Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway.

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Published in Curr Cancer Drug Targets on March 01, 2009

Authors

Todd M Morgan1, Theodore D Koreckij, Eva Corey

Author Affiliations

1: Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Associated clinical trials:

Ridaforolimus (AP23573/MK-8669) in Participants With Taxane-Resistant Androgen-Independent Prostate Cancer (AIPC)(MK-8669-017) | NCT00110188

Everolimus and Gefitinib in Treating Patients With Progressive Glioblastoma Multiforme or Progressive Metastatic Prostate Cancer | NCT00085566

Safety Study & Effectiveness of Docetaxel With RAD001 and Bevacizumab in Men With Advanced Prostate Cancer | NCT00574769

The Use of RAD001 With Docetaxel in the Treatment of Metastatic, Androgen Independent Prostate Cancer | NCT00459186

Phase II Study of RAD001 in a Neoadjuvant Setting in Men With Intermediate or High Risk Prostate Cancer | NCT00657982

RAD001 in Patients With Metastatic, Hormone-Refractory Prostate Cancer | NCT00629525

RAD001 and Bicalutamide for Androgen Independent Prostate Cancer | NCT00630344

Sirolimus Before Surgery in Treating Patients With Advanced Localized Prostate Cancer | NCT00311623

An Open Label Exploratory Study in Newly Diagnosed Prostate Cancer Patients | NCT00235794

Molecular, Genetic, and Genomic Assessments From Patients Treated With RAD001 | NCT00636090

Neoadjuvant CCI-779 Followed By Radical Prostatectomy in Treating Patients With Newly Diagnosed Prostate Cancer Who Have a High Risk of Relapse | NCT00071968

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