Integrated studies of biology: multiplexed imaging assays from molecules to man and back.

PubWeight™: 0.85‹?›

🔗 View Article (PMID 19394811)

Published in Curr Opin Biotechnol on April 24, 2009

Authors

Kevin W Eliceiri, Christopher H Contag

Articles by these authors

(truncated to the top 100)

NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics (2011) 12.98

Metadata matters: access to image data in the real world. J Cell Biol (2010) 12.49

Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med (2006) 6.44

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature (2004) 5.61

Collagen density promotes mammary tumor initiation and progression. BMC Med (2008) 5.13

Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy. Nat Med (2008) 4.83

In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia. Proc Natl Acad Sci U S A (2007) 4.53

Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A (2003) 4.41

Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol (2004) 4.16

Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol (2011) 3.70

Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J (2008) 3.49

Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood (2006) 3.33

Dual-axis confocal microscope for high-resolution in vivo imaging. Opt Lett (2003) 3.16

In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood (2005) 3.13

Bioimage informatics for experimental biology. Annu Rev Biophys (2009) 3.04

Open source bioimage informatics for cell biology. Trends Cell Biol (2009) 2.93

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89

Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging. Blood (2002) 2.79

Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo. J Biomed Opt (2005) 2.69

Extracellular replication of Listeria monocytogenes in the murine gall bladder. Science (2004) 2.58

Chemical control of protein stability and function in living mice. Nat Med (2008) 2.37

Synergistic antitumor effects of immune cell-viral biotherapy. Science (2006) 2.37

Multiphoton microscopy of endogenous fluorescence differentiates normal, precancerous, and cancerous squamous epithelial tissues. Cancer Res (2005) 2.28

Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation (2008) 2.22

Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging. Photochem Photobiol (2002) 2.18

Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia. J Biomed Opt (2006) 2.17

Metabolic mapping of MCF10A human breast cells via multiphoton fluorescence lifetime imaging of the coenzyme NADH. Cancer Res (2005) 2.15

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. Nat Med (2011) 2.12

In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia. J Biomed Opt (2007) 2.09

In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease. Nat Rev Immunol (2006) 2.06

Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner. Opt Lett (2007) 2.06

Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture. J Biomed Opt (2008) 1.99

Optical monitoring and treatment of potentially lethal wound infections in vivo. J Infect Dis (2003) 1.98

Guided by the light: visualizing biomolecular processes in living animals with bioluminescence. Curr Opin Chem Biol (2009) 1.97

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol (2013) 1.93

Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium. Stem Cells (2007) 1.93

Design and evaluation of a variable aperture collimator for conformal radiotherapy of small animals using a microCT scanner. Med Phys (2007) 1.90

In vivo bioluminescence imaging for integrated studies of infection. Cell Microbiol (2004) 1.89

In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood (2006) 1.89

OpenSPIM: an open-access light-sheet microscopy platform. Nat Methods (2013) 1.88

Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathology. Clin Gastroenterol Hepatol (2007) 1.85

Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Transplantation (2005) 1.82

Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol (2008) 1.82

In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury. FASEB J (2005) 1.80

Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation (2009) 1.73

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters. Proc Natl Acad Sci U S A (2008) 1.71

Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors. Blood (2008) 1.70

Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1. J Mol Med (Berl) (2002) 1.70

Development of therapeutic siRNAs for pachyonychia congenita. J Invest Dermatol (2007) 1.67

Luciferin derivatives for enhanced in vitro and in vivo bioluminescence assays. Biochemistry (2006) 1.67

Generic and personalized RNAi-based therapeutics for a dominant-negative epidermal fragility disorder. J Invest Dermatol (2012) 1.66

Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment. Clin Exp Metastasis (2008) 1.51

In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract. J Biomed Opt (2012) 1.49

Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood (2007) 1.48

Optical workstation with concurrent, independent multiphoton imaging and experimental laser microbeam capabilities. Rev Sci Instrum (2003) 1.48

Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell (2009) 1.47

Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. J Invest Dermatol (2007) 1.46

Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice. Am J Pathol (2009) 1.44

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integr Biol (Camb) (2010) 1.41

A call for bioimaging software usability. Nat Methods (2012) 1.39

Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol (2005) 1.39

Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials (2009) 1.37

p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J Immunol (2004) 1.36

Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope. Opt Express (2008) 1.35

Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation. Bioconjug Chem (2006) 1.35

Quantifying cell-surface biomarker expression in thick tissues with ratiometric three-dimensional microscopy. Biophys J (2009) 1.33

Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase. Development (2007) 1.33

Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease. Blood (2006) 1.31

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. J Clin Invest (2005) 1.31

Animal models of bone metastasis. Cancer (2003) 1.29

Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection. Opt Lett (2003) 1.29

Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery. J Biomed Opt (2010) 1.27

Enhancing poxvirus oncolytic effects through increased spread and immune evasion. Cancer Res (2008) 1.26

Monitoring age-related susceptibility of young mice to oral Salmonella enterica serovar Typhimurium infection using an in vivo murine model. Pediatr Res (2005) 1.26

Evaluation of effector cell fate and function by in vivo bioluminescence imaging. Methods (2003) 1.25

Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation, osteoclast recruitment, and bone turnover. Tissue Eng (2005) 1.23

Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release. J Am Chem Soc (2006) 1.23

VisBio: a computational tool for visualization of multidimensional biological image data. Traffic (2004) 1.22

Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. Blood (2002) 1.21

Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapine. J Infect Dis (2005) 1.20

Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study. Clin Cancer Res (2006) 1.20

A Raman-based endoscopic strategy for multiplexed molecular imaging. Proc Natl Acad Sci U S A (2013) 1.18

Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning. J Biomed Opt (2004) 1.16

Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Mol Imaging (2004) 1.16

Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy. Proc Natl Acad Sci U S A (2007) 1.16

Targeting localized immune suppression within the tumor through repeat cycles of immune cell-oncolytic virus combination therapy. Mol Ther (2010) 1.15

Simultaneous two-photon spectral and lifetime fluorescence microscopy. Appl Opt (2004) 1.15

Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells. J Biol Chem (2013) 1.15

Visualization approaches for multidimensional biological image data. Biotechniques (2007) 1.15

Microtubules regulate GEF-H1 in response to extracellular matrix stiffness. Mol Biol Cell (2012) 1.14

In vivo micro-image mosaicing. IEEE Trans Biomed Eng (2010) 1.14

Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer. J Biomed Opt (2008) 1.14

Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast. Cell Biochem Biophys (2009) 1.13

Induced biliary excretion of Listeria monocytogenes. Infect Immun (2006) 1.13

Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice. Proc Natl Acad Sci U S A (2007) 1.12

Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther (2003) 1.12

The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals. J Immunol (2009) 1.11

Point-of-care pathology with miniature microscopes. Anal Cell Pathol (Amst) (2011) 1.11

Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells. Blood (2009) 1.10