Published in Br J Haematol on October 01, 1991
Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Proc Natl Acad Sci U S A (2002) 1.56
Interferon-alpha-2a for the treatment of complex hemangiomas of infancy and childhood. Ann Surg (1994) 0.93
Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha. Neoplasia (2001) 0.90
Vascular potential of human pluripotent stem cells. Arterioscler Thromb Vasc Biol (2010) 0.85
A phase 2 study of pegylated interferon α-2b (PEG-Intron(®)) in children with diffuse intrinsic pontine glioma. Cancer (2011) 0.83
A review of Judah Folkman's remarkable achievements in biomedicine. Proc Natl Acad Sci U S A (2008) 0.79
Educational paper: therapy of infantile haemangioma--history and current state (part II). Eur J Pediatr (2014) 0.76
Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell (1996) 23.99
Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med (1991) 19.46
Angiogenic factors. Science (1987) 15.22
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 13.94
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell (1994) 13.76
What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst (1990) 13.41
Role of cell shape in growth control. Nature (1978) 12.46
Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst (1992) 8.69
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (1997) 7.66
Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med (1995) 7.37
Isolation of a tumor factor responsible for angiogenesis. J Exp Med (1971) 7.12
Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol (1993) 6.55
Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A (1994) 6.48
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res (2000) 6.42
Human vascular endothelial cells in culture. Growth and DNA synthesis. J Cell Biol (1974) 5.95
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol (1994) 5.76
Long-term culture of capillary endothelial cells. Proc Natl Acad Sci U S A (1979) 5.70
Tumor angiogenesis. Adv Cancer Res (1985) 5.66
Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res (1977) 5.19
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature (1990) 5.15
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (1999) 4.91
Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J Cell Biol (1989) 4.85
Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci U S A (1987) 4.83
Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med (1992) 4.76
Angiogenesis in vitro. Nature (1980) 4.46
Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg (1972) 4.37
Tumor dormancy in vivo by prevention of neovascularization. J Exp Med (1972) 4.34
Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science (1984) 4.27
Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst (1974) 4.05
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol (1994) 3.76
Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med (1996) 3.64
Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst (1995) 3.53
Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation (1999) 3.53
A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci (1996) 3.49
Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol (1976) 3.21
Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg (1966) 3.00
Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest (1994) 2.97
Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol (1996) 2.95
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88
Self-regulation of growth in three dimensions. J Exp Med (1973) 2.87
How does extracellular matrix control capillary morphogenesis? Cell (1989) 2.84
Polymers for the sustained release of proteins and other macromolecules. Nature (1976) 2.81
Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci U S A (2001) 2.81
Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest (1993) 2.71
How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture. Cancer Res (1986) 2.69
Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy. Cancer Res (1999) 2.58
Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun (1993) 2.56
Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell (1991) 2.52
Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst (1972) 2.52
Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst (1994) 2.50
Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry (1989) 2.49
Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood (1999) 2.49
Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science (1983) 2.47
A simple procedure for the long-term cultivation of chicken embryos. Dev Biol (1974) 2.46
Tumor angiogenesis. Adv Cancer Res (1974) 2.38
Protamine is an inhibitor of angiogenesis. Nature (1982) 2.30
Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J Exp Med (1980) 2.27
Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell (1998) 2.17
Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature (1969) 2.16
Fine structure of vascular endothelium in culture. J Ultrastruct Res (1975) 2.15
Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics (1999) 2.12
Betacellulin: a mitogen from pancreatic beta cell tumors. Science (1993) 2.10
Heterogeneity of angiogenic activity in a human liposarcoma: a proposed mechanism for "no take" of human tumors in mice. J Natl Cancer Inst (2001) 2.10
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci U S A (1996) 2.07
Involvement of platelets in tumour angiogenesis? Lancet (1998) 2.03
Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol (1997) 1.98
Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst (1973) 1.95
Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy. J Pediatr (1998) 1.95
Isolation and characterization of endothelial progenitor cells from mouse embryos. Development (1998) 1.94
Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion. In Vitro Cell Dev Biol (1987) 1.93
Application of the biological principle of induced osteogenesis for craniofacial defects. Lancet (1981) 1.92
Proceedings: Tumor angiogenesis factor. Cancer Res (1974) 1.86
Influence of geometry on control of cell growth. Biochim Biophys Acta (1975) 1.79
Isolations of a cartilage factor that inhibits tumor neovascularization. Science (1976) 1.79
Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J Biol Chem (1999) 1.78
Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med (1995) 1.78
Angiogenesis is stimulated by a tumor-derived endothelial cell growth factor. J Cell Biochem (1985) 1.77
Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. Am J Pathol (1975) 1.77
The hemostatic system as a regulator of angiogenesis. J Biol Chem (2000) 1.76
Inhibition of tumor angiogenesis mediated by cartilage. J Exp Med (1975) 1.74
Elevated basic fibroblast growth factor in the serum of patients with Duchenne muscular dystrophy. Ann Neurol (1994) 1.73
Tumor angiogenesis. Rapid induction of endothelial mitoses demonstrated by autoradiography. J Cell Biol (1972) 1.72
Mast cells and tumor angiogenesis. Int J Cancer (1976) 1.71
Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Biochem Biophys Res Commun (1991) 1.67
Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science (1999) 1.67
Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc Natl Acad Sci U S A (1998) 1.66
In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J Clin Invest (1996) 1.65
Radiation therapy to a primary tumor accelerates metastatic growth in mice. Cancer Res (2001) 1.64
Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells. J Biol Chem (1996) 1.63
Tumor vascularity, proliferation, and apoptosis in human melanoma micrometastases and macrometastases. Arch Dermatol (1998) 1.60
Tumor angiogenesis: a possible control point in tumor growth. Ann Intern Med (1975) 1.60
Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). Br J Cancer (1994) 1.60
Inhibition of angiogenesis through modulation of collagen metabolism. Lab Invest (1988) 1.58
Angiogenesis: initiation and control. Ann N Y Acad Sci (1982) 1.57
Angiogenesis and breast cancer. J Clin Oncol (1994) 1.56
Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model. Cancer Res (2001) 1.55
A possible mechanism for inhibition of angiogenesis by angiostatic steroids: induction of capillary basement membrane dissolution. Endocrinology (1986) 1.55
The vascularization of tumors. Sci Am (1976) 1.51