Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

PubWeight™: 3.23‹?› | Rank: Top 1%

🔗 View Article (PMC 2667713)

Published in J Immunol on March 15, 2009

Authors

Hiromasa Hamada1, Maria de la Luz Garcia-Hernandez, Joyce B Reome, Sara K Misra, Tara M Strutt, Kai K McKinstry, Andrea M Cooper, Susan L Swain, Richard W Dutton

Author Affiliations

1: Trudeau Institute, Saranac Lake, NY 12983, USA.

Articles citing this

(truncated to the top 100)

In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature (2009) 14.59

Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Crit Care (2009) 3.48

Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension (2009) 3.06

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol (2009) 3.01

Critical role of IL-17RA in immunopathology of influenza infection. J Immunol (2009) 2.51

Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arterioscler Thromb Vasc Biol (2011) 2.27

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A (2010) 2.19

IL-17 family member cytokines: regulation and function in innate immunity. Cytokine Growth Factor Rev (2010) 1.76

Lymphocytes in cancer development: polarization towards pro-tumor immunity. Cytokine Growth Factor Rev (2009) 1.68

The role of Th17 cytokines in primary mucosal immunity. Cytokine Growth Factor Rev (2010) 1.64

Interleukin-22: immunobiology and pathology. Annu Rev Immunol (2015) 1.60

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection. Nat Biotechnol (2012) 1.49

Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J Immunol (2010) 1.40

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest (2012) 1.40

Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults. PLoS One (2011) 1.35

IL-17 response mediates acute lung injury induced by the 2009 pandemic influenza A (H1N1) virus. Cell Res (2011) 1.30

Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense. Immunol Rev (2014) 1.28

IL-22 is essential for lung epithelial repair following influenza infection. Am J Pathol (2013) 1.26

The Th1 immune response to Plasmodium falciparum circumsporozoite protein is boosted by adenovirus vectors 35 and 26 with a homologous insert. Clin Vaccine Immunol (2010) 1.17

Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS One (2012) 1.16

Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responses. J Immunol (2010) 1.16

Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J Immunol (2012) 1.14

Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors. Proc Natl Acad Sci U S A (2012) 1.10

The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection. J Immunol (2010) 1.09

CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease. Respir Res (2011) 1.07

Intestinal T-cell responses in celiac disease - impact of celiac disease associated bacteria. PLoS One (2013) 1.07

Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol (2010) 1.06

CD161-expressing human T cells. Front Immunol (2011) 1.05

Vaccination with dendritic cells loaded with allogeneic brain tumor cells for recurrent malignant brain tumors induces a CD4(+)IL17(+) response. J Immunother Cancer (2014) 1.03

A novel inactivated intranasal respiratory syncytial virus vaccine promotes viral clearance without Th2 associated vaccine-enhanced disease. PLoS One (2011) 1.02

Th17 cells and regulatory T cells in elite control over HIV and SIV. Curr Opin HIV AIDS (2011) 1.01

Interleukin-9 as a T helper type 17 cytokine. Immunology (2010) 1.01

Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog (2012) 1.01

CD4 T cell subsets in the mucosa are CD28+Ki-67-HLA-DR-CD69+ but show differential infection based on alpha4beta7 receptor expression during acute SIV infection. J Med Primatol (2009) 1.00

IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. J Immunol (2009) 1.00

T cell-mediated host immune defenses in the lung. Annu Rev Immunol (2013) 1.00

Th17 cytokines in mucosal immunity and inflammation. Curr Opin HIV AIDS (2010) 0.98

Role of T cell immunity in recovery from influenza virus infection. Curr Opin Virol (2013) 0.98

IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax (2013) 0.97

Conservation and diversity of influenza A H1N1 HLA-restricted T cell epitope candidates for epitope-based vaccines. PLoS One (2010) 0.97

A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection. Cell Mol Immunol (2011) 0.97

Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis. J Invest Dermatol (2009) 0.95

Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model. J Virol (2010) 0.95

IL-17 in the rheumatologist's line of sight. Biomed Res Int (2013) 0.95

Increased number of Tc17 and correlation with Th17 cells in patients with immune thrombocytopenia. PLoS One (2011) 0.94

Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus. Immunol Rev (2013) 0.93

Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis. Future Virol (2012) 0.93

Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity. J Interferon Cytokine Res (2010) 0.92

Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes. Proc Natl Acad Sci U S A (2013) 0.92

Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection. PLoS One (2013) 0.91

Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP(S) expression. J Biol Chem (2011) 0.90

A novel immunoregulatory function for IL-23: Inhibition of IL-12-dependent IFN-γ production. Eur J Immunol (2010) 0.89

Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection. PLoS Pathog (2014) 0.89

Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers. PLoS One (2012) 0.87

IL-17 contributes to neutrophil recruitment but not to control of viral replication during acute mouse adenovirus type 1 respiratory infection. Virology (2014) 0.87

Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proc Natl Acad Sci U S A (2012) 0.87

Anti-IFN-γ and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza A-specific memory T cells. J Immunol (2013) 0.87

Balancing Immune Protection and Immune Pathology by CD8(+) T-Cell Responses to Influenza Infection. Front Immunol (2016) 0.86

A tale of two cytokines: IL-17 and IL-22 in asthma and infection. Expert Rev Respir Med (2013) 0.86

Galectin-9 prolongs the survival of septic mice by expanding Tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages. Crit Care (2013) 0.85

Pulmonary immune responses to Aspergillus fumigatus in an immunocompetent mouse model of repeated exposures. J Immunotoxicol (2013) 0.83

The aryl hydrocarbon receptor: differential contribution to T helper 17 and T cytotoxic 17 cell development. PLoS One (2014) 0.82

Praziquantel facilitates IFN-γ-producing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA vaccination in mice. PLoS One (2011) 0.82

A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine. Influenza Other Respir Viruses (2012) 0.82

Polarizing T and B Cell Responses by APC-Targeted Subunit Vaccines. Front Immunol (2015) 0.81

Controlling influenza by cytotoxic T-cells: calling for help from destroyers. J Biomed Biotechnol (2010) 0.81

IL-17-dependent, IFN-gamma-independent tumor rejection is mediated by cytotoxic T lymphocytes and occurs at extraocular sites, but is excluded from the eye. J Immunol (2011) 0.81

Strong viremia control in vaccinated macaques does not prevent gradual Th17 cell loss from central memory. Vaccine (2011) 0.81

The WSX-1 pathway restrains intestinal T-cell immunity. Int Immunol (2011) 0.80

Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques. J Neuroimmunol (2013) 0.80

The inducible costimulator augments Tc17 cell responses to self and tumor tissue. J Immunol (2015) 0.80

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice. Hum Vaccin Immunother (2013) 0.80

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells. PLoS One (2014) 0.80

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol (2011) 0.80

Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in HIV-unexposed newborn infants in South Africa. Clin Vaccine Immunol (2016) 0.79

Increased Immune Response Variability during Simultaneous Viral Coinfection Leads to Unpredictability in CD8 T Cell Immunity and Pathogenesis. J Virol (2015) 0.79

Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge. PLoS One (2014) 0.79

Increasing a robust antigen-specific cytotoxic T lymphocyte response by FMDV DNA vaccination with IL-9 expressing construct. J Biomed Biotechnol (2010) 0.79

Pleural mesothelial cells promote expansion of IL-17-producing CD8+ T cells in tuberculous pleural effusion. J Clin Immunol (2013) 0.79

IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy. Virchows Arch (2012) 0.79

Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines. Front Immunol (2016) 0.79

Tc17 cells in patients with uterine cervical cancer. PLoS One (2014) 0.79

Epitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosis. J Virol (2012) 0.79

Exploiting IL-17-producing CD4(+) and CD8(+) T cells to improve cancer immunotherapy in the clinic. Cancer Immunol Immunother (2016) 0.79

CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets. PLoS One (2011) 0.78

Use of praziquantel as an adjuvant enhances protection and Tc-17 responses to killed H5N1 virus vaccine in mice. PLoS One (2012) 0.78

Anti-inflammatory effect of qingpeng ointment in atopic dermatitis-like murine model. Evid Based Complement Alternat Med (2013) 0.78

Diagnosis and inflammatory response of patients with candiduria. Mycoses (2012) 0.78

A murine inhalation model to characterize pulmonary exposure to dry Aspergillus fumigatus conidia. PLoS One (2014) 0.78

IL-17+ CD8+ T cells: Differentiation, phenotype and role in inflammatory disease. Immunol Lett (2016) 0.78

T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin. Biomed Res Int (2015) 0.77

IL-17A expression in HIV-specific CD8 T cells is regulated by IL-4/IL-13 following HIV-1 prime-boost immunization. J Interferon Cytokine Res (2014) 0.77

Nocardia brasiliensis induces an immunosuppressive microenvironment that favors chronic infection in BALB/c mice. Infect Immun (2012) 0.77

Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis. Allergo J Int (2015) 0.77

Distinctive expression of interleukin-23 receptor subunits on human Th17 and γδ T cells. Immunol Cell Biol (2016) 0.76

Oropharyngeal Candidiasis in HIV Infection: Analysis of Impaired Mucosal Immune Response to Candida albicans in Mice Expressing the HIV-1 Transgene. Pathogens (2015) 0.76

Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges. Vaccines (Basel) (2015) 0.76

Interleukin-22 in Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation. Front Immunol (2016) 0.75

CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells. Immunology (2015) 0.75

Gut Homing CD4+ and CD8+ T-Cell Frequencies in HIV Infected Individuals on Antiretroviral Treatment. PLoS One (2016) 0.75

Articles cited by this

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol (1989) 31.72

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17

Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 25.91

IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem (2002) 14.34

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 14.28

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med (2006) 13.74

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol (2007) 13.70

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 12.79

Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol (2007) 12.76

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med (2007) 11.80

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71

The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity (2008) 10.55

Retinoic acid imprints gut-homing specificity on T cells. Immunity (2004) 9.76

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med (1996) 8.59

Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol (1994) 8.43

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol (2006) 7.89

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol (2006) 6.82

Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis (2004) 6.54

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med (2005) 6.37

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99

Foxp3 in control of the regulatory T cell lineage. Nat Immunol (2007) 5.94

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med (2007) 5.58

Th17 cell differentiation: the long and winding road. Immunity (2008) 5.40

Differentiation and function of Th17 T cells. Curr Opin Immunol (2007) 5.14

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci U S A (2003) 5.09

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol (2007) 4.66

IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol (2005) 3.90

IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol (2004) 3.84

From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity (2006) 3.56

The JAM test. A simple assay for DNA fragmentation and cell death. J Immunol Methods (1991) 3.33

CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J Exp Med (2002) 3.28

Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol (2004) 3.23

Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev (1991) 3.21

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med (1994) 3.02

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A (2007) 2.92

IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol (2007) 2.82

IL-17 enhances chemokine gene expression through mRNA stabilization. J Immunol (2007) 2.74

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol (2007) 2.60

Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J Immunol (2003) 2.50

Interleukin-17. Int Rev Immunol (1998) 2.31

Generation and in vivo persistence of polarized Th1 and Th2 memory cells. Immunity (1994) 2.19

The role of IL-21 in regulating B-cell function in health and disease. Immunol Rev (2008) 2.09

Migration kinetics and final destination of type 1 and type 2 CD8 effector cells predict protection against pulmonary virus infection. J Exp Med (1999) 2.09

CD8+ T cells can be primed in vitro to produce IL-4. J Immunol (1992) 1.91

IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation. Am J Physiol Heart Circ Physiol (2007) 1.82

Type 1 and type 2: a fundamental dichotomy for all T-cell subsets. Curr Opin Immunol (1996) 1.60

Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J Leukoc Biol (2007) 1.52

IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype. J Immunol (2007) 1.45

In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines. J Immunol (1998) 1.43

CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response. J Exp Med (2007) 1.41

The role of adoptively transferred CD8 T cells and host cells in the control of the growth of the EG7 thymoma: factors that determine the relative effectiveness and homing properties of Tc1 and Tc2 effectors. J Immunol (2001) 1.34

Local development of effector and memory T helper cells. Curr Opin Immunol (2007) 1.28

Differentiation of human T(H)-17 cells does require TGF-beta! Nat Immunol (2008) 1.27

B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones. J Immunol (2008) 1.26

Heterogeneity in lymphokine profiles of CD4+ and CD8+ T cells and clones activated in vivo and in vitro. Immunol Rev (1991) 1.09

CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency. Clin Immunol (2004) 1.07

IL-17A promotes the growth of airway epithelial cells through ERK-dependent signaling pathway. Biochem Biophys Res Commun (2006) 1.07

Association of gamma interferon and interleukin-17 production in intestinal CD4+ T cells with protection against rotavirus shedding in mice intranasally immunized with VP6 and the adjuvant LT(R192G). J Virol (2007) 1.04

Therapeutic effects of tumor-reactive type 1 and type 2 CD8+ T cell subpopulations in established pulmonary metastases. J Immunol (1999) 1.03

A role for the cytoplasmic adaptor protein Act1 in mediating IL-17 signaling. Sci STKE (2007) 1.01

Role of effector cell-derived IL-4, IL-5, and perforin in early and late stages of type 2 CD8 effector cell-mediated tumor rejection. J Immunol (2001) 1.01

IL-15 exacerbates collagen-induced arthritis with an enhanced CD4+ T cell response to produce IL-17. Eur J Immunol (2007) 0.98

The Roaring Twenties. Immunity (2008) 0.88

T-cell subsets: the more the merrier. Curr Biol (2007) 0.84

Articles by these authors

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71

IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol (2005) 3.90

CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J Exp Med (2002) 3.28

CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol (2006) 2.99

Expanding roles for CD4⁺ T cells in immunity to viruses. Nat Rev Immunol (2012) 2.94

IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med (2003) 2.87

IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol (2009) 2.74

Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J Immunol (2006) 2.64

Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med (2010) 2.61

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med (2005) 2.59

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med (2006) 2.55

IL-23 and IL-17 in tuberculosis. Cytokine (2008) 2.35

ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes. Proc Natl Acad Sci U S A (2008) 2.10

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med (2010) 2.10

In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. J Immunol (2002) 2.04

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest (2012) 1.95

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A (2003) 1.89

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis (2011) 1.86

IL-17 and Th17 cells in tuberculosis. Cytokine Growth Factor Rev (2010) 1.86

Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J Immunol (2004) 1.83

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. J Immunol (2007) 1.78

Why aging T cells fail: implications for vaccination. Immunity (2006) 1.78

Rapid default transition of CD4 T cell effectors to functional memory cells. J Exp Med (2007) 1.69

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. J Immunol (2007) 1.68

CD4 T cell responses to influenza infection. Semin Immunol (2004) 1.68

IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice. J Immunol (2004) 1.66

Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection. J Virol (2012) 1.61

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J Exp Med (2005) 1.59

Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection. J Leukoc Biol (2005) 1.58

Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way. Cell Microbiol (2003) 1.57

IL-7: maintaining T-cell memory and achieving homeostasis. Trends Immunol (2005) 1.55

T-cell immunosenescence: lessons learned from mouse models of aging. Trends Immunol (2009) 1.55

Cytotoxic CD4 T cells in antiviral immunity. J Biomed Biotechnol (2011) 1.49

CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis. Cell Immunol (2002) 1.42

Heterogeneity of CD4(+) and CD8(+) T cells. Curr Opin Immunol (2003) 1.41

The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12. J Exp Med (2002) 1.40

The potential of CD4 T-cell memory. Immunology (2010) 1.40

IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung. J Immunol (2011) 1.40

Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J Immunol (2010) 1.40

In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity. J Immunol (2009) 1.38

Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol (2008) 1.36

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci U S A (2009) 1.34

Repeated stimulation of CD4 effector T cells can limit their protective function. J Exp Med (2005) 1.31

Uneven distribution of MHC class II epitopes within the influenza virus. Vaccine (2005) 1.31

Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis. Immunology (2003) 1.26

IFN-gamma regulates donor CD8 T cell expansion, migration, and leads to apoptosis of cells of a solid tumor. J Immunol (2006) 1.26

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells. Cell Immunol (2009) 1.26

Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice. J Immunol (2007) 1.22

Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun (2005) 1.21

SAP is required for Th cell function and for immunity to influenza. J Immunol (2006) 1.18

IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol (2007) 1.18

Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation. J Biol Chem (2006) 1.15

Regulation of CD4+ T-cell contraction during pathogen challenge. Immunol Rev (2010) 1.14

Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J Immunol (2012) 1.14

Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages. J Immunol (2002) 1.13

T cell responses to influenza virus infection: effector and memory cells. Viral Immunol (2004) 1.12

Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells. Proc Natl Acad Sci U S A (2007) 1.12

The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis. J Immunol (2004) 1.11

Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors. Proc Natl Acad Sci U S A (2012) 1.10

Cellular response to mycobacteria: balancing protection and pathology. Trends Immunol (2011) 1.10

Immunological basis of the development of necrotic lesions following Mycobacterium avium infection. Immunology (2002) 1.09

Cutting edge: regulation of CD8+ T cell effector population size. J Immunol (2004) 1.09

Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol (2008) 1.08

CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency. Clin Immunol (2004) 1.07

The effector to memory transition of CD4 T cells. Immunol Res (2008) 1.06

Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol (2010) 1.06

Effect of age on naive CD4 responses: impact on effector generation and memory development. Springer Semin Immunopathol (2002) 1.03

Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses. J Immunol (2008) 1.02

Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates. J Immunol (2005) 1.01

Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects. Semin Immunol (2012) 1.01

TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism. J Immunol (2010) 1.00

Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects. J Immunol (2008) 1.00

CD8-mediated type 1 antitumor responses selectively modulate endogenous differentiated and nondifferentiated T cell localization, activation, and function in progressive breast cancer. J Immunol (2006) 1.00

Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J Immunol (2010) 0.98

SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J Immunol (2008) 0.98

Cytokines in the balance of protection and pathology during mycobacterial infections. Adv Exp Med Biol (2013) 0.97

A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival. Infect Immun (2004) 0.97

The study of Mycobacterium leprae infection in interferon-gamma gene--disrupted mice as a model to explore the immunopathologic spectrum of leprosy. J Infect Dis (2002) 0.96

Effector cell-derived lymphotoxin alpha and Fas ligand, but not perforin, promote Tc1 and Tc2 effector cell-mediated tumor therapy in established pulmonary metastases. Cancer Res (2004) 0.96

Functionally diverse subsets in CD4 T cell responses against influenza. J Clin Immunol (2008) 0.95