Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.

PubWeight™: 1.70‹?› | Rank: Top 3%

🔗 View Article (PMC 2845476)

Published in Nat Med on January 18, 2009

Authors

Frédéric Van Gool1, Mara Gallí, Cyril Gueydan, Véronique Kruys, Pierre-Paul Prevot, Antonio Bedalov, Raul Mostoslavsky, Frederick W Alt, Thibaut De Smedt, Oberdan Leo

Author Affiliations

1: Laboratoire de Physiologie Animale, Institut de Biologie et Médecine Moléculaire, Université Libre de Bruxelles, 12 rue des Professeur Jeneer et Brachet, 6041 Gosselies, Belgium.

Articles citing this

Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52

From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem (2011) 1.46

Sirtuins at a glance. J Cell Sci (2011) 1.41

Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. PLoS One (2015) 1.39

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications. J Biol Chem (2012) 1.36

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol (2011) 1.35

Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem (2011) 1.31

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PLoS One (2009) 1.30

Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci (2014) 1.27

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood (2012) 1.23

Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17

Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem (2012) 1.13

The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J Biol Chem (2012) 1.11

Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol (2015) 1.06

Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging (Albany NY) (2009) 1.05

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. Antioxid Redox Signal (2012) 1.04

The multifaceted functions of sirtuins in cancer. Nat Rev Cancer (2015) 1.04

Rejuvenating sirtuins: the rise of a new family of cancer drug targets. Curr Pharm Des (2013) 1.01

Nicotinamide Phosphoribosyltransferase in Human Diseases. J Bioanal Biomed (2011) 1.01

Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal (2012) 1.01

Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br J Pharmacol (2016) 0.98

Transcriptome analysis of monocyte-HIV interactions. Retrovirology (2010) 0.98

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res (2013) 0.98

NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes. J Biol Chem (2012) 0.96

Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells. Mediators Inflamm (2012) 0.93

Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. PLoS One (2014) 0.93

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation (2012) 0.91

Inflammaging and cancer: a challenge for the Mediterranean diet. Nutrients (2015) 0.91

Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. PLoS One (2011) 0.90

Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One (2014) 0.88

Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer (2013) 0.88

Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study. J Transl Med (2010) 0.88

Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury. Am J Respir Cell Mol Biol (2014) 0.88

Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages. FEBS J (2010) 0.87

Immunometabolism in obese asthmatics: are we there yet? Nutrients (2013) 0.86

Histone deacetylases: a saga of perturbed acetylation homeostasis in cancer. J Histochem Cytochem (2013) 0.86

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD. Nat Struct Mol Biol (2015) 0.84

Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells. J Biol Chem (2012) 0.83

Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes. Mol Biol Cell (2013) 0.83

SIRT1 links CIITA deacetylation to MHC II activation. Nucleic Acids Res (2011) 0.82

Stretch and inflammation-induced Pre-B cell colony-enhancing factor (PBEF/Visfatin) and Interleukin-8 in amniotic epithelial cells. Placenta (2010) 0.82

NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun (2014) 0.81

NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages. PLoS One (2014) 0.80

Prognostic value of serum nicotinamide phosphoribosyltransferase in patients with bladder cancer. Croat Med J (2014) 0.79

Vitamin B3 boosts neutrophil counts. Nat Med (2009) 0.79

Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice. Sci Rep (2016) 0.78

A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery. Biol Reprod (2016) 0.77

Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages. Biosci Rep (2016) 0.77

NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity. Exp Hematol (2013) 0.77

The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome. Cell Mol Life Sci (2016) 0.76

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med (2016) 0.76

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension. Circulation (2017) 0.76

Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY) (2016) 0.76

GM-CSF and IL-3 Modulate Human Monocyte TNF-α Production and Renewal in In Vitro Models of Trained Immunity. Front Immunol (2017) 0.75

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866. Drug Des Devel Ther (2017) 0.75

Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats. Respir Res (2017) 0.75

Defining a genotoxic profile with mouse embryonic stem cells. Exp Biol Med (Maywood) (2013) 0.75

Hypophosphatemia after Hepatectomy or Pancreatectomy: Role of the Nicotinamide Phosphoribosyltransferase. J Am Coll Surg (2017) 0.75

Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD(+)/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. Stroke (2017) 0.75

Niacin inhibits carrageenan-induced neutrophil migration in mice. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.75

Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale. Int J Tryptophan Res (2017) 0.75

Articles cited by this

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

Points of control in inflammation. Nature (2002) 10.61

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev (2006) 8.48

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48

Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30

The PARP superfamily. Bioessays (2004) 6.14

AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell (2007) 5.87

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (2007) 5.49

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem (2004) 5.37

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell (2003) 5.23

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med (1993) 4.30

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res (2003) 4.04

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A (2000) 3.94

Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med (2003) 3.89

Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res (2000) 3.79

Sirtuins as potential targets for metabolic syndrome. Nature (2006) 3.38

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem (2005) 3.31

Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med (2004) 3.19

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res (2006) 2.92

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem (2001) 2.80

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J (1999) 2.75

Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest (2004) 2.72

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell (2004) 2.71

The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci (2002) 2.61

Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol (2002) 2.60

SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat Struct Mol Biol (2006) 2.21

New functions of a long-known molecule. Emerging roles of NAD in cellular signaling. Eur J Biochem (2000) 1.89

Dampening inflammation. Nat Immunol (2005) 1.80

Reconstructing eukaryotic NAD metabolism. Bioessays (2003) 1.80

Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. Mol Cell (2007) 1.77

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol (2004) 1.73

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol Cell (2005) 1.71

Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo. J Biol Chem (1989) 1.61

Posttranscriptional mechanisms regulating the inflammatory response. Adv Immunol (2006) 1.59

NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity. AAPS J (2006) 1.57

Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked? Bioessays (2003) 1.17

Nicotinamide is a potent inhibitor of proinflammatory cytokines. Clin Exp Immunol (2003) 1.16

Shock, inflammation and PARP. Pharmacol Res (2005) 1.12

The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet (2005) 1.12

Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway. J Exp Med (1993) 1.10

Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice. Biochem Biophys Res Commun (1999) 0.95

Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-alpha. Immunol Lett (1997) 0.94

The protective effect of niacinamide on ischemia-reperfusion-induced liver injury. J Biomed Sci (2001) 0.91

Nicotinamide: a jack of all trades (but master of none?). Intensive Care Med (2003) 0.79

Articles by these authors

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97

Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48

The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09

IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05

Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol (2005) 5.82

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76

SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68

DNA repair, genome stability, and aging. Cell (2005) 5.52

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48

Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26

Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07

A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther (2007) 4.65

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81

Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol (2008) 3.66

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53

Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46

SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33

DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. Proc Natl Acad Sci U S A (2007) 3.32

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12

Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08

Genetic basis of proteome variation in yeast. Nat Genet (2007) 3.04

Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95

Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res (2006) 2.92

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. Neuromuscul Disord (2007) 2.85

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74

Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73

The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72

The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol (2007) 2.68

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63

CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62

Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol (2002) 2.60

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev (2010) 2.55

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell (2002) 2.49

Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (2006) 2.49

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature (2011) 2.47

The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44

Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43

Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38

The influence of transcriptional orientation on endogenous switch region function. Nat Immunol (2003) 2.38

Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet (2006) 2.36

Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med (2003) 2.36

Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27

Unraveling V(D)J recombination; insights into gene regulation. Cell (2004) 2.25

Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol (2005) 2.19

Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci U S A (2006) 2.17

H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle (2004) 2.16

Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med (2003) 2.15

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity (2007) 2.11

AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med (2008) 2.10

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell (2003) 2.08

Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol (2011) 2.08

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05

The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer. Cancer Res (2009) 2.04

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98

An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nat Immunol (2004) 1.98

Microbial colonization influences early B-lineage development in the gut lamina propria. Nature (2013) 1.96

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95

Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J Immunol (2003) 1.91

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91