Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.

PubWeight™: 6.36‹?› | Rank: Top 1%

🔗 View Article (PMC 2916661)

Published in JAMA on April 08, 2009

Authors

Christopher M O'Connor1, David J Whellan, Kerry L Lee, Steven J Keteyian, Lawton S Cooper, Stephen J Ellis, Eric S Leifer, William E Kraus, Dalane W Kitzman, James A Blumenthal, David S Rendall, Nancy Houston Miller, Jerome L Fleg, Kevin A Schulman, Robert S McKelvie, Faiez Zannad, Ileana L Piña, HF-ACTION Investigators

Author Affiliations

1: Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA. oconn002@mc.duke.edu

Associated clinical trials:

Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart Failure | NCT00047437

Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure | NCT01053091

Outpatient Cardiac Rehabilitation in Austria | NCT01540006

Different Endurance Training Protocols in Cardiac Rehabilitation | NCT01493193

Building Strength Through Rehabilitation for Heart Failure Patients (BISTRO-STUDY) | NCT03615469

OptiVol for Precision Medical Management of Heart Failure ((OPTIMED-HF)) | NCT04206501

Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study (PLEASE) | NCT04425785

Effect of Nutritional Supplementation and Pulmonary Rehabilitation on the Clinical Status of HF and COPD | NCT04432194

Randomised Controlled Study of Physical Exercise Intervention in Breast Cancer Patients at Risk of Anthracycline-induced Cardiomyopathy: The EMBRACE Study (EMBRACE) | NCT04467411

Moderate Intensity Training in Patients With Truncating Genetic Variants in TTN. | NCT05180188

Articles citing this

(truncated to the top 100)

Clinical implications of chronic heart failure phenotypes defined by cluster analysis. J Am Coll Cardiol (2014) 3.48

Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial. JAMA (2012) 3.46

Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial. JAMA (2012) 3.30

6-min walk test provides prognostic utility comparable to cardiopulmonary exercise testing in ambulatory outpatients with systolic heart failure. J Am Coll Cardiol (2012) 3.03

Tai chi exercise in patients with chronic heart failure: a randomized clinical trial. Arch Intern Med (2011) 2.60

Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials. Circ Heart Fail (2014) 2.30

Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model. Circ Heart Fail (2011) 2.28

Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure. JACC Heart Fail (2014) 2.14

Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiaries. Circulation (2009) 2.11

Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial. JAMA (2017) 2.03

Prospective randomized trial of moderately strenuous aerobic exercise after an implantable cardioverter defibrillator. Circulation (2015) 1.98

Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ Heart Fail (2010) 1.93

miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab (2015) 1.85

Can exercise teach us how to treat heart disease? Circulation (2012) 1.70

Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction. Am Heart J (2012) 1.68

Risk factors for hospital admission among older persons with newly diagnosed heart failure: findings from the Cardiovascular Health Study. J Am Coll Cardiol (2013) 1.67

Adrenergic nervous system in heart failure: pathophysiology and therapy. Circ Res (2013) 1.62

Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J Am Coll Cardiol (2012) 1.59

Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial. J Am Geriatr Soc (2009) 1.54

Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure. Cardiovasc Res (2011) 1.53

Chronic heart failure: contemporary diagnosis and management. Mayo Clin Proc (2010) 1.51

What strategies are effective for exercise adherence in heart failure? A systematic review of controlled studies. Heart Fail Rev (2012) 1.49

Contribution of Major Lifestyle Risk Factors for Incident Heart Failure in Older Adults: The Cardiovascular Health Study. JACC Heart Fail (2015) 1.49

What do we know about the cardiac benefits of exercise? Trends Cardiovasc Med (2014) 1.45

AKT signalling in the failing heart. Eur J Heart Fail (2011) 1.41

Variables Measured During Cardiopulmonary Exercise Testing as Predictors of Mortality in Chronic Systolic Heart Failure. J Am Coll Cardiol (2016) 1.40

Identifying biomarker patterns and predictors of inflammation and myocardial stress. J Card Fail (2015) 1.38

Exercise training for systolic heart failure: Cochrane systematic review and meta-analysis. Eur J Heart Fail (2010) 1.34

Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation (2011) 1.30

Cardiac rehabilitation exercise and self-care for chronic heart failure. JACC Heart Fail (2013) 1.30

Frailty and healthcare utilization among patients with heart failure in the community. JACC Heart Fail (2013) 1.29

The 6-minute walk is associated with frailty and predicts mortality in older adults with heart failure. Congest Heart Fail (2010) 1.26

Age disparities in heart failure research. JAMA (2010) 1.23

Relation between volume of exercise and clinical outcomes in patients with heart failure. J Am Coll Cardiol (2012) 1.20

Benefits of intensive treadmill exercise training on cardiorespiratory function and quality of life in patients with pulmonary hypertension. Chest (2013) 1.20

Exercise and the cardiovascular system: clinical science and cardiovascular outcomes. Circ Res (2015) 1.20

Frailty and multiple comorbidities in the elderly patient with heart failure: implications for management. Heart Fail Rev (2012) 1.14

Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training. Circ Heart Fail (2012) 1.12

Relationship of Doppler-Echocardiographic left ventricular diastolic function to exercise performance in systolic heart failure: the HF-ACTION study. Am Heart J (2009) 1.11

Cardiac rehabilitation past, present and future: an overview. Cardiovasc Diagn Ther (2012) 1.09

Cardiovascular response to exercise training in the systemic right ventricle of adults with transposition of the great arteries. J Physiol (2015) 1.09

Soluble ST2 in ambulatory patients with heart failure: Association with functional capacity and long-term outcomes. Circ Heart Fail (2013) 1.07

Depression is associated with reduced physical activity in persons with heart failure. Health Psychol (2012) 1.05

Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O2 balance and diastolic function. J Appl Physiol (1985) (2012) 1.05

Associations of self-reported physical activity types and levels with quality of life, depression symptoms, and mortality in hemodialysis patients: the DOPPS. Clin J Am Soc Nephrol (2014) 1.05

Practices and impact of primary outcome adjustment in randomized controlled trials: meta-epidemiologic study. BMJ (2013) 1.03

Method for establishing authorship in a multicenter clinical trial. Ann Intern Med (2009) 1.02

Relationship of beta-blocker dose with outcomes in ambulatory heart failure patients with systolic dysfunction: results from the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial. J Am Coll Cardiol (2012) 1.02

Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. Am J Physiol Endocrinol Metab (2013) 1.01

Exercise-based rehabilitation for heart failure: systematic review and meta-analysis. Open Heart (2015) 1.00

Measuring frailty in heart failure: a community perspective. Am Heart J (2013) 1.00

Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION). Am Heart J (2012) 1.00

Effect of exercise training on the quality of life and echocardiography parameter of systolic function in patients with chronic heart failure: a randomized trial. Asian J Sports Med (2015) 0.98

Baseline characteristics and treatment of patients in prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF). Eur J Heart Fail (2014) 0.98

Effects of Combined Early In-Patient Cardiac Rehabilitation and Structured Home-based Program on Function among Patients with Congestive Heart Failure: A Randomized Controlled Trial. Heart Views (2011) 0.97

A randomised controlled study of the long-term effects of exercise training on mortality in elderly people: study protocol for the Generation 100 study. BMJ Open (2015) 0.97

Maximum daily 6 minutes of activity: an index of functional capacity derived from actigraphy and its application to older adults with heart failure. J Am Geriatr Soc (2010) 0.96

Effect of resistance training on physical disability in chronic heart failure. Med Sci Sports Exerc (2011) 0.96

Exercise intolerance in heart failure with preserved ejection fraction: shifting focus from the heart to peripheral skeletal muscle. J Am Coll Cardiol (2012) 0.95

Poorer physical fitness is associated with reduced structural brain integrity in heart failure. J Neurol Sci (2013) 0.95

Should high-intensity-aerobic interval training become the clinical standard in heart failure? Heart Fail Rev (2013) 0.95

Economic evaluation of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized controlled trial: an exercise training study of patients with chronic heart failure. Circ Cardiovasc Qual Outcomes (2010) 0.95

Exercise training as therapy for heart failure: current status and future directions. Circ Heart Fail (2015) 0.95

Tai chi in patients with heart failure with preserved ejection fraction. Congest Heart Fail (2012) 0.94

Race, exercise training, and outcomes in chronic heart failure: findings from Heart Failure - a Controlled Trial Investigating Outcomes in Exercise TraiNing (HF-ACTION). Am Heart J (2013) 0.94

Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning? Heart Fail Rev (2012) 0.92

Is exercise adherence associated with clinical outcomes in patients with advanced heart failure? Phys Sportsmed (2010) 0.92

Suppression of cerebral hemodynamics is associated with reduced functional capacity in patients with heart failure. Am J Physiol Heart Circ Physiol (2011) 0.91

Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II. Am J Physiol Regul Integr Comp Physiol (2012) 0.91

Exercise training and implantable cardioverter-defibrillator shocks in patients with heart failure: results from HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing). JACC Heart Fail (2013) 0.91

Central neural control of sympathetic nerve activity in heart failure following exercise training. Am J Physiol Heart Circ Physiol (2011) 0.91

Home-based cardiac rehabilitation is an attractive alternative to no cardiac rehabilitation for elderly patients with coronary heart disease: results from a randomised clinical trial. BMJ Open (2012) 0.90

Using exercise to measure and modify cardiac function. Cell Metab (2015) 0.90

Exercise as a nonpharmacologic intervention in patients with heart failure. Phys Sportsmed (2011) 0.87

Combined aerobic and resistance exercise program improves task performance in patients with heart failure. Arch Phys Med Rehabil (2011) 0.87

Moving toward comprehensive acute heart failure risk assessment in the emergency department: the importance of self-care and shared decision making. JACC Heart Fail (2013) 0.87

In-hospital resource use and medical costs in the last year of life by mode of death (from the HF-ACTION randomized controlled trial). Am J Cardiol (2012) 0.87

Unraveling new mechanisms of exercise intolerance in chronic heart failure: role of exercise training. Heart Fail Rev (2013) 0.86

N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study. Am Heart J (2009) 0.86

Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol (1975) 0.86

Functional electrical stimulation of lower limbs in patients with chronic heart failure. Heart Fail Rev (2010) 0.86

Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy. Am J Physiol Heart Circ Physiol (2011) 0.86

Cardiac rehabilitation outcomes: impact of comorbidities and age. J Cardiopulm Rehabil Prev (2011) 0.86

Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving β-blocker therapy: data from the HF-ACTION trial. Eur Heart J (2013) 0.86

Associations between Seattle Heart Failure Model scores and health utilities: findings from HF-ACTION. J Card Fail (2013) 0.86

CpG-ODN attenuates pathological cardiac hypertrophy and heart failure by activation of PI3Kα-Akt signaling. PLoS One (2013) 0.86

Carotid inflammation is unaltered by exercise in hypercholesterolemic Swine. Med Sci Sports Exerc (2012) 0.86

Decreases in daily physical activity predict acute decline in attention and executive function in heart failure. J Card Fail (2015) 0.85

Exercise and heart failure in the elderly. Heart Fail Rev (2012) 0.85

An Internet-Based Counseling Intervention With Email Reminders that Promotes Self-Care in Adults With Chronic Heart Failure: Randomized Controlled Trial Protocol. JMIR Res Protoc (2014) 0.85

Association between adrenergic receptor genotypes and beta-blocker dose in heart failure patients: analysis from the HF-ACTION DNA substudy. Eur J Heart Fail (2012) 0.85

Cardiopulmonary exercise testing, prehabilitation, and Enhanced Recovery After Surgery (ERAS). Can J Anaesth (2015) 0.85

A combined aerobic and resistance exercise program improves physical functional performance in patients with heart failure: a pilot study. J Cardiovasc Nurs (2012) 0.85

Heart failure preserved ejection fraction (HFpEF): an integrated and strategic review. Heart Fail Rev (2015) 0.84

Benefit of exercise therapy for systolic heart failure in relation to disease severity and etiology-findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training study. Am Heart J (2011) 0.84

Central mechanisms of abnormal sympathoexcitation in chronic heart failure. Cardiol Res Pract (2012) 0.84

Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients. PLoS One (2015) 0.84

Heart failure: mitochondrial dysfunction and oxidative stress in CHF. Nat Rev Cardiol (2014) 0.83

Increasing physical activity of high intensity to reduce the prevalence of chronic diseases and improve public health. Open Cardiovasc Med J (2013) 0.83

Exercise training normalizes the blunted central component of the baroreflex in rats with heart failure: role of the PVN. Am J Physiol Heart Circ Physiol (2013) 0.83

Articles cited by this

A multiple testing procedure for clinical trials. Biometrics (1979) 26.80

The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med (2005) 20.72

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation (2005) 18.90

Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med (2004) 18.38

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J (2008) 12.32

Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet (2003) 9.98

A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med (2001) 9.75

Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems. Stat Med (2002) 7.41

Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA (2007) 6.25

Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation (1999) 3.71

Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function. Circulation (1992) 3.56

Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ (2004) 3.39

Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale. Am Heart J (2007) 3.34

Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and management. Can J Cardiol (2006) 3.20

Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity. Am J Med (2004) 2.81

The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med (1984) 2.80

Incidence and prevalence of heart failure in elderly persons, 1994-2003. Arch Intern Med (2008) 2.65

Physical training in patients with stable chronic heart failure: effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. J Am Coll Cardiol (1995) 2.11

Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing). Am J Cardiol (2008) 1.79

Exercise training in patients with heart failure: clinical outcomes, safety, and indications. Heart Fail Rev (2008) 1.36

A placebo-controlled trial of captopril in refractory chronic congestive heart failure. Captopril Multicenter Research Group. J Am Coll Cardiol (1983) 1.35

Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. The Captopril-Digoxin Multicenter Research Group. JAMA (1988) 1.33

What is the ideal study design for evaluation of treatment for heart failure? Insights from trials assessing the effect of ACE inhibitors on exercise capacity. Eur Heart J (1996) 1.23

Articles by these authors

Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med (2005) 27.36

2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens (2013) 18.17

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J (2012) 16.00

Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA (2003) 13.82

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J (2012) 13.74

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med (2003) 13.25

Delivering affordable cancer care in high-income countries. Lancet Oncol (2011) 12.79

Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med (2009) 12.73

2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J (2013) 12.73

Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med (2011) 11.99

Ethical and scientific implications of the globalization of clinical research. N Engl J Med (2009) 11.42

Telemonitoring in patients with heart failure. N Engl J Med (2010) 10.82

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail (2012) 10.38

Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med (2011) 10.29

Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. Am J Cardiol (2007) 9.62

AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation (2002) 9.04

Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med (2013) 8.74

Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med (2015) 8.70

Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med (2015) 8.61

Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med (2012) 8.28

Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA (2006) 7.81

Coronary bypass surgery with or without surgical ventricular reconstruction. N Engl J Med (2009) 7.71

Spironolactone for heart failure with preserved ejection fraction. N Engl J Med (2014) 7.48

Myocardial viability and survival in ischemic left ventricular dysfunction. N Engl J Med (2011) 6.65

Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA (2007) 6.25

Rhythm control versus rate control for atrial fibrillation and heart failure. N Engl J Med (2008) 6.17

Is it important to examine gender differences in the epidemiology and outcome of severe heart failure? J Thorac Cardiovasc Surg (2004) 5.35

The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol (2005) 5.33

Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA (2013) 5.31

Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the american heart association. Circulation (2011) 5.26

Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation (2008) 5.15

Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med (2008) 5.13

Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail (2013) 4.98

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA (2013) 4.85

Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med (2012) 4.72

Home use of automated external defibrillators for sudden cardiac arrest. N Engl J Med (2008) 4.64

Risks of mortality, myocardial infarction, bleeding, and stroke associated with therapies for age-related macular degeneration. Arch Ophthalmol (2010) 4.50

Quality of life with defibrillator therapy or amiodarone in heart failure. N Engl J Med (2008) 4.33

Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials. JAMA (2007) 4.30

Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised study. Lancet (2005) 4.29

Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol (2007) 4.14

Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation (2003) 3.97

Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosom Med (2004) 3.94

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88

Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation (2010) 3.83

Pay for performance, quality of care, and outcomes in acute myocardial infarction. JAMA (2007) 3.79

Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care (2009) 3.69

Inappropriate prescribing for elderly Americans in a large outpatient population. Arch Intern Med (2004) 3.64

Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults: a scientific statement from the American Heart Association. Circulation (2010) 3.63

Linking inpatient clinical registry data to Medicare claims data using indirect identifiers. Am Heart J (2009) 3.57

Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med (2010) 3.57

Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST). Circulation (2003) 3.57

Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy. Circulation (2008) 3.54

Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol (2005) 3.53

Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation (2003) 3.49

Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial. JAMA (2012) 3.46

Digoxin reduces 30-day all-cause hospital admission in older patients with chronic systolic heart failure. Am J Med (2013) 3.46

The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. J Thorac Cardiovasc Surg (2007) 3.45

Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psychiatry (2005) 3.41

Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial. Circulation (2006) 3.40

Care management for low-risk patients with heart failure: a randomized, controlled trial. Ann Intern Med (2004) 3.40

The amyloidogenic V122I transthyretin variant in elderly black Americans. N Engl J Med (2015) 3.36

Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. N Engl J Med (2002) 3.35

State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail (2008) 3.35

Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale. Am Heart J (2007) 3.34

Clinical implications of QRS duration in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction. JAMA (2008) 3.31

Perceptions of patients and physicians regarding phase I cancer clinical trials: implications for physician-patient communication. J Clin Oncol (2003) 3.31

Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE--a randomized controlled study. Arch Intern Med (2004) 3.30

Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation (2004) 3.30

The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J Card Fail (2005) 3.26

Diastolic dysfunction in heart failure with preserved systolic function: need for objective evidence:results from the CHARM Echocardiographic Substudy-CHARMES. J Am Coll Cardiol (2007) 3.23

Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med (2011) 3.20

Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and management. Can J Cardiol (2006) 3.20

Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J Am Coll Cardiol (2011) 3.19

Call to action on use and reimbursement for home blood pressure monitoring: executive summary: a joint scientific statement from the American Heart Association, American Society Of Hypertension, and Preventive Cardiovascular Nurses Association. Hypertension (2008) 3.19

Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol (1985) (2003) 3.18

Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial. Circulation (2009) 3.18

Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study. Ann Intern Med (2002) 3.17

Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med (2010) 3.17

Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the SANDS randomized trial. JAMA (2008) 3.16

Inducible myocardial ischemia and outcomes in patients with coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol (2013) 3.15

Safety and efficacy of a totally subcutaneous implantable-cardioverter defibrillator. Circulation (2013) 3.14

Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial. Ann Intern Med (2013) 3.08

State of the science: promoting self-care in persons with heart failure: a scientific statement from the American Heart Association. Circulation (2009) 3.05

6-min walk test provides prognostic utility comparable to cardiopulmonary exercise testing in ambulatory outpatients with systolic heart failure. J Am Coll Cardiol (2012) 3.03