Published in J Leukoc Biol on April 24, 2009
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood (2012) 2.10
Renal cortical hemopexin accumulation in response to acute kidney injury. Am J Physiol Renal Physiol (2012) 1.59
Animal models of sepsis. Virulence (2013) 1.22
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill. Physiol Rev (2015) 1.20
Editorial: Hemopexin: newest member of the anti-inflammatory mediator club. J Leukoc Biol (2009) 1.17
Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. J Biol Chem (2010) 1.15
Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin. J Infect Dis (2010) 1.14
Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development. Front Physiol (2014) 1.10
Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation. J Immunol (2012) 1.07
Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg (2010) 1.06
Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. J Immunol (2010) 0.93
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood (2015) 0.90
An alternative view of the proposed alternative activities of hemopexin. Protein Sci (2011) 0.88
Hepatocytes: a key cell type for innate immunity. Cell Mol Immunol (2015) 0.86
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders. Front Physiol (2015) 0.85
Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasis. Oxid Med Cell Longev (2013) 0.84
Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics. Biomaterials (2014) 0.80
Dengue-2 structural proteins associate with human proteins to produce a coagulation and innate immune response biased interactome. BMC Infect Dis (2011) 0.80
Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states. J Neurochem (2013) 0.80
Inflammatory targets of therapy in sickle cell disease. Transl Res (2015) 0.80
Elevated cytokines, thrombin and PAI-1 in severe HCPS patients due to Sin Nombre virus. Viruses (2015) 0.80
Hemopexin decreases hemin accumulation and catabolism by neural cells. Neurochem Int (2012) 0.79
Potential plasma biomarkers for progression of knee osteoarthritis using glycoproteomic analysis coupled with a 2D-LC-MALDI system. Proteome Sci (2012) 0.78
Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children. Malar J (2015) 0.78
Identification of reduced circulating haptoglobin concentration as a biomarker of the severity of pulmonary embolism: a nontargeted proteomic study. PLoS One (2014) 0.78
Emergence of the acute-phase protein hemopexin in jawed vertebrates. Mol Immunol (2010) 0.76
Hemopexin: anti-inflammatory, pro-inflammatory, or both? J Leukoc Biol (2010) 0.76
Role of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases. Curr Opin Lipidol (2015) 0.75
Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells. Circulation (2016) 0.75
Peroxisome Proliferator-Activated Receptor γ Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung. Am J Respir Cell Mol Biol (2017) 0.75
Turbot (Scophthalmus maximus) vs. VHSV (Viral Hemorrhagic Septicemia Virus): A Review. Front Physiol (2016) 0.75
Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cells. Biochem Biophys Rep (2017) 0.75
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
Lipopolysaccharide endotoxins. Annu Rev Biochem (2001) 18.88
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
Toll-like receptors in innate immunity. Int Immunol (2005) 12.24
Structure and function of lipopolysaccharide binding protein. Science (1990) 7.76
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med (2000) 6.32
Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med (2002) 6.00
Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol (2003) 5.34
Novel strategies for the treatment of sepsis. Nat Med (2003) 5.14
THE ROLE OF ENDOTOXIN IN THE EXTRACELLULAR COAGULATION OF LIMULUS BLOOD. Bull Johns Hopkins Hosp (1964) 4.81
TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest (2007) 4.77
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med (2002) 3.91
Animal models of sepsis: setting the stage. Nat Rev Drug Discov (2005) 3.63
Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med (1996) 3.61
Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol (2000) 3.10
Characterization of heme as activator of Toll-like receptor 4. J Biol Chem (2007) 2.38
MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol (2007) 2.26
Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest (2008) 2.04
Identification of the receptor scavenging hemopexin-heme complexes. Blood (2005) 1.97
Hemoglobin infusion augments the tumor necrosis factor response to bacterial endotoxin (lipopolysaccharide) in mice. Crit Care Med (1999) 1.87
Hemopexin: structure, function, and regulation. DNA Cell Biol (2002) 1.75
Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells. Immunol Res (2007) 1.63
Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J Biol Chem (1995) 1.54
Detoxifying endotoxin: time, place and person. J Endotoxin Res (2005) 1.51
The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. Immunobiology (1993) 1.48
Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages. J Immunol (2002) 1.47
Hyperthermia protects mice against the lethal effects of endotoxin. Am J Physiol (1993) 1.39
Turbidimetric method for quantifying serum inhibition of Limulus amoebocyte lysate. J Clin Microbiol (1985) 1.30
Neutralization of bacterial lipopolysaccharides by human plasma. J Clin Microbiol (1985) 1.25
Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. J Biol Chem (2002) 1.23
Lipopolysaccharide (LPS)-binding proteins BPI and LBP form different types of complexes with LPS. J Biol Chem (1997) 1.17
Hemopexin. Methods Enzymol (1988) 1.07
Hemoglobin increases mortality from bacterial endotoxin. Infect Immun (1997) 1.02
Role of plasma, lipopolysaccharide-binding protein, and CD14 in response of mouse peritoneal exudate macrophages to endotoxin. Infect Immun (2001) 0.94
Hemoglobin and LPS act in synergy to amplify the inflammatory response. J Dent Res (2007) 0.88
Increased burn-induced immunosuppression in lipopolysaccharide-resistant mice. Cell Immunol (2000) 0.88
Free hemoglobin enhances tumor necrosis factor-alpha production in isolated human monocytes. J Trauma (2002) 0.85
Hemopexin levels in mice. Int J Immunopharmacol (1984) 0.82
Hemopexins suppress phorbol ester-induced necrosis of polymorphonuclear leucocytes. Cell Struct Funct (2001) 0.81
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
Septic shock. Lancet (2005) 6.67
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome. Circulation (2002) 3.16
Acute inflammatory response to endotoxin in mice and humans. Clin Diagn Lab Immunol (2005) 2.47
Compensatory anti-inflammatory response syndrome. Thromb Haemost (2009) 2.31
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol (2007) 2.26
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A (2008) 1.97
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med (2013) 1.94
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol (2005) 1.90
Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Proc Natl Acad Sci U S A (2013) 1.89
Prevalence and outcomes of antimicrobial treatment for Staphylococcus aureus bacteremia in outpatients with ESRD. J Am Soc Nephrol (2012) 1.77
Resilience to bacterial infection: difference between species could be due to proteins in serum. J Infect Dis (2010) 1.73
Does the shape of lipid A determine the interaction of LPS with Toll-like receptors? Trends Immunol (2002) 1.72
Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*. Crit Care Med (2012) 1.49
Low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection. Am J Respir Crit Care Med (2014) 1.45
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol (2010) 1.44
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27
Natural killer (NK) cells in antibacterial innate immunity: angels or devils? Mol Med (2012) 1.25
Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Lett (2007) 1.24
Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. J Biol Chem (2002) 1.23
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology (2012) 1.20
Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Crit Care Med (2006) 1.19
Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infect Immun (2006) 1.19
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis (2011) 1.18
Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol (2010) 1.17
A role for intestinal alkaline phosphatase in the maintenance of local gut immunity. Dig Dis Sci (2010) 1.17
Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2003) 1.16
Corticosteroids in sepsis: from bench to bedside? Shock (2003) 1.15
Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide. J Infect Dis (2005) 1.15
Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin. J Infect Dis (2010) 1.14
LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation. J Biol Chem (2006) 1.12
Compartmentalization of tolerance to endotoxin. J Infect Dis (2004) 1.12
Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation. Am J Respir Crit Care Med (2003) 1.11
The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response. Infect Immun (2012) 1.09
Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection. Shock (2007) 1.09
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis. BMC Microbiol (2010) 1.07
Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation. J Immunol (2012) 1.07
Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury. Ann Surg (2009) 1.06
Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability. Am J Pathol (2007) 1.06
Untranslated regions of a mobile transcript mediate RNA metabolism. Plant Physiol (2009) 1.06
DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients. PLoS One (2012) 1.03
Editorial: Mouse models to study sepsis syndrome in humans. J Leukoc Biol (2009) 1.02
Bench-to-bedside review: Platelets and active immune functions - new clues for immunopathology? Crit Care (2013) 1.02
Occurrence and distribution of organochlorine pesticides (OCPs) in surface sediments of the Bohai Sea, China. Chemosphere (2009) 1.02
Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia. Microbes Infect (2010) 1.00
Early events in innate immunity in the recognition of microbial pathogens. Expert Opin Biol Ther (2007) 1.00
Neutrophils in cystic fibrosis display a distinct gene expression pattern. Mol Med (2008) 1.00
Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors. Int Immunol (2003) 0.99
Identification of residues essential for carbohydrate recognition by the insulin-like growth factor II/mannose 6-phosphate receptor. J Biol Chem (2002) 0.99
Toll-like receptors expression and interferon-γ production by NK cells in human sepsis. Crit Care (2012) 0.98
Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate. Am J Physiol Gastrointest Liver Physiol (2013) 0.98
Identification and interpretation of longitudinal gene expression changes in trauma. PLoS One (2010) 0.98
Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women. Age (Dordr) (2011) 0.98
Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation. Crit Care (2010) 0.97
High-resolution depositional records of polycyclic aromatic hydrocarbons in the central continental shelf mud of the East China Sea. Environ Sci Technol (2006) 0.97
[Validation of a Chinese version of the child perception questionnaire]. Hua Xi Kou Qiang Yi Xue Za Zhi (2008) 0.94
The Bw cells, a novel B cell population conserved in the whole genus Mus. J Immunol (2007) 0.93
NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis. J Immunol (2012) 0.92
Simple method for repurification of endotoxins for biological use. Appl Environ Microbiol (2007) 0.92
Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB. J Cell Mol Med (2007) 0.91
Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes. Innate Immun (2009) 0.89
Adherence influences monocyte responsiveness to interleukin-10. J Leukoc Biol (2003) 0.89
Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice. J Infect Dis (2011) 0.88
CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis. J Immunol (2014) 0.88
Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides. J Infect Dis (2003) 0.87
Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment. Acta Neuropathol (2013) 0.86
Phloem-mobile messenger RNAs and root development. Front Plant Sci (2013) 0.86
Immune status and apoptosis activation during brain death. Shock (2010) 0.86
Angiogenin mediates androgen-stimulated prostate cancer growth and enables castration resistance. Mol Cancer Res (2013) 0.85
Adherence modifies the regulation of gene expression induced by interleukin-10. Cytokine (2005) 0.85
The BEL1-like family of transcription factors in potato. J Exp Bot (2014) 0.85
Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects. Vaccine (2003) 0.85
Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10. Cytokine (2007) 0.84
Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING). J Biol Chem (2013) 0.84
Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes. Am J Physiol Cell Physiol (2011) 0.84
Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock. J Infect Dis (2004) 0.84
Translocation of bacterial NOD2 agonist and its link with inflammation. Crit Care (2009) 0.84
Distribution and mass inventory of polycyclic aromatic hydrocarbons in the sediments of the south Bohai Sea, China. Mar Pollut Bull (2010) 0.84
Occurrence and sources of polycyclic aromatic hydrocarbons and n-alkanes in PM(2.5) in the roadside environment of a major city in China. J Hazard Mater (2009) 0.84
Case records of the Massachusetts General Hospital. Case 19-2012. A premature newborn boy with respiratory distress. N Engl J Med (2012) 0.83
VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever. Hum Vaccin Immunother (2014) 0.83
Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice. J Gastrointest Surg (2011) 0.83
Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry (2010) 0.83
Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells. Infect Immun (2004) 0.83
Human genetics: an inflammatory issue. Nature (2004) 0.82
Host response biomarkers in the diagnosis of sepsis: a general overview. Methods Mol Biol (2015) 0.82
Polybrominated diphenyl ethers (PBDEs) in sediments of the coastal East China Sea: occurrence, distribution and mass inventory. Environ Pollut (2012) 0.82
Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis. Mol Med (2007) 0.81
Reply to Osterburg et al.: To study human inflammatory diseases in humans. Proc Natl Acad Sci U S A (2013) 0.81
High-throughput continuous hydrothermal flow synthesis of Zn-Ce oxides: unprecedented solubility of Zn in the nanoparticle fluorite lattice. Philos Trans A Math Phys Eng Sci (2010) 0.81
Richard Pfeiffer and Alexandre Besredka: creators of the concept of endotoxin and anti-endotoxin. Microbes Infect (2003) 0.81