James R Downing

Author PubWeight™ 360.95‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 MicroRNA expression profiles classify human cancers. Nature 2005 69.12
2 Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013 19.87
3 Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007 17.68
4 Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002 11.83
5 Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009 10.54
6 BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008 10.12
7 The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012 9.89
8 Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 2008 9.25
9 Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med 2009 7.95
10 Acute lymphoblastic leukemia. N Engl J Med 2004 7.83
11 Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 2012 7.61
12 Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002 6.64
13 Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 2011 6.39
14 Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014 5.37
15 CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat Methods 2011 5.34
16 A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 2012 5.02
17 JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 2009 4.98
18 Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol 2009 4.89
19 Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 2002 4.88
20 Novel mutations target distinct subgroups of medulloblastoma. Nature 2012 4.82
21 Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003 4.54
22 Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 2009 4.43
23 Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell 2012 4.41
24 Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet 2009 4.35
25 Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital. Blood 2004 4.21
26 Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood 2010 4.00
27 Gene expression profiling of pediatric acute myelogenous leukemia. Blood 2004 3.77
28 Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial. Lancet Oncol 2010 3.76
29 CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 2011 3.72
30 Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood 2010 3.66
31 Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet 2013 3.51
32 The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet 2013 3.43
33 Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 2002 3.41
34 Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood 2011 3.40
35 Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Blood 2009 2.86
36 Results of therapy for acute lymphoblastic leukemia in black and white children. JAMA 2003 2.77
37 Mouse models of human AML accurately predict chemotherapy response. Genes Dev 2009 2.75
38 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA 2009 2.72
39 Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital. Blood 2009 2.70
40 Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA 2012 2.49
41 Genomics and the continuum of cancer care. N Engl J Med 2011 2.26
42 A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia. Blood 2007 2.19
43 Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest 2007 2.05
44 Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Proc Natl Acad Sci U S A 2009 1.92
45 Reference alignment of SNP microarray signals for copy number analysis of tumors. Bioinformatics 2008 1.91
46 Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood 2008 1.89
47 Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nat Genet 2003 1.79
48 New markers for minimal residual disease detection in acute lymphoblastic leukemia. Blood 2011 1.78
49 Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet 2013 1.77
50 An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell 2012 1.61
51 High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood 2012 1.58
52 Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia. J Clin Oncol 2005 1.53
53 Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project. Blood 2012 1.47
54 Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood 2003 1.46
55 Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics. J Clin Invest 2005 1.46
56 The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood 2011 1.45
57 Clinical significance of residual disease during treatment in childhood acute myeloid leukaemia. Br J Haematol 2003 1.41
58 Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. Blood 2006 1.41
59 Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. Lancet Oncol 2004 1.41
60 ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases. Blood 2003 1.36
61 Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. Cancer Cell 2009 1.36
62 Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors. Blood 2004 1.35
63 Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med 2011 1.34
64 Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL. Genes Dev 2008 1.33
65 An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase. Br J Haematol 2008 1.33
66 Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. J Clin Oncol 2014 1.31
67 Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia. J Clin Oncol 2012 1.30
68 Treatment outcomes in black and white children with cancer: results from the SEER database and St Jude Children's Research Hospital, 1992 through 2007. J Clin Oncol 2012 1.25
69 Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. PLoS Genet 2009 1.19
70 Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia. J Clin Invest 2013 1.19
71 Improved prognosis for older adolescents with acute lymphoblastic leukemia. J Clin Oncol 2010 1.16
72 Pediatric acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program 2003 1.13
73 Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Res 2012 1.09
74 High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations. Blood 2012 1.09
75 Favorable impact of the t(9;11) in childhood acute myeloid leukemia. J Clin Oncol 2002 1.05
76 PROMISE: a tool to identify genomic features with a specific biologically interesting pattern of associations with multiple endpoint variables. Bioinformatics 2009 1.05
77 Global genomic characterization of acute lymphoblastic leukemia. Semin Hematol 2009 1.02
78 The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood 2002 0.99
79 Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol 2009 0.97
80 RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget 2014 0.96
81 Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols. Blood 2006 0.96
82 Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 2013 0.96
83 Simple rules underlying gene expression profiles of more than six subtypes of acute lymphoblastic leukemia (ALL) patients. Bioinformatics 2003 0.95
84 Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data. Genome Biol 2012 0.95
85 Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo. Blood 2013 0.95
86 Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes. Pharmacogenomics 2011 0.93
87 Genomic assessment of pediatric acute leukemia. Cancer J 2005 0.87
88 Real-time polymerase chain reaction as an aid for the detection of SYT-SSX1 and SYT-SSX2 transcripts in fresh and archival pediatric synovial sarcoma specimens: report of 25 cases from St. Jude Children's Research Hospital. Pediatr Dev Pathol 2002 0.86
89 Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. Br J Haematol 2014 0.84
90 Cancer genomes--continuing progress. N Engl J Med 2009 0.84
91 Global gene expression as a function of germline genetic variation. Hum Mol Genet 2005 0.83
92 Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs. PLoS One 2008 0.80
93 Germline Mutations in Predisposition Genes in Pediatric Cancer. N Engl J Med 2016 0.76