Published in Annu Rev Genomics Hum Genet on January 01, 2009
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Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genet (2011) 1.29
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Short telomeres compromise β-cell signaling and survival. PLoS One (2011) 1.17
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Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem (2009) 1.17
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Telomerase at the intersection of cancer and aging. Trends Genet (2013) 1.16
Telomerase mutations in smokers with severe emphysema. J Clin Invest (2014) 1.11
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RNA-protein binding interface in the telomerase ribonucleoprotein. Proc Natl Acad Sci U S A (2011) 1.06
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The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Res (2009) 1.05
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Aging, antagonistic pleiotropy and fibrotic disease. Int J Biochem Cell Biol (2010) 1.01
The gastrointestinal manifestations of telomere-mediated disease. Aging Cell (2013) 1.00
Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk. Cancer Epidemiol Biomarkers Prev (2012) 1.00
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol (2017) 1.00
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The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures. Nucleic Acids Res (2015) 0.97
Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis. Chest (2015) 0.97
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase. Nucleic Acids Res (2009) 0.97
Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Clin Sci (Lond) (2015) 0.95
Telomeres and immune competency. Curr Opin Immunol (2012) 0.94
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Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step. Proc Natl Acad Sci U S A (2011) 0.92
A Cajal body-independent pathway for telomerase trafficking in mice. Exp Cell Res (2010) 0.91
A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes Dev (2014) 0.91
The molecular genetics of the telomere biology disorders. RNA Biol (2015) 0.91
Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study. Aging (Albany NY) (2014) 0.91
Molecular regulation of telomerase activity in aging. Protein Cell (2011) 0.90
Regulated assembly and disassembly of the yeast telomerase quaternary complex. Genes Dev (2014) 0.88
The role of telomeres in the ageing of human skin. Exp Dermatol (2011) 0.87
Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies. Curr Pharmacogenomics Person Med (2010) 0.87
The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements. RNA (2012) 0.86
Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase. Histochem Cell Biol (2013) 0.85
Investigation of Telomerase/Telomeres system in Bone Marrow Mesenchymal Stem Cells derived from IPF and RA-UIP. J Inflamm (Lond) (2012) 0.85
Mechanisms of pulmonary fibrosis: role of activated myofibroblasts and NADPH oxidase. Fibrogenesis Tissue Repair (2012) 0.85
Telomere and telomerase in chronic liver disease and hepatocarcinoma. World J Gastroenterol (2014) 0.85
Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Sci Transl Med (2016) 0.85
Telomere length homeostasis responds to changes in intracellular dNTP pools. Genetics (2013) 0.84
Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response. Am J Physiol Lung Cell Mol Physiol (2011) 0.84
The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita. Hum Mol Genet (2011) 0.83
Hereditary genodermatoses with cancer predisposition. Hematol Oncol Clin North Am (2010) 0.83
ATM controls proper mitotic spindle structure. Cell Cycle (2014) 0.83
Telomere Length as an Indicator of the Robustness of B- and T-Cell Response to Influenza in Older Adults. J Infect Dis (2015) 0.83
Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death. Nucleic Acids Res (2015) 0.83
Medical genetics and epigenetics of telomerase. J Cell Mol Med (2011) 0.82
Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin. Nucleic Acids Res (2011) 0.82
Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways. Clin Transl Med (2016) 0.81
Therapeutic opportunities: telomere maintenance in inducible pluripotent stem cells. Mutat Res (2011) 0.81
Regulating telomere length from the inside out: the replication fork model. Genes Dev (2016) 0.81
Worldwide genetic structure in 37 genes important in telomere biology. Heredity (Edinb) (2011) 0.81
Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability. DNA Repair (Amst) (2010) 0.81
Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations. Ann N Y Acad Sci (2014) 0.81
Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia. Cancers (Basel) (2013) 0.80
Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast. Aging Cell (2013) 0.80
Telomerase and retrotransposons: reverse transcriptases that shaped genomes. Proc Natl Acad Sci U S A (2011) 0.80
Telomere end processing: unexpected complexity at the end game. Genes Dev (2012) 0.79
I walk the line: how to tell MDS from other bone marrow failure conditions. Curr Hematol Malig Rep (2014) 0.79
Telomerase reverse transcriptase and Wnt signaling. Mol Cell Biol (2011) 0.78
Insights into the evolution of mammalian telomerase: platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes. BMC Genomics (2012) 0.78
TeloPIN: a database of telomeric proteins interaction network in mammalian cells. Database (Oxford) (2015) 0.77
The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev (2017) 0.77
The challenging world of cytopenias: distinguishing myelodysplastic syndromes from other disorders of marrow failure. Oncologist (2014) 0.77
A sequence-dependent exonuclease activity from Tetrahymena thermophila. BMC Biochem (2010) 0.76
Characterization of population-based variation and putative functional elements for the multiple-cancer susceptibility loci at 5p15.33. F1000Res (2014) 0.75
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Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
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Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature (2001) 7.95
A telomerase component is defective in the human disease dyskeratosis congenita. Nature (1999) 7.91
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (2000) 7.28
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Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci U S A (2005) 4.64
Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat Genet (2004) 4.63
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TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12
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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet (2000) 2.34
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood (2003) 2.29
Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis. Cancer Res (2002) 2.24
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