Published in Dev Dyn on March 01, 2009
Inhibition of histone deacetylase expands the renal progenitor cell population. J Am Soc Nephrol (2010) 1.94
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol (2009) 1.88
Automated high-throughput mapping of promoter-enhancer interactions in zebrafish embryos. Nat Methods (2009) 1.61
Chemical genetic screening in the zebrafish embryo. Nat Protoc (2009) 1.49
High-throughput screening and small animal models, where are we? Br J Pharmacol (2010) 1.37
Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs). Mol Endocrinol (2009) 1.25
A novel method to reduce time investment when processing videos from camera trap studies. PLoS One (2014) 1.21
Automated processing of zebrafish imaging data: a survey. Zebrafish (2013) 1.14
Characterization of an lhx1a transgenic reporter in zebrafish. Int J Dev Biol (2010) 1.08
Development of automated imaging and analysis for zebrafish chemical screens. J Vis Exp (2010) 1.07
Zebrafish kidney development: basic science to translational research. Birth Defects Res C Embryo Today (2011) 1.02
Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLoS One (2011) 1.02
Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One (2012) 1.01
Miniaturized embryo array for automated trapping, immobilization and microperfusion of zebrafish embryos. PLoS One (2012) 0.98
Zebrafish: an in vivo model for nano EHS studies. Small (2012) 0.96
Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models. Neurobiol Dis (2011) 0.94
Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. Biochem J (2009) 0.91
Phenotype classification of zebrafish embryos by supervised learning. PLoS One (2015) 0.91
Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials. PLoS One (2012) 0.89
A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. Mol Cancer Ther (2011) 0.88
High-content screening in zebrafish embryos identifies butafenacil as a potent inducer of anemia. PLoS One (2014) 0.87
Development of an automated imaging pipeline for the analysis of the zebrafish larval kidney. PLoS One (2013) 0.87
A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling. Birth Defects Res C Embryo Today (2011) 0.86
Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small (2012) 0.86
Advances in zebrafish chemical screening technologies. Future Med Chem (2012) 0.86
Fluorescent transgenic zebrafish Tg(nkx2.2a:mEGFP) provides a highly sensitive monitoring tool for neurotoxins. PLoS One (2013) 0.86
Developmental toxicity assay using high content screening of zebrafish embryos. J Appl Toxicol (2014) 0.85
High-content analysis of cancer-cell-specific apoptosis and inhibition of in vivo angiogenesis by synthetic (-)-pironetin and analogs. Chem Biol Drug Des (2009) 0.84
Advancing toxicology research using in vivo high throughput toxicology with small fish models. ALTEX (2016) 0.83
Zebrafish: modeling for herpes simplex virus infections. Zebrafish (2013) 0.82
The application of phenotypic high-throughput screening techniques to cardiovascular research. Trends Cardiovasc Med (2009) 0.82
Development of high-content assays for kidney progenitor cell expansion in transgenic zebrafish. J Biomol Screen (2013) 0.82
A manual small molecule screen approaching high-throughput using zebrafish embryos. J Vis Exp (2014) 0.82
Generation of Tg(cyp1a:gfp) Transgenic Zebrafish for Development of a Convenient and Sensitive In Vivo Assay for Aryl Hydrocarbon Receptor Activity. Mar Biotechnol (NY) (2015) 0.79
Manipulating the air-filled zebrafish swim bladder as a neutrophilic inflammation model for acute lung injury. Cell Death Dis (2016) 0.75
Automated Segmentation and Object Classification of CT Images: Application to In Vivo Molecular Imaging of Avian Embryos. Int J Biomed Imaging (2013) 0.75
High content screening in neurodegenerative diseases. J Vis Exp (2012) 0.75
Semi-automated imaging of tissue-specific fluorescence in zebrafish embryos. J Vis Exp (2014) 0.75
High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models. Expert Opin Drug Discov (2015) 0.75
Tetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay. ACS Med Chem Lett (2013) 0.75
In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol (2002) 11.62
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (1996) 8.87
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol (2007) 8.08
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
In vivo drug discovery in the zebrafish. Nat Rev Drug Discov (2005) 6.56
Statistical practice in high-throughput screening data analysis. Nat Biotechnol (2006) 5.85
Angiogenic network formation in the developing vertebrate trunk. Development (2003) 3.66
Improved statistical methods for hit selection in high-throughput screening. J Biomol Screen (2003) 3.15
Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci U S A (2000) 2.67
High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nat Chem Biol (2005) 2.64
The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res (1996) 2.57
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol (2004) 2.57
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res (2007) 1.88
Target-based drug discovery: is something wrong? Drug Discov Today (2005) 1.88
Generation of FGF reporter transgenic zebrafish and their utility in chemical screens. BMC Dev Biol (2007) 1.74
Zebrafish-based small molecule discovery. Chem Biol (2003) 1.53
What's wrong with our cancer models? Nat Rev Drug Discov (2005) 1.52
A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des (2006) 1.50
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. Assay Drug Dev Technol (2007) 1.40
Chemical discovery and global gene expression analysis in zebrafish. Nat Biotechnol (2003) 1.33
Back to the future: the 'old-fashioned' way to new medications for neurodegeneration. Nat Med (2004) 1.31
Identification of a novel retinoid by small molecule screening with zebrafish embryos. PLoS One (2008) 1.30
Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. Mol Pharmacol (2005) 1.27
Catalytic asymmetric assembly of stereodefined propionate units: an enantioselective total synthesis of (-)-pironetin. J Am Chem Soc (2006) 1.22
Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J Biol Chem (1999) 1.21
Automated segmentation of lateral ventricles from human and primate magnetic resonance images using cognition network technology. Magn Reson Imaging (2006) 0.96
Functional cell-based uHTS in chemical genomic drug discovery. Trends Biotechnol (2002) 0.93
Evaluation of murine liver transmission electron micrographs by an innovative object-based quantitative image analysis system (Cellenger). Eur J Med Res (2003) 0.81
Chemical genetics of Plasmodium falciparum. Nature (2010) 5.52
Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene (2003) 2.57
Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature (2011) 2.42
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res (2009) 2.32
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med (2012) 2.19
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest (2009) 2.09
Improved low molecular weight Myc-Max inhibitors. Mol Cancer Ther (2007) 1.95
Inhibition of histone deacetylase expands the renal progenitor cell population. J Am Soc Nephrol (2010) 1.94
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol (2009) 1.88
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem (2004) 1.75
Generation of FGF reporter transgenic zebrafish and their utility in chemical screens. BMC Dev Biol (2007) 1.74
Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem (2008) 1.74
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. PLoS One (2010) 1.62
Lipid lowering efficacy of atorvastatin. Cochrane Database Syst Rev (2012) 1.62
GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling. Hum Mol Genet (2011) 1.52
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. Assay Drug Dev Technol (2007) 1.40
Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp. Bioorg Med Chem (2005) 1.40
Requirement for endoderm and FGF3 in ventral head skeleton formation. Development (2002) 1.38
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother Pharmacol (2008) 1.38
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem (2003) 1.37
Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase. J Biol Chem (2002) 1.37
The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. J Biol Chem (2005) 1.31
The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci U S A (2005) 1.31
The substrate recognition domains of the N-end rule pathway. J Biol Chem (2008) 1.31
Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C. Oncogene (2005) 1.30
PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. Cancer Res (2007) 1.28
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Proc Natl Acad Sci U S A (2002) 1.28
Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta (2010) 1.25
Au(I)-catalyzed annulation of enantioenriched allenes in the enantioselective total synthesis of (-)-rhazinilam. J Am Chem Soc (2006) 1.22
Catalytic asymmetric assembly of stereodefined propionate units: an enantioselective total synthesis of (-)-pironetin. J Am Chem Soc (2006) 1.22
Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat Cell Biol (2012) 1.21
Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol (2010) 1.20
Dual-specificity phosphatases as targets for antineoplastic agents. Nat Rev Drug Discov (2002) 1.19
Histone deacetylase inhibitor enhances recovery after AKI. J Am Soc Nephrol (2013) 1.19
Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease. Annu Rev Pharmacol Toxicol (2005) 1.18
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. ACS Chem Biol (2009) 1.18
The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Dev Biol (2005) 1.15
Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model. J Med Chem (2009) 1.14
Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen. PLoS Negl Trop Dis (2009) 1.14
Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents. Assay Drug Dev Technol (2008) 1.14
Intravenous microinjections of zebrafish larvae to study acute kidney injury. J Vis Exp (2010) 1.13
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther (2010) 1.11
Identification of survival genes in human glioblastoma cells by small interfering RNA screening. Mol Pharmacol (2009) 1.11
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis (2010) 1.10
A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Mol Cancer Ther (2008) 1.10
Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments. Assay Drug Dev Technol (2010) 1.10
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol (2013) 1.09
Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene. Nucleic Acids Res (2007) 1.08
Characterization of an lhx1a transgenic reporter in zebrafish. Int J Dev Biol (2010) 1.08
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. PLoS One (2013) 1.07
Development of automated imaging and analysis for zebrafish chemical screens. J Vis Exp (2010) 1.07
Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors. Assay Drug Dev Technol (2007) 1.07
The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish. Development (2010) 1.06
Discovery of exceptionally efficient catalysts for solvent-free enantioselective hetero-Diels-Alder reaction. J Am Chem Soc (2002) 1.06
Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product. Chem Biol Drug Des (2006) 1.05
Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One (2009) 1.05
Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol (2013) 1.05
Redox regulation of Cdc25B by cell-active quinolinediones. Mol Pharmacol (2005) 1.04
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J Am Soc Nephrol (2005) 1.03
Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Dev Biol (2010) 1.02
Zebrafish kidney development: basic science to translational research. Birth Defects Res C Embryo Today (2011) 1.02
Amphidinolide B: asymmetric synthesis of a C7-C20 synthon. Org Lett (2006) 1.02
Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library. Assay Drug Dev Technol (2009) 1.02
Cinchona alkaloid-lewis acid catalyst systems for enantioselective ketene-aldehyde cycloadditions. J Am Chem Soc (2004) 1.02
Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione. J Biol Chem (2002) 1.02
Development and optimization of high-throughput in vitro protein phosphatase screening assays. Nat Protoc (2007) 1.01
Induction of Cdc25B regulates cell cycle resumption after genotoxic stress. Cancer Res (2007) 1.01
Design, Synthesis, and Biological Evaluation of PKD Inhibitors. Pharmaceutics (2011) 0.99
Cell-active dual specificity phosphatase inhibitors identified by high-content screening. Chem Biol (2003) 0.99
NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J Pharmacol Exp Ther (2004) 0.99
Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21. Cell Cycle (2009) 0.98
Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D. ACS Med Chem Lett (2011) 0.97
Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review. J Biomol Screen (2010) 0.96
Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase. Mol Pharmacol (2004) 0.96
Microtubule binding and disruption and induction of premature senescence by disorazole C(1). J Pharmacol Exp Ther (2008) 0.96
OCRL1 modulates cilia length in renal epithelial cells. Traffic (2012) 0.96
Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targets. J Neurosci Methods (2009) 0.95
Systems cell biology knowledge created from high content screening. Assay Drug Dev Technol (2005) 0.94
A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity. Oncol Res (2004) 0.94
Automated screening of neurite outgrowth. J Biomol Screen (2003) 0.94
Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Proc Natl Acad Sci U S A (2004) 0.94
Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries. Nat Protoc (2008) 0.94
The mych gene is required for neural crest survival during zebrafish development. PLoS One (2008) 0.93
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta. J Nat Prod (2004) 0.93
Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor. Int Immunopharmacol (2011) 0.93
Strategies for discovery of small molecule radiation protectors and radiation mitigators. Front Oncol (2012) 0.92
Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics. J Pharmacol Exp Ther (2010) 0.92
High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol (2013) 0.91
A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury. Am J Physiol Renal Physiol (2013) 0.90
Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses. J Immunol (2007) 0.90
Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284). Anticancer Res (2007) 0.90
MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem Biophys Res Commun (2005) 0.90
Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype. Mol Cancer Ther (2012) 0.89
The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Mol Cancer Ther (2002) 0.89
Binding and inhibition of Cdc25 phosphatases by vitamin K analogues. Biochemistry (2003) 0.89