Published in FASEB J on May 05, 2009
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev (2010) 2.09
PredictProtein--an open resource for online prediction of protein structural and functional features. Nucleic Acids Res (2014) 2.00
Disease-related mutations predicted to impact protein function. BMC Genomics (2012) 0.96
Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist. Biochemistry (2010) 0.92
HeatMapViewer: interactive display of 2D data in biology. F1000Res (2014) 0.88
Evidence of trem2 variant associated with triple risk of Alzheimer's disease. PLoS One (2014) 0.81
Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR. Nat Chem Biol (2012) 0.79
Molecular Analysis of Factor VIII and Factor IX Genes in Hemophilia Patients: Identification of Novel Mutations and Molecular Dynamics Studies. J Clin Med Res (2017) 0.75
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. Front Pharmacol (2016) 0.75
Functional alterations due to amino acid changes and evolutionary comparative analysis of ARPKD and ADPKD genes. Genom Data (2016) 0.75
Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling. Hum Mutat (2017) 0.75
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci U S A (1992) 61.33
The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res (2003) 52.80
Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct (2000) 17.81
SNAP predicts effect of mutations on protein function. Bioinformatics (2008) 15.39
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J Mol Biol (1990) 13.72
Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. J Mol Biol (1992) 11.97
Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 11.35
Twilight zone of protein sequence alignments. Protein Eng (1999) 9.83
SNAP: predict effect of non-synonymous polymorphisms on function. Nucleic Acids Res (2007) 8.46
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med (2003) 6.87
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature (1994) 3.70
PHAT: a transmembrane-specific substitution matrix. Predicted hydrophobic and transmembrane. Bioinformatics (2000) 3.66
Critical assessment of methods of protein structure prediction-Round VII. Proteins (2007) 3.23
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest (2000) 3.10
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol (2003) 3.05
The Protein Mutant Database. Nucleic Acids Res (1999) 2.87
Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet (2004) 2.17
Comprehensive in silico mutagenesis highlights functionally important residues in proteins. Bioinformatics (2008) 1.74
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest (2004) 1.55
The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling. J Biol Chem (1998) 1.54
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity. J Clin Endocrinol Metab (2004) 1.50
Beyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery. Drug Discov Today (2005) 1.46
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry (2006) 1.42
Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet (2008) 1.30
Automated protein structure homology modeling: a progress report. Pharmacogenomics (2004) 1.19
Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants. Biochemistry (2001) 1.19
Membrane protein prediction methods. Methods (2007) 1.17
Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Peptides (2005) 1.13
Molecular basis for the interaction of [Nle4,D-Phe7]melanocyte stimulating hormone with the human melanocortin-1 receptor. J Biol Chem (1997) 1.13
Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects. J Clin Endocrinol Metab (2005) 1.10
Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Mol Cell Endocrinol (2005) 1.10
Agouti and agouti-related protein: analogies and contrasts. J Biol Chem (2000) 1.08
Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications. Pharmacol Ther (2006) 1.07
Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity. J Biol Chem (2003) 1.07
Constitutive traffic of melanocortin-4 receptor in Neuro2A cells and immortalized hypothalamic neurons. J Biol Chem (2006) 1.04
Inverse agonist activity of agouti and agouti-related protein. Peptides (2003) 1.03
Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor. Endocrinology (2008) 0.98
Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling. J Biol Chem (2007) 0.97
Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry (2005) 0.90
A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans. J Clin Endocrinol Metab (2004) 0.90
Inverse agonism gains weight. Trends Pharmacol Sci (2003) 0.90
Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist. Biochem Biophys Res Commun (2001) 0.89
Molecular determinants of melanocortin 4 receptor ligand binding and MC4/MC3 receptor selectivity. J Pharmacol Exp Ther (2003) 0.89
Activation of the melanocortin-4 receptor mobilizes intracellular free calcium in immortalized hypothalamic neurons. J Surg Res (2006) 0.89
Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma. Arch Dermatol Res (2006) 0.87
Structural and signaling requirements of the human melanocortin 4 receptor for MAP kinase activation. Regul Pept (2007) 0.87
The role of the DRY motif of human MC4R for receptor activation. Biosci Biotechnol Biochem (2004) 0.87
Cell surface expression of the melanocortin-4 receptor is dependent on a C-terminal di-isoleucine sequence at codons 316/317. J Biol Chem (2003) 0.86
Molecular basis of melanocortin-4 receptor for AGRP inverse agonism. Regul Pept (2006) 0.85
Molecular determination of agouti-related protein binding to human melanocortin-4 receptor. Mol Pharmacol (2003) 0.84
Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity. Biochem Biophys Res Commun (2007) 0.83
Gene polymorphisms and their effects in the melanocortin system. Peptides (2005) 0.82
Evidence for the interaction of protein kinase C and melanocortin 3-receptor signaling pathways. Neuropeptides (2003) 0.81
Unusual genomic structure: melanocortin receptors in Fugu. Ann N Y Acad Sci (2005) 0.79
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
SNAP predicts effect of mutations on protein function. Bioinformatics (2008) 15.39
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
SNAP: predict effect of non-synonymous polymorphisms on function. Nucleic Acids Res (2007) 8.46
Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature (2005) 6.43
Medical sequencing at the extremes of human body mass. Am J Hum Genet (2007) 5.61
Improving the prediction of protein secondary structure in three and eight classes using recurrent neural networks and profiles. Proteins (2002) 5.29
The long-term stability of the human gut microbiota. Science (2013) 5.15
A large-scale evaluation of computational protein function prediction. Nat Methods (2013) 4.61
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet (2011) 4.52
A statistical approach for array CGH data analysis. BMC Bioinformatics (2005) 4.05
Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Critical assessment of methods of protein structure prediction-Round VII. Proteins (2007) 3.23
Mimicking cellular sorting improves prediction of subcellular localization. J Mol Biol (2005) 3.21
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10
Three-dimensional structures of membrane proteins from genomic sequencing. Cell (2012) 3.02
Analysing six types of protein-protein interfaces. J Mol Biol (2003) 2.96
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 2.76
Critical assessment of methods of protein structure prediction (CASP)--round 6. Proteins (2005) 2.58
Alignments grow, secondary structure prediction improves. Proteins (2002) 2.56
EVA: Evaluation of protein structure prediction servers. Nucleic Acids Res (2003) 2.50
Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest (2008) 2.44
Reliability of assessment of protein structure prediction methods. Structure (2002) 2.39
Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance. Diabetes (2004) 2.36
Sequence conserved for subcellular localization. Protein Sci (2002) 2.36
Automatic target selection for structural genomics on eukaryotes. Proteins (2004) 2.34
Outcome of a workshop on archiving structural models of biological macromolecules. Structure (2006) 2.32
The protein target list of the Northeast Structural Genomics Consortium. Proteins (2004) 2.31
Transmembrane helix predictions revisited. Protein Sci (2002) 2.28
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol (2003) 2.28
Critical assessment of methods of protein structure prediction - Round VIII. Proteins (2009) 2.25
Protein-protein interaction hotspots carved into sequences. PLoS Comput Biol (2007) 2.15
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr (2008) 2.13
PROFbval: predict flexible and rigid residues in proteins. Bioinformatics (2006) 2.04
Domains, motifs and clusters in the protein universe. Curr Opin Chem Biol (2003) 2.02
Transanal hemorrhoidal dearterialization: a systematic review. Dis Colon Rectum (2009) 2.01
Predicted protein-protein interaction sites from local sequence information. FEBS Lett (2003) 2.00
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med (2009) 1.99
Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med (2002) 1.97
Loopy proteins appear conserved in evolution. J Mol Biol (2002) 1.96
PSI-2: structural genomics to cover protein domain family space. Structure (2009) 1.92
Protein names precisely peeled off free text. Bioinformatics (2004) 1.87
Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab (2006) 1.84
Predicting transmembrane beta-barrels in proteomes. Nucleic Acids Res (2004) 1.83
Distinguishing protein-coding from non-coding RNAs through support vector machines. PLoS Genet (2006) 1.81
NLSdb: database of nuclear localization signals. Nucleic Acids Res (2003) 1.81
PROFcon: novel prediction of long-range contacts. Bioinformatics (2005) 1.81
UniqueProt: Creating representative protein sequence sets. Nucleic Acids Res (2003) 1.78
Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data. Nat Biotechnol (2009) 1.78
Comprehensive in silico mutagenesis highlights functionally important residues in proteins. Bioinformatics (2008) 1.74
Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73
Prediction of DNA-binding residues from sequence. Bioinformatics (2007) 1.72
ISIS: interaction sites identified from sequence. Bioinformatics (2007) 1.71
Epitome: database of structure-inferred antigenic epitopes. Nucleic Acids Res (2006) 1.70
To eat or not to eat - how the gut talks to the brain. N Engl J Med (2003) 1.68
Improved disorder prediction by combination of orthogonal approaches. PLoS One (2009) 1.63
Continuum secondary structure captures protein flexibility. Structure (2002) 1.63
Better prediction of sub-cellular localization by combining evolutionary and structural information. Proteins (2003) 1.61
Protein-protein interactions more conserved within species than across species. PLoS Comput Biol (2006) 1.61
Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS Biol (2005) 1.59
Protein flexibility and rigidity predicted from sequence. Proteins (2005) 1.58
NORSp: Predictions of long regions without regular secondary structure. Nucleic Acids Res (2003) 1.58
Novel leverage of structural genomics. Nat Biotechnol (2007) 1.57
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
Inferring sub-cellular localization through automated lexical analysis. Bioinformatics (2002) 1.55
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest (2004) 1.55
Structural genomics is the largest contributor of novel structural leverage. J Struct Funct Genomics (2009) 1.52
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Beyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery. Drug Discov Today (2005) 1.46
Dietary fat is not a major determinant of body fat. Am J Med (2002) 1.46
Natively unstructured regions in proteins identified from contact predictions. Bioinformatics (2007) 1.45
Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.45
Lessons from extreme human obesity: monogenic disorders. Endocrinol Metab Clin North Am (2008) 1.45
PEP: Predictions for Entire Proteomes. Nucleic Acids Res (2003) 1.39
CASP6 assessment of contact prediction. Proteins (2005) 1.39
Protein disorder--a breakthrough invention of evolution? Curr Opin Struct Biol (2011) 1.37
Primary carcinoids of the liver: a review of symptoms, diagnosis and treatments. Dig Surg (2008) 1.35
Identifying cysteines and histidines in transition-metal-binding sites using support vector machines and neural networks. Proteins (2006) 1.35
Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr (2005) 1.34
Target space for structural genomics revisited. Bioinformatics (2002) 1.32
Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet (2008) 1.30
Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Hum Mol Genet (2003) 1.28
Solution NMR structure of the NlpC/P60 domain of lipoprotein Spr from Escherichia coli: structural evidence for a novel cysteine peptidase catalytic triad. Biochemistry (2008) 1.27
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab (2006) 1.27
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg (2011) 1.25
Crystal structure of a potassium ion transporter, TrkH. Nature (2011) 1.25
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
PAX4 gene variations predispose to ketosis-prone diabetes. Hum Mol Genet (2004) 1.23
Homologue structure of the SLAC1 anion channel for closing stomata in leaves. Nature (2010) 1.22
Energy intake in weight-reduced humans. Brain Res (2010) 1.21
Challenges and opportunities of defining clinical leptin resistance. Cell Metab (2012) 1.21