Published in J Am Med Inform Assoc on March 04, 2009
Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inform Assoc (2010) 10.51
Mining electronic health records: towards better research applications and clinical care. Nat Rev Genet (2012) 4.42
Discovering peripheral arterial disease cases from radiology notes using natural language processing. AMIA Annu Symp Proc (2010) 1.86
SHRINE: enabling nationally scalable multi-site disease studies. PLoS One (2013) 1.80
Exploiting time in electronic health record correlations. J Am Med Inform Assoc (2011) 1.39
Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. Mol Med (2010) 1.14
Evaluation of smoking status identification using electronic health records and open-text information in a large mental health case register. PLoS One (2013) 1.12
Modeling disease severity in multiple sclerosis using electronic health records. PLoS One (2013) 1.06
Opportunities and challenges in developing risk prediction models with electronic health records data: a systematic review. J Am Med Inform Assoc (2016) 1.00
Clinical Decision Support Systems (CDSS) for preventive management of COPD patients. J Transl Med (2014) 0.96
Predicting response to short-acting bronchodilator medication using Bayesian networks. Pharmacogenomics (2009) 0.92
Trends in biomedical informatics: most cited topics from recent years. J Am Med Inform Assoc (2011) 0.91
Practical applications for natural language processing in clinical research: The 2014 i2b2/UTHealth shared tasks. J Biomed Inform (2015) 0.91
Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes. BMC Med Genet (2011) 0.89
Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics (2012) 0.81
Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet (2010) 0.81
Recent development and biomedical applications of probabilistic Boolean networks. Cell Commun Signal (2013) 0.81
Bayesian predictors of very poor health related quality of life and mortality in patients with COPD. BMC Med Inform Decis Mak (2013) 0.80
Marco Ramoni: an appreciation of academic achievement. J Am Med Inform Assoc (2011) 0.79
Construction and validation of synthetic electronic medical records. Online J Public Health Inform (2009) 0.77
Predicting changes in systolic blood pressure using longitudinal patient records. J Biomed Inform (2015) 0.77
Relationship between serum leptin and chronic obstructive pulmonary disease in US adults: results from the third National Health and Nutrition Examination Survey. J Investig Med (2014) 0.75
Identifying Peripheral Arterial Disease Cases Using Natural Language Processing of Clinical Notes. IEEE EMBS Int Conf Biomed Health Inform (2016) 0.75
Data-driven approach for creating synthetic electronic medical records. BMC Med Inform Decis Mak (2010) 0.75
Predicting Risk of Suicide Attempt Using History of Physical Illnesses From Electronic Medical Records. JMIR Ment Health (2016) 0.75
Application of density estimation algorithms in analyzing co-morbidities of migraine. Netw Model Anal Health Inform Bioinform (2013) 0.75
An Approach for Incorporating Context in Building Probabilistic Predictive Models. Proc IEEE Int Conf Healthc Inform Imaging Syst Biol (2012) 0.75
Context Relevant Prediction Model for COPD Domain Using Bayesian Belief Network. Sensors (Basel) (2017) 0.75
Enhancing Electronic Health Record Data with Geospatial Information. AMIA Jt Summits Transl Sci Proc (2017) 0.75
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics (1988) 70.41
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86
Diagnostic performance of digital versus film mammography for breast-cancer screening. N Engl J Med (2005) 14.47
Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA (1994) 10.46
Identifying patient smoking status from medical discharge records. J Am Med Inform Assoc (2007) 10.35
Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system. BMC Med Inform Decis Mak (2006) 9.98
Global burden of COPD: risk factors, prevalence, and future trends. Lancet (2007) 9.50
Technical description of RODS: a real-time public health surveillance system. J Am Med Inform Assoc (2003) 5.67
What is a support vector machine? Nat Biotechnol (2006) 5.10
Assessing comorbidity using claims data: an overview. Med Care (2002) 4.94
The use of receiver operating characteristic curves in biomedical informatics. J Biomed Inform (2005) 4.88
A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med (1998) 4.52
Effect of verification bias on screening for prostate cancer by measurement of prostate-specific antigen. N Engl J Med (2003) 4.30
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nat Genet (2005) 4.21
Developing COPD: a 25 year follow up study of the general population. Thorax (2006) 3.72
COPD exacerbations: defining their cause and prevention. Lancet (2007) 3.46
Chronic obstructive pulmonary disease surveillance--United States, 1971-2000. Respir Care (2002) 3.02
Calculating the benefits of a Research Patient Data Repository. AMIA Annu Symp Proc (2006) 2.78
Integration of clinical and genetic data in the i2b2 architecture. AMIA Annu Symp Proc (2006) 2.74
Use of an electronic medical record for the identification of research subjects with diabetes mellitus. Clin Med Res (2007) 2.48
A network model to predict the risk of death in sickle cell disease. Blood (2007) 2.39
Electronic medical records for clinical research: application to the identification of heart failure. Am J Manag Care (2007) 2.18
Asthma as a risk factor for COPD in a longitudinal study. Chest (2004) 1.82
Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet (2000) 1.78
Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley Lecture. Chest (2000) 1.47
What are artificial neural networks? Nat Biotechnol (2008) 1.43
Airways responsiveness and development and remission of chronic respiratory symptoms in adults. Lancet (1997) 1.33
Combining geometric and probabilistic reasoning for computer-based penetrating-trauma assessment. J Am Med Inform Assoc (2002) 1.05
Detecting asthma exacerbations in a pediatric emergency department using a Bayesian network. AMIA Annu Symp Proc (2006) 1.02
Accuracy in the diagnostic prediction of acute appendicitis based on the Bayesian network model. Methods Inf Med (2007) 0.92
Generating prior probabilities for classifiers of brain tumours using belief networks. BMC Med Inform Decis Mak (2007) 0.90
Prognostic Bayesian networks II: an application in the domain of cardiac surgery. J Biomed Inform (2007) 0.90
Using literature and data to learn Bayesian networks as clinical models of ovarian tumors. Artif Intell Med (2004) 0.80
Managing incidental findings and research results in genomic research involving biobanks and archived data sets. Genet Med (2012) 9.65
Discovering statistically significant pathways in expression profiling studies. Proc Natl Acad Sci U S A (2005) 8.75
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet (2006) 7.16
Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics (2002) 7.07
The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories. J Am Med Inform Assoc (2009) 6.49
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
Creation and implications of a phenome-genome network. Nat Biotechnol (2006) 5.79
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Tectonic shifts in the health information economy. N Engl J Med (2008) 5.42
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med (2009) 4.64
Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements. Nucleic Acids Res (2004) 4.43
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nat Genet (2005) 4.21
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol (2004) 4.17
Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol (2007) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr (2007) 3.89
Cluster analysis of gene expression dynamics. Proc Natl Acad Sci U S A (2002) 3.83
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol (2005) 3.72
Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A (2007) 3.72
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements. BMC Bioinformatics (2005) 3.66
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr (2007) 3.40
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics (2005) 3.23
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
No small change for the health information economy. N Engl J Med (2009) 2.92
Gene expression signature with independent prognostic significance in epithelial ovarian cancer. J Clin Oncol (2004) 2.91
Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks. BMC Bioinformatics (2005) 2.83
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med (2008) 2.61
Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle. Proc Natl Acad Sci U S A (2002) 2.60
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
Network-based analysis of affected biological processes in type 2 diabetes models. PLoS Genet (2007) 2.54
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction. PLoS One (2007) 2.52
Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics (2004) 2.51
The SMART Platform: early experience enabling substitutable applications for electronic health records. J Am Med Inform Assoc (2012) 2.48
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Uric acid and the development of hypertension: the normative aging study. Hypertension (2006) 2.45
Obesity and asthma. Am J Respir Crit Care Med (2006) 2.43
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med (2013) 2.36
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
Expression profiling and identification of novel genes involved in myogenic differentiation. FASEB J (2003) 2.30
A submission model for use in the indexing, searching, and retrieval of distributed pathology case and tissue specimens. Stud Health Technol Inform (2004) 2.28
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet (2009) 2.27
Ontology engineering. Nat Biotechnol (2010) 2.24
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23
Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics (2003) 2.20
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16
Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol (2005) 2.16
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy. J Allergy Clin Immunol (2004) 2.11
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med (2009) 2.10
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PLoS One (2008) 2.10
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort study. Am J Respir Crit Care Med (2002) 2.02
The PING personally controlled electronic medical record system: technical architecture. J Am Med Inform Assoc (2004) 2.01
Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records. Diabetes Care (2009) 2.00
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci (2004) 1.99
Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med (2003) 1.98
GO PaD: the Gene Ontology Partition Database. Nucleic Acids Res (2006) 1.98
Escaping the EHR trap--the future of health IT. N Engl J Med (2012) 1.96
Pharmacogenomics: challenges and opportunities. Ann Intern Med (2006) 1.96
Technical desiderata for the integration of genomic data into Electronic Health Records. J Biomed Inform (2011) 1.96
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma. J Allergy Clin Immunol (2007) 1.93
The burden of asthma in the United States: level and distribution are dependent on interpretation of the national asthma education and prevention program guidelines. Am J Respir Crit Care Med (2002) 1.92
Finding the missing link for big biomedical data. JAMA (2014) 1.90
A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered (2003) 1.89
A self-scaling, distributed information architecture for public health, research, and clinical care. J Am Med Inform Assoc (2007) 1.88
Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am J Respir Crit Care Med (2012) 1.88
Transcriptomic analysis of human lung development. Am J Respir Crit Care Med (2009) 1.87
Asthma in Hispanics. Am J Respir Crit Care Med (2005) 1.84
Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis (2011) 1.82
SHRINE: enabling nationally scalable multi-site disease studies. PLoS One (2013) 1.80
The MAPPER database: a multi-genome catalog of putative transcription factor binding sites. Nucleic Acids Res (2005) 1.80
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. J Allergy Clin Immunol (2008) 1.80
Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut. Chest (2004) 1.79
The TREAT-NMD Duchenne muscular dystrophy registries: conception, design, and utilization by industry and academia. Hum Mutat (2013) 1.78
Does collocation inform the impact of collaboration? PLoS One (2010) 1.78