The molecular architecture of ribbon presynaptic terminals.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMC 2701268)

Published in Mol Neurobiol on March 03, 2009

Authors

George Zanazzi1, Gary Matthews

Author Affiliations

1: Department of Neurobiology & Behavior, State Universtiy of New York, Stony Brook, NY 11794-5230, USA.

Articles citing this

The diverse roles of ribbon synapses in sensory neurotransmission. Nat Rev Neurosci (2010) 1.83

Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels. Pflugers Arch (2010) 1.45

Role for a novel Usher protein complex in hair cell synaptic maturation. PLoS One (2012) 0.98

Sustaining rapid vesicular release at active zones: potential roles for vesicle tethering. Trends Neurosci (2012) 0.98

Mouse b-wave mutants. Doc Ophthalmol (2014) 0.97

Rabconnectin3α promotes stable activity of the H+ pump on synaptic vesicles in hair cells. J Neurosci (2012) 0.94

The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins. Vis Neurosci (2011) 0.93

Q344ter mutation causes mislocalization of rhodopsin molecules that are catalytically active: a mouse model of Q344ter-induced retinal degeneration. PLoS One (2010) 0.93

Conical tomography of a ribbon synapse: structural evidence for vesicle fusion. PLoS One (2011) 0.93

Store-operated channels regulate intracellular calcium in mammalian rods. J Physiol (2012) 0.92

How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release. EMBO J (2016) 0.91

Usher protein functions in hair cells and photoreceptors. Int J Biochem Cell Biol (2013) 0.91

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet (2012) 0.91

Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans. J Cell Biol (2013) 0.91

Functional assembly of mammalian cochlear hair cells. Exp Physiol (2011) 0.90

Presynaptic active zones in invertebrates and vertebrates. EMBO Rep (2015) 0.88

Global Ca2+ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapses. J Neurosci (2014) 0.86

Synaptic release at mammalian bipolar cell terminals. Vis Neurosci (2011) 0.85

Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains. J Physiol (2015) 0.84

Regulation of presynaptic strength by controlling Ca2+ channel mobility: effects of cholesterol depletion on release at the cone ribbon synapse. J Neurophysiol (2012) 0.83

Structural organization of the presynaptic density at identified synapses in the locust central nervous system. J Comp Neurol (2012) 0.82

High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy. Microsc Microanal (2012) 0.82

Tracking vesicle fusion from hair cell ribbon synapses using a high frequency, dual sine wave stimulus paradigm. Commun Integr Biol (2011) 0.81

Bassoon and piccolo regulate ubiquitination and link presynaptic molecular dynamics with activity-regulated gene expression. J Physiol (2016) 0.79

Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation. Hum Mol Genet (2014) 0.79

Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development. Neural Dev (2010) 0.79

Overexpression of guanylate cyclase activating protein 2 in rod photoreceptors in vivo leads to morphological changes at the synaptic ribbon. PLoS One (2012) 0.79

Plasticity of Scarpa's Ganglion Neurons as a Possible Basis for Functional Restoration within Vestibular Endorgans. Front Neurol (2012) 0.78

Functional roles of complexin in neurotransmitter release at ribbon synapses of mouse retinal bipolar neurons. J Neurosci (2015) 0.78

Molecular basis of ancestral vertebrate electroreception. Nature (2017) 0.78

Lateral mobility of L-type calcium channels in synaptic terminals of retinal bipolar cells. Mol Vis (2013) 0.77

Variants of OTOF and PJVK genes in Chinese patients with auditory neuropathy spectrum disorder. PLoS One (2011) 0.77

Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats. Dis Model Mech (2015) 0.76

AAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy. PLoS One (2016) 0.75

Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca(2+) channels. Proc Natl Acad Sci U S A (2017) 0.75

Articles cited by this

(truncated to the top 100)

Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Cell (2000) 5.08

Microdomains of intracellular Ca2+: molecular determinants and functional consequences. Physiol Rev (2006) 4.87

Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature (1994) 4.77

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections. J Cell Biol (1983) 4.73

Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells. J Neurosci (1990) 4.62

Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell (2000) 4.51

Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22

Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals. Nature (1994) 4.17

Transmitter release at the hair cell ribbon synapse. Nat Neurosci (2002) 4.08

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell (2006) 3.71

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature (1997) 3.63

Hair cell synaptic ribbons are essential for synchronous auditory signalling. Nature (2005) 3.54

VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci (2004) 3.45

Electron microscope observations on synaptic vesicles in synapses of the retinal rods and cones. J Biophys Biochem Cytol (1956) 3.42

RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. Neuron (2000) 3.21

The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. Neuron (2003) 3.16

Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse. Proc Natl Acad Sci U S A (2000) 3.07

Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J Neurosci (2001) 2.99

Localization of calcium signals by a mobile calcium buffer in frog saccular hair cells. J Neurosci (1994) 2.96

Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron (2008) 2.96

KIF3A is a new microtubule-based anterograde motor in the nerve axon. J Cell Biol (1994) 2.86

Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse. J Neurosci (2005) 2.85

alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. J Biol Chem (2001) 2.77

Submillisecond kinetics of glutamate release from a sensory synapse. Neuron (1998) 2.70

Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci (2004) 2.62

Spatial calcium buffering in saccular hair cells. Nature (1993) 2.56

Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Nat Genet (1998) 2.56

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron (2001) 2.49

An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness. Nat Genet (1998) 2.48

Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex. J Cell Biol (2005) 2.48

Calcium dependence of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse. Neuron (2001) 2.43

Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. J Neurosci (2008) 2.36

Imaging calcium entry sites and ribbon structures in two presynaptic cells. J Neurosci (2003) 2.32

A membrane marker leaves synaptic vesicles in milliseconds after exocytosis in retinal bipolar cells. Neuron (2002) 2.29

Ultrafast exocytosis elicited by calcium current in synaptic terminals of retinal bipolar neurons. Neuron (1996) 2.28

Mutation of the calcium channel gene Cacna1f disrupts calcium signaling, synaptic transmission and cellular organization in mouse retina. Hum Mol Genet (2005) 2.22

Molecular organization of the presynaptic active zone. Cell Tissue Res (2006) 2.22

Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice. Nat Genet (1998) 2.20

Coordinated multivesicular release at a mammalian ribbon synapse. Nat Neurosci (2004) 2.20

Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease. Exp Eye Res (2006) 2.19

Evidence that vesicles on the synaptic ribbon of retinal bipolar neurons can be rapidly released. Neuron (1996) 2.18

The effect of efferent stimulation on basilar membrane displacement in the basal turn of the guinea pig cochlea. J Neurosci (1996) 2.15

CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells. J Neurosci (2003) 2.12

Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundles. J Neurosci (2001) 2.05

Functional structure of the organ of Corti: a review. Hear Res (1986) 2.02

Bulk membrane retrieval in the synaptic terminal of retinal bipolar cells. J Neurosci (2003) 1.99

Visualizing synaptic ribbons in the living cell. J Neurosci (2004) 1.98

Immunocytochemical description of five bipolar cell types of the mouse retina. J Comp Neurol (2003) 1.96

Ultrastructure of retinal rod synapses of the guinea pig eye as revealed by three-dimensional reconstructions from serial sections. J Ultrastruct Res (1958) 1.94

Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol (2005) 1.93

Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex. J Cell Biol (1996) 1.93

Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells. J Neurosci (2006) 1.92

A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci (2007) 1.90

Clustering of Ca2+ channels and Ca(2+)-activated K+ channels at fluorescently labeled presynaptic active zones of hair cells. Proc Natl Acad Sci U S A (1994) 1.89

Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc Natl Acad Sci U S A (1996) 1.88

Synaptic transmission at retinal ribbon synapses. Prog Retin Eye Res (2005) 1.85

Intramembrane organization of specialized contacts in the outer plexiform layer of the retina. A freeze-fracture study in monkeys and rabbits. J Cell Biol (1975) 1.84

Origin of reproducibility in the responses of retinal rods to single photons. Biophys J (1998) 1.84

Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci (2002) 1.79

Synapse formation is arrested in retinal photoreceptors of the zebrafish nrc mutant. J Neurosci (2001) 1.79

Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness. Am J Hum Genet (2006) 1.77

Clathrin-dependent and clathrin-independent retrieval of synaptic vesicles in retinal bipolar cells. Neuron (2005) 1.76

The fine structure of the rod-bipolar cell synapse in the retina of the albino rat. J Biophys Biochem Cytol (1958) 1.76

Structure and function of the hair cell ribbon synapse. J Membr Biol (2006) 1.73

Synaptotagmin I and II are present in distinct subsets of central synapses. J Comp Neurol (2007) 1.73

Calcium influx and calcium current in single synaptic terminals of goldfish retinal bipolar neurons. J Physiol (1992) 1.68

Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem (2003) 1.66

Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. Am J Hum Genet (2008) 1.65

Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. J Cell Biol (2002) 1.65

Localization of the alpha(1F) calcium channel subunit in the rat retina. Invest Ophthalmol Vis Sci (2001) 1.64

Continuous vesicle cycling in the synaptic terminal of retinal bipolar cells. Neuron (1996) 1.64

Synaptic ribbon. Conveyor belt or safety belt? Neuron (2003) 1.63

Depolarization redistributes synaptic membrane and creates a gradient of vesicles on the synaptic body at a ribbon synapse. Neuron (2002) 1.60

SNARE complex at the ribbon synapses of cochlear hair cells: analysis of synaptic vesicle- and synaptic membrane-associated proteins. Eur J Neurosci (1999) 1.59

Endocytosis and vesicle recycling at a ribbon synapse. J Neurosci (2003) 1.58

On understanding the organisation of the retinal receptor synapses. Brain Res (1971) 1.58

The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring. J Neurosci (2004) 1.55

Processivity of the single-headed kinesin KIF1A through biased binding to tubulin. Nature (2003) 1.55

The multiple activities of CtBP/BARS proteins: the Golgi view. Trends Cell Biol (2006) 1.54

Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. Definition of candidate Ca2+ sensors for the fast and slow components of neurotransmitter release. J Biol Chem (1995) 1.54

Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses. J Neurosci (2008) 1.53

Membrane recycling in the cone cell endings of the turtle retina. J Cell Biol (1978) 1.53

OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9. Am J Hum Genet (2000) 1.52

Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate. J Neurosci (2003) 1.50

Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. J Cell Biol (2004) 1.48

Asynchronous transmitter release: control of exocytosis and endocytosis at the salamander rod synapse. J Physiol (1996) 1.48

The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors. J Neurosci (1999) 1.47

Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation. J Neurosci (2003) 1.47

Parvalbumin 3 is an abundant Ca2+ buffer in hair cells. J Assoc Res Otolaryngol (2002) 1.47

Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells. J Physiol (2007) 1.45

Evidence that vesicles undergo compound fusion on the synaptic ribbon. J Neurosci (2008) 1.45

Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina. J Comp Neurol (2004) 1.41

Synapsins in the vertebrate retina: absence from ribbon synapses and heterogeneous distribution among conventional synapses. Neuron (1990) 1.41

Clathrin-mediated endocytosis at synapses. Traffic (2007) 1.41

Characterization of an amacrine cell type of the mammalian retina immunoreactive for vesicular glutamate transporter 3. J Comp Neurol (2004) 1.40

A multicenter study on the prevalence and spectrum of mutations in the otoferlin gene (OTOF) in subjects with nonsyndromic hearing impairment and auditory neuropathy. Hum Mutat (2008) 1.39

Streamlined synaptic vesicle cycle in cone photoreceptor terminals. Neuron (2004) 1.39

Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci U S A (1998) 1.38

Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Invest Ophthalmol Vis Sci (2006) 1.38

Structural and functional abnormalities of retinal ribbon synapses due to Cacna2d4 mutation. Invest Ophthalmol Vis Sci (2006) 1.38

Articles by these authors

Structure and function of ribbon synapses. Trends Neurosci (2005) 2.45

Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol (2007) 2.26

Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J Neurosci (2003) 2.04

Visualizing synaptic ribbons in the living cell. J Neurosci (2004) 1.98

Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron (2007) 1.84

Endocytosis and vesicle recycling at a ribbon synapse. J Neurosci (2003) 1.58

Impaired firing and cell-specific compensation in neurons lacking nav1.6 sodium channels. J Neurosci (2006) 1.49

Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming. Nat Neurosci (2011) 1.44

Roles of ATP in depletion and replenishment of the releasable pool of synaptic vesicles. J Neurophysiol (2002) 1.30

Multiple components of membrane retrieval in synaptic terminals revealed by changes in hydrostatic pressure. J Neurophysiol (2002) 1.14

The role of ribbons at sensory synapses. Neuroscientist (2009) 1.12

Mobility and turnover of vesicles at the synaptic ribbon. J Neurosci (2008) 1.11

Alterations of action potentials and the localization of Nav1.6 sodium channels in spared axons after hemisection injury of the spinal cord in adult rats. J Neurophysiol (2010) 1.05

Novel clustering of sodium channel Na(v)1.1 with ankyrin-G and neurofascin at discrete sites in the inner plexiform layer of the retina. Mol Cell Neurosci (2005) 1.02

Endocytosis at ribbon synapses. Traffic (2007) 0.91

Expression of sodium channels Nav1.2 and Nav1.6 during postnatal development of the retina. Neurosci Lett (2006) 0.91

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a. Neurosci Lett (2008) 0.88

Identification of calcium channel alpha1 subunit mRNA expressed in retinal bipolar neurons. Mol Vis (2006) 0.87

Stabilization of spontaneous neurotransmitter release at ribbon synapses by ribbon-specific subtypes of complexin. J Neurosci (2013) 0.87

Calcium dependence of exocytosis in lacrimal gland acinar cells. Am J Physiol Cell Physiol (2002) 0.86

Characterization of a novel cyclic nucleotide-gated channel from zebrafish brain. Biochem Biophys Res Commun (2006) 0.82

The synaptic vesicle cycle: is kissing overrated? Neuron (2006) 0.81

Differences in stimulus induced calcium increases in lacrimal gland acinar cells from normal and NZB/NZW F1 female mice. Curr Eye Res (2002) 0.81

Vesicle priming and depriming: a SNAP decision. Neuron (2004) 0.80

Retinal bipolar neurons express the cyclic nucleotide-gated channel of cone photoreceptors. J Neurophysiol (2003) 0.80

Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development. Neural Dev (2010) 0.79

The ribbon-associated protein C-terminal-binding protein 1 is not essential for the structure and function of retinal ribbon synapses. Mol Vis (2013) 0.78

Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression. Sci Rep (2013) 0.76

A doubleheader in endocytosis. Neuron (2007) 0.75

Making the retina approachable. J Neurophysiol (2005) 0.75