A three-dimensional view of the molecular machinery of RNA interference.

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Published in Nature on January 22, 2009

Authors

Martin Jinek1, Jennifer A Doudna

Author Affiliations

1: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

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eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature (2016) 0.78

Biochemistry. Guided tour to the heart of RISC. Science (2012) 0.78

RNAs regulate biology. ACS Chem Biol (2006) 0.76

RNA: primed for packing? Chem Biol (2004) 0.75

Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. PLoS One (2017) 0.75

Activating silent argonautes. Nat Struct Mol Biol (2013) 0.75

A higher degree of difficulty. ACS Chem Biol (2007) 0.75

Nucleic acids and their protein partners. Curr Opin Struct Biol (2008) 0.75