Published in Curr Alzheimer Res on April 01, 2009
The adverse effects of air pollution on the nervous system. J Toxicol (2012) 1.28
Animal models in the drug discovery pipeline for Alzheimer's disease. Br J Pharmacol (2011) 1.13
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proc Natl Acad Sci U S A (2012) 1.00
A digital atlas of the dog brain. PLoS One (2012) 1.00
Recent rodent models for Alzheimer's disease: clinical implications and basic research. J Neural Transm (Vienna) (2011) 0.99
Integrative Understanding of Emergent Brain Properties, Quantum Brain Hypotheses, and Connectome Alterations in Dementia are Key Challenges to Conquer Alzheimer's Disease. Front Neurol (2010) 0.96
Endogenous amyloidogenesis in long-term rat hippocampal cell cultures. BMC Neurosci (2011) 0.93
Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats. PLoS One (2012) 0.84
Quantitative expression analysis of APP pathway and tau phosphorylation-related genes in the ICV STZ-induced non-human primate model of sporadic Alzheimer's disease. Int J Mol Sci (2015) 0.81
Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer's Disease. J Alzheimers Dis (2016) 0.78
Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line. J Mol Neurosci (2010) 0.78
Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds. Oxid Med Cell Longev (2015) 0.77
A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap. Neurobiol Aging (2013) 0.77
The chick as a model for the study of the cellular mechanisms and potential therapies for Alzheimer's disease. Int J Alzheimers Dis (2010) 0.76
Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord. J Vet Sci (2014) 0.75
Computational Prediction of Alzheimer's and Parkinson's Disease MicroRNAs in Domestic Animals. Asian-Australas J Anim Sci (2015) 0.75
Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies. Aging Cell (2016) 0.75
Comparison of α-synuclein immunoreactivity in the hippocampus between the adult and aged beagle dogs. Cell Mol Neurobiol (2012) 0.75
Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med (2000) 4.99
A single IGF1 allele is a major determinant of small size in dogs. Science (2007) 4.68
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron (2004) 4.21
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci (2001) 3.85
The domestication of social cognition in dogs. Science (2002) 3.82
Body size, energy metabolism and lifespan. J Exp Biol (2005) 3.80
Human-like social skills in dogs? Trends Cogn Sci (2005) 3.49
Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci (1998) 3.03
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci (2000) 2.54
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci (2007) 2.25
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci (2000) 2.22
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci (2005) 2.21
Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 2.02
Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging? Neurobiol Aging (2006) 1.84
Alzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci (2002) 1.83
Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol (2004) 1.66
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell (1994) 1.64
Neurofibrillary tangles and senile plaques in aged bears. J Neuropathol Exp Neurol (1988) 1.56
Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Brain Res Mol Brain Res (1991) 1.44
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol (2006) 1.31
Does my mouse have Alzheimer's disease? Genes Brain Behav (2002) 1.28
Tauopathy with paired helical filaments in an aged chimpanzee. J Comp Neurol (2008) 1.27
Deposition of iron and beta-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. J Neurochem (2006) 1.26
Cellular and molecular biology of Alzheimer's disease and animal models. Annu Rev Med (1994) 1.24
Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging (2002) 1.21
Age-related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy. Aging Cell (2003) 1.19
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging (2006) 1.17
Transgenic mouse models of Alzheimer's disease: phenotype and application. Behav Pharmacol (2003) 1.15
The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? Traffic (2002) 1.14
Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging (1999) 1.13
Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem (1996) 1.11
The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins. Neurodegener Dis (2006) 1.11
Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging (2000) 1.10
Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology. J Nutr Health Aging (2006) 1.09
The canine as an animal model of human aging and dementia. Neurobiol Aging (1996) 1.08
Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease? Genes Brain Behav (2006) 1.07
Oxidative damage increases with age in a canine model of human brain aging. J Neurochem (2002) 1.07
Spatial learning and memory as a function of age in the dog. Behav Neurosci (1995) 1.07
Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neurosci Lett (1994) 1.06
Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex. Am J Pathol (1994) 1.05
Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog. Learn Mem (2002) 1.04
beta-Amyloid (A beta) deposition in the brains of aged orangutans. Neurobiol Aging (1997) 1.02
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging (2006) 1.01
A rabbit model of Alzheimer's disease: valid at neuropathological, cognitive, and therapeutic levels. J Alzheimers Dis (2007) 1.00
Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behav Brain Res (2000) 0.99
Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment. Genes Brain Behav (2008) 0.99
Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain Res (2006) 0.97
Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. J Am Vet Med Assoc (2001) 0.96
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.96
The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res (1997) 0.93
Transgenic mouse models for APP processing and Alzheimer's disease: early and late defects. Subcell Biochem (2005) 0.93
Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo. Neurochem Res (2003) 0.92
Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver. Curr Alzheimer Res (2007) 0.90
Vascular and parenchymal Abeta deposition in the aging dog: correlation with behavior. Neurobiol Aging (2000) 0.90
Neurofibrillary tangles in the cerebral cortex of sheep. Neurosci Lett (1994) 0.88
Effects of beta-amyloid protein on serotoninergic, noradrenergic, and cholinergic markers in neurons of the pontomesencephalic tegmentum in the rat. J Chem Neuroanat (2003) 0.88
Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development. Anal Bioanal Chem (2008) 0.87
Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.86
Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease? Rejuvenation Res (2008) 0.85
Age-related progression of tau pathology in brains of baboons. Neurobiol Aging (2001) 0.84
Dominance of amyloid precursor protein sequence over host cell secretases in determining beta-amyloid profiles studies of interspecies variation and drug action by internally standardized immunoprecipitation/mass spectrometry. J Pharmacol Exp Ther (2007) 0.83
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine (2006) 0.83
Ultrastructure of neurofibrillary tangles in the cerebral cortex of sheep. Neurobiol Aging (1995) 0.82
Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs. Biochem J (1996) 0.82
The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing. Neuroscience (2005) 0.82
Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mech Ageing Dev (2004) 0.81
Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm. Learn Mem (2003) 0.81
Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits. Acta Neuropathol (2006) 0.80
A beta-associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo). Neurobiol Aging (1996) 0.80
Canine cognitive deficit correlates with diffuse plaque maturation and S100beta (-) astrocytosis but not with insulin cerebrospinal fluid level. Acta Neuropathol (2006) 0.80
A retrospective study of canine senile plaques and cerebral amyloid angiopathy. Vet Pathol (1996) 0.80
Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging. Ann N Y Acad Sci (2007) 0.79
Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.79
Distribution of beta-amyloid in the canine brain. Neuroreport (1997) 0.79
Predicting behavioral changes associated with age-related cognitive impairment in dogs. J Am Vet Med Assoc (2001) 0.79
Familial influence on plaque formation in the beagle brain. Neuroreport (1992) 0.78
Dogs with canine counterpart of Alzheimer's disease lose noradrenergic neurons. Neurobiol Aging (2008) 0.78
Alzheimer's disease: molecular genetics and transgenic animal models. Behav Brain Res (1993) 0.78
Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age. J Chem Neuroanat (2005) 0.78
Alzheimer beta-amyloid precursor proteins display specific patterns of expression during embryogenesis. Mech Dev (2000) 0.77
Region- and cell-type-specific pattern of tau phosphorylation in dog brain. Brain Res (1998) 0.77
Beta APP gene expression is increased in the rat brain after motor neuron axotomy. Eur J Neurosci (1993) 0.76
Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. Am J Vet Res (2000) 0.76
Development of a gas chromatography-time-of-flight mass spectrometry method for the determination of buagafuran, a promising antianxiety drug in dog blood. J Pharm Biomed Anal (2008) 0.76
The immunohistochemical localization of neuronal nitric oxide synthase in the basal forebrain of the dog. J Chem Neuroanat (2006) 0.76
Subpopulation of dogs with severe brain parenchymal beta amyloidosis distinguished with cluster analysis. Brain Res (1996) 0.76
Several direct and calculated biomarkers from the amyloid-β pool in blood are associated with an increased likelihood of suffering from mild cognitive impairment. J Alzheimers Dis (2013) 0.85
Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease. Exp Gerontol (2011) 0.79
Beta-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog. J Comp Neurol (2009) 0.78
Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer's Disease. J Alzheimers Dis (2016) 0.78
Dogs with canine counterpart of Alzheimer's disease lose noradrenergic neurons. Neurobiol Aging (2008) 0.78
Identification of β-amyloid species in canine cerebrospinal fluid by mass spectrometry. Neurobiol Aging (2013) 0.78
Optimized protocol for amyloid-β extraction from the brain. J Alzheimers Dis (2013) 0.76
The immunohistochemical localization of neuronal nitric oxide synthase in the basal forebrain of the dog. J Chem Neuroanat (2006) 0.76
Validation of Immunoassay-Based Tools for the Comprehensive Quantification of Aβ40 and Aβ42 Peptides in Plasma. J Alzheimers Dis (2016) 0.75
Prevention of amyloid-β fibril formation using antibodies against the C-terminal region of amyloid-β1-40 and amyloid-β1-42. J Alzheimers Dis (2013) 0.75
Expression of p75(NTR), a marker for basal forebrain cholinergic neurons, in young and aged dogs with or without cognitive dysfunction syndrome. J Alzheimers Dis (2012) 0.75
Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains. J Alzheimers Dis (2017) 0.75