Structural basis for leucine-rich nuclear export signal recognition by CRM1.

Nuclear export of proteins and drug resistance in cancer. Biochem Pharmacol (2011) 2.43

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood (2012) 2.27

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol (2010) 2.12

Recognition of nuclear targeting signals by Karyopherin-β proteins. Curr Opin Struct Biol (2010) 1.98

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia (2012) 1.77

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol (2013) 1.68

SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients. Leukemia (2013) 1.66

NESdb: a database of NES-containing CRM1 cargoes. Mol Biol Cell (2012) 1.57

An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1. EMBO J (2010) 1.42

Ran-dependent nuclear export mediators: a structural perspective. EMBO J (2011) 1.42

The transience of transient overexpression. Nat Methods (2013) 1.41

A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication. J Virol (2012) 1.28

Emerging roles for the influenza A virus nuclear export protein (NEP). PLoS Pathog (2012) 1.23

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc Natl Acad Sci U S A (2013) 1.21

The importin β binding domain as a master regulator of nucleocytoplasmic transport. Biochim Biophys Acta (2010) 1.19

LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins. Bioinformatics (2014) 1.17

Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell (2012) 1.15

The CRM1 nuclear export protein in normal development and disease. Int J Biochem Mol Biol (2012) 1.14

Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry. Mol Cell Proteomics (2012) 1.14

A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export. Mol Cell Biol (2010) 1.10

Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase. Mol Biol Cell (2010) 1.10

A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus. Hum Mol Genet (2013) 1.07

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer. Oncotarget (2014) 1.05

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Nat Struct Mol Biol (2013) 1.04

Prediction of leucine-rich nuclear export signal containing proteins with NESsential. Nucleic Acids Res (2011) 1.03

FoxO6 integrates insulin signaling with gluconeogenesis in the liver. Diabetes (2011) 1.03

The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila. EMBO J (2010) 1.02

Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol (2014) 1.01

Structural basis for cooperativity of CRM1 export complex formation. Proc Natl Acad Sci U S A (2012) 0.98

NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles. PLoS Comput Biol (2014) 0.96

Atomic basis of CRM1-cargo recognition, release and inhibition. Semin Cancer Biol (2014) 0.96

A second CRM1-dependent nuclear export signal in the influenza A virus NS2 protein contributes to the nuclear export of viral ribonucleoproteins. J Virol (2012) 0.95

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice. Leukemia (2015) 0.95

DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. PLoS One (2012) 0.94

Snail nuclear transport: the gateways regulating epithelial-to-mesenchymal transition? Semin Cancer Biol (2014) 0.94

The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA. Elife (2014) 0.94

Regulation of the activity and cellular localization of the circadian clock protein FRQ. J Biol Chem (2011) 0.94

shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance. Blood (2015) 0.93

The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex. J Biol Chem (2010) 0.93

Repression of classical nuclear export by S-nitrosylation of CRM1. J Cell Sci (2009) 0.93

Interpretation of solution x-ray scattering by explicit-solvent molecular dynamics. Biophys J (2015) 0.92

Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein. Pharmacol Ther (2015) 0.91

KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma. Cancer Chemother Pharmacol (2014) 0.91

p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1. Mol Biol Cell (2013) 0.90

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Mol Biol Cell (2011) 0.89

Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators. Mol Genet Genomics (2009) 0.89

Aiding and abetting cancer: mRNA export and the nuclear pore. Trends Cell Biol (2013) 0.88

Selective inhibitors of nuclear export (SINE) in hematological malignancies. Exp Hematol Oncol (2015) 0.88

Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. J Virol (2014) 0.88

Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4. PLoS One (2012) 0.87

Fluorescent recovery after photobleaching (FRAP) analysis of nuclear export rates identifies intrinsic features of nucleocytoplasmic transport. J Biol Chem (2011) 0.87

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife (2015) 0.87

Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts. PLoS One (2014) 0.87

Electrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo. J Biol Chem (2011) 0.86

Evolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replication. PLoS Pathog (2011) 0.86

Highly polarized C-terminal transition state of the leucine-rich repeat domain of PP32 is governed by local stability. Proc Natl Acad Sci U S A (2015) 0.85

Genetic analysis of the ribosome biogenesis factor Ltv1 of Saccharomyces cerevisiae. Genetics (2014) 0.85

The first identified nucleocytoplasmic shuttling herpesviral capsid protein: herpes simplex virus type 1 VP19C. PLoS One (2012) 0.85

Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation. Proc Natl Acad Sci U S A (2015) 0.85

Feline immunodeficiency virus Gag is a nuclear shuttling protein. J Virol (2012) 0.84

A novel N-terminal domain may dictate the glucose response of Mondo proteins. PLoS One (2012) 0.84

The interaction of CRM1 and the nuclear pore protein Tpr. PLoS One (2014) 0.84

FoxO6 in glucose metabolism (FoxO6). J Diabetes (2013) 0.83

Karyopherins in nuclear transport of homeodomain proteins during development. Biochim Biophys Acta (2011) 0.83

Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry. Cell Div (2010) 0.82

Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. J Virol (2012) 0.82

Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA. PLoS Genet (2015) 0.82

Identification of a novel nucleocytoplasmic shuttling RNA helicase of trypanosomes. PLoS One (2014) 0.81

Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism. J Virol (2014) 0.81

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α. FEBS Lett (2013) 0.80

Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife (2015) 0.80

Structural basis for the nuclear export activity of Importin13. EMBO J (2013) 0.80

Mitogen-activated protein kinase phosphatase PHS1 is retained in the cytoplasm by nuclear extrusion signal-dependent and independent mechanisms. Planta (2010) 0.79

Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1. J Biol Chem (2012) 0.79

Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain. PLoS One (2011) 0.79

Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1. PLoS One (2015) 0.78

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia (2016) 0.78

Nuclear import of UBL-domain protein Mdy2 is required for heat-induced stress response in Saccharomyces cerevisiae. PLoS One (2012) 0.78

Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/importin-7 in snRNP biogenesis. Mol Biol Cell (2013) 0.78

Allosteric control of the exportin CRM1 unraveled by crystal structure analysis. FEBS J (2014) 0.78

Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis. Angew Chem Int Ed Engl (2016) 0.78

Solving the NES problem. Nat Struct Mol Biol (2010) 0.77

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition. Sci Rep (2015) 0.77

Structural Basis of Targeting the Exportin CRM1 in Cancer. Cells (2015) 0.77

The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway. Microb Cell Fact (2014) 0.77

Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport. PLoS One (2015) 0.77

The Intracellular Domain of the Frazzled/DCC Receptor Is a Transcription Factor Required for Commissural Axon Guidance. Neuron (2015) 0.77

The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export. J Biol Chem (2016) 0.75

Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent. Exp Biol Med (Maywood) (2015) 0.75

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia (2016) 0.75

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1. PLoS One (2016) 0.75

Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus Infection. PLoS One (2016) 0.75

Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun (2016) 0.75

XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy. J Hematol Oncol (2017) 0.75

Really exasperating viral protein from HIV. Elife (2015) 0.75

Mechanistic insights from the recent structures of the CRM1 nuclear export complex and its disassembly intermediate. Biophysics (Nagoya-shi) (2012) 0.75

Nucleocytoplasmic shuttling of the HSV-2 serine/threonine kinase Us3. Virology (2011) 0.75

FoxO integration of insulin signaling with glucose and lipid metabolism. J Endocrinol (2017) 0.75

NES masking regulates HIV-1 Rev trafficking and viral RNA nuclear export. J Virol (2016) 0.75

Oligomeric viral proteins: small in size, large in presence. Crit Rev Biochem Mol Biol (2016) 0.75

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Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. J Cell Sci (2003) 2.02

Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals. PLoS Biol (2008) 1.90

Coupled prediction of protein secondary and tertiary structure. Proc Natl Acad Sci U S A (2003) 1.90

Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Mol Cell (2004) 1.72

Structure-based design of a pathway-specific nuclear import inhibitor. Nat Struct Mol Biol (2007) 1.64

RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. EMBO Rep (2001) 1.46

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Structural basis for assembly and disassembly of the CRM1 nuclear export complex. Nat Struct Mol Biol (2009) 1.35

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SnapShot: nuclear transport. Cell (2007) 1.11

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Atomic resolution structures in nuclear transport. Methods (2006) 0.93

ER targeting signals: more than meets the eye? Cell (2006) 0.87

Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell (2006) 3.44

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood (2012) 2.27

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Structure-based design of a pathway-specific nuclear import inhibitor. Nat Struct Mol Biol (2007) 1.64

NESdb: a database of NES-containing CRM1 cargoes. Mol Biol Cell (2012) 1.57

AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem (2004) 1.46

Structural basis for assembly and disassembly of the CRM1 nuclear export complex. Nat Struct Mol Biol (2009) 1.35

The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity (2006) 1.32

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells. Mol Cell Neurosci (2013) 1.25

Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression. Proc Natl Acad Sci U S A (2014) 1.22

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc Natl Acad Sci U S A (2013) 1.21

NF-kappaB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem J (2010) 1.18

Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc Natl Acad Sci U S A (2012) 1.16

Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell (2012) 1.15

SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol (2011) 1.09

Role of complement activation in obliterative bronchiolitis post-lung transplantation. J Immunol (2013) 1.01

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Atomic resolution structures in nuclear transport. Methods (2006) 0.93

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Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP). J Biol Chem (2011) 0.92

Testosterone-down-regulated Akt pathway during cardiac ischemia/reperfusion: a mechanism involving BAD, Bcl-2 and FOXO3a. J Surg Res (2010) 0.92

Lipid induced overexpression of NF-kappaB in skeletal muscle cells is linked to insulin resistance. Biochim Biophys Acta (2009) 0.91

Type V collagen induced tolerance suppresses collagen deposition, TGF-β and associated transcripts in pulmonary fibrosis. PLoS One (2013) 0.91

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Mol Biol Cell (2011) 0.89

GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary. Mol Endocrinol (2011) 0.87

Cajanus cajan Linn. (Leguminosae) prevents alcohol-induced rat liver damage and augments cytoprotective function. J Ethnopharmacol (2008) 0.85

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration. Mol Biol Cell (2014) 0.84

Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus. J Biol Chem (2009) 0.84

Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. J Struct Funct Genomics (2013) 0.83

How hair cells hear: the molecular basis of hair-cell mechanotransduction. Curr Opin Otolaryngol Head Neck Surg (2008) 0.81

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Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs. J Am Chem Soc (2016) 0.79

Distinct patterns of histone modifications at cardiac-specific gene promoters between cardiac stem cells and mesenchymal stem cells. Am J Physiol Cell Physiol (2013) 0.78

Identification of an amino acid residue in ATP-binding cassette transport G1 critical for mediating cholesterol efflux. Biochim Biophys Acta (2011) 0.77

Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. Biochem Pharmacol (2011) 0.76

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