The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol (2012) 1.33
Overview of the immune response. J Allergy Clin Immunol (2010) 1.32
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chem Biol (2010) 1.01
Potential barriers to therapeutics utilizing pluripotent cell derivatives: intrinsic immunogenicity of in vitro maintained and matured populations. Semin Immunopathol (2011) 0.98
Characterization of mononuclear phagocytic cells in medaka fish transgenic for a cxcr3a:gfp reporter. Proc Natl Acad Sci U S A (2010) 0.86
A peptide's perspective on antigen presentation to the immune system. Nat Chem Biol (2013) 0.84
Prophylactic cancer vaccination by targeting functional non-self. Ann Med (2011) 0.84
Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice. Am J Physiol Endocrinol Metab (2012) 0.83
Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus. Cell Rep (2016) 0.83
Maturation and emigration of single-positive thymocytes. Clin Dev Immunol (2013) 0.82
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J Biol Chem (2012) 0.82
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development. Proc Natl Acad Sci U S A (2013) 0.82
The enigma of CD4-lineage specification. Eur J Immunol (2011) 0.81
Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection. Aging Dis (2012) 0.80
Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6. PLoS One (2014) 0.80
SOX2 gene expression in normal human thymus and thymoma. Clin Exp Med (2010) 0.79
Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives. Methods Mol Biol (2013) 0.79
Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants. Comput Struct Biotechnol J (2014) 0.78
Increased leptin response and inhibition of apoptosis in thymocytes of young rats offspring from protein deprived dams during lactation. PLoS One (2013) 0.78
The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses. Biomed Res Int (2012) 0.78
T Cell Adaptive Immunity Proceeds through Environment-Induced Adaptation from the Exposure of Cryptic Genetic Variation. Front Genet (2012) 0.76
Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?). Clin Exp Immunol (2016) 0.75
Immunohistological analysis of the jun family and the signal transducers and activators of transcription in thymus. Anat Res Int (2015) 0.75
On the issue of peptide recognition in T cell development. Self Nonself (2010) 0.75
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Autophagy regulates lipid metabolism. Nature (2009) 13.33
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature (2007) 7.21
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab (2008) 5.55
A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J (2006) 4.95
Matching categorical object representations in inferior temporal cortex of man and monkey. Neuron (2008) 4.71
Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab (2008) 4.33
Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem (2008) 4.20
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A (2007) 3.92
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell (2005) 3.85
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex. Nature (2011) 3.77
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Neuronal correlates of goal-based motor selection in the prefrontal cortex. Science (2003) 3.53
The structure of the mammalian 20S proteasome at 2.75 A resolution. Structure (2002) 3.44
Medial prefrontal cell activity signaling prediction errors of action values. Nat Neurosci (2007) 3.29
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28
Regulation of CD8+ T cell development by thymus-specific proteasomes. Science (2007) 3.11
Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem (2002) 3.01
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91
Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol (2009) 2.82
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood (2006) 2.72
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J (2006) 2.69
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64
Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro. J Biol Chem (2005) 2.60
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol (2008) 2.57
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57
Object category structure in response patterns of neuronal population in monkey inferior temporal cortex. J Neurophysiol (2007) 2.55
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun (2012) 2.55
CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med (2004) 2.52
Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem (2005) 2.44
Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex. Nat Rev Neurosci (2009) 2.42
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32
E3 ubiquitin ligase that recognizes sugar chains. Nature (2002) 2.17
Contrast adaptation and representation in human early visual cortex. Neuron (2005) 2.17
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. Mol Biol Cell (2008) 2.14
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity (2006) 2.12
Noninvasive ventilation in pulmonary edema complicating acute myocardial infarction. Circ J (2012) 2.09
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity (2008) 2.07
Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions. Science (2009) 2.05
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. J Biol Chem (2006) 2.03
A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature (2005) 2.03
Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care (2012) 2.02
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain. EMBO Rep (2003) 2.01
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J (2004) 1.99
IAN family critically regulates survival and development of T lymphocytes. PLoS Biol (2006) 1.95
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell (2013) 1.95
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity (2012) 1.94
Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome. EMBO J (2009) 1.93
Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Cell (2009) 1.92
NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J Immunol (2004) 1.92
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol (2005) 1.88
Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. J Biol Chem (2005) 1.88
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 1.87
Thymic epithelial cells: working class heroes for T cell development and repertoire selection. Trends Immunol (2012) 1.85
Mnemonic function of the dorsolateral prefrontal cortex in conflict-induced behavioral adjustment. Science (2007) 1.83
Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell (2009) 1.81
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome. Proc Natl Acad Sci U S A (2011) 1.80
An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis. Cell (2009) 1.78
The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun (2009) 1.77
Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein. J Virol (2003) 1.76
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol (2003) 1.75
CHIP: a quality-control E3 ligase collaborating with molecular chaperones. Int J Biochem Cell Biol (2003) 1.72
Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy (2008) 1.71
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood (2006) 1.66
In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem (2005) 1.66
A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mech Dev (2004) 1.65
Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates. Structure (2010) 1.63
Loss of autophagy promotes murine acetaminophen hepatotoxicity. J Gastroenterol (2011) 1.61
SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell (2007) 1.60
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy (2011) 1.59
The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome. EMBO J (2003) 1.58