Published in Crit Care Med on March 01, 2009
Lotta Alla Sepsi Ospedaliera - Fighting Hospital Sepsis | NCT01804764
Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med (2014) 1.81
Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*. Crit Care Med (2012) 1.69
Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis. Antimicrob Agents Chemother (2010) 1.27
Fluid balance and cardiac function in septic shock as predictors of hospital mortality. Crit Care (2013) 1.14
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care (2016) 1.04
Effect of performance improvement programs on compliance with sepsis bundles and mortality: a systematic review and meta-analysis of observational studies. PLoS One (2015) 1.02
Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95
Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center. Support Care Cancer (2012) 0.88
An alternate pathophysiologic paradigm of sepsis and septic shock: implications for optimizing antimicrobial therapy. Virulence (2013) 0.86
Pro/con debate: Should antimicrobial stewardship programs be adopted universally in the intensive care unit? Crit Care (2010) 0.86
Association between hospital volume and network membership and an analgesia, sedation and delirium order set quality score: a cohort study. Crit Care (2012) 0.82
Default options in the ICU: widely used but insufficiently understood. Curr Opin Crit Care (2014) 0.81
Effectiveness of Evidence-Based Congestive Heart Failure (CHF) CPOE Order Sets Measured by Health Outcomes. AMIA Annu Symp Proc (2014) 0.81
Unintended consequences of a standard admission order set on venous thromboembolism prophylaxis and patient outcomes. J Gen Intern Med (2011) 0.79
Standardized approaches to syncope evaluation for reducing hospital admissions and costs in overcrowded emergency departments. Yonsei Med J (2013) 0.78
Triage sepsis alert and sepsis protocol lower times to fluids and antibiotics in the ED. Am J Emerg Med (2015) 0.76
Design and Construction of a Single-Tube, LATE-PCR, Multiplex Endpoint Assay with Lights-On/Lights-Off Probes for the Detection of Pathogens Associated with Sepsis. J Pathog (2012) 0.76
Using an 'action set' for the management of acute upper gastrointestinal bleeding. Therap Adv Gastroenterol (2013) 0.75
Standardized order sets for the treatment of severe sepsis and septic shock. Expert Rev Anti Infect Ther (2009) 0.75
Impact of physician specialty on quality care for patients hospitalized with decompensated cirrhosis. PLoS One (2015) 0.75
Solutions for care of patients with severe sepsis: where and how? Crit Care Med (2009) 0.75
Utilization of methylnaltrexone (relistor) for opioid-induced constipation in an oncology hospital. P T (2011) 0.75
Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002. J Thorac Dis (2017) 0.75
Effectiveness of Evidence-based Pneumonia CPOE Order Sets Measured by Health Outcomes. Online J Public Health Inform (2015) 0.75
Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis. Shock (2017) 0.75
Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis (2012) 7.97
Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest (2002) 6.13
Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest (2003) 5.64
Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother (2005) 5.35
Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med (2006) 4.10
Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest (2002) 3.98
Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005. Emerg Infect Dis (2008) 3.88
Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department. Clin Infect Dis (2011) 3.78
The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs (2007) 3.63
Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother (2005) 3.49
Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens. Clin Infect Dis (2011) 3.20
Pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis (2008) 3.13
The importance of fluid management in acute lung injury secondary to septic shock. Chest (2009) 2.92
Impact of Sepsis Classification and Multidrug-Resistance Status on Outcome Among Patients Treated With Appropriate Therapy. Crit Care Med (2015) 2.87
Time to Appropriate Antibiotic Therapy Is an Independent Determinant of Postinfection ICU and Hospital Lengths of Stay in Patients With Sepsis. Crit Care Med (2015) 2.86
Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis. Crit Care Med (2005) 2.70
Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med (2003) 2.59
Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med (2006) 2.51
Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother (2007) 2.49
Implementation of a real-time computerized sepsis alert in nonintensive care unit patients. Crit Care Med (2011) 2.35
Short- vs long-duration antibiotic regimens for ventilator-associated pneumonia: a systematic review and meta-analysis. Chest (2013) 2.32
A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia. Chest (2004) 2.26
Quality of traditional surveillance for public reporting of nosocomial bloodstream infection rates. JAMA (2010) 2.23
Endotracheal tube intraluminal volume loss among mechanically ventilated patients. Crit Care Med (2004) 2.20
Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay. Crit Care Med (2011) 2.16
Early versus late enteral feeding of mechanically ventilated patients: results of a clinical trial. JPEN J Parenter Enteral Nutr (2002) 2.15
Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med (2010) 2.15
Occurrence of co-colonization or co-infection with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol (2004) 2.13
Association between a silver-coated endotracheal tube and reduced mortality in patients with ventilator-associated pneumonia. Chest (2009) 2.09
Pneumonia Pathogen Characterization Is an Independent Determinant of Hospital Readmission. Chest (2015) 2.09
Using commercial knowledge bases for clinical decision support: opportunities, hurdles, and recommendations. J Am Med Inform Assoc (2006) 2.07
Treatment-related risk factors for hospital mortality in Candida bloodstream infections. Crit Care Med (2008) 2.06
A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia. Clin Ther (2007) 2.05
Attitudes of respiratory therapists and nurses about measures to prevent ventilator-associated pneumonia: a multicenter, cross-sectional survey study. Respir Care (2007) 2.03
Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated medical patients. Crit Care Med (2005) 1.92
Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs? Crit Care Med (2007) 1.88
Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment. Crit Care Med (2006) 1.86
Epidemiology, microbiology and outcomes of healthcare-associated and community-acquired bacteremia: a multicenter cohort study. J Infect (2010) 1.83
A comparison of ventilator-associated pneumonia rates as identified according to the National Healthcare Safety Network and American College of Chest Physicians criteria. Crit Care Med (2012) 1.82
Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest (2008) 1.81
Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy. Crit Care Med (2006) 1.80
Septic shock attributed to Candida infection: importance of empiric therapy and source control. Clin Infect Dis (2012) 1.73
Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med (2002) 1.72
Inappropriate therapy for methicillin-resistant Staphylococcus aureus: resource utilization and cost implications. Crit Care Med (2008) 1.72
Antimicrobial stewardship in the intensive care unit: advances and obstacles. Am J Respir Crit Care Med (2009) 1.71
Implementing a commercial rule base as a medication order safety net. J Am Med Inform Assoc (2005) 1.69
Silver-coated endotracheal tubes associated with reduced bacterial burden in the lungs of mechanically ventilated dogs. Chest (2002) 1.63
Use of adjunctive aerosolized antimicrobial therapy in the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii ventilator-associated pneumonia. Respir Care (2012) 1.62
Using the number needed to treat to assess appropriate antimicrobial therapy as a determinant of outcome in severe sepsis and septic shock. Crit Care Med (2014) 1.61
Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol (2007) 1.61
Nursing adherence with evidence-based guidelines for preventing ventilator-associated pneumonia. Crit Care Med (2003) 1.61
Heparin or 0.9% sodium chloride to maintain central venous catheter patency: a randomized trial. Crit Care Med (2012) 1.61
Identifying critically ill patients at risk for inappropriate antibiotic therapy: a pilot study of a point-of-care decision support alert. Crit Care Med (2014) 1.60
Readmission following hospitalization for pneumonia: the impact of pneumonia type and its implication for hospitals. Clin Infect Dis (2013) 1.60
A prospective evaluation of ventilator-associated conditions and infection-related ventilator-associated conditions. Chest (2015) 1.59
Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med (2008) 1.58
Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med (2006) 1.57
Use of a handheld computer by respiratory care practitioners to improve the efficiency of weaning patients from mechanical ventilation. Crit Care Med (2002) 1.56
A randomized trial of conventional chest physical therapy versus high frequency chest wall compressions in intubated and non-intubated adults. Respir Care (2011) 1.51
Patient safety event reporting in critical care: a study of three intensive care units. Crit Care Med (2007) 1.51
Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit Care Med (2004) 1.49
Antimicrobial therapy escalation and hospital mortality among patients with health-care-associated pneumonia: a single-center experience. Chest (2008) 1.47
Epidemiology and outcomes of clostridium difficile-associated disease among patients on prolonged acute mechanical ventilation. Chest (2009) 1.47
Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: an observational cohort study. Crit Care (2009) 1.47
Physicians' estimates of cardiac index and intravascular volume based on clinical assessment versus transesophageal Doppler measurements obtained by critical care nurses. Am J Crit Care (2003) 1.46
Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa. Chest (2004) 1.45