Identification of IL-17-producing FOXP3+ regulatory T cells in humans.

PubWeight™: 4.10‹?› | Rank: Top 1%

🔗 View Article (PMC 2653560)

Published in Proc Natl Acad Sci U S A on March 09, 2009

Authors

Kui Shin Voo1, Yui-Hsi Wang, Fabio R Santori, Cesar Boggiano, Yi-Hong Wang, Kazuhiko Arima, Laura Bover, Shino Hanabuchi, Jahan Khalili, Ekaterina Marinova, Biao Zheng, Dan R Littman, Yong-Jun Liu

Author Affiliations

1: Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

Articles citing this

(truncated to the top 100)

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Autoimmune T cell responses in the central nervous system. Nat Rev Immunol (2009) 4.73

T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol (2010) 3.39

Heterogeneity and plasticity of T helper cells. Cell Res (2009) 3.09

Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol (2009) 2.65

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res (2009) 2.43

GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. J Clin Invest (2011) 2.43

Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS One (2009) 2.36

Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med (2011) 2.14

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A (2009) 2.06

How do regulatory T cells work? Scand J Immunol (2009) 2.02

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood (2012) 2.00

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology (2010) 1.92

Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol (2009) 1.78

The dual nature of T(H)17 cells: shifting the focus to function. Nat Immunol (2010) 1.78

Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells. Arthritis Rheum (2013) 1.71

Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol (2010) 1.70

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature (2014) 1.66

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood (2012) 1.64

Helper T cell diversity and plasticity. Curr Opin Immunol (2012) 1.63

Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype. Am J Transplant (2010) 1.55

Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors. J Immunol (2014) 1.53

Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy. Diabetes (2011) 1.52

Immune responses to malignancies. J Allergy Clin Immunol (2010) 1.48

CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J Mol Cell Biol (2011) 1.45

Heterogeneity of human effector CD4+ T cells. Arthritis Res Ther (2009) 1.44

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest (2015) 1.43

Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest (2013) 1.43

Molecular mechanisms of treg-mediated T cell suppression. Front Immunol (2012) 1.41

Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol (2009) 1.37

Mechanisms controlling Th17 cytokine expression and host defense. J Leukoc Biol (2011) 1.33

Up for Mischief? IL-17/Th17 in the tumour microenvironment. Oncogene (2010) 1.32

Human RORγt+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors. Proc Natl Acad Sci U S A (2010) 1.31

The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol (2013) 1.29

Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer (2010) 1.28

Once a Treg, always a Treg? Immunol Rev (2014) 1.27

Metabolic control of the Treg/Th17 axis. Immunol Rev (2013) 1.26

Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol (2009) 1.26

Plasticity of human CD4 T cell subsets. Front Immunol (2014) 1.25

Autoimmunity: increasing suspects in the CD4+ T cell lineup. Nat Immunol (2009) 1.21

A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells. PLoS Comput Biol (2011) 1.18

Diversity and plasticity of Th cell types predicted from regulatory network modelling. PLoS Comput Biol (2010) 1.17

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Front Immunol (2012) 1.17

IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol (2010) 1.17

Treating human autoimmunity: current practice and future prospects. Sci Transl Med (2012) 1.16

Inflammatory cytokines in systemic lupus erythematosus. J Biomed Biotechnol (2011) 1.16

Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. Indian J Med Res (2013) 1.13

IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol Rev (2010) 1.12

Human CD4 memory T cells can become CD4+IL-9+ T cells. PLoS One (2010) 1.12

Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity. FEBS Lett (2011) 1.11

Plasticity of T-cell phenotype and function: the T helper type 17 example. Immunology (2009) 1.11

Development, regulation and functional capacities of Th17 cells. Semin Immunopathol (2010) 1.10

Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A (2011) 1.10

The role and regulation of human Th17 cells in tumor immunity. Am J Pathol (2012) 1.09

Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice. J Nutr (2011) 1.08

The impact of Th17 cells on transplant rejection and the induction of tolerance. Curr Opin Organ Transplant (2010) 1.07

IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts. J Immunol (2011) 1.07

Paradoxically increased FOXP3+ T cells in IBD do not preferentially express the isoform of FOXP3 lacking exon 2. Dig Dis Sci (2012) 1.07

Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management. Hepatol Int (2010) 1.05

Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells. Clin Exp Immunol (2009) 1.05

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol (2012) 1.05

The female lower genital tract is a privileged compartment with IL-10 producing dendritic cells and poor Th1 immunity following Chlamydia trachomatis infection. PLoS Pathog (2010) 1.05

Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation. Clin Exp Immunol (2009) 1.04

Current views on the functions of interleukin-17A-producing cells in atherosclerosis. Thromb Haemost (2011) 1.03

FOXP3+ regulatory T cells and their functional regulation. Cell Mol Immunol (2015) 1.02

Nature and nurture in Foxp3(+) regulatory T cell development, stability, and function. Hum Immunol (2011) 1.02

Human FOXP3+ regulatory T cells in transplantation. Am J Transplant (2009) 1.02

Expression and function of TNF and IL-1 receptors on human regulatory T cells. PLoS One (2010) 1.01

Multiple treg suppressive modules and their adaptability. Front Immunol (2012) 1.01

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol (2015) 1.00

Cytokines in autoimmunity: role in induction, regulation, and treatment. J Interferon Cytokine Res (2011) 1.00

IL-17 promotes immune privilege of corneal allografts. J Immunol (2010) 1.00

The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease. Clin Exp Immunol (2010) 0.99

Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells. Int Immunopharmacol (2011) 0.99

CD16+ monocytes control T-cell subset development in immune thrombocytopenia. Blood (2012) 0.99

Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model. Brain Behav Immun (2009) 0.99

Plasticity of T reg at infected sites. Mucosal Immunol (2010) 0.98

Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease. Clin Exp Immunol (2012) 0.97

A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells. BMC Syst Biol (2012) 0.97

Imbalance of Th17 cells and regulatory T cells in tuberculous pleural effusion. Clin Vaccine Immunol (2011) 0.96

CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol (2011) 0.96

CC Chemokine Ligand 20 and Its Cognate Receptor CCR6 in Mucosal T Cell Immunology and Inflammatory Bowel Disease: Odd Couple or Axis of Evil? Front Immunol (2013) 0.96

Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low/-) T cells in patients with myasthenia gravis. Clin Immunol (2012) 0.95

Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases. Mediators Inflamm (2010) 0.94

The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer. Clin Immunol (2013) 0.93

Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut (2014) 0.93

T cells in the control of organ-specific autoimmunity. J Clin Invest (2015) 0.93

Basic biology and role of interleukin-17 in immunity and inflammation. Periodontol 2000 (2015) 0.92

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease. Gut (2015) 0.92

Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun (2015) 0.92

Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients. BMC Immunol (2011) 0.92

Diversity of IL-17-producing T lymphocytes. Cell Mol Life Sci (2012) 0.91

Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling. J Biol Chem (2012) 0.91

Translating tolerogenic therapies to the clinic - where do we stand? Front Immunol (2012) 0.91

Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J Immunol (2011) 0.90

T regulatory cells and the control of alloimmunity: from characterisation to clinical application. Curr Opin Immunol (2010) 0.90

Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive? Am J Clin Exp Immunol (2013) 0.90

Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS One (2013) 0.90

Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells. Proc Natl Acad Sci U S A (2011) 0.90

Nonsegmental vitiligo and autoimmune mechanism. Dermatol Res Pract (2011) 0.89

Articles cited by this

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol (2004) 17.40

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature (2007) 16.59

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21

Interleukin-17 family members and inflammation. Immunity (2004) 16.16

IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 14.28

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature (2006) 13.75

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol (2007) 13.70

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol (2005) 13.03

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 12.79

Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol (2007) 12.76

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol (2007) 12.72

IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol (2006) 10.33

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol (2003) 10.21

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med (1996) 8.59

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol (2006) 7.89

A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med (2006) 7.87

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol (2006) 6.82

Human IL-17: a novel cytokine derived from T cells. J Immunol (1995) 6.65

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol (1996) 5.79

Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science (2000) 5.78

Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev (2003) 5.57

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med (2007) 5.41

IL-17: prototype member of an emerging cytokine family. J Leukoc Biol (2002) 4.39

IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12

IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol (2001) 3.32

Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science (1990) 3.17

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis (2006) 3.09

Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med (1996) 2.31

Interleukin-10 production by effector T cells: Th1 cells show self control. J Exp Med (2007) 2.18

Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood (2001) 2.11

Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells. J Immunol (1987) 1.86

Neutrophils, interleukin-17A and lung disease. Eur Respir J (2005) 1.86

Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J Immunol (2001) 1.55

Neutrophilic airway inflammation and IL-17. Allergy (2002) 1.28

Articles by these authors

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08

Interactions between the microbiota and the immune system. Science (2012) 10.45

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol (2002) 10.15

Mouse and human dendritic cell subtypes. Nat Rev Immunol (2002) 10.01

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64

Plasmacytoid dendritic cells in immunity. Nat Immunol (2004) 9.11

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88

Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50

Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23

Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med (2006) 6.86

Nomenclature of monocytes and dendritic cells in blood. Blood (2010) 6.63

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44

Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol (2008) 6.17

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med (2005) 5.77

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science (2004) 5.66

Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med (2011) 5.60

Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol (2011) 5.34

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78

DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity (2002) 4.62

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature (2005) 4.60

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med (2011) 4.50

TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol (2007) 4.39

Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med (2005) 4.04

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92

The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med (2002) 3.91

Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90

Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86

PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest (2004) 3.86

Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med (2007) 3.78

The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med (2007) 3.66

Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity (2008) 3.64

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol (2009) 3.42

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med (2003) 3.41

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature (2011) 3.37

Dendritic cell apoptosis in the maintenance of immune tolerance. Science (2006) 3.33

Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol (2006) 3.24

A gene in the multidrug and toxic compound extrusion (MATE) family confers aluminum tolerance in sorghum. Nat Genet (2007) 3.19

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology (2008) 3.13

Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation. J Exp Med (2011) 3.12

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol (2004) 3.12

Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol (2004) 3.10

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 3.09

Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe (2010) 3.08

Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med (2002) 3.02

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature (2013) 2.95

Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity (2006) 2.95

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat Immunol (2008) 2.93

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84

Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity (2008) 2.78

Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica (2006) 2.75

Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity (2005) 2.72

Relationship of obesity with osteoporosis. J Clin Endocrinol Metab (2007) 2.71

Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat Immunol (2006) 2.69

Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med (2009) 2.63