Published in J Membr Biol on April 14, 2009
The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07
Identification of renal transporters involved in sulfate excretion in marine teleost fish. Am J Physiol Regul Integr Comp Physiol (2009) 1.52
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev (2013) 1.50
The SLC26 gene family of anion transporters and channels. Mol Aspects Med (2013) 1.50
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1. J Biol Chem (2009) 1.47
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. Nat Genet (2012) 1.26
Regulation of electroneutral NaCl absorption by the small intestine. Annu Rev Physiol (2011) 1.15
The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride. J Am Soc Nephrol (2014) 1.12
Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities. Hum Genet (2013) 1.10
Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain. J Biol Chem (2009) 1.08
Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct. Am J Physiol Cell Physiol (2010) 1.02
Identification of uterine ion transporters for mineralisation precursors of the avian eggshell. BMC Physiol (2012) 0.93
SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation. J Clin Invest (2012) 0.91
Anion transport by the cochlear motor protein prestin. J Physiol (2011) 0.90
Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans. EMBO J (2011) 0.90
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases. Mediators Inflamm (2015) 0.87
Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo. J Physiol (2013) 0.87
Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a Mendelian randomization study. Diabetes (2014) 0.83
Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3(-) transport and reduces survival in CFTR-deficient mice. Pflugers Arch (2014) 0.83
CFTR-SLC26 transporter interactions in epithelia. Biophys Rev (2012) 0.82
Deletion of the Cl-/HCO3- exchanger pendrin downregulates calcium-absorbing proteins in the kidney and causes calcium wasting. Nephrol Dial Transplant (2011) 0.80
The properties, functions, and pathophysiology of maxi-anion channels. Pflugers Arch (2016) 0.79
Variants in Solute Carrier SLC26A9 Modify Prenatal Exocrine Pancreatic Damage in Cystic Fibrosis. J Pediatr (2015) 0.79
Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H⁺-ATPase. Pflugers Arch (2013) 0.78
Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9. Hum Mutat (2012) 0.77
Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Cl- channels. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Primers on molecular pathways: bicarbonate transport by the pancreas. Pancreatology (2011) 0.76
Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators Inflamm (2016) 0.75
Extracellular Cl(-) regulates human SO4 (2-)/anion exchanger SLC26A1 by altering pH sensitivity of anion transport. Pflugers Arch (2016) 0.75
The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nat Genet (1992) 15.62
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs. Neuron (1992) 10.25
Prestin is the motor protein of cochlear outer hair cells. Nature (2000) 7.41
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Nature (2004) 5.54
Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet (1997) 4.43
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature (2005) 3.60
Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature (2005) 3.58
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch (2003) 3.04
Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter. Nature (1997) 2.57
The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet (1999) 2.32
Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis. Nature (2001) 2.19
Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell (2000) 2.15
Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol (2002) 2.14
Human pendrin expressed in Xenopus laevis oocytes mediates chloride/formate exchange. Am J Physiol Cell Physiol (2000) 2.13
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J (2002) 2.11
Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex. Am J Physiol Renal Physiol (2001) 2.08
Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A (2001) 2.00
Cloning and functional expression of rNBC, an electrogenic Na(+)-HCO3- cotransporter from rat kidney. Am J Physiol (1998) 1.86
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. J Biol Chem (2004) 1.71
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol (2003) 1.59
Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci U S A (1993) 1.58
Cation and voltage dependence of rat kidney electrogenic Na(+)-HCO(-)(3) cotransporter, rkNBC, expressed in oocytes. Am J Physiol (1999) 1.57
Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics (2000) 1.57
CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands. Am J Physiol (1999) 1.54
Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem (2002) 1.50
Downregulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea. Am J Physiol (1999) 1.47
Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J Biol Chem (1994) 1.46
Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger. J Biol Chem (2000) 1.43
Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. J Biol Chem (2000) 1.42
Immunolocalization of the electrogenic Na+-HCO-3 cotransporter in mammalian and amphibian kidney. Am J Physiol (1999) 1.40
Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet (1997) 1.39
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney. Am J Physiol (1998) 1.22
SLC26A7 is a Cl- channel regulated by intracellular pH. J Biol Chem (2004) 1.22
Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO3- salvage mechanisms in model systems and the mouse pancreatic duct. J Biol Chem (2001) 1.19
Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci U S A (2008) 1.18
CFTR induces the expression of DRA along with Cl(-)/HCO(3)(-) exchange activity in tracheal epithelial cells. Am J Physiol Cell Physiol (2000) 1.18
Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish. Am J Physiol Regul Integr Comp Physiol (2008) 1.17
SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Am J Physiol Cell Physiol (2005) 1.15
Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans. J Biol Chem (1998) 1.10
Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cells. Am J Physiol Gastrointest Liver Physiol (2001) 1.08
A family of mammalian anion transporters and their involvement in human genetic diseases. Hum Mol Genet (1999) 1.07
The congenital chloride diarrhea gene is expressed in seminal vesicle, sweat gland, inflammatory colon epithelium, and in some dysplastic colon cells. Histochem Cell Biol (2000) 1.03
Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells. Am J Physiol Gastrointest Liver Physiol (2003) 1.01
SLC26A2 (diastrophic dysplasia sulfate transporter) is expressed in developing and mature cartilage but also in other tissues and cell types. J Histochem Cytochem (2001) 0.99
Surfactant proteins in the digestive tract, mesentery, and other organs: evolutionary significance. Comp Biochem Physiol A Mol Integr Physiol (2001) 0.96
Localization of endogenous and recombinant Na(+)-driven anion exchanger protein NDAE1 from Drosophila melanogaster. Am J Physiol Cell Physiol (2001) 0.95
Physiology of electrogenic SLC26 paralogues. Novartis Found Symp (2006) 0.94
Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8). J Biol Chem (2007) 0.92
Isoforms of the Na-K-2Cl cotransporter in murine TAL I. Molecular characterization and intrarenal localization. Am J Physiol (1999) 0.89
Five tropical air-breathing fishes, six different strategies to defend against ammonia toxicity on land. Physiol Biochem Zool (2004) 0.84
Sulfate transport in chondrodysplasia. Ann N Y Acad Sci (1996) 0.80
Positional candidate genes for congenital chloride diarrhea suggested by high-resolution physical mapping in chromosome region 7q31. Genome Res (1996) 0.80
Pulmonary mechanoreceptors in the dipnoi lungfish Protopterus and Lepidosiren. Am J Physiol (1983) 0.77
Pathogenesis of gout. Ann Intern Med (2005) 4.50
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch (2003) 3.76
Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med (2009) 3.76
The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch (2003) 3.04
Roles of the cation-chloride cotransporters in neurological disease. Nat Clin Pract Neurol (2008) 2.19
Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol (2002) 2.14
Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci U S A (2011) 2.11
Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus (2002) 2.06
SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A (2003) 2.01
A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. J Biol Chem (2004) 1.71
Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflugers Arch (2003) 1.69
DASH-style diet and 24-hour urine composition. Clin J Am Soc Nephrol (2010) 1.65
Human and murine phenotypes associated with defects in cation-chloride cotransport. Annu Rev Physiol (2002) 1.61
Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol (2012) 1.59
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol (2004) 1.53
Identification of renal transporters involved in sulfate excretion in marine teleost fish. Am J Physiol Regul Integr Comp Physiol (2009) 1.52
The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet (2002) 1.51
The genetics of hyperuricaemia and gout. Nat Rev Rheumatol (2012) 1.47
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1. J Biol Chem (2009) 1.47
Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes. Pflugers Arch (2005) 1.46
Impact of bone lead and bone resorption on plasma and whole blood lead levels during pregnancy. Am J Epidemiol (2004) 1.40
WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc Natl Acad Sci U S A (2006) 1.33
Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. Brain Res Mol Brain Res (2002) 1.24
Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. Mol Pharmacol (2010) 1.21
Entry to "formula tunnel" revealed by SLC4A4 human mutation and structural model. J Biol Chem (2008) 1.20
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption. Am J Physiol Cell Physiol (2010) 1.20
Drosophila provides rapid modeling of renal development, function, and disease. Am J Physiol Renal Physiol (2010) 1.18
Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish. Am J Physiol Regul Integr Comp Physiol (2008) 1.17
Mechanism of acid adaptation of a fish living in a pH 3.5 lake. Am J Physiol Regul Integr Comp Physiol (2003) 1.17
Neurogenic role of the depolarizing chloride gradient revealed by global overexpression of KCC2 from the onset of development. J Neurosci (2008) 1.16
Regulation of electroneutral NaCl absorption by the small intestine. Annu Rev Physiol (2011) 1.15
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital. Am J Kidney Dis (2005) 1.14
Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions. J Biol Chem (2003) 1.14
Association of prevalent hypertension with 24-hour urinary excretion of calcium, citrate, and other factors. Am J Kidney Dis (2006) 1.13
Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1). Mol Vis (2006) 1.13
Genetics of gout. Curr Opin Rheumatol (2010) 1.12
The MgtC virulence factor of Salmonella enterica serovar Typhimurium activates Na(+),K(+)-ATPase. J Bacteriol (2006) 1.10
Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens (2007) 1.09
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet (2011) 1.09
Electroneutral cation-chloride cotransporters in the central nervous system. Neurochem Res (2004) 1.09
Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain. J Biol Chem (2009) 1.08
NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter. Am J Physiol Renal Physiol (2005) 1.06
A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport. J Biol Chem (2005) 1.06
2011 Recommendations for the diagnosis and management of gout and hyperuricemia. Postgrad Med (2011) 1.06
Activity of the renal Na+-K+-2Cl- cotransporter is reduced by mutagenesis of N-glycosylation sites: role for protein surface charge in Cl- transport. Am J Physiol Renal Physiol (2005) 1.05
Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. Am J Physiol Renal Physiol (2006) 1.04
The relationship between lead in plasma and whole blood in women. Environ Health Perspect (2002) 1.02
Renal urate transport. Rheum Dis Clin North Am (2006) 1.01
Conformational changes in a pore-lining helix coupled to cystic fibrosis transmembrane conductance regulator channel gating. J Biol Chem (2007) 1.01
cAMP-dependent activation of the renal-specific Na+-K+-2Cl- cotransporter is mediated by regulation of cotransporter trafficking. Am J Physiol Renal Physiol (2003) 0.97
The molecular physiology of uric acid homeostasis. Annu Rev Physiol (2014) 0.96
The independent association between serum uric acid and graft outcomes after kidney transplantation. Transplantation (2010) 0.96
Physiology of electrogenic SLC26 paralogues. Novartis Found Symp (2006) 0.94
Expression and regulation of the vitamin D receptor in the zebrafish, Danio rerio. J Bone Miner Res (2008) 0.94
Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater. Am J Physiol Regul Integr Comp Physiol (2005) 0.94
Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu. Epigenomics (2013) 0.92
Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8). J Biol Chem (2007) 0.92
Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion. Cancer Res (2009) 0.92
The independent association between parathyroid hormone levels and hyperuricemia: a national population study. Arthritis Res Ther (2012) 0.92
Drosophila melanogaster as an emerging translational model of human nephrolithiasis. J Urol (2013) 0.91
Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans. EMBO J (2011) 0.90
In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol (2012) 0.89
Similar effects of all WNK3 variants on SLC12 cotransporters. Am J Physiol Cell Physiol (2011) 0.89
Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain. Genetics (2009) 0.88
Cloning, localization, and functional expression of the electrogenic Na+ bicarbonate cotransporter (NBCe1) from zebrafish. Am J Physiol Cell Physiol (2009) 0.87
Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4. J Biol Chem (2010) 0.87
ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye. Invest Ophthalmol Vis Sci (2011) 0.87
Frequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretion. PLoS One (2013) 0.87
NHE3 in an ancestral vertebrate: primary sequence, distribution, localization, and function in gills. Am J Physiol Regul Integr Comp Physiol (2005) 0.86
The Thellungiella salsuginea tonoplast aquaporin TsTIP1;2 functions in protection against multiple abiotic stresses. Plant Cell Physiol (2013) 0.86
Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation. J Immunol (2010) 0.86
Membrane trafficking and the regulation of NKCC2. Am J Physiol Renal Physiol (2006) 0.86
Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain. J Neurosci (2012) 0.85