Published in Infect Immun on March 09, 2009
Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. J Immunol (2009) 1.63
Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. PLoS One (2009) 1.14
Updating perspectives on the initiation of Bacillus anthracis growth and dissemination through its host. Infect Immun (2012) 1.10
Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages. Infect Immun (2011) 0.90
AB toxins: a paradigm switch from deadly to desirable. Toxins (Basel) (2010) 0.88
Debridement increases survival in a mouse model of subcutaneous anthrax. PLoS One (2012) 0.84
Cellular and physiological effects of anthrax exotoxin and its relevance to disease. Front Cell Infect Microbiol (2012) 0.84
Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding. Biochemistry (2010) 0.82
Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant. J Immunol (2010) 0.81
Modeling the host response to inhalation anthrax. J Theor Biol (2011) 0.81
Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells. J Immunol (2010) 0.80
Both lethal and edema toxins of Bacillus anthracis disrupt the human dendritic cell chemokine network. PLoS One (2012) 0.79
Crossing of the epithelial barriers by Bacillus anthracis: the Known and the Unknown. Front Microbiol (2015) 0.75
Dendritic cells and the control of immunity. Nature (1998) 56.54
Immunobiology of dendritic cells. Annu Rev Immunol (2000) 23.65
Cell migration: a physically integrated molecular process. Cell (1996) 23.49
How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science (1998) 10.53
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A (1982) 10.36
Identification of the cellular receptor for anthrax toxin. Nature (2001) 8.78
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A (2003) 5.95
Anthrax toxin. Annu Rev Cell Dev Biol (2003) 5.92
Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J Biol Chem (1986) 5.86
Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol (2005) 5.20
Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochem Biophys Res Commun (1998) 4.44
Dendritic cell immunotherapy: mapping the way. Nat Med (2004) 4.28
Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science (2002) 4.26
Contribution of individual toxin components to virulence of Bacillus anthracis. Infect Immun (1991) 4.17
Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N Engl J Med (2004) 4.10
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem J (2000) 3.83
Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus. Mol Microbiol (1995) 2.96
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect Immun (1995) 2.87
Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 2.86
Stoichiometry of anthrax toxin complexes. Biochemistry (2002) 2.86
Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature (2003) 2.83
Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol Microbiol (1994) 2.65
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood (2002) 2.61
Effects of anthrax toxin components on human neutrophils. Infect Immun (1985) 2.51
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol (2004) 2.31
Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood (2002) 2.30
Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A (2004) 2.23
DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents. J Immunol (2002) 2.16
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling. J Exp Med (2005) 1.90
The alveolar macrophage: the Trojan horse of Bacillus anthracis. Trends Microbiol (2002) 1.88
Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys J (2004) 1.87
Mucosal adjuvants. Vaccine (2005) 1.86
Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming. Eur J Immunol (2000) 1.85
Anthrax toxic complex. Fed Proc (1967) 1.84
pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen. Mol Microbiol (1993) 1.81
Anthrax lethal toxin induces endothelial barrier dysfunction. Am J Pathol (2005) 1.81
Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis. J Immunol (2005) 1.78
Chemokines: attractive mediators of the immune response. Semin Immunol (2003) 1.66
Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells. J Immunol (2005) 1.59
Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route. J Immunol (2007) 1.56
Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B. Infect Immun (1976) 1.53
Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem (2007) 1.44
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc Natl Acad Sci U S A (2008) 1.39
Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses. J Immunol (2001) 1.37
Nasal vaccination, Escherichia coli enterotoxin, and Bell's palsy. N Engl J Med (2004) 1.34
Anthrax lethal toxin paralyzes neutrophil actin-based motility. J Infect Dis (2005) 1.32
Cholera toxin induces migration of dendritic cells from the subepithelial dome region to T- and B-cell areas of Peyer's patches. Infect Immun (2003) 1.29
Differentiation of human monocytic cell lines confers susceptibility to Bacillus anthracis lethal toxin. Cell Microbiol (2005) 1.29
Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response. PLoS Pathog (2005) 1.28
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation. EMBO J (2007) 1.25
Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity. Cell Microbiol (2005) 1.25
Cholera toxin and heat-labile enterotoxin activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cyclic AMP-dependent pathway. Infect Immun (2002) 1.20
Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: applications for oral infections. J Dent Res (2005) 1.17
Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway. J Leukoc Biol (2002) 1.17
Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells. Mol Microbiol (2006) 1.16
Bordetella type III secretion and adenylate cyclase toxin synergize to drive dendritic cells into a semimature state. J Immunol (2004) 1.15
Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling. Cell Microbiol (2006) 1.15
New insights into the functions of anthrax toxin. Expert Rev Mol Med (2006) 1.11
Resident CD11c+ lung cells are impaired by anthrax toxins after spore infection. J Infect Dis (2006) 1.11
Cell entry and cAMP imaging of anthrax edema toxin. EMBO J (2006) 1.09
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent. J Leukoc Biol (2004) 1.07
Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun (2005) 0.97
Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J Immunol (2006) 0.97
Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. J Biol Chem (2004) 0.96
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin. Cell Microbiol (2008) 0.95
Large-scale structural changes accompany binding of lethal factor to anthrax protective antigen: a cryo-electron microscopic study. Structure (2004) 0.89
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A (2003) 5.95
Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano (2010) 2.29
Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials. ACS Nano (2011) 1.68
Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. J Immunol (2009) 1.63
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A (2013) 1.60
Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge. Cell Microbiol (2005) 1.42
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. J Biol Chem (2006) 1.25
Isolation of cell lines that show novel, murine leukemia virus-specific blocks to early steps of retroviral replication. J Virol (2005) 1.16
Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells. Mol Microbiol (2006) 1.16
Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. PLoS One (2009) 1.14
A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther (2011) 1.13
New insights into the functions of anthrax toxin. Expert Rev Mol Med (2006) 1.11
Early interactions between fully virulent Bacillus anthracis and macrophages that influence the balance between spore clearance and development of a lethal infection. Microbes Infect (2008) 1.10
Submicron streptavidin patterns for protein assembly. Langmuir (2006) 1.09
Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol. J Biol Chem (2010) 1.06
The University of California Center for the Environmental Implications of Nanotechnology. Environ Sci Technol (2009) 1.05
Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun (2009) 1.01
Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1. Cell Microbiol (2006) 0.99
Ion channel and toxin measurement using a high throughput lipid membrane platform. Biosens Bioelectron (2008) 0.97
Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages. Infect Immun (2011) 0.90
Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother (2007) 0.88
Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis. PLoS Pathog (2011) 0.85
Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi. J Biol Chem (2013) 0.84
Genome-wide bacterial toxicity screening uncovers the mechanisms of toxicity of a cationic polystyrene nanomaterial. Environ Sci Technol (2012) 0.83
Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli. Protein Expr Purif (2006) 0.83
Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding. Biochemistry (2010) 0.82
SILENCE: a new forward genetic technology. Nat Methods (2006) 0.82
CHD1 and CHD2 are positive regulators of HIV-1 gene expression. Virol J (2014) 0.78
Efficient construction of an inverted minimal H1 promoter driven siRNA expression cassette: facilitation of promoter and siRNA sequence exchange. PLoS One (2007) 0.77
Anthrax toxin: can a little be a good thing? Trends Microbiol (2004) 0.77
Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways. J Acquir Immune Defic Syndr (2008) 0.76
Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background. PLoS One (2012) 0.75