The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

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Published in EMBO J on December 01, 1991

Authors

M L Schmitz1, P A Baeuerle

Author Affiliations

1: Laboratorium für Molekulare Biologie, Ludwig-Maximillians-Universität München, Martinsried, FRG.

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Constitutive nuclear NF-kappa B in cells of the monocyte lineage. Biochem J (1994) 1.14

Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates. Methods (1997) 1.13

Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines. Br J Cancer (2005) 1.12

Endoplasmicreticulum-induced signal transduction and gene expression. Trends Cell Biol (1997) 1.11

The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B. Eur J Biochem (1995) 1.09

Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid. Biochem Biophys Res Commun (1996) 1.08

Distinct domains of the RelA NF-kappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor. J Biol Chem (1997) 1.07

Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter. Cytokine (1990) 1.05

Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway. J Biol Chem (1997) 1.05

Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. Mol Cell Biol (1994) 1.04

Transcriptome analysis reveals a role of interferon-gamma in human neointima formation. Mol Cell (2001) 1.02

Differential activation of transcription factors NF-kappa B and AP-1 in rat liver macrophages. Hepatology (1995) 1.01

Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B. Cell Growth Differ (1993) 1.01

Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model. Ann Rheum Dis (2008) 1.00

Transcription factor NF-kappa B is activated in microglia during experimental autoimmune encephalomyelitis. J Neuroimmunol (1994) 1.00

Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes. Mol Cell Biol (1991) 0.98

GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice. Ann Rheum Dis (2006) 0.96

Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct. Leukemia (2003) 0.96

The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K. Mol Cell Biol (1996) 0.94