Published in PLoS One on January 23, 2009
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Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases. Nat Cell Biol (2007) 1.81
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Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay. Proc Natl Acad Sci U S A (2002) 1.30
A molecular pathogenesis for transcription factor associated poly-alanine tract expansions. Hum Mol Genet (2004) 1.29
UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome. Nucleic Acids Res (2008) 1.28
HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. Stem Cells (2014) 1.23
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. Hum Mol Genet (2005) 1.21
Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers. J Mol Biol (2012) 1.16
A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells. Mol Cell Proteomics (2008) 1.15
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J (2010) 1.14
Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease. J Biol Chem (2003) 1.13
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics (2005) 1.13
A Y2H-seq approach defines the human protein methyltransferase interactome. Nat Methods (2013) 1.10
Detection of alpha-rod protein repeats using a neural network and application to huntingtin. PLoS Comput Biol (2009) 1.09
The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes. J Neurosci (2007) 1.08
The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev (2002) 1.06
Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy. Neurodegener Dis (2007) 1.02
Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease. Neurobiol Dis (2005) 1.02
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The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. Hum Genet (2008) 1.00
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Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis. J Hum Genet (2010) 0.98
Multiplex approaches in protein microarray technology. Expert Rev Proteomics (2005) 0.97
Mutant huntingtin impairs Ku70-mediated DNA repair. J Cell Biol (2010) 0.97
Systematic functional assessment of human protein-protein interaction maps. Genome Inform (2006) 0.97
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J Cell Biol (2006) 0.95
Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain. Biochem Biophys Res Commun (2008) 0.95
Involvement of IL-1beta and IL-10 in IFN-alpha-mediated antiviral gene induction in human hepatoma cells. Biochem Biophys Res Commun (2002) 0.94
Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture. Biochem Biophys Res Commun (2010) 0.94
Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein. J Neurochem (2003) 0.92
Enhanced SUMOylation in polyglutamine diseases. Biochem Biophys Res Commun (2002) 0.92
Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease. J Neurochem (2006) 0.92
Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Gene Expr Patterns (2003) 0.90
670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease? Photomed Laser Surg (2011) 0.90
Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1. PLoS Genet (2012) 0.90
Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases? EPMA J (2013) 0.89
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. Eur J Neurosci (2008) 0.89
Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein. J Neurochem (2004) 0.88
Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Proc Natl Acad Sci U S A (2012) 0.88
SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. Cell Rep (2013) 0.88
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. PLoS Genet (2013) 0.87
A novel multiplex cell viability assay for high-throughput RNAi screening. PLoS One (2011) 0.87
Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis. Biotechniques (2005) 0.87
Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain. Mech Dev (2002) 0.86
Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. J Neurosci (2010) 0.86
Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils. Biochemistry (2011) 0.86
Myc inhibition impairs autophagosome formation. Hum Mol Genet (2013) 0.85
Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage. Nucleic Acids Res (2002) 0.85
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. PLoS One (2009) 0.84
Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship. FEBS Lett (2006) 0.84
PQBP-1 is expressed predominantly in the central nervous system during development. Eur J Neurosci (2005) 0.84
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PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype. Hum Mol Genet (2003) 0.84
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Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers. Biochem Biophys Res Commun (2009) 0.83
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Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. PLoS One (2011) 0.83
Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism. PLoS One (2009) 0.82
Knock-down of PQBP1 impairs anxiety-related cognition in mouse. Hum Mol Genet (2009) 0.82
Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis. PLoS One (2010) 0.81